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■ Abbreviation / Long Form : TAK1 / transforming growth factor-beta-activated kinase 1

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Total Number of Papers: 373
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Abbreviation:   TAK1  (>> Co-occurring Abbreviation)
Long Form:   transforming growth factor-beta-activated kinase 1
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2020 A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. IRAK-1
2020 A novel variant in MAP3K7 associated with an expanded cardiospondylocarpofacial syndrome phenotype. CSCFS, FMD2
2020 A potential therapeutic effect of catalpol in Duchenne muscular dystrophy revealed by binding with TAK1. DIA, DMD, TA
2020 Anti-Inflammatory and Anti-Oxidative Effects of luteolin-7-O-glucuronide in LPS-Stimulated Murine Macrophages through TAK1 Inhibition and Nrf2 Activation. COX-2, GCLC, HO-1, IL-6, iNOS, JNK, L7Gn, LPS, NF-kappaB, NO, NQO1, Nrf2, TNF-alpha
2020 Apolipoprotein E Signals via TLR4 to Induce CXCL5 Secretion by Asthmatic Airway Epithelial Cells. APOE, CXCL5, MAPK, SAECs, TLR4, Tpl2
2020 CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1. CARD3-TG, IR
2020 Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis. CN, NFATc1, PGC-1beta, TRAF6
2020 Early appearance of key transcription factors influence the spatiotemporal development of the human inner ear. GATA3, LGR5, SRY
2020 Estrogen downregulates TAK1 expression in human fibroblast-like synoviocytes and in a rheumatoid arthritis model. CIA, FLS, RA
10  2020 FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway. FBXW5, MAPK, PE
11  2020 Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma. HCC
12  2020 Inhibition of TGFbeta-activated protein kinase 1 ameliorates myocardial ischaemia/reperfusion injury via endoplasmic reticulum stress suppression. ER, MI/R
13  2020 Insights into the molecular pathogenesis of cardiospondylocarpofacial syndrome: MAP3K7 c.737-7A>G variant alters the TGFbeta-mediated alpha-SMA cytoskeleton assembly and autophagy. CSCFS
14  2020 Long non‑coding RNA MCM3AP‑AS1 drives ovarian cancer progression via the microRNA‑143‑3p/TAK1 axis. ce, lncRNA, OC
15  2020 MAP3K7 and CHD1 Are Novel Mediators of Resistance to Oncolytic Vesicular Stomatitis Virus in Prostate Cancer Cells. ISGs, VSV
16  2020 Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke. OGD
17  2020 Mungbean seed coat water extract inhibits inflammation in LPS-induced acute liver injury mice and LPS-stimulated RAW 246.7 macrophages via the inhibition of TAK1/IkappaBalpha/NF-kappaB. LPS, MSWE
18  2020 Natural Xanthone alpha-Mangostin Inhibits LPS-Induced Microglial Inflammatory Responses and Memory Impairment by Blocking the TAK1/NF-kappaB Signaling Pathway. alpha-M, ELISA, iNOS, LPS, NF-kappaB, TLR4
19  2020 Paclitaxel induces apoptosis through the TAK1-JNK activation pathway. ERK, NF-kappaB, p38 MAPK, PARP, PTX, TAB1
20  2020 Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells. BC, DOX, MAPK, MDM2, MDMX, MDR, siRNA
21  2020 Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension. ASK1
22  2020 Regeneration of Damaged Tendon-Bone Junctions (Entheses)-TAK1 as a Potential Node Factor. ---
23  2020 Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1. BA, IL-18
24  2020 Six-Transmembrane Epithelial Antigen of the Prostate 3 Deficiency in Hepatocytes Protects the Liver Against Ischemia-Reperfusion Injury by Suppressing Transforming Growth Factor-beta-Activated Kinase 1. I/R, JNK, Steap3, Steap3-KO
