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■ Abbreviation / Long Form : TIMP2 / tissue inhibitor of metalloproteinase 2

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Total Number of Papers: 127
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Abbreviation:   TIMP2  (>> Co-occurring Abbreviation)
Long Form:   tissue inhibitor of metalloproteinase 2
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2020 Association between maternal/newborn genetic variants, placental pathology and spontaneous preterm birth risk: a Romanian population-based study. FGF-1, IL-6R, PCR, SNPs, sPTB
2020 Characteristics of Neuropeptide-Containing Innervation, Tissue Remodeling, Growth, and Vascularity in Noses of Patients With Cleft Lip and Palate. CD34, CLP, MMP2, PGP, TGF-beta1, VEGF
2020 Long noncoding RNA MEG3 silencing protects against hypoxia-induced pheochromocytoma-12 cell injury through inhibition of TIMP2 promoter methylation. LDH, lncRNAs, MDA, MEG3, PC12, ROS, SOD
2020 Microenvironment-induced TIMP2 loss by cancer-secreted exosomal miR-4443 promotes liver metastasis of breast cancer. BCa, MMPs
2020 The effect of 8weeks of high-intensity interval training and moderate-intensity continuous training on cardiac angiogenesis factor in diabetic male rats. HIIT, MICT, MMP2, TGF-beta, VEGF
2019 Additional evidence supports association of common genetic variants in MMP3 and TIMP2 with increased risk of chronic Achilles tendinopathy susceptibility. AT, ECM, MMP3
2019 Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis. eHSP90, MMP2
2019 Correlations of TIMP2 and TIMP3 gene polymorphisms with primary open-angle glaucoma. ET-1, FIB, Hct, NO, POAG, PV
2019 DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats. ADMA, DCM, DDAH2, MMP2, NO, NOS
10  2019 Detection of Pro- and Antiangiogenic Factors in the Human Sclera. FBLN5, HGF, PROX1, SEMA3F, TGFA
11  2019 Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-kappab pathway. AKI, CLP, HK-2, LPS, NF
12  2019 Ethanol extract of Ligustrum lucidum Ait. leaves suppressed hepatocellular carcinoma in vitro and in vivo. Bax, Bcl-2, CCK-8, EEL, FCM, MMP2, MSP, qRT-PCR
13  2019 HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503. ---
14  2019 LncRNA FENDRR suppresses the progression of NSCLC via regulating miR-761/TIMP2 axis. lncRNA, NSCLC
15  2019 LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p. ccRCC, DKK1, lncRNA
16  2019 MicroRNA-130a regulated by HPV18 E6 promotes proliferation and invasion of cervical cancer cells by targeting TIMP2. HPVs, miR-130a, MMP2
17  2019 MicroRNA-93 promotes the tumorigenesis of osteosarcoma by targeting TIMP2. EMT, miR-93, OS
18  2019 miR-616 promotes breast cancer migration and invasion by targeting TIMP2 and regulating MMP signaling. miR-616, MMP, RT-qPCR
19  2019 Netrin-1 plays a role in the effect of moderate exercise on myocardial fibrosis in rats. AMI, DCC, IL-6, LVEDP, LVSP, MMP-2, -9, TNF-alpha
20  2019 Remote ischaemic preconditioning does not modulate the systemic inflammatory response or renal tubular stress biomarkers after endotoxaemia in healthy human volunteers: a single-centre, mechanistic, randomised controlled trial. IL-6, LPS, RIPC, TNF-alpha
21  2019 The effects of aging, diabetes mellitus, and antiplatelet drugs on growth factors and anti-aging proteins in platelet-rich plasma. CVD, DM, EGF, FGF, GDF, IGF-1, PDGF, PRP, VEGF
22  2019 Upregulation of long noncoding RNA TUG1 by EGR1 promotes adenomyotic epithelial cell migration and invasion through recruiting EZH2 and suppressing TIMP2. Egr-1, EZH2, TUG1
