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■ Abbreviation / Long Form : SphK / sphingosine kinase

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Total Number of Papers: 248
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Abbreviation:   SphK  (>> Co-occurring Abbreviation)
Long Form:   sphingosine kinase
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No. Year Title Co-occurring Abbreviation
2019 De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer. DH-S1P, FASN, S1P, SPHK1 and 2
2019 Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus. pDCs
2019 Light Stress-Induced Increase of Sphingosine 1-Phosphate in Photoreceptors and Its Relevance to Retinal Degeneration. S1P
2019 Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium. DCs, MV, S1P
2019 Protective role of epigallocatechin-3-gallate in NADPH oxidase-MMP2-Spm-Cer-S1P signalling axis mediated ET-1 induced pulmonary artery smooth muscle cell proliferation. BPASMCs, EGCG, ET-1, PASMC, S1P, SMase
2019 Pseudomonas aeruginosa stimulates nuclear sphingosine-1-phosphate generation and epigenetic regulation of lung inflammatory injury. CF, PA, PKC, S1P
2019 Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages. S1P, S1P3
2019 S1P mediates human amniotic cells proliferation induced by a 50-Hz magnetic field exposure via ERK1/2 signaling pathway. ELF-EMF, MF, S1P
2019 Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells. ESC, IL-1beta, mRNA, S1P
10  2019 Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation. LPS
11  2019 SPHK1 Is a Novel Target of Metformin in Ovarian Cancer. S1P
12  2019 Targeting Ceramide Metabolism in Hepatocellular Carcinoma: New Points for Therapeutic Intervention. HCC
13  2019 The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy. S1P
14  2019 Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls. HC, S1P, S1P1-5, T2D
15  2018 Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes beta-Cell Impairment via Mitochondrial Dysregulation. GSIS, Mfn1, MIN6, PHB, S1P, SphKi
16  2018 Essential Role of Sphingosine Kinase 2 in the Regulation of Cargo Contents in the Exosomes from K562 Cells. DMS, S1P
17  2018 Inhibition of SphK2 Stimulated Hepatic Gluconeogenesis Associated with Dephosphorylation and Deacetylation of STAT3. ---
18  2018 Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia. S1P, tGCI
19  2018 Involvement of released sphingosine 1-phosphate/sphingosine 1-phosphate receptor axis in skeletal muscle atrophy. S1P, SkM
20  2018 Mast cells and sphingosine-1-phosphate underlie prelesional remodeling in a mouse model of eczema. AD, MC, S1P
21  2018 Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism. ASD, S1P, VPA
22  2018 Nuclear Insulin-Like Growth Factor Binding Protein-3 As a Biomarker in Triple-Negative Breast Cancer Xenograft Tumors: Effect of Targeted Therapy and Comparison With Chemotherapy. EGFR, IGFBP-3, IHC, S1P, TNBC
23  2018 Sphingolipids in early viral replication and innate immune activation. HBV, IFN, S1P
24  2018 Sphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase. CS, MV, PEEP, S1PL, VILI
25  2018 Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. alpha-SMA, BDL, BMT, HSCs, KCs, WT
26  2018 Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice. ALL
27  2018 Sphingosine-1-Phosphate Modulates the Effect of Estrogen in Human Osteoblasts. HOB, S1P, S1PR1, SKI, STAT
28  2018 SPHK-2 Promotes the Particle-Induced Inflammation of RAW264.7 by Maintaining Consistent Expression of TNF-alpha and IL-6. IL, SphKs, TNF
29  2018 Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT. Chk2, DDR, MC, S1P
30  2018 Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice. IAV
31  2017 "Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer. ---
32  2017 Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents. ACh
33  2017 Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits. S1P
34  2017 Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling. 5-FU, HCC
35  2017 Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats. IR, P/A, S1P, S1PL
36  2017 Fas/S1P1 crosstalk via NF-kappaB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis. RA, RANKL, S1P1, TMJ
37  2017 Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade. TNBC
38  2017 Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer. CI, ER, SKI-II
39  2017 Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget. ---
40  2017 Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. DEN, S1P
41  2017 Neutrophil extracellular traps are critical for pregnancy loss in sphingosine kinase-deficient mice on 129Sv/C57BL/6 background. NETs, PAD4
42  2017 Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. Cer, GJ, GJIC, S1P, SL
43  2017 Sphingolipid Metabolism of a Sea Anemone Is Altered by the Presence of Dinoflagellate Symbionts. S1P, Sph
44  2017 Sphingosine kinase 1/sphingosine-1-phosphate (S1P)/S1P receptor axis is involved in ovarian cancer angiogenesis. MVD, S1P, S1PR
45  2017 Sphingosine-1-phosphate is involved in inflammatory reactions in patients with Graves' orbitopathy. COX-2, GO, ICAM-1, IL, S1P
46  2017 Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. 3'UTR, miRNA, S1P, TIMP-3
47  2017 Targeting sphingosine-1-phosphate signaling for cancer therapy. S1P, S1PR1-5
48  2017 The role of sphingolipid signalling in diabetes‑associated pathologies (Review). GPCRs, S1P, Sph
