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■ Abbreviation / Long Form : Smac / second mitochondria-derived activator of caspase

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Total Number of Papers: 248
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Abbreviation:   Smac  (>> Co-occurring Abbreviation)
Long Form:   second mitochondria-derived activator of caspase
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No. Year Title Co-occurring Abbreviation
2020 Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE. IAP, XIAP
2020 ANTP-SmacN7 fusion peptide-induced radiosensitization in A549 cells and its potential mechanisms. ANTP
2020 Biomarker profile for prediction of response to SMAC mimetic monotherapy in pediatric precursor B-cell acute lymphoblastic leukemia. BCP-ALL, IAPs
2020 Molecular basis of SMAC-XIAP binding and the effect of electrostatic polarization. BIR, MD, XIAP
2020 Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy. IAP, IAPs, SMs
2020 Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B-cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis. CFZ, CI, cIAP, CRISPR, DLBCL, MMP, pre
2020 SMAC mimetic birinapant inhibits hepatocellular carcinoma growth by activating the cIAP1/TRAF3 signaling pathway. cIAP1, TRAF3
2020 Smac mimetic promotes TNF-alpha to induce apoptosis of gallbladder carcinoma cells. RIPK1, TNF-alpha
2020 SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases. IAPs, MAPKs, NF-kappaB, RIPKs, SMs
10  2020 The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells. IAPs, MPN
11  2020 Tumor necrosis factor‑related apoptosis‑inducing ligand as a therapeutic option in urothelial cancer cells with acquired resistance against first‑line chemotherapy. cIAP, TRAIL, XIAP
12  2019 A novel thermogel system of self-assembling peptides manipulated by enzymatic dephosphorylation. EISA, IGF
13  2019 Bivalent SMAC Mimetics for Treating Cancer by Antagonizing Inhibitor of Apoptosis Proteins. BIR2, IAPs, XIAP
14  2019 Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics. ADPKD
15  2019 Gemcitabine combined with an engineered oncolytic vaccinia virus exhibits a synergistic suppressive effect on the tumor growth of pancreatic cancer. OVV, PC
16  2019 Induction of Necroptosis in Human Breast Cancer Drug-Resistant Cells by SMAC Analog LCL161 After Caspase Inhibition Requires RIP3. IAP
17  2019 Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives. IAP, IAPs, PCD
18  2019 Inhibitor of apoptosis proteins are potential targets for treatment of granulosa cell tumors - implications from studies in KGN. GCTs, IAPs, TMA
19  2019 LCL161, a SMAC-mimetic, Preferentially Radiosensitizes Human Papillomavirus-negative Head and Neck Squamous Cell Carcinoma. HNSCC, IAP
20  2019 Overexpression of Smac is associated with the development of primary Sjogren's syndrome. ESR, pSS
21  2019 Role of Smac, survivin, XIAP, and Omi/HtrA2 proteins in determining the chemotherapeutic response of patients with cervical cancer treated with neoadjuvant chemotherapy. NACT, XIAP
22  2019 Single-domain antibody fusion proteins can target and shuttle functional proteins into macrophage mannose receptor expressing macrophages. sdAbs, SFPs, TAMs
23  2019 SMAC Mimetic Debio 1143 and Ablative Radiation Therapy Synergize to Enhance Antitumor Immunity against Lung Cancer. ART, MDSC, TAM
24  2019 Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress. CHOP, cIAP, ER, GRP78, IAP, NF-kappaB, PERK, TG, TM, UPR, XBP1
25  2019 SMAC mimetics as potential cancer therapeutics in myeloid malignancies. IAPs
26  2019 SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation. IAPs, IL-17, NIK, Th17
27  2019 Sp3-cificity of TNF-alpha expression promotes the Smac mimetic-mediated killing of cancer cells. SP3, TNF-alpha
28  2019 Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro. aa, AREL1, NEDD4
29  2019 Targeting inhibitors of apoptosis in oral squamous cell carcinoma invitro. FasL, FasR, IAPs, Nec-1
30  2019 The modulation of Smac/DIABLO on mitochondrial apoptosis induced by LPS in Crassostrea gigas. IAP, LPS, RNAi
31  2019 The Neuroprotective Effect of miR-181a After Oxygen-Glucose Deprivation/Reperfusion and the Associated Mechanism. IAPs, XIAP