23  2019 Using urinary biomarkers to reduce acute kidney injury following cardiac surgery. AKI, AKRT, IGFBP7, UB
24  2018 Expression and role of microRNA-1271 in the pathogenesis of osteosarcoma. miR
25  2018 Extracorporeal Membrane Oxygenation Improving Survival and Alleviating Kidney Injury in a Swine Model of Cardiac Arrest Compared to Conventional Cardiopulmonary Resuscitation. AKI, CA, CCPR, ECMO, IGFBP7, KIM-1, L-FABP, NGAL, ROSC, TEM
26  2018 Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes. COL3A1, COL4A1
27  2018 IL-1beta-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway. IL-1beta, IL-1ra, MMP-1, MSCs, PAR1, TIMP1
28  2018 Inhibition of microRNA‑939 suppresses the development of human non‑small cell lung cancer via the upregulation of tissue inhibitor of metalloproteinases 2. NSCLC
29  2018 Intensive fibrosarcoma-binding capability of the reconstituted analog and its antitumor activity. MMPs
30  2018 Knockdown of long noncoding RNA urothelial carcinoma-associated 1 inhibits cell viability, migration, and invasion by regulating microRNA-182 in gastric carcinoma. GC, GSK3beta, miR-182, NF-kappaB, PI3K, UCA1
31  2018 MicroRNA-616 promotes the progression of ovarian cancer by targeting TIMP2. DFS, EMT, IHC, miRNAs, OC, OS, TNM
32  2018 Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/beta-Catenin Pathway. CCK-8, ECM, EMT, MMP, MTA1, MYH10, NM IIB, qRT-PCR
33  2018 Protective effects of Liuweiwuling tablets on carbon tetrachloride-induced hepatic fibrosis in rats. alpha-SMA, CFDA, collagen I, ECM, HSC, LWWL, PDGF, RT-qPCR, TIMP1
34  2018 Silence of Stomatin-Like Protein 2 Represses Migration and Invasion Ability of Human Liver Cancer Cells via Inhibiting the Nuclear Factor Kappa B (NF-kappaB) Pathway. CCK-8, IkappaB, MMP-2, MTA1, NF-kappaB, qRT-PCR, STOML2
35  2018 The Antihelminthic Niclosamide Inhibits Cancer Stemness, Extracellular Matrix Remodeling, and Metastasis through Dysregulation of the Nuclear beta-catenin/c-Myc axis in OSCC. DVL2, EMT, OSCC, p-GSK3beta
36  2018 The role of Parkin protein in cardiac function and ventricular remodeling in myocardial infarction rats. AI, H-Parkin group, HE, L-Parkin group, LVEDV, LVESV, M-Parkin group, MI, MMP2, MMP9, SD, Sham group, TIMP1, TTC
37  2018 TIMP2 is a Poor Prognostic Factor and Predicts Metastatic Biological Behavior in Gastric Cancer. GC
38  2017 Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts. GCAF, GNF, M-CSF
39  2017 EZH2-mediated epigenetic silencing of TIMP2 promotes ovarian cancer migration and invasion. EZH2
40  2017 Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. ---
41  2017 Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. Matn3, miRNAs, OA
42  2017 MicroRNA-15b promotes proliferation and invasion of non‑small cell lung carcinoma cells by directly targeting TIMP2. miR-15b, NSCLC
43  2017 MicroRNA-93 promotes proliferation and metastasis of gastric cancer via targeting TIMP2. miRNAs, TNM
44  2017 Migfilin promotes migration and invasion in glioma by driving EGFR and MMP-2 signalings: A positive feedback loop regulation. CNS, EGFR, MMP-2
45  2017 miRNA-221 acts as an oncogenic role by directly targeting TIMP2 in non-small-cell lung carcinoma. miRNA-221, NSCLC
46  2017 Promotion of astrocytoma cell invasion by micro RNA-22 targeting of tissue inhibitor of matrix metalloproteinase-2. DAs, miR-22, miRNAs, mRNA
47  2017 Transforming growth factor beta-1 (TGF-beta1) stimulates collagen synthesis in cultured rainbow trout cardiac fibroblasts. COL1A1, ECM, MMP-9, TGF-beta1
48  2016 Common chronic conditions do not affect performance of cell cycle arrest biomarkers for risk stratification of acute kidney injury. AKI, CHF, CKD, KDIGO, ROC
