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■ Abbreviation / Long Form : TAK1 / TGF-beta-activated kinase 1

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Total Number of Papers: 278
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Abbreviation:   TAK1  (>> Co-occurring Abbreviation)
Long Form:   TGF-beta-activated kinase 1
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
1  2020 A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation. EBV, IKK2, JNK, LMP1, Tpl2
2  2020 CALML6 Controls TAK1 Ubiquitination and Confers Protection against Acute Inflammation. CALML6
3  2020 Dichotomous role of TGF-beta controls inducible regulatory T-cell fate in allergic airway disease through Smad3 and TGF-beta-activated kinase 1. FOXP3
4  2020 Differences in the sensitivity of classically and alternatively activated macrophages to TAK1 inhibitor-induced necroptosis. RIPK1
5  2020 DUSP11 Attenuates Lipopolysaccharide-Induced Macrophage Activation by Targeting TAK1. ---
6  2020 Effects of intermittent hypoxia on cell survival and inflammatory responses in the intertidal marine bivalves Mytilus edulis and Crassostrea gigas. ---
7  2020 Expression of high mobility group B1 and toll-like receptor-nuclear factor kappaB signaling pathway in chronic subdural hematomas. CSDH, HMGB1, IKKbeta, IL-6, IRAK4, IRF3, MyD88, NF-kappaB, TLRs, TRAF6
8  2020 Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia. CNS, GVHD
9  2020 Hepatic Regulator of G protein Signaling 5 Ameliorates NAFLD by Suppressing TAK1-JNK/p38 Signaling. GPCR, NAFLD, RGS
10  2020 IL-1beta dysregulates cGMP signaling in the newborn lung. cGMP, NF-kappaB, RelA
11  2020 Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-kappaB activation through interaction with TAK1 and IKK complex. DRG, IKK, LPS, MAPKs, MrgprD, TLR4
12  2020 Modulating TAK1 Expression Inhibits YAP and TAZ Oncogenic Functions in Pancreatic Cancer. GSK
13  2020 Protective Effects of Lixisenatide against Lipopolysaccharide-Induced Inflammation Response in MAC-T Bovine Mammary Epithelial Cells: A Therapeutic Implication in Mastitis. GLP-1, IL-1beta, IL-6, LPS, MECs, MMP-2, MyD88, NADPH, NF-kappaB, ROS, TLR4, TNF-alpha
14  2020 PSPH induces cell autophagy and promotes cell proliferation and invasion in the hepatocellular carcinoma cell line Huh7 via the AMPK/mTOR/ULK1 signaling pathway. CaMKK, HCC, LKB1, PSPH
15  2020 Recent Advances in Understanding Mechanisms of TGF Beta Signaling and Its Role in Glioma Pathogenesis. MAPK, TGF-beta
16  2020 Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer. EMT, FGFR1, GC
17  2020 Small molecule inhibition of non-canonical (TAK1-mediated) BMP signaling results in reduced chondrogenic ossification and heterotopic ossification in a rat model of blast-associated combat-related lower limb trauma. BMP, HO, MPCs, OCPs
18  2020 TAK1 is a pivotal therapeutic target for tumor progression and bone destruction in myeloma. BMSCs, MM, RANKL, VCAM-1
19  2020 TAK1 signaling activity links the mast cell cytokine response and degranulation in allergic inflammation. OZ
20  2020 TGF-beta-activated kinase 1 (TAK1) mediates cadmium-induced autophagy in osteoblasts via the AMPK / mTORC1 / ULK1 pathway. Cd, OB
21  2020 Tripartite motif-containing 27 attenuates liver ischemia/reperfusion injury by suppressing TAK1 via TAB2/3 degradation. I/R, TRIM27, Trim27-KO mice
22  2020 WNK1-TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages. JNK, LPS, MAPK, NF-kappaB, shRNA
23  2019 A mouse model for functional dissection of TAB1 O-GlcNAcylation. S393A, TAB1
24  2019 Bone Metastasis Phenotype and Growth Undergo Regulation by Micro-Environment Stimuli: Efficacy of Early Therapy with HGF or TGFbeta1-Type I Receptor Blockade. HAI-1, HGF, RI, TGF-beta1
25  2019 Creg in Hepatocytes Ameliorates Liver Ischemia/Reperfusion Injury in a TAK1-Dependent Manner in Mice. I/R, MAPK
26  2019 Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death. ---
27  2019 Exercise ameliorates insulin resistance via regulating TGFbeta-activated kinase 1 (TAK1)-mediated insulin signaling in liver of high-fat diet-induced obese rats. DUSP14, HFD, IRS-1, JNK1, TRAF3, TRIM8, USP4
28  2019 Growth/differentiation factor 15 causes TGFbeta-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension. GDF15, MCT, PAH, TA
29  2019 Incremental load training improves renal fibrosis by regulating the TGF‑beta1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice. MAPK, TGF, YC group
