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■ Abbreviation / Long Form : TLCK / N-alpha-p-tosyl-L-lysine chloromethyl ketone

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Total Number of Papers: 238
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Abbreviation:   TLCK  (>> Co-occurring Abbreviation)
Long Form:   N-alpha-p-tosyl-L-lysine chloromethyl ketone
 Abbreviation Variation
 Long Form Variation
 Pair(Abbreviation/Long Form) Variation
No. Year Title Co-occurring Abbreviation
2019 The role of thrombin in the pathogenesis of diabetic neuropathy. NAPAP, PAR1, STZ
2018 Blocking Thrombin Significantly Ameliorates Experimental Autoimmune Neuritis. CFA, EAN, GBS, PAR1
2016 Activation of Bt Protoxin Cry1Ac in Resistant and Susceptible Cotton Bollworm. Bt, Cry, TPCK
2016 Bovine pancreatic trypsin inhibitor immobilized onto sepharose as a new strategy to purify a thermostable alkaline peptidase from cobia (Rachycentron canadum) processing waste. AE, BApNA, BPTI, SDS-PAGE
2016 Features of cell death, mitochondrial activation and caspase dependence of rabbit anti-T-lymphocyte globulin signaling in lymphoblastic Jurkat cells are distinct from classical apoptosis signaling of CD95. ATG, DCI, MMP, NAC, PI
2016 [Unfractionated heparin inhibits lipopolysaccharide-induced expression of chemokines in human endothelial cells through nuclear factor-KappaB signaling pathway]. ELISA, HPMECs, IL-8, LPS, MCP-1, NF-KappaB, PBS, UFH
2015 Effect of different serine protease inhibitors in validating the 115 kDa Leishmania donovani secretory serine protease as chemotherapeutic target. Bza, SPIs, TPCK
2015 Protease Inhibitors Cause Necrotic Cell Death in Chlamydomonas reinhardtii by Inducing the Generation of Reactive Oxygen Species. ROS, TPCK
2015 Serine protease inhibitors interact with IFN-gamma through up-regulation of FasR; a novel therapeutic strategy against cancer. CLP, EI, FasR, TLPs, TPCK
10  2014 Development of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors. Gluc, HuNoVs, NV, PRO
11  2013 Angiogenic changes in co-cultures of mast cells and myocardial microvascular endothelial cells under hyperglycemic conditions. Flt-1, MCGs, MCs, MMVECs, RT, TPCK, VEGF
12  2013 Clinical and Immunological Analysis of Cutaneous Leishmaniasis before and after Different Treatments. CL, DTH, ELISA, Glu, IDR, IOD, NP-40, SR
13  2013 Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases. PD
14  2013 Multiplicity-dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway. ROS, vMIA
15  2013 Proteolytic activity of gut bacteria isolated from the velvet bean caterpillar Anticarsia gemmatalis. EDTA, L-BApNA, L-TAME
16  2013 Trypsin from viscera of vermiculated sailfin catfish, Pterygoplichthys disjunctivus, Weber, 1991: its purification and characterization. BAPNA, EDTA, PMSF, TPCK
17  2013 TvMP50 is an immunogenic metalloproteinase during male trichomoniasis. MS
18  2013 [Expression of Bim, Bax and Bak in the process of gingipain-induced osteoblast apoptosis]. Bak, Bax, Bim, DAPI, PI
19  2013 [Expression of integrin alpha5 and beta1 in osteoblast in the process of gingipains-induced apoptosis]. ---
20  2012 The mineralocorticoid receptor-p38MAPK-NFkappaB or ERK-Sp1 signal pathways mediate aldosterone-stimulated inflammatory and profibrotic responses in rat vascular smooth muscle cells. COX-2, MR, VSMCs
21  2011 Erratum: Purification of a toxic cysteine protease produced by pathogenic Aeromonas hydrophila isolated from rainbow trout. EDTA
22  2011 Fibrinolysis and anticoagulant potential of a metallo protease produced by Bacillus subtilis K42. AC, AN, BU, DE, DFP, EA, EDTA, ET, IP, ME, PMSF, SBTI, TO, TPCK
23  2011 Purification of a toxic metalloprotease produced by the pathogenic Photobacterium damselae subsp. piscicida isolated from cobia (Rachycentron canadum). EDTA, EGTA, SDS, TPCK
24  2011 Synthesis and acrosin inhibitory activity of substituted 4-amino-N-(diaminomethylene) benzenesulfonamide derivatives. ---
25  2010 Alkaline chymotrypsin from striped seabream (Lithognathus mormyrus) viscera: purification and characterization. PMSF, SAAPNA, SBTI, SDS-PAGE
26  2010 Biochemical properties of anionic trypsin acting at high concentration of NaCl purified from the intestine of a carnivorous fish: smooth hound (Mustelus mustelus). BAPNA, SBTI, SDS-PAGE, TAME
27  2010 Exogenous and endogenous protease inhibitors in the gut of the fall armyworm larvae, Spodoptera frugiperda. SBTI
28  2010 Partial purification and characterization of trypsin-like proteinases from insecticide-resistant and -susceptible strains of the maize weevil, Sitophilus zeamais. L-BApNA, L-TAME, PMSF, SBTI