32  2018 A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity. HBV, HCC, IAPs
33  2018 Application of Native ESI-MS to Characterize Interactions between Compounds Derived from Fragment-Based Discovery Campaigns and Two Pharmaceutically Relevant Proteins. CDK2, ESI-MS, FBDD, ITC, XIAP
34  2018 Cationic liposome co-encapsulation of SMAC mimetic and zVAD using a novel lipid bilayer fusion loaded with MLKL-pDNA for tumour inhibition in vivo. MLKL
35  2018 Chrysotoxene induces apoptosis of human hepatoblastoma HepG2 cells in vitro and in vivo via activation of the mitochondria-mediated apoptotic signaling pathway. Apaf-1, Bax, Bcl-2
36  2018 Combination of a Latency-Reversing Agent With a Smac Mimetic Minimizes Secondary HIV-1 Infection in vitro. HIV-1, LRAs
37  2018 DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death. IAP, XIAP
38  2018 Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1. MAPK, MK2, Ripk1, TNF-alpha, XIAP
39  2018 Efficacy of phosphocreatine pre-administration on XIAP and Smac in ischemic penumbra of rats with focal cerebral ischemia reperfusion injury. CIRI, IR, PCr-PA, SD, XIAP
40  2018 MAP30 promotes apoptosis of U251 and U87 cells by suppressing the LGR5 and Wnt/beta-catenin signaling pathway, and enhancing Smac expression. LGR5, MAP30
41  2018 MOMP, cell suicide as a BCL-2 family business. MOMP
42  2018 MOMP, cell suicide as a BCL-2 family business. MOMP
43  2018 Restoring the switch for cancer cell death: Targeting the apoptosis signaling pathway. BH3, MDM2
44  2018 Resveratrol Sensitizes Carfilzomib-Induced Apoptosis via Promoting Oxidative Stress in Multiple Myeloma Cells. CFZ, MM, ROS, RSV
45  2018 SMAC protein expression as a potent favorable prognostic factor in locally advanced breast cancer. DFS, LABC, NCT
46  2018 The SMAC Mimetic APG-1387 Sensitizes Immune-Mediated Cell Apoptosis in Hepatocellular Carcinoma. HCC, IAP, TNF-alpha, TRAIL, XIAP
47  2018 The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma. IAP, RGV, RRCLs
48  2018 XIAP impairs mitochondrial function during apoptosis by regulating the Bcl-2 family in renal cell carcinoma. Apaf-1, cyt c, MOMP, XIAP
49  2017 Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications. CD36
50  2017 Downregulation of Smac attenuates H2O2-induced apoptosis via endoplasmic reticulum stress in human lens epithelial cells. ERS, HLEC
51  2017 Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis. HSF1, HSPs
52  2017 Hyperosmotic stress enhances cytotoxicity of SMAC mimetics. IAP, SM, TNF
53  2017 IAPs protect host target tissues from graft-versus-host disease in mice. B6-WT, BMT, cIAP, GVHD, IAPs, XIAP
54  2017 Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-Mediated Destruction of Intestinal Epithelial Cells. IAPs, TNF, YAMC
55  2017 Isoimperatorin induces apoptosis of the SGC-7901 human gastric cancer cell line via the mitochondria-mediated pathway. Bax, Bcl-2, Bcl-xL, Mcl-1
56  2017 NCTD promotes Birinapant-mediated anticancer activity in breast cancer cells by downregulation of c-FLIP. c-FLIP, c-FLIPL, c-FLIPS
57  2017 Negative correlation between X-linked inhibitors of apoptosis and second mitochondria-derived activator of caspase expression levels in cervical carcinoma and cervical intraepithelial neoplasia. CIN, XIAP
58  2017 Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs). IAPs, IAPs, PCD
59  2017 Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice. CRC, RIP3
60  2017 Selective replication of oncolytic virus M1 results in a bystander killing effect that is potentiated by Smac mimetics. IAPs
61  2017 Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms. ---
62  2017 Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells. ALL, AML, MLKL, RIP, TNF
63  2017 Synergistic antitumor effects of CDK inhibitor SNS‑032 and an oncolytic adenovirus co‑expressing TRAIL and Smac in pancreatic cancer. CDK, TRAIL
64  2017 Synergistic Effects of a Smac Mimetic with Doxorubicin Against Human Osteosarcoma. IAPs
65  2017 Tetramethylpyrazine Protects against Early Brain Injury after Experimental Subarachnoid Hemorrhage by Affecting Mitochondrial-Dependent Caspase-3 Apoptotic Pathway. Bcl-2, cyt c, SAH, TMP