30  2019 Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology. BBB, BECs, EndoMT, IL, MS, TFs, TGF
31  2019 IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion. HIPK2, IRF6, MEE, TGF-beta3
32  2019 Kaempferol reduces K63-linked polyubiquitination to inhibit nuclear factor-kappaB and inflammatory responses in acute lung injury in mice. ALI, ARDS, IRAK1, KPF, LPS, NF-kappaB, TRAF6
33  2019 LRRC62 attenuates Toll-like receptor signaling by deubiquitinating TAK1 via CYLD. LRRC62, TLR
34  2019 MPB, a novel berberine derivative, enhances lysosomal and bactericidal properties via TGF-beta-activated kinase 1-dependent activation of the transcription factor EB. TFEB
35  2019 Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells. TREG
36  2019 Octreotide remits endoplasmic reticulum stress to reduce autophagy of intestinal epithelial cell line Caco-2 via upregulation of miR-101. ERS, GPR78, LPS, miR, OCT
37  2019 Oxidization of TGFbeta-activated kinase by MPT53 is required for immunity to Mycobacterium tuberculosis. Mtb
38  2019 RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury. LPC
39  2019 Role of cannabinoid receptor 2 in mediating interleukin-1beta-induced inflammation in rheumatoid arthritis synovial fibroblasts. AP-1, CB2, COX-2, NF-kappaBp65, RASFs, siRNA
40  2019 Role of TGF-beta-activated kinase 1 (TAK1) activation in H5N1 influenza A virus-induced c-Jun terminal kinase activation and virus replication. IAV, JNK, MKK4, NS1
41  2019 TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity. ECs
42  2019 TAK1 regulates endothelial cell necroptosis and tumor metastasis. ---
43  2019 TGF-beta-induced alternative splicing of TAK1 promotes EMT and drug resistance. EMT, NF-kappaB, PCBP1, Rbfox2, TGF-beta
44  2019 Transforming Growth Factor beta-Activated Kinase 1 Regulates Mesenchymal Stem Cell Proliferation Through Stabilization of Yap1/Taz Proteins. BM-MSCs
45  2019 USP19 Inhibits TNF-alpha- and IL-1beta-Triggered NF-kappaB Activation by Deubiquitinating TAK1. USP
46  2018 A recognizable systemic connective tissue disorder with polyvalvular heart dystrophy and dysmorphism associated with TAB2 mutations. TAB2, WES
47  2018 Activation of TGF-beta-activated kinase 1 (TAK1)restricts Salmonella Typhimurium growth by inducing AMPK activation and autophagy. AMPK, mTOR, SCV, ULK1
48  2018 Angiotensin-converting enzyme inhibitor works as a scar formation inhibitor by down-regulating Smad and TGF-beta-activated kinase 1 (TAK1) pathways in mice. ACE, ACEI, KO
49  2018 Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. GSDMD, GSDME
50  2018 Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-kappaB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells. AP-1, COX-2, DCEO, ELISA, ERK, IL-1beta, IL-6, iNOS, IRAK, IRAK1, IRF3, JNK, LPS, MCP-1, MIP, NF-kappaB, NO, PGE2, PI3K, qRT-PCR, TBK1, TNF-alpha
51  2018 Effect of TAK1 on osteogenic differentiation of mesenchymal stem cells by regulating BMP-2 via Wnt/beta-catenin and MAPK pathway. ALP, BSP, MSCs, OSC
52  2018 GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice. IL, iNOS, LPS, NF, TGF, TNF
53  2018 Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. GDF11, TGF-beta
54  2018 Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates. ALS, AMPK, ATG7, mTOR, S6K1, SOD1, ULK1
55  2018 MicroRNA 143-5p regulates alpaca melanocyte migration, proliferation and melanogenesis. miRNAs, MITF, UTR
56  2018 MicroRNA-26b inhibits the immune response to Mycobacterium tuberculosis (M.tb) infection in THP-1 cells via targeting TGFbeta-activated kinase-1 (TAK1), a promoter of the NF-kappaB pathway. Mtb, TB
57  2018 NF-kappaB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification. BMPs, FOP
58  2018 Octreotide Alleviates Autophagy by Up-Regulation of MicroRNA-101 in Intestinal Epithelial Cell Line Caco-2. LPS, OCT, TEER
59  2018 Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy. 3-MA, alpha-SMA, ECM, EGFR, HN, NF-kappaB, TGF-beta1
60  2018 Pristimerin Inhibits LPS-Triggered Neurotoxicity in BV-2 Microglia Cells Through Modulating IRAK1/TRAF6/TAK1-Mediated NF-kappaB and AP-1 Signaling Pathways In Vitro. IRAK1, LPS, NO, RANTES, TGF-beta1, TNF-alpha, TRAF6
61  2018 Retinal neuroinflammatory induced neuronal degeneration - Role of toll-like receptor-4 and relationship with gliosis. CT, DIV, GFAP, GS, LPS, TLR4
62  2018 Role of TGF-beta activated kinase-1 inhibitor on the interaction between macrophages and mesangial cells on the condition of high glucose. TAB1
