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■ Abbreviation / Long Form : SPR / sepiapterin reductase

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Total Number of Papers: 55
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Abbreviation:   SPR  (>> Co-occurring Abbreviation)
Long Form:   sepiapterin reductase
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No. Year Title Co-occurring Abbreviation
2020 Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice. CAIA
2019 Analysis of Catecholamines and Pterins in Inborn Errors of Monoamine Neurotransmitter Metabolism-From Past to Future. AADC, CSF, DHPR, PCD, PTPS, TH
2019 Anti-tumor effect of sulfasalazine in neuroblastoma. i.p, NB, NO, SSZ
2019 CRISPR/Cas9 Ribonucleoprotein-mediated Precise Gene Editing by Tube Electroporation. Cas9, DeepSeq, EGFR, HBB, IL2RG, RNP, ssODN, TE
2019 Genetic study in a family with dopa-responsive dystonia revealed a novel mutation in sepiapterin reductase gene. WES
2019 Persistently Upregulated Hippocampal mTOR Signals Mediated by Fecal SCFAs Impair Memory in Male Pups with SMM Exposure in Utero. mTOR, PI3K, PND, S6K1, SCFAs, SMM
2019 Pharmacological Assessment of Sepiapterin Reductase Inhibition on Tactile Response in the Rat. ---
2019 Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard. BCO2
2019 Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway. hSPR
10  2018 Combining Human and Rodent Genetics to Identify New Analgesics. GCH1
11  2018 De novo tetrahydrobiopterin biosynthesis is impaired in the inflammed striatum of parkin(-/-) mice. LPS, PD
12  2017 A novel tyrosine hydroxylase variant in a group of Chinese patients with dopa-responsive dystonia. DRD, TH
13  2017 Expression and Enzyme Activity Detection of a Sepiapterin Reductase Gene from Musca domestica Larva. SP
14  2017 Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia. NO
15  2016 Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid. ---
16  2015 Combined Sepiapterin Reductase and Methylmalonyl-CoA Epimerase Deficiency in a Second Patient: Cerebrospinal Fluid Polyunsaturated Fatty Acid Level and Follow-Up Under L-DOPA, 5-HTP and BH4 Trials. MCEE, MMA, SRD
17  2015 Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target. NB, PA, SSZ
18  2015 Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. ---
19  2015 Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase. ROS
20  2015 Valproic acid exposure leads to upregulation and increased promoter histone acetylation of sepiapterin reductase in a serotonergic cell line. HDACi, VPA
21  2014 Clinical and genetic studies in a family with a novel mutation in the sepiapterin reductase gene. ---
22  2014 Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation. NB, ODC
23  2013 Increase in tetrahydrobiopterin concentration with aging in the cerebral cortex of the senescence-accelerated mouse prone 10 strain caused by abnormal regulation of tetrahydrobiopterin biosynthesis. DHFR, SAMP10, TH
24  2013 Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis. EnMT, eNOS, GCH1, iNOS, IPF, NOS
25  2013 Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. ---
26  2012 A homozygous frameshift mutation of sepiapterin reductase gene causing parkinsonism with onset in childhood. SRD
27  2012 Analgesia by inhibiting tetrahydrobiopterin synthesis. GCH1, SSZ
28  2012 Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension. eNOS
29  2011 Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease. GEO-PD, PD, UTR
30  2010 Dystonia-plus syndromes. AR, DRD, M-D, SGCE, TH
31  2010 Identification of genes influencing skeletal phenotypes in congenic P/NP rats. aBMD, BMC, FDR, LEW, NP, NPY, qPCR, QTL, vBMD
32  2010 The tetrahydrobiopterin pathway and pain. GCH1
33  2009 Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia. PTS, TH
34  2009 Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues. HPA
35  2009 Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. ---
36  2009 Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. RNAi
37  2009 The silkworm mutant lemon (lemon lethal) is a potential insect model for human sepiapterin reductase deficiency. lem
38  2008 A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease. ---
39  2008 Proteomic analysis of embryonic stem cell-derived neural cells exposed to the antidepressant paroxetine. ---
40  2007 Molecular genetics of tetrahydrobiopterin (BH4) deficiency in the Maltese population. aPKU, DHPR, DRD, SR
41  2007 Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. PD
42  2006 A murine model for human sepiapterin-reductase deficiency. ---
43  2006 The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations. LD, SNP
44  2006 The zebrafish mutation m865 affects formation of dopaminergic neurons and neuronal survival, and maps to a genetic interval containing the sepiapterin reductase locus. ---
45  2004 Heterozygous mutation in 5'-untranslated region of sepiapterin reductase gene (SPR) in a patient with dopa-responsive dystonia. DRD
46  2003 Effect of antisense oligodeoxynucleotide for sepiapterin reductase on the viability of PC12 cells in the presence of exogenous carbonyl compounds. SDR
47  2003 Genetic engineering of Escherichia coli for production of tetrahydrobiopterin. E. coli, GCH-I, PTPS
48  2003 Localization of sepiapterin reductase in pigment cells of Oryzias latipes. ---
49  2002 Disorders of tetrahydrobiopterin metabolism and their treatment. DHPR, GTP, GTPCH, HPA, PCD
50  2002 Localization of sepiapterin reductase in the human brain. CN, CTX, GCH, hSPR, MO, NOS, SN, TH
51  2002 Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II. rSPR
52  1999 Cloning of mouse sepiapterin reductase gene and characterization of its promoter region. ---
53  1999 Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase. SDR
54  1998 Genomic organization and chromosomal localization of the human sepiapterin reductase gene. ---
55  1992 The properties of monoclonal antibody against sepiapterin reductase from fat body of the silkworm, Bombyx mori. ---