49  2016 Edaravone protects against cobalt chloride-induced dysfunctions in apoptosis and invasion in trophoblast cells. CASP3, MMP2, ROS
50  2016 Genetic variation associated with preterm birth inAfrican-Americanwomen. FLT1, IL16, LIFR-AS1, MMP1, MMP2, PRKCA
51  2016 HMGB1 Turns Renal Tubular Epithelial Cells into Inflammatory Promoters by Interacting with TLR4 During Sepsis. HMGB1, IL-1, IL-6, TECs, TLR4
52  2016 LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p. BC, MMP, qRT-PCR
53  2016 Therapy with Multipotent Mesenchymal Stromal Cells Protects Lungs from Radiation-Induced Injury and Reduces the Risk of Lung Metastasis. MMP2, MSCs, WTI
54  2015 Alterations in enhancer of zeste homolog 2, matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression are associated with ex vivo and in vitro bone metastasis in renal cell carcinoma. EZH2, MMP2, PCR, RCC
55  2015 Gene polymorphism -418 G/C of tissue inhibitor of metalloproteinases 2 is associated with abdominal aortic aneurysm. AAA, OR, TIMPs
56  2015 MiR-301a promotes cell proliferation by directly targeting TIMP2 in multiple myeloma. MM
57  2015 MiR-761 Promotes Progression and Metastasis of Non-Small Cell Lung Cancer by Targeting ING4 and TIMP2. NSCLC, qRT-PCR
58  2015 NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. ARF6, MMP14
59  2015 Poly (ADP-ribose) polymerase-1: an emerging target in right ventricle dysfunction associated with pulmonary hypertension. ATP, MCT, MMPs, NAD, PH, RV, RVH, RVP, TUNEL
60  2014 A chromatin modifier regulates Sertoli cell response to mono-(2-ethylhexyl) phthalate (MEHP) via tissue inhibitor of metalloproteinase 2 (TIMP2) signaling. MEHP, MMP2, mta1, SCs
61  2014 Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs. MMP
62  2014 Calcitriol modulates receptor for advanced glycation end products (RAGE) in diabetic hearts. AT1R, MMP2, RAGE
63  2014 HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. 5-aza-dC, HDAC, HSPC117, MMP14, MMP2, qPCR, TSA
64  2014 Relaxin decreases the severity of established hepatic fibrosis in mice. ---
65  2014 Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial. MMP2, MMP9, PC-R, S-RC, VEGF-A
66  2014 The change of break modulus drives human fibroblast differentiation in 3D collagen gels. alpha-SMA, MMP-9, p-MYPT1
67  2014 The complex regulation of tanshinone IIA in rats with hypertension-induced left ventricular hypertrophy. ECM, GS, HLVH, MDA, MMP2, SOD
68  2013 A Disintegrin and Metalloprotease with Thrombospondin Motif 2 May Contribute to Cirrhosis in Humans through the Transforming Growth Factor-beta/SMAD Pathway. MMP2, TGF-beta1, TGF-betaRII
69  2013 Cloning and characterization of a novel oocyte-specific gene encoding an F-Box protein in rainbow trout (Oncorhynchus mykiss). ESTs
70  2013 Effects of Musca domestica cecropin on the adhesion and migration of human hepatocellular carcinoma BEL-7402 cells. E-cadherin, MMP2, qPCR, SEM
71  2013 Exogenous high-mobility group box 1 protein prevents postinfarction adverse myocardial remodeling through TGF-beta/Smad signaling pathway. HMGB1, LVEDD, LVEF, LVESD, MI, MMP2, p-Smad2, PBS, TGF-beta
72  2013 Keratinocytes and head and neck squamous cell carcinoma cells regulate urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in fibroblasts. IL-1alpha, MMP1, NOK, PAI-1, PCR, SCC, uPA
73  2013 Left and right ventricle late remodeling following myocardial infarction in rats. CTGF, LOX, MI, RV, TGF-beta
74  2013 Markers of breast cancer stromal fibroblasts in the primary tumour site associated with lymph node metastasis: a systematic review including our case series. Cav-1, LGALS1, OR, PLAU, PLAUR, THBS1