63  2018 TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth. MT
64  2018 TAK1 inhibition ameliorates survival from graft-versus-host disease in an allogeneic murine marrow transplantation model. allo-HCT, GVHD
65  2018 TAK1 regulates skeletal muscle mass and mitochondrial function. ---
66  2018 TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. ERK, NLR, TLR, TNF
67  2018 TGF-beta Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction. ECM
68  2017 Abscisic acid induces a transient shift in signaling that enhances NF-kappaB-mediated parasite killing in the midgut of Anopheles stephensi without reducing lifespan or fecundity. ABA, NO
69  2017 Activation of TGF-beta activated kinase 1 promotes colon mucosal pathogenesis in inflammatory bowel disease. CD, IBD, UC
70  2017 Anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation. IRAK4, LPS, MyD88
71  2017 Arjunolic acid, a peroxisome proliferator-activated receptor alpha agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-beta signaling. AA, PPARalpha
72  2017 Autosomal dominant frontometaphyseal dysplasia: Delineation of the clinical phenotype. AD-FMD, FMD, TAB2
73  2017 BMP-TAK1 (MAP3K7) Induces Adipocyte Differentiation Through PPARgamma Signaling. MSCs, TAB1
74  2017 c-Kit modifies the inflammatory status of smooth muscle cells. NLK, SMC
75  2017 C/EBP homologous protein promotes NSAID-activated gene 1-linked pro-inflammatory signals and enterocyte invasion by enteropathogenic Escherichia coli. CHOP, EPEC, NAG-1
76  2017 Co-Inflammatory Roles of TGFbeta1 in the Presence of TNFalpha Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells. COX-2, IL-8, MSCs, TGF-beta1, TNF-alpha
77  2017 Effect of curcumin on acute spinal cord injury in mice via inhibition of inflammation and TAK1 pathway. BMS, ELISA, IKK, SCI, TGF, TLR
78  2017 Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-kappaB pathway. ICAM, LPS, MCP
79  2017 Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3. DKO, IKK, IL-1, JNK1, MAP, siRNA, TAB2, TRAF6, Ubc13
80  2017 Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization. AKI, TRIF
81  2017 Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activity. ALF, AP-1, GalN, MyD88, NF-kappaB, PMOC, TLR
82  2017 Protective benefits of AMP-activated protein kinase in hepatic ischemia-reperfusion injury. AMPK, CaMKKbeta, HIRI, LKB1, ROS
83  2017 Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice. DSS, IEC, RKIP, TNBS
84  2017 Role of the MAPKs/TGF-beta1/TRAF6 signaling pathway in postoperative atrial fibrillation. AF, Ang II, CTGF, ELISA, RHD, SR
85  2017 TGF-beta Down-regulates Apolipoprotein M Expression through the TAK-1-JNK-c-Jun Pathway in HepG2 Cells. AP-1, apoM, JNK, TGF-beta
86  2017 TGFbeta1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity. ALK, qPCR, TGF-beta
87  2017 The Us2 Gene Product of Herpes Simplex Virus 2 modulates NF-kappaB activation by targeting TAK1. US
88  2017 Transforming growth factor-beta-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. EAM, iDCM, SFRP2, TCF, TGF-beta
89  2016 Blockade of TGF-beta-activated kinase 1 prevents advanced glycation end products-induced inflammatory response in macrophages. AGEs, BMMs, DN, MAPKs, MCP-1, NF-kappaB, TNF-alpha
90  2016 Dephosphorylation of Tak1 at Ser412 greatly contributes to the spermatocyte-specific testis toxicity induced by (5R)-5-hydroxytriptolide in C57BL/6 mice. ---
91  2016 Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. HFD, NAFLD, TRAF3
92  2016 Increased apoptosis and browning of TAK1-deficient adipocytes protects against obesity. ---
93  2016 Inhibition of BMP and of TGFbeta receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death. BMP, XIAP
94  2016 Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen. GAP, GDI1, GEF
95  2016 LYATK1 potently inhibits LPS-mediated pro-inflammatory response. BMDMs, IL-1beta, IL-6, LPS, NF-kappaB, PBMCs, TNF-alpha
96  2016 NSAID-activated gene 1 mediates pro-inflammatory signaling activation and paclitaxel chemoresistance in type I human epithelial ovarian cancer stem-like cells. EOC, NAG-1
97  2016 PGC-1beta suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation. FFAs, NF-kappaB, PA, PGC-1beta, SFAs, TAB1
98  2016 Prp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/twist1 pathway. HCC, MAPK, Prp19
99  2016 TAK1 inhibitor NG25 enhances doxorubicin-mediated apoptosis in breast cancer cells. NF-kappaB
100  2016 TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints. TRADD