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[Related PubMed/MEDLINE]
Total Number of Papers: 373
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| No. |
Year |
Title |
Co-occurring Abbreviation |
| 1 |
2020 |
A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. |
IRAK-1 |
| 2 |
2020 |
A novel variant in MAP3K7 associated with an expanded cardiospondylocarpofacial syndrome phenotype. |
CSCFS, FMD2 |
| 3 |
2020 |
A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1. |
DIA, DMD, TA |
| 4 |
2020 |
Anti-Inflammatory and Anti-Oxidative Effects of luteolin-7-O-glucuronide in LPS-Stimulated Murine Macrophages through TAK1 Inhibition and Nrf2 Activation. |
COX-2, GCLC, HO-1, IL-6, iNOS, JNK, L7Gn, LPS, NF-kappaB, NO, NQO1, Nrf2, TNF-alpha |
| 5 |
2020 |
Apolipoprotein E Signals via TLR4 to Induce CXCL5 Secretion by Asthmatic Airway Epithelial Cells. |
APOE, CXCL5, MAPK, SAECs, TLR4, Tpl2 |
| 6 |
2020 |
CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1. |
CARD3-TG, IR |
| 7 |
2020 |
Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis. |
CN, NFATc1, PGC-1beta, TRAF6 |
| 8 |
2020 |
Early appearance of key transcription factors influence the spatiotemporal development of the human inner ear. |
GATA3, LGR5, SRY |
| 9 |
2020 |
Estrogen downregulates TAK1 expression in human fibroblast-like synoviocytes and in a rheumatoid arthritis model. |
CIA, FLS, RA |
| 10 |
2020 |
FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway. |
FBXW5, MAPK, PE |
| 11 |
2020 |
Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma. |
HCC |
| 12 |
2020 |
Inhibition of TGFbeta-activated protein kinase 1 ameliorates myocardial ischaemia/reperfusion injury via endoplasmic reticulum stress suppression. |
ER, MI/R |
| 13 |
2020 |
Insights into the molecular pathogenesis of cardiospondylocarpofacial syndrome: MAP3K7 c.737-7A>G variant alters the TGFbeta-mediated alpha-SMA cytoskeleton assembly and autophagy. |
CSCFS |
| 14 |
2020 |
Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis. |
ce, lncRNA, OC |
| 15 |
2020 |
MAP3K7 and CHD1 Are Novel Mediators of Resistance to Oncolytic Vesicular Stomatitis Virus in Prostate Cancer Cells. |
ISGs, VSV |
| 16 |
2020 |
Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke. |
OGD |
| 17 |
2020 |
Mungbean seed coat water extract inhibits inflammation in LPS-induced acute liver injury mice and LPS-stimulated RAW 246.7 macrophages via the inhibition of TAK1/IkappaBalpha/NF-kappaB. |
LPS, MSWE |
| 18 |
2020 |
Natural Xanthone alpha-Mangostin Inhibits LPS-Induced Microglial Inflammatory Responses and Memory Impairment by Blocking the TAK1/NF-kappaB Signaling Pathway. |
alpha-M, ELISA, iNOS, LPS, NF-kappaB, TLR4 |
| 19 |
2020 |
Paclitaxel induces apoptosis through the TAK1-JNK activation pathway. |
ERK, NF-kappaB, p38 MAPK, PARP, PTX, TAB1 |
| 20 |
2020 |
Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells. |
BC, DOX, MAPK, MDM2, MDMX, MDR, siRNA |
| 21 |
2020 |
Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension. |
ASK1 |
| 22 |
2020 |
Regeneration of Damaged Tendon-Bone Junctions (Entheses)-TAK1 as a Potential Node Factor. |
--- |
| 23 |
2020 |
Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1. |
BA, IL-18 |
| 24 |
2020 |
Six-Transmembrane Epithelial Antigen of the Prostate 3 Deficiency in Hepatocytes Protects the Liver Against Ischemia-Reperfusion Injury by Suppressing Transforming Growth Factor-beta-Activated Kinase 1. |
I/R, JNK, Steap3, Steap3-KO |
| 25 |
2020 |
Suppression of Fpr2 expression protects against endotoxin-induced acute lung injury by interacting with Nrf2-regulated TAK1 activation. |