25  2020 Suppression of Fpr2 expression protects against endotoxin-induced acute lung injury by interacting with Nrf2-regulated TAK1 activation. ALI, BALF, FPR2, HO-1, LPS, MAPKs, MDA, NF-kappaB, ROS, SOD
26  2020 Suppression of peripheral NGF attenuates neuropathic pain induced by chronic constriction injury through the TAK1-MAPK/NF-kappaB signaling pathways. DRG, l-CDL, MAPKs, NGF
27  2020 Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors. MAPK
28  2020 TAB3 upregulates PIM1 expression by directly activating the TAK1-STAT3 complex to promote colorectal cancer growth. CRC, PIM1
29  2020 TAK1 deficiency attenuates cisplatin-induced acute kidney injury. AKI
30  2020 Tak1 in the astrocytes of mediobasal hypothalamus regulates anxiety-like behavior in mice. MBH
31  2020 TAK1 inhibition in mouse astrocyte cultures ameliorates cytokine-induced chemokine production and neutrophil migration. CNS
32  2020 TAK1 lessens the activity of the paracaspase MALT1 during T cell receptor signaling. CBM, NF-kappaB
33  2020 TAK1 preserves skeletal muscle mass and mitochondrial function through redox homeostasis. ---
34  2020 TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades. TNF
35  2020 TAK1: a potent tumour necrosis factor inhibitor for the treatment of inflammatory diseases. NF, RA, TNF
36  2020 Therapeutic effect of omega-3 fatty acids on T cell-mediated autoimmune diseases. EAE, GPR120, omega-3 FAs, PIA, TAB1
37  2020 TLR13, TLR22, TRAF6, and TAK1 in the soiny mullet (Liza haematocheila): Molecular characterization and expression profiling analysis. TLRs, TRAF6
38  2020 TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia. HDAC6, LPS, MAPK, Sig-1R, TLR4
39  2020 TRIM31 promotes apoptosis via TAK1-mediated activation of NF-kappaB signaling in sepsis-induced myocardial dysfunction. SIMD, TRIM31
40  2020 Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway. NRCMs, PE, TAC, USP19
41  2020 USP15 potentiates NF-kappaB activation by differentially stabilizing TAB2 and TAB3. DUBs, IL-1beta, NF-kappaB, TNF-alpha, USP15
42  2020 [Transforming growth factor-beta-activated kinase 1 and pathological myocardial hypertrophy]. Ang II, HIF-1alpha, MAPKKK, TGF-beta1
43  2019 C1q-tumour necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice. CTRP3, PKA, ROS
44  2019 Coordinating Tissue Regeneration Through Transforming Growth Factor-beta Activated Kinase 1 Inactivation and Reactivation. COSIEN
45  2019 Curcumin ameliorates peritoneal fibrosis via inhibition of transforming growth factor-activated kinase 1 (TAK1) pathway in a rat model of peritoneal dialysis. MTG, PD, PET, PF, UFV
46  2019 Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells (HMrSV5) through regulation of transforming growth factor-activated kinase 1 (TAK1). CCK-8, EMT, HPMCs, PD, PDS, PMCs
47  2019 Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways. DAA, NO, Src, Syk
48  2019 Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers. HSP, IFN, IL, MAPK, MyD88, NF-kappaB, NOD1, TLR, TN, TNF
49  2019 Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. DUSP26, KO, NAFLD
50  2019 Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway. DOX, EMT, MAPK, MDM2, MDMX, TAB1, TNBC
51  2019 Enterohemorrhagic Escherichia coli Tir inhibits TAK1 activation and mediates immune evasion. EHEC, ITIMs, MAP, Tir
52  2019 Fibroblast Growth Factor-1 Improves Insulin Resistance via Repression of JNK-Mediated Inflammation. DIO, FGF-1, JNK, TAB1