29  2010 Proteolysis activity of IgM antibodies from rheumatoid arthritis patients' sera: evidence of atypical catalytic site. Abs, RA
30  2010 Purification and characterization of trypsin from the intestine of hybrid tilapia (Oreochromis niloticusxO.aureus). CBZ-Lys.pNP, PAGE, PMSF, SDS
31  2010 Purification of a toxic cysteine protease produced by pathogenic Aeromonas hydrophila isolated from rainbow trout. EDTA
32  2010 Trypsin from the processing waste of the lane snapper (Lutjanus synagris) and its compatibility with oxidants, surfactants and commercial detergents. BApNA, PMSF
33  2009 [Nandeshi: a powerful inhibitor of human acrosin activity]. ---
34  2008 Comparative study on the proteases from fish pyloric caeca and the use for production of gelatin hydrolysate with antioxidative activity. AS, DH, SBTI
35  2008 Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) are potent inhibitors of activated caspase proteases. delta psi, ETP, STS, TPCK
36  2008 Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) do not inhibit caspase-3 and caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli. TPCK
37  2007 Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite Leishmania. LdMC1, PCD
38  2007 Effects of serine protease inhibitors on viability and morphology of Leishmania (Leishmania) amazonensis promastigotes. Bza, TPCK
39  2007 Protease-activated receptor 2 mediates human beta-defensin 2 and CC chemokine ligand 20 mRNA expression in response to proteases secreted by Porphyromonas gingivalis. CCL20, GECs, hBDs, PARs
40  2007 Trypsin from the pyloric caeca of bluefish (Pomatomus saltatrix). BAPNA, PMSF, SBTI, SDS-PAGE
41  2006 Leptin induces nitric oxide synthase type II in C6 glioma cells. Role for nuclear factor-kappaB in hormone effect. iNOS, PDTC
42  2006 Morphology and preliminary enzyme characterization of the salivary glands from the predatory bug Podisus nigrispinus (Heteroptera: Pentatomidae). L-BApNA
43  2005 A chymotrypsin-like proteinase from the midgut of Tenebrio molitor larvae. PMSF, STI, TPCK
44  2005 An arginine specific protease from Spirulina platensis. ---
45  2005 Modulation of tryptase release from human tonsil mast cells by protease inhibitors. TPCK
46  2005 Partial purification and characterization of digestive trypsin-like proteases from the velvet bean caterpillar, Anticarsia gemmatalis. EDTA, L-BApNA, L-TAME, PMSF, SDS
47  2005 Pseudomonas aeruginosa protease IV degrades surfactant proteins and inhibits surfactant host defense and biophysical functions. SP
48  2004 Do alkylating agents modify the histidine residue of the desensitized butyrylcholinesterase? BChE, TPCK
49  2004 Dual effects of cycloheximide on U937 apoptosis induced by its combination with VP-16. CHX
50  2004 Dual role of NF-kappaB in apoptosis of THP-1 cells during treatment with etoposide and lipopolysaccharide. ActD, LPS, XIAP
51  2004 Effects of proteinase inhibitors on fertilization in sea lamprey (Petromyzon marinus). AGB, BAPNA, GPNA, TPCK
52  2004 Inhibition of tryptase release from human colon mast cells by protease inhibitors. TPCK
53  2004 Internucleosomal DNA cleavage in apoptotic WEHI 231 cells is mediated by a chymotrypsin-like protease. ICAD, PARP-1, TPCK
54  2004 Modulation of histamine release from human colon mast cells by protease inhibitors. TPCK
55  2004 Modulation of tryptase and histamine release from human lung mast cells by protease inhibitors. TPCK
56  2004 N-alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK) suppresses neuritic degeneration caused by different experimental paradigms including in vitro Wallerian degeneration. TPCK
57  2003 Characterization of a serine protease activity in Sarcocystis neurona merozoites. BT, EGTA, PMSF
58  2003 Characterization of a trypsin-like serine protease of activated B cells mediating the cleavage of surface proteins. STI
59  2003 Enhancement of lipopolysaccharide-stimulated JNK activity in rat aortic smooth muscle cells by pharmacological and adenovirus-mediated inhibition of inhibitory kappa B kinase signalling. IKKs, JNK, LPS, MAP kinase, NF-kappaB, PDTC, RASMCs
60  2003 gamma-Irradiation-induced DNA damage enhances NO production via NF-kappaB activation in RAW264.7 cells. 3-AB, IFN-gamma, iNOS, LPS, NAC, NF-kappaB, NO
61  2003 Porphyromonas gingivalis modulates the production of interleukin 8 and monocyte chemotactic protein 1 in human vascular endothelial cells. ELISA, HUVEC, IL-8, MCP-1, RT-PCR
62  2002 Heat-stable protease from the marine sponge Geodia cydonium. BAPNA, PMSF
63  2002 High glucose induced nuclear factor kappa B mediated inhibition of endothelial cell migration. HAEC, L-NAME, NF-kappaB, NO
64  2002 In vitro assessment of intestinal IGF-I stability. CPPE, IGF-I
65  2002 Nuclear targeting of Porphyromonas gingivalis W50 protease in epithelial cells. ---
66  2002 Purification and characterization of a collagenolytic protease from the filefish, Novoden modestrus. DFP
67  2002 Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy. ---
68  2002 Role of glutathione metabolism of Treponema denticola in bacterial growth and virulence expression. CysGly
69  2002 Suppression of sulfur mustard-increased IL-8 in human keratinocyte cell cultures by serine protease inhibitors: implications for toxicity and medical countermeasures. HEK
70  2001 A serine protease inhibitor, N-alpha-tosyl-l-lysine chloromethyl ketone, prolongs rat hepatic allograft survival. IFN, TNF
71  2001 Effect of inhibitors of cysteine and serine proteases in anticancer drug-induced apoptosis in gastric cancer cells. 5-FU, ADM, TPCK
72  2001 Ethanol-induced apoptosis in hepatoma cells proceeds via intracellular Ca(2+) elevation, activation of TLCK-sensitive proteases, and cytochrome c release. ---
73  2001 Fas aggregation does not correlate with Fas-mediated apoptosis. ---
74  2001 Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction. AEBSF
75  2001 Involvement of TLCK-sensitive serine protease in colchicine-induced cell death of sympathetic neurons in culture. SCG, TPCK
76  2001 Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells. HUVECs, IRF, JAK, LPS, NF-kappaB, PDTC, TNF
77  2001 Protective action of the serine protease inhibitor N-tosyl-L-lysine chloromethyl ketone (TLCK) against acute soman poisoning. ---
78  2001 Protective role of nuclear factor kappa B against nitric oxide-induced apoptosis in J774 macrophages. GSNO, NF-kappaB, NO, PDTC, SNP
79  2001 The "in vivo" and "ex vivo" roles of cylcooxygenase-2, nuclear factor-kappaB and protein kinases pathways in the up-regulation of B1 receptor-mediated contraction of the rabbit aorta. COX, des-Arg9-BK, DEXA, NA, NF-kappaB, PDTC
80  2000 A role for serine proteases in mediating phorbol ester-induced differentiation of HL-60 cells. AEBSF, TPA, TPCK
81  2000 Characteristics of sperm acrosin-like activity of paddlefish (Polyodon spathula Walbaum). AGB, TPCK
82  2000 Inhibition of NF-kappaB by IkappaB prevents cytokine-induced NO production and promotes enterocyte apoptosis in vitro. iNOS, N-kappaB, n-LLnL, NO, PDTC, TNF-alpha
83  2000 Proteases with plasminogen activator activity in hamster oviduct. BAPNA, OE, OF, PA, PMSF, SBTI, TAME, tPA, Triton-CMF, uPA
84  2000 Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathway. DC, IL-6, rAd
85  1999 Activities of the Porphyromonas gingivalis PrtP proteinase determined by construction of prtP-deficient mutants and expression of the gene in Bacteroides species. CHAPS
86  1999 Chloromethyl ketones inhibit interleukin-12 production in mouse macrophages stimulated with lipopolysaccharide. IL-12, LPS, p40-kappaB, TPCK
87  1999 Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha. IL-1beta, LLnL, PDTC
88  1999 Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. mEH, sEH
89  1999 Ionizing radiation-induced, Bax-mediated cell death is dependent on activation of cysteine and serine proteases. ---
90  1999 Purification and characterization of an extracellular protease from alkaliphilic and thermophilic Bacillus sp. PS719. CBZ, DCI, PMSF
91  1999 Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells. TPCK
92  1999 Targeted disruption of fibronectin-integrin interactions in human gingival fibroblasts by the RI protease of Porphyromonas gingivalis W50. HGF
93  1999 Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells. BRECs, ERK, MCP-1, NAC, VEGF
94  1998 Characterization of a second cell-associated Arg-specific cysteine proteinase of Porphyromonas gingivalis and identification of an adhesin-binding motif involved in association of the prtR and prtK proteinases and adhesins into large complexes. ABM
95  1998 Chloromethyl ketones are insulin-like stimulators of lipid synthesis in locust fat body. BSA, LeuCK, PheCK, TPCK
96  1998 Comparative properties of envelope-associated arginine-gingipains and lysine-gingipain of Porphyromonas gingivalis. ---
97  1998 Diisopropylfluorophosphate (DFP) inhibits ricin-induced apoptosis of MDCK cells. DFP
98  1998 Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. IL-1beta, iNOS
99  1998 Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases. DCI, TPCK, Z-DEVD-AFC, zVAD-fmk
100  1998 High adenoviral loads stimulate NF kappaB-dependent gene expression in human vascular smooth muscle cells. CMV-IEP