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■ Abbreviation / Long Form : SPP / sphingosine-1-phosphate

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Total Number of Papers: 116
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Abbreviation:   SPP  (>> Co-occurring Abbreviation)
Long Form:   sphingosine-1-phosphate
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2016 [Metabolomics analysis on serum biomarkers timing characteristics of type 2 diabetic rats intervened by exercise]. Arg, PLC, STZ, T2DM
2009 Intracellular IL-15 controls mast cell survival. ASMase, BMMCs, CTSD, WT
2008 Trans-fatty acids induce pro-inflammatory responses and endothelial cell dysfunction. HAEC, TFA
2007 Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation. NHLF, ROCK, TGF-beta1
2005 Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells. AP, DHS, PPPP, TNF, TRE
2004 Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1. MDCK, NPRAP, SphK
2003 Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. EDG, GLP-1, PMA
2003 Identification of plateled-derived growth factor-BB as cardiogenesis-inducing factor in mouse embryonic stem cells under serum-free conditions. DMEM, EBs, ES, FCS, PDGF-BB, SRM
2003 Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase. ERK, MAPK
10  2003 VEGF receptor expression and signaling in human bladder tumors. GAP, GEFs, SPK1, VEGFRs
11  2002 Ca+2 homeostasis and cytoskeletal rearrangement operated by sphingosine 1-phosphate in C2C12 myoblastic cells. ---
12  2002 Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. ERK, MITF, PKB
13  2002 Hypergravity affects cell cycle progression and caveolin-1 expression of in vitro cultured human primary endothelial cells. ---
14  2002 Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells. GTPCH, iNOS, TNF-alpha
15  2002 Lipid mediators of angiogenesis and the signalling pathways they initiate. EDG
16  2002 Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response. ECs, SMCs
17  2002 Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells. ARF, LPA, PA, PLD
18  2002 Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. PKC, PLD
19  2002 Sphingosine 1-phosphate evokes calcium signals in C2C12 myoblasts via Edg3 and Edg5 receptors. ODN
20  2002 Sphingosine 1-phosphate induces Ca2+ transients and cytoskeletal rearrangement in C2C12 myoblastic cells. C2C12, EDG
21  2002 The influence of membrane lipid metabolites on lymphocyte potassium channel activity. HDL, LPA, SPC, Sph, TL
22  2002 The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. ---
23  2001 A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells. 2-APB, EDG, ER, LPA, PTX, SPC, Sph
24  2001 An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials. AP, dihydro-SPP, OPA
25  2001 Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. CFTR
26  2001 Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. ---
27  2001 Dual regulation of sphingosine 1-phosphate-induced phospholipase D activity through RhoA and protein kinase C-alpha in C2C12 myoblasts. PKCalpha, PLD, RhoGDI
28  2001 EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. PDGF
29  2001 Effect of phosphatidic acid on human breast cancer cells exposed to doxorubicin. EGF, LPA, PA
30  2001 Genomic analysis of a mouse model of immunoglobulin A nephropathy reveals an enhanced PDGF-EDG5 cascade. EDG5, HIGA, IgAN, PDGF
31  2001 Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release. ---
32  2001 Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats. SPPC
33  2001 Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate. LPA
34  2001 Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo. ---
35  2001 Platelet-released phospholipids link haemostasis and angiogenesis. EDG, LPA, PA, PA
36  2001 Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. GPCR, PDGF
37  2001 Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. EDG, eNOS, PI 3-kinase
38  2001 Sphingosine 1-phosphate receptors. EDG, GPCR, Mil
39  2001 Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. HUVEC
40  2001 Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. EDG-1, SAPK/JNK
41  2001 Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors. GPCRs, PLC
42  2001 Sphingosine kinase: a mediator of vital cellular functions. ---
43  2001 Sphingosine-1-phosphate: an emerging therapeutic target. EDG-1, GPCR
44  2001 Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. SPC
45  2001 The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility. GPCR, PDGF-BB
46  2000 Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. EDG
47  2000 Enhancement of the migration of metastatic human breast cancer cells by phosphatidic acid. LPA, PA, PI
48  2000 Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes. EDG, SPPC
49  2000 Functional characterization of human sphingosine kinase-1. ---
50  2000 High-efficiency transient transfection of endothelial cells for functional analysis. betaARKct, FACS, GFP
51  2000 Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution. DAG, PI, PIP
52  2000 Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. ---
53  2000 Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. SphK1
54  2000 Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. AC, TNF
55  2000 Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. PKC
56  2000 Prenatal alcohol exposure increases TNFalpha-induced cytotoxicity in primary astrocytes. DMS, PAE, SMase
57  2000 Selective stimulation by ceramide of the expression of the alpha isoform of retinoic acid and retinoid X receptors in osteoblastic cells. A role of sphingosine 1-phosphate-mediated AP-1 in the ligand-dependent transcriptional activity of these receptors. AP-1, CAT, DR-5, RAR-alpha, RXRalpha
58  2000 Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility. LPA, PTX, SPPC
59  2000 Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. ---
60  2000 Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor. PLD
61  2000 Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. SPPC
62  2000 Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. EDG, ERK, LPA
63  2000 Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner. ---
64  2000 Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. GPCR, LPA, MAP kinase
65  2000 Sphingosine-1-phosphate: signaling inside and out. ---
66  2000 Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. SPC
67  2000 Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation. ---
68  1999 Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. NGF
69  1999 Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. GPCRs
70  1999 Enzymatic measurement of sphingosine 1-phosphate. ---
71  1999 Evidence that lipoproteins are carriers of bioactive factors. PTX, SPC
72  1999 Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. ---
73  1999 Involvement of focal adhesion kinase in inhibition of motility of human breast cancer cells by sphingosine 1-phosphate. FAK
74  1999 Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. GFP
75  1999 Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. DMS
76  1999 Receptor-mediated activation of phospholipase D by sphingosine 1-phosphate in skeletal muscle C2C12 cells. A role for protein kinase C. PKC, PLD
77  1999 Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes. Cer, ERK2, MAPKs, OLGs, Sph
78  1999 Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptor. EGF, PLC, SPK
79  1999 Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. BAEC, HUVEC
80  1999 Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. ---
81  1999 Sphingosine 1-phosphate: a prototype of a new class of second messengers. ---
82  1999 Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. ---
83  1999 Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. EDG
84  1999 Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? ---
85  1999 Structure-activity analysis of the effects of lysophosphatidic acid on platelet aggregation. cPA
86  1999 The role of glutathione, membrane sphingomyelin, and its metabolites in oxidative stress-induced calcium "dysregulation" in PC12 cells. Cer, GSH, Lcc, OS, Sase, SPH
87  1999 Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. ---
88  1998 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. DMS
89  1998 Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. ---
90  1998 Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells. GPS, SPPC
91  1998 Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. LPA
92  1998 Molecular cloning and functional characterization of murine sphingosine kinase. ---
93  1998 N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. DMS
94  1998 Roles of sphingosine-1-phosphate in cell growth, differentiation, and death. ---
95  1998 Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. PARP, TPA
96  1998 Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. GPCRs, mAChRs, PLC
97  1998 Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. G protein
98  1998 Sphingosine-1-phosphate in cell growth and cell death. ---
99  1997 Activation of mitogen-activated protein kinase is involved in sphingosine 1-phosphate-stimulated interleukin-6 synthesis in osteoblasts. IL-6, MAP
100  1997 Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. DHS, EGF, PDGF