53  2019 Florfenicol alleviated lipopolysaccharide (LPS)-induced inflammatory responses in Ctenopharyngodon idella through inhibiting toll / NF-kappaB signaling pathways. COX-2, FFC, HK, LPS, MyD88, NF-kappaB, NO, PGE 2, TLR2, TRAF6
54  2019 Gal-3BP Negatively Regulates NF-kappaB Signaling by Inhibiting the Activation of TAK1. Gal-3BP, LPS, MEFs, SRCR
55  2019 JAZF1 Suppresses Papillary Thyroid Carcinoma Cell Proliferation and Facilitates Apoptosis via Regulating TAK1/NF-kappaB Pathways. JAZF1, LI, NF-kappaB p65, PTC
56  2019 Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene. LPSs, MLCK, MyD, TJ, TLR
57  2019 LncRNA RMST activates TAK1-mediated NF-kappaB signaling and promotes activation of microglial cells via competitively binding with hnRNPK. hnRNP K, lncRNA, NF-kappaB, OGD, RIP, RMST
58  2019 MiR-32-5p aggravates intestinal epithelial cell injury in pediatric enteritis induced by Helicobacter pylori. H. pylori, miRNAs, SMAD6
59  2019 Molecular identification and expression analysis of TAB1 from orange-spotted grouper (Epinephelus coioides). GS
60  2019 NG25, a novel inhibitor of TAK1, suppresses KRAS-mutant colorectal cancer growth in vitro and in vivo. Bcl-2, CRC, IAP
61  2019 NOD2 signaling pathway is involved in fibronectin fragment-induced pro-catabolic factor expressions in human articular chondrocytes. IL-1beta, MMP, NF-kappaB, NOD, OA, qRT-PCR, RIP2, TLR2, TNF-alpha
62  2019 Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice. CIA, RA, RA-FLS, TNF
63  2019 Phylogenetically conserved TAK1 participates in Branchiostoma belcheri innate immune response to LPS stimulus. ---
64  2019 PLCbeta2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1. CVA16, PLC
65  2019 Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from Toxoplasma gondii. MICs, NF-kappaB, TLR
66  2019 SHARPIN overexpression promotes TAK1 expression and activates JNKs and NF-kappaB pathway in Mycosis Fungoides. CTCL, JNKs, MAPKs, MF, SHARPIN
67  2019 Silencing of Long Noncoding RNA Nespas Aggravates Microglial Cell Death and Neuroinflammation in Ischemic Stroke. TRIM8
68  2019 Sparassis crispa exerts anti-inflammatory activity via suppression of TLR-mediated NF-kappaB and MAPK signaling pathways in LPS-induced RAW264.7 macrophage cells. COX-2, ELISA, HPLC, IkappaBalpha, IL, iNOS, LPS, MAPKs, NF-kappaB, NO, PGE2, TLR, TNF
69  2019 Synthesis and anti-tumor activity of imidazopyrazines as TAK1 inhibitors. ---
70  2019 TAB2 c.1398dup variant leads to haploinsufficiency and impairs extracellular matrix homeostasis. ECM, MAPK, NF-kappaB, TABs
71  2019 TAK1 knock-down in macrophage alleviate lung inflammation induced by black carbon and aged black carbon. 1,4NQ-BC, BC
72  2019 TAK1 may promote the development of diabetic nephropathy by reducing the stability of SnoN protein. DN, ECM, EMT, SnoN
73  2019 TAK1 of black carp positively regulates IRF7-mediated antiviral signaling in innate immune activation. bcTAK1, GCRV, MPK, ORF, SVCV
74  2019 TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma. ---
75  2019 Tanshinone IIA inhibits lipopolysaccharide‑induced inflammatory responses through the TLR4/TAK1/NF‑kappaB signaling pathway in vascular smooth muscle cells. IL, iNOS, LPS, MCP, NF, NO, Tan IIA, TLR4, TNF, VSMCs
76  2019 Taraxasterol suppresses inflammation in IL-1beta-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice. ASC, CIA, HFLS-RA, IkappaB, IKK, IL, MMPs, NF-kappaB, NLRP3, RA, TAR, TNF-alpha