49  2017 Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity. S1P
50  2016 Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. BP, MCAO, OGD, S1P
51  2016 Cross talk between MMP2-Spm-Cer-S1P and ERK1/2 in proliferation of pulmonary artery smooth muscle cells under angiotensin II stimulation. SMase
52  2016 Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice. COX-2, DSS, IL, S1P, SAR
53  2016 Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts. FB1, HDAC, MEFs, NTDs, Sa, SA1P
54  2016 Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. ALF, IkappaB, IL, NF-kappaB, RHDV, S1P, TLR, TNF-alpha
55  2016 Sphingosine 1-phosphate in metabolic syndrome (Review). MetS, S1P
56  2016 Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1alpha. HIF, HRE, S1P
57  2016 Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. BCAS, HIF, OPC, S1P, WML
58  2016 [The drug development based on sphingosine-1-phosphate signaling pathway]. S1P, S1PR
59  2015 Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice. ATF, ER, FA, HFD, S1P, UPR
60  2015 Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. S1P, S1P1
61  2015 Differential modulation of S1PR(1-5) and specific activities of SphK and nSMase in pulmonary and cerebral tissues of rats exposed to hypobaric hypoxia. nSMase, S1P, S1PR1-5
62  2015 Drugging sphingosine kinases. S1P, Sph
63  2015 Increased SPHK2 Transcription of Human Colon Cancer Cells in Serum-Depleted Culture: The Involvement of CREB Transcription Factor. ---
64  2015 Inhibition of sphingosine kinase prevents lipopolysaccharide-induced preterm birth and suppresses proinflammatory responses in a murine model. ---
65  2015 Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet. DAG, HFHS, LFD, TAG
66  2015 Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. oxLDL, S1P
67  2015 Role of Spm-Cer-S1P signalling pathway in MMP-2 mediated U46619-induced proliferation of pulmonary artery smooth muscle cells: protective role of epigallocatechin-3-gallate. EGCG, PASMCs, S1P, SMase, Spm-Cer-S1P, TXA2
68  2015 Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo. S1P
69  2015 Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. CAMP, KC, MHP, S1P
70  2015 Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells. CRC, ER, S1P
71  2015 Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. S1P
72  2015 Sphingosine Kinase Regulates Microtubule Dynamics and Organelle Positioning Necessary for Proper G1/S Cell Cycle Transition in Trypanosoma brucei. TbSPHK
73  2015 Sphingosine-1-Phosphate Is a Crucial Signal for Migration of Retina Muller Glial Cells. ERK/MAPK, PI3K, S1P, SphKI 2
74  2015 Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors. S1P
75  2014 Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen. ABC, S1P, S1PRs, Spns2
76  2014 Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors. S1P
77  2014 Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons. iPSC, NPC, PNs, VEGF
78  2014 S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer. IBD, S1P
79  2014 Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells. DGKtheta, DHEA, HMG-CoA red, PLD, SF-1, shRNA, SREBPs
80  2014 Sphingosine kinase (SphK) 1 and SphK2 play equivalent roles in mediating insulin's mitogenic action. ---
81  2014 Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. KSHV, PEL, S1P
82  2013 A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. AHR, NF-kappaB, OVA, S1P
83  2013 Aberrant sphingolipid metabolism in the human fallopian tube with ectopic pregnancy. S1P, S1P1-5
84  2013 Cationic ceramides and analogues, LCL30 and LCL85, as adjuvants to photodynamic therapy of tumors. DES, PDT, SL
85  2013 Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors. DMS, HPPCn, HSC, S1P, S1PRs, TNF-alpha
86  2013 Increased expression of sphingosine kinase in the amnion during labor. PTGS, S1P
87  2013 Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets. S1P
88  2013 Sphingosine 1-phosphate and cancer: lessons from thyroid cancer cells. S1P
89  2013 Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells. ERK, S1P
90  2013 Sphingosine kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine kinase 2. ---
91  2013 Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis. HSCs, S1P, S1PR, SKI
92  2013 Sphingosine kinase: a novel putative target for the prevention of infection-triggered preterm birth. ET-1, PROM, S1P
93  2013 Structure guided design of a series of sphingosine kinase (SphK) inhibitors. S1P, SphKs
94  2013 Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. IPF, S1P, TGF-beta
95  2012 A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression. OGD, S1P
96  2012 Bone marrow-derived mesenchymal stem cells differentiate to hepatic myofibroblasts by transforming growth factor-beta1 via sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis. BMSCs, S1P, TGF-beta1
97  2012 Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis. ABA, PA, phyto-S1P, WT
98  2012 Contrary effects of sphingosine-1-phosphate on expression of alpha-smooth muscle actin in transforming growth factor beta1-stimulated lung fibroblasts. alpha-SMA, S1P, TGF-beta1
99  2012 Crosstalk between Phospholipase D and Sphingosine Kinase in Plant Stress Signaling. ABA, PA, phyto-S1P, PLD
100  2012 Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. S1P