66  2017 The SMAC mimetic birinapant attenuates lipopolysaccharide-induced liver injury by inhibiting the tumor necrosis factor receptor-associated factor 3 degradation in Kupffer cells. cIAP1, LPS, MAPK, TRAF3
67  2017 The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer. IAPs, XIAP
68  2017 Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways. FADD, HNSCC, IAP
69  2016 Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL. ALL, RIP1, SM
70  2016 An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924). IAPs, NAE
71  2016 Application of constrained aza-valine analogs for Smac mimicry. ---
72  2016 Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis. BIR, FP, IAP, LTalpha, SAR, TNF
73  2016 Chemosensitization of Prostate Carcinoma Cells with a Receptor-directed Smac Conjugate. BPH, HEK, IAPs
74  2016 Differential susceptibility to acetaminophen-induced liver injury insub-strains of C57BL/6 mice: 6N versus 6J. AIF
75  2016 Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy. TRAIL, XIAP
76  2016 Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway. AIF, Cyt C, EndoG, GC, MMP, ROS
77  2016 Oxidative Stress and Cell Apoptosis in Caprine Liver Induced by Molybdenum and Cadmium in Combination. caspase-3, Cd, Cp, Cyt C, MDA, Mo, mRNA, NO, NOS, T-AOC, T-SOD
78  2016 RSL3 and Erastin differentially regulate redox signaling to promote Smac mimetic-induced cell death. ALL, alpha-Toc, DFO, Fer, ROS
79  2016 Smac mimetic triggers necroptosis in pancreatic carcinoma cells when caspase activation is blocked. IAP, MLKL, PC, RIP, RIPK3, TNF, TNFR1
80  2016 Targeting Inhibitor of Apoptosis Proteins Protects from Bleomycin-Induced Lung Fibrosis. cIAP, IAP, XIAP
81  2016 The SMAC mimetic BV6 induces cell death and sensitizes different cell lines to TNF-alpha and TRAIL-induced apoptosis. NF-kappaB, NIK, TNF-alpha, TRAIL
82  2016 The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock. IAPs
83  2016 USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics. cIAPs
84  2016 XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC. fSmac, mSmac, XIAP
85  2016 [Radiosensitization Induced by ANTP-SmacN7 Fusion Peptide in H460 Cell Line]. ---
86  2015 A Phase I Study of the SMAC-Mimetic Birinapant in Adults with Refractory Solid Tumors or Lymphoma. IAP, MTD, PK/PD
87  2015 Beclin-1-independent autophagy mediates programmed cancer cell death through interplays with endoplasmic reticulum and/or mitochondria in colbat chloride-induced hypoxia. Atg5, C/EBP, ER, PCD
88  2015 Bypassing the need for pre-sensitization of cancer cells for anticancer TRAIL therapy with secretion of novel cell penetrable form of Smac from hA-MSCs as cellular delivery vehicle. hA-MSC-ST, TRAIL, XIAP
89  2015 Combination effects of SMAC mimetic birinapant with TNFalpha, TRAIL, and docetaxel in preclinical models of HNSCC. HNSCC, TNF-alpha, TRAIL
90  2015 Effect of Second mitochondria-derived activator of caspase in combination with Docetaxel on lung cancer cell A549. ---
91  2015 Effect of Smac in combination with cisplatin on esophageal cancer cell line ECA109. ---
92  2015 Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury. ATP, GGA, HSP72, I/R, XIAP
93  2015 Indomethacin induces apoptosis in the EC109 esophageal cancer cell line by releasing second mitochondria-derived activator of caspase and activating caspase-3. NSAIDs
94  2015 Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma. VSV
95  2015 LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging. AEC-CP, bLF, CT, EpCAM, ERK, FADD, IL, KC, LNA, MAPK, MRI, NCs, NIR, NPs, NT, TAR
96  2015 Phosphorylation of Smac by Akt promotes the caspase-3 activation during etoposide-induced apoptosis in HeLa cells. XIAP
97  2015 Proapoptotic activity of a monomeric smac mimetic on human fibroblast-like synoviocytes from patients with rheumatoid arthritis. FLS, IAPs, RA
98  2015 Promises and Challenges of Smac Mimetics as Cancer Therapeutics. IAP
99  2015 Reversal of Chemoresistance in Human Lung Cancer Cell Line A549/Taxol by Synthetic Second Mitochondria-Derived Activator of Caspase Peptide. IAPs
100  2015 Role of Smac in apoptosis of lung cancer cells A549 induced by Taxol. IAPs