75  2013 MicroRNA-200b is overexpressed in endometrial adenocarcinomas and enhances MMP2 activity by downregulating TIMP2 in human endometrial cancer cell line HEC-1A cells. miRNAs, MMP2
76  2013 Preventive effect of halofuginone on concanavalin A-induced liver fibrosis. AST, Con A, HA, HF, NF, PC III
77  2013 Pyruvate minimizes rtPA toxicity from in vitro oxygen-glucose deprivation and reoxygenation. MMP2, OGD, ROS, rt-PA
78  2013 Release of tissue inhibitor of metalloproteinase-2 from alginate microcapsule encapsulating genetically engineered cells. ---
79  2012 Comparative characterization of stem cells from human exfoliated deciduous teeth and dental pulp stem cells. CBB, CFUs, DPSCs, IL-6, MMP1, MMP2, PCNA, SHED, TIMP1
80  2012 Control and inhibition analysis of complex formation processes. ECM, MMP2, MMPIs, MMPs, MT1-MMP
81  2012 Effect of asynchronous transfer on bovine embryonic development and relationship with early cycle uterine proteome profiles. ULF
82  2012 Enhanced immunoreactivity of TIMP-2 in the stromal compartment of tumor as a marker of favorable prognosis in ovarian cancer patients. MMP-2, OC
83  2012 Is matrix metalloproteinase required in postnatal testicular tubules for germ cell maturation? MMP, MMP2, MT1-MMP
84  2012 Simvastatin decreases invasiveness of human endometrial stromal cells. FPP, GGPP, HES, HMGCR, MMP2
85  2012 TIMP2 deficient mice develop accelerated osteoarthritis via promotion of angiogenesis upon destabilization of the medial meniscus. DMM, OA
86  2011 Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy. CRAds, MMPs
87  2011 NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-beta1/Smad pathway and altering the MMP2/TIMP2 ratio in rats. DMN, ECM, HSCs, MMP2, NDRG2
88  2011 Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age. FN1, IPA, MDR, PLAU, SGA
89  2010 Effect of TGFss1 and TIMP2 on disease activity in asthma and COPD. COPD, PFT
90  2010 Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-beta-disrupted diffuse-type gastric carcinoma. dnTbetaRII, TGF
91  2010 Herbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice. HCC, MMP2, VEGF
92  2010 Matrix metalloproteinase 2 in reduced-size liver transplantation: beyond the matrix. JNK, MMP2, MMP9, PC, ROLT
93  2010 Metalloproteinase 2 cleaves in vitro recombinant TRAIL: potential implications for the decreased serum levels of TRAIL after acute myocardial infarction. AMI, TRAIL
94  2010 [Expression of tissue inhibitor of metalloproteinase-2 in nasopharyngeal carcinoma]. ---
95  2009 Altered pattern of circulating matrix metalloproteinases -2,- 9 and tissue inhibitor of metalloproteinase-2 in patients with HCV-related chronic hepatitis. Relationship to histological features. HAI
96  2009 Antifibrotic activity of anisodamine in vivo is associated with changed intrahepatic levels of matrix metalloproteinase-2 and its inhibitor tissue inhibitors of metalloproteinases-2 and transforming growth factor beta1 in rats with carbon tetrachloride-induced liver injury. Hyp, MDA, MMP2, TGF-beta1
97  2009 Cartilage gene expression correlates with radiographic severity of canine elbow osteoarthritis. CTSD, LUM, MMP2, OA
98  2009 Differential effect of 17-beta-estradiol on smooth muscle cell and aortic explant MMP2. IL, MMP2, RASMCs
99  2009 Synergistic effect of mitral expression of tissue inhibitor of metalloproteinase-2 with hypertension on the occurrence of mitral chordae tendinae rupture. CI, MCTR, OR
100  2008 Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry. BE, DFS, MMP, PCa