77  2019 Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells. AMPK, FASN
78  2019 Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells. AMPK, FASN
79  2019 The critical role for TAK1 in trichloroethylene-induced contact hypersensitivity in vivo and in CD4+ T cell function alteration by trichloroethylene and its metabolites in vitro. CHS, DCA, TCA, TCE
80  2019 Transforming growth factor-beta-activating kinase 1 and its binding protein 1 participate in the innate immune responses via modulating the IMDNFkappaB signaling in mud crab (Scylla paramamosain). AMP, ORF, TAB1
81  2019 Tripartite Motif 8 Deficiency Relieves Hepatic Ischaemia/reperfusion Injury via TAK1-dependent Signalling Pathways. I/R, Trim
82  2019 USP10 protects against cerebral ischemia injury by suppressing inflammation and apoptosis through the inhibition of TAK1 signaling. I/R, JNK-MAPK, KO, NF-kappaB, USP10, WT
83  2019 USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling. I/R, NF-kappaB, USP4
84  2019 Vitamin E delta-tocotrienol inhibits TNF-alpha-stimulated NF-kappaB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides. CYLD, deltaTE, NF-kappaB
85  2019 [Correlation of K-ras Gene Mutations with the Protein Expressions of TAK1 and MAP4K2 in Colorectal Cancer]. ---
86  2019 [Heiguteng Zhuifenghuoluo capsule inhibits the expression of NF-kappaB in synovial tissues of rats with collagen-induced arthritis and alleviates joint inflammation]. CXCL1, HZC, MCP-1, MIP-1, NF-kappaB, p-NF-kappaBp65, RANKL, TAB1
87  2018 A Combination of Chitosan, Cellulose, and Seaweed Polysaccharide Inhibits Postoperative Intra-abdominal Adhesion in Rats. ERK, JNK, MAPK, MEK, NF-kappaB, PAI-1, SAPK
88  2018 A novel MAP3K7 splice mutation causes cardiospondylocarpofacial syndrome with features of hereditary connective tissue disorder. CSCFS
89  2018 alpha-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering beta-arrestin2-TAB1 interaction in astrocytes. PD
90  2018 beta-arrestin2 regulates the anti-inflammatory effects of Salmeterol in lipopolysaccharide-stimulated BV2 cells. beta2AR, IL-1beta, LPS, NF-kappaB, PD, TAB1, TNF-alpha
91  2018 Curcumin's Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-kappaB Pathway. COX-2, CUR, NF-kappaB, OHC, THC
92  2018 Dexamethasone restores transforming growth factor-beta activated kinase 1 expression and phagocytosis activity of Kupffer cells in cholestatic liver injury. DEX, IL, KCs, PBE
93  2018 Ectopic fibroblast growth factor receptor 1 promotes inflammation by promoting nuclear factor-kappaB signaling in prostate cancer cells. CID, FGF, FGFR1, PCa, PLCgamma
94  2018 Effect of deubiquitinase USP8 on hypoxia/reoxygenation‑induced inflammation by deubiquitination of TAK1 in renal tubular epithelial cells. IHR, USP8
95  2018 Effect of TLR4 on the growth of SiHa human cervical cancer cells via the MyD88-TRAF6-TAK1 and NF-kappaB-cyclin D1-STAT3 signaling pathways. LPS, MyD88, NF-kappaB, PI, qPCR, STAT3, TLR4, TRAF6
96  2018 EPO modified MSCs can inhibit asthmatic airway remodeling in an animal model. BALF, EPO, IL-13, IL-4, IL-5, MSCs, p38 MAPK, TGF-beta1
97  2018 Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion. IFN-gamma, LPS, NF-kappaB
98  2018 Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver. DUSP14, HFD, NAFLD
99  2018 IL-1beta induced IL-8 and uPA expression/production of dental pulp cells: Role of TAK1 and MEK/ERK signaling. ERK, IL-1beta, MEK, RT-PCR, uPA
100  2018 Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke. MCAO, WT