ALI, BALF, FPR2, HO-1, LPS, MAPKs, MDA, NF-kappaB, ROS, SOD |
| 26 |
2020 |
Suppression of peripheral NGF attenuates neuropathic pain induced by chronic constriction injury through the TAK1-MAPK/NF-kappaB signaling pathways. |
DRG, l-CDL, MAPKs, NGF |
| 27 |
2020 |
Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors. |
MAPK |
| 28 |
2020 |
TAB3 upregulates PIM1 expression by directly activating the TAK1-STAT3 complex to promote colorectal cancer growth. |
CRC, PIM1 |
| 29 |
2020 |
TAK1 deficiency attenuates cisplatin-induced acute kidney injury. |
AKI |
| 30 |
2020 |
Tak1 in the astrocytes of mediobasal hypothalamus regulates anxiety-like behavior in mice. |
MBH |
| 31 |
2020 |
TAK1 inhibition in mouse astrocyte cultures ameliorates cytokine-induced chemokine production and neutrophil migration. |
CNS |
| 32 |
2020 |
TAK1 lessens the activity of the paracaspase MALT1 during T cell receptor signaling. |
CBM, NF-kappaB |
| 33 |
2020 |
TAK1 preserves skeletal muscle mass and mitochondrial function through redox homeostasis. |
--- |
| 34 |
2020 |
TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades. |
TNF |
| 35 |
2020 |
TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases. |
NF, RA, TNF |
| 36 |
2020 |
Therapeutic effect of omega-3 fatty acids on T cell-mediated autoimmune diseases. |
EAE, GPR120, omega-3 FAs, PIA, TAB1 |
| 37 |
2020 |
TLR13, TLR22, TRAF6, and TAK1 in the soiny mullet (Liza haematocheila): Molecular characterization and expression profiling analysis. |
TLRs, TRAF6 |
| 38 |
2020 |
TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia. |
HDAC6, LPS, MAPK, Sig-1R, TLR4 |
| 39 |
2020 |
TRIM31 promotes apoptosis via TAK1-mediated activation of NF-kappaB signaling in sepsis-induced myocardial dysfunction. |
SIMD, TRIM31 |
| 40 |
2020 |
Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway. |
NRCMs, PE, TAC, USP19 |
| 41 |
2020 |
USP15 potentiates NF-kappaB activation by differentially stabilizing TAB2 and TAB3. |
DUBs, IL-1beta, NF-kappaB, TNF-alpha, USP15 |
| 42 |
2020 |
[Transforming growth factor-beta-activated kinase 1 and pathological myocardial hypertrophy]. |
Ang II, HIF-1alpha, MAPKKK, TGF-beta1 |
| 43 |
2019 |
C1q-tumour necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice. |
CTRP3, PKA, ROS |
| 44 |
2019 |
Coordinating Tissue Regeneration Through Transforming Growth Factor-beta Activated Kinase 1 Inactivation and Reactivation. |
COSIEN |
| 45 |
2019 |
Curcumin ameliorates peritoneal fibrosis via inhibition of transforming growth factor-activated kinase 1 (TAK1) pathway in a rat model of peritoneal dialysis. |
MTG, PD, PET, PF, UFV |
| 46 |
2019 |
Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells (HMrSV5) through regulation of transforming growth factor-activated kinase 1 (TAK1). |
CCK-8, EMT, HPMCs, PD, PDS, PMCs |
| 47 |
2019 |
Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways. |
DAA, NO, Src, Syk |
| 48 |
2019 |
Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers. |
HSP, IFN, IL, MAPK, MyD88, NF-kappaB, NOD1, TLR, TN, TNF |
| 49 |
2019 |
Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. |
DUSP26, KO, NAFLD |
| 50 |
2019 |
Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway. |
DOX, EMT, MAPK, MDM2, MDMX, TAB1, TNBC |
| 51 |
2019 |
Enterohemorrhagic Escherichia coli Tir inhibits TAK1 activation and mediates immune evasion. |
EHEC, ITIMs, MAP, Tir |
| 52 |
2019 |
Fibroblast Growth Factor-1 Improves Insulin Resistance via Repression of JNK-Mediated Inflammation. |
DIO, FGF-1, JNK, TAB1 |
| 53 |
2019 |
Florfenicol alleviated lipopolysaccharide (LPS)-induced inflammatory responses in Ctenopharyngodon idella through inhibiting toll / NF-kappaB signaling pathways. |
COX-2, FFC, HK, LPS, MyD88, NF-kappaB, NO, PGE 2, TLR2, TRAF6 |
| 54 |
2019 |
Gal-3BP Negatively Regulates NF-kappaB Signaling by Inhibiting the Activation of TAK1. |
Gal-3BP, LPS, MEFs, SRCR |
| 55 |
2019 |
JAZF1 Suppresses Papillary Thyroid Carcinoma Cell Proliferation and Facilitates Apoptosis via Regulating TAK1/NF-kappaB Pathways. |
JAZF1, LI, NF-kappaB p65, PTC |
| 56 |
2019 |
Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene. |
LPSs, MLCK, MyD, TJ, TLR |
| 57 |
2019 |
LncRNA RMST activates TAK1-mediated NF-kappaB signaling and promotes activation of microglial cells via competitively binding with hnRNPK. |
hnRNP K, lncRNA, NF-kappaB, OGD, RIP, RMST |
| 58 |
2019 |
MiR-32-5p aggravates intestinal epithelial cell injury in pediatric enteritis induced by Helicobacter pylori. |
H. pylori, miRNAs, SMAD6 |
| 59 |
2019 |
Molecular identification and expression analysis of TAB1 from orange-spotted grouper (Epinephelus coioides). |
GS |
| 60 |
2019 |
NG25, a novel inhibitor of TAK1, suppresses KRAS-mutant colorectal cancer growth in vitro and in vivo. |
Bcl-2, CRC, IAP |
| 61 |
2019 |
NOD2 signaling pathway is involved in fibronectin fragment-induced pro-catabolic factor expressions in human articular chondrocytes. |
IL-1beta, MMP, NF-kappaB, NOD, OA, qRT-PCR, RIP2, TLR2, TNF-alpha |
| 62 |
2019 |
Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice. |
CIA, RA, RA-FLS, TNF |
| 63 |
2019 |
Phylogenetically conserved TAK1 participates in Branchiostoma belcheri innate immune response to LPS stimulus. |
--- |
| 64 |
2019 |
PLCbeta2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1. |
CVA16, PLC |
| 65 |
2019 |
Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from Toxoplasma gondii. |
MICs, NF-kappaB, TLR |
| 66 |
2019 |
SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF-kappaB pathway in Mycosis Fungoides. |
CTCL, JNKs, MAPKs, MF, SHARPIN |
| 67 |
2019 |
Silencing of Long Noncoding RNA Nespas Aggravates Microglial Cell Death and Neuroinflammation in Ischemic Stroke. |
TRIM8 |
| 68 |
2019 |
Sparassis crispa exerts anti-inflammatory activity via suppression of TLR-mediated NF-kappaB and MAPK signaling pathways in LPS-induced RAW264.7 macrophage cells. |
COX-2, ELISA, HPLC, IkappaBalpha, IL, iNOS, LPS, MAPKs, NF-kappaB, NO, PGE2, TLR, TNF |
| 69 |
2019 |
Synthesis and anti-tumor activity of imidazopyrazines as TAK1 inhibitors. |
--- |
| 70 |
2019 |
TAB2 c.1398dup variant leads to haploinsufficiency and impairs extracellular matrix homeostasis. |
ECM, MAPK, NF-kappaB, TABs |
| 71 |
2019 |
TAK1 knock-down in macrophage alleviate lung inflammation induced by black carbon and aged black carbon. |
1,4NQ-BC, BC |
| 72 |
2019 |
TAK1 may promote the development of diabetic nephropathy by reducing the stability of SnoN protein. |
DN, ECM, EMT, SnoN |
| 73 |
2019 |
TAK1 of black carp positively regulates IRF7-mediated antiviral signaling in innate immune activation. |
bcTAK1, GCRV, MPK, ORF, SVCV |
| 74 |
2019 |
TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma. |
--- |
| 75 |
2019 |
Tanshinone IIA inhibits lipopolysaccharide‑induced inflammatory responses through the TLR4/TAK1/NF‑kappaB signaling pathway in vascular smooth muscle cells. |
IL, iNOS, LPS, MCP, NF, NO, Tan IIA, TLR4, TNF, VSMCs |
| 76 |
2019 |
Taraxasterol suppresses inflammation in IL-1beta-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice. |
ASC, CIA, HFLS-RA, IkappaB, IKK, IL, MMPs, NF-kappaB, NLRP3, RA, TAR, TNF-alpha |
| 77 |
2019 |
Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells. |
AMPK, FASN |
| 78 |
2019 |
Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells. |
AMPK, FASN |
| 79 |
2019 |
The critical role for TAK1 in trichloroethylene-induced contact hypersensitivity in vivo and in CD4+ T cell function alteration by trichloroethylene and its metabolites in vitro. |
CHS, DCA, TCA, TCE |
| 80 |
2019 |
Transforming growth factor-beta-activating kinase 1 and its binding protein 1 participate in the innate immune responses via modulating the IMDNFkappaB signaling in mud crab (Scylla paramamosain). |
AMP, ORF, TAB1 |
| 81 |
2019 |
Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. |
I/R, Trim |
| 82 |
2019 |
USP10 protects against cerebral ischemia injury by suppressing inflammation and apoptosis through the inhibition of TAK1 signaling. |
I/R, JNK-MAPK, KO, NF-kappaB, USP10, WT |
| 83 |
2019 |
USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling. |
I/R, NF-kappaB, USP4 |
| 84 |
2019 |
Vitamin E delta-tocotrienol inhibits TNF-alpha-stimulated NF-kappaB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides. |
CYLD, deltaTE, NF-kappaB |
| 85 |
2019 |
[Correlation of K-ras Gene Mutations with the Protein Expressions of TAK1 and MAP4K2 in Colorectal Cancer]. |
--- |
| 86 |
2019 |
[Heiguteng Zhuifenghuoluo capsule inhibits the expression of NF-kappaB in synovial tissues of rats with collagen-induced arthritis and alleviates joint inflammation]. |
CXCL1, HZC, MCP-1, MIP-1, NF-kappaB, p-NF-kappaBp65, RANKL, TAB1 |
| 87 |
2018 |
A Combination of Chitosan, Cellulose, and Seaweed Polysaccharide Inhibits Postoperative Intra-abdominal Adhesion in Rats. |
ERK, JNK, MAPK, MEK, NF-kappaB, PAI-1, SAPK |
| 88 |
2018 |
A novel MAP3K7 splice mutation causes cardiospondylocarpofacial syndrome with features of hereditary connective tissue disorder. |
CSCFS |
| 89 |
2018 |
alpha-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering beta-arrestin2-TAB1 interaction in astrocytes. |
PD |
| 90 |
2018 |
beta-arrestin2 regulates the anti-inflammatory effects of Salmeterol in lipopolysaccharide-stimulated BV2 cells. |
beta2AR, IL-1beta, LPS, NF-kappaB, PD, TAB1, TNF-alpha |
| 91 |
2018 |
Curcumin's Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-kappaB Pathway. |
COX-2, CUR, NF-kappaB, OHC, THC |
| 92 |
2018 |
Dexamethasone restores transforming growth factor-beta activated kinase 1 expression and phagocytosis activity of Kupffer cells in cholestatic liver injury. |
DEX, IL, KCs, PBE |
| 93 |
2018 |
Ectopic fibroblast growth factor receptor 1 promotes inflammation by promoting nuclear factor-kappaB signaling in prostate cancer cells. |
CID, FGF, FGFR1, PCa, PLCgamma |
| 94 |
2018 |
Effect of deubiquitinase USP8 on hypoxia/reoxygenation‑induced inflammation by deubiquitination of TAK1 in renal tubular epithelial cells. |
IHR, USP8 |
| 95 |
2018 |
Effect of TLR4 on the growth of SiHa human cervical cancer cells via the MyD88-TRAF6-TAK1 and NF-kappaB-cyclin D1-STAT3 signaling pathways. |
LPS, MyD88, NF-kappaB, PI, qPCR, STAT3, TLR4, TRAF6 |
| 96 |
2018 |
EPO modified MSCs can inhibit asthmatic airway remodeling in an animal model. |
BALF, EPO, IL-13, IL-4, IL-5, MSCs, p38 MAPK, TGF-beta1 |
| 97 |
2018 |
Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion. |
IFN-gamma, LPS, NF-kappaB |
| 98 |
2018 |
Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver. |
DUSP14, HFD, NAFLD |
| 99 |
2018 |
IL-1beta induced IL-8 and uPA expression/production of dental pulp cells: Role of TAK1 and MEK/ERK signaling. |
ERK, IL-1beta, MEK, RT-PCR, uPA |
| 100 |
2018 |
Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke. |
MCAO, WT |
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