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■ Abbreviation / Long Form : TSC2 / tuberous sclerosis complex 2

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Total Number of Papers: 138
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Abbreviation:   TSC2  (>> Co-occurring Abbreviation)
Long Form:   tuberous sclerosis complex 2
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No. Year Title Co-occurring Abbreviation
2019 GSK-3beta at the Crossroads in Regulating Protein Synthesis and Lipid Deposition in Zebrafish. ACC, ACL, FAS, HMGCR, mTOR, NEFA, PPARgamma, S6K1, TC, TG
2019 Involvement of C/EBPbeta-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. cyto c, DDIT4, METH, siRNA
2019 Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells. AMPKSer485, AMPKThr172, IGF-1R, IRS-1, mTOR
2019 Rationally Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High-Content Drug Screening. mTORC1
2019 Regulation of Small Intestinal Epithelial Homeostasis by Tsc2-mTORC1 Signaling. IECs, mTORC1
2019 Sevoflurane Postconditioning Inhibits Autophagy Through Activation of the Extracellular Signal-Regulated Kinase Cascade, Alleviating Hypoxic-Ischemic Brain Injury in Neonatal Rats. HIBI, LC3-II, p-mTOR, SPC
2019 Upregulation of C/EBPbeta and TSC2 by an HDAC inhibitor CG200745 protects heart from DOCA-induced hypertrophy. ChIP, HDACs, mTORC1, Pol II, qRT-PCR
2018 AMPK/TSC2/mTOR pathway regulates replicative senescence of human vascular smooth muscle cells. AMPK, mTOR, S6K1, VSMCs
2018 ARD1 contributes to IKKbeta-mediated breast cancer tumorigenesis. ARD1, HSP70, IKKbeta, mTOR
10  2018 Autophagy mediators (FOXO1, SESN3 and TSC2) in Lewy body disease and aging. DLB, FOXO1, LBs, mTOR, PD, SESN3
11  2018 Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator. BAKE, IRS2, KLF4
12  2018 Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson's Disease. ATG12, LAMP 2, LC3, p-mTOR, PD, PI3K, SIRT1
13  2018 Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat. FACS, mTORC1
14  2018 Downregulation of PERK activity and eIF2alpha serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells. ER, mTORC1, ROS
15  2018 Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment. mTORC1
16  2018 Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy. AMPK, COPD, GR, ISR, mTORC1
17  2018 Lithium promotes the production of reactive oxygen species via GSK-3beta/TSC2/TOR signaling in the gill of zebrafish (Danio rerio). CAT, DCFH-DA, GSH-Px, GSK-3beta, Li, MMP, POD, ROS, SOD, TOR
18  2018 Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways. MM, mTOR
19  2018 Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells. LAM, MEFs
20  2017 Advances in the diagnosis of hereditary kidney cancer: Initial results of a multigene panel test. FH, FLCN, MET, PMS2
21  2017 BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity. PDAC
22  2017 Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells. AMPK, CPT, mTORC1, S6K1
23  2017 Dengue Virus Activates the AMP Kinase-mTOR Axis To Stimulate a Proviral Lipophagy. AMPK, DENV, mTORC1
24  2017 Hyperglycemia-Induced Oxidative-Nitrosative Stress Induces Inflammation and Neurodegeneration via Augmented Tuberous Sclerosis Complex-2 (TSC-2) Activation in Neuronal Cells. CNS, HG, mTOR, PI3K, ROS
25  2017 IL-4 up-regulates cyclooxygenase-1 expression in macrophages. AMPK, BMDMs, IL, mTORC, PG
26  2017 Mammalian target of rapamycin signaling is a mechanistic link between increased endoplasmic reticulum stress and autophagy in the placentas of pregnancies complicated by growth restriction. ER, IUGR, mTOR, OGD, REDD1
27  2017 Stimulation of ovarian follicle growth after AMPK inhibition. AMPK, CTGF, eIF4B, HIF1A, VEGFR2, YAP
28  2017 Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors. FOXO, LAM, mTORC1, uPA
29  2016 Activation of extracellular regulated kinase and mechanistic target of rapamycin pathway in focal cortical dysplasia. DRE, ERK, FCD, FCD, mTOR, pERK, pTSC2, TS
30  2016 Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression. HDACs, mTOR, mTORC1, TAC
31  2016 Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity. EC
32  2016 Loss of Tuberous Sclerosis Complex 2 (TSC2) as a Predictive Biomarker of Response to mTOR Inhibitor Treatment in Patients with Hepatocellular Carcinoma. HCC, IHC, mTOR, PDCs, PFS
33  2016 MARCKSL1 exhibits anti-angiogenic effects through suppression of VEGFR-2-dependent Akt/PDK-1/mTOR phosphorylation. GSK-3beta, HIF-1alpha, HUVEC, MARCKSL1, mTOR, p70S6K, VEGF, VEGFR2
34  2016 Metabolic abnormalities induced by mitochondrial dysfunction in skeletal muscle of the renal carcinoma Eker (TSC2+/-) rat model. ---
35  2016 Porcine Circovirus Type 2 Activates CaMMKbeta to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium. AMPK, CaMKI, CaMKKbeta, ERK, mTOR, PCV2, PLCgamma, RNAi
36  2016 Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis. mTORC1, TSC
37  2016 The impact of mosaicism in preimplantation genetic diagnosis (PGD): approaches to PGD for dominant disorders in couples without family history. NF1, PGD
38  2016 Tissue kallikrein protects SH-SY5Y neuronal cells against oxygen and glucose deprivation-induced injury through bradykinin B2 receptor-dependent regulation of autophagy induction. AMPK, B2R, BafA1, ERK, mTOR, OGD, TK
39  2015 AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, and TSC1/TSC2. PCa
40  2015 Effects of metformin on fertilisation of bovine oocytes and early embryo development: possible involvement of AMPK3-mediated TSC2 activation. AMPK, COC, IVF, IVP
41  2015 Identification of an AMPK phosphorylation site in Drosophila TSC2 (gigas) that regulate cell growth. AMPK, mTORC1
42  2015 Imbalanced mechanistic target of rapamycin C1 and C2 activity in the cerebellum of Angelman syndrome mice impairs motor function. AS, mTOR, S6K1, UBE3A
43  2015 Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus. HCC, TSC
44  2015 mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation. mTORC1, Rheb
45  2015 Pharmacological targeting of VEGFR signaling with axitinib inhibits Tsc2-null lesion growth in the mouse model of lymphangioleiomyomatosis. LAM, VEGF-D, VEGFR
46  2015 Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38. HCMV, MOI, mTORC1
47  2014 A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation. TSC2A
48  2014 Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IkappaB kinase alpha (IKKalpha). IKKalpha, mTOR
49  2014 Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy. GSK3beta, HCC
50  2014 Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. COX-2, LAM
51  2014 Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes. IGF, IR
52  2014 Loss of TSC2 confers resistance to ceramide and nutrient deprivation. MEFs, mTORC1
53  2014 Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility. apo, Bad, HSD3B, Mtor, NF-kB
54  2014 Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis. LAM, mTOR
55  2014 Role of AMP-activated protein kinase in cancer therapy. AMPK, mTOR, PTEN
56  2014 The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. AMPK, BNIP3, FOXO, LKB1, mTORC1, TSC1
57  2014 Tnfaip8l1/Oxi-beta binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. DA, mTOR, OS, PD
58  2013 Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis. AA, COX-2, cPLA2, LOX, mTOR, mTORC1, PI3K, Rheb, VEGF
59  2013 Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome. ECs, mTOR
60  2013 Energy depletion of bovine mammary epithelial cells activates AMPK and suppresses protein synthesis through inhibition of mTORC1 signaling. AMPK, mTORC1
61  2013 Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure. CRF, GLUT1, IS, mTOR, S6K, VSMC
62  2013 Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. FAK, FAK-KD, IGF-1, MPS, SCR
63  2013 Pancreatic neuroendocrine tumor in a child with a tuberous sclerosis complex 2 (TSC2) mutation. mTOR, PanNETs, TSC, WHO
64  2013 Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. IRS2, mTORC1, PC-TP, Them2
65  2013 Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway. miRNA, PIK3alpha, PTEN, SC, SE
66  2013 Tuberin and p27 expression in breast cancer patients with or without BRCA germline mutations. ---
67  2013 Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia. Abeta, AD, AMPK, PS
68  2012 A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2). mTOR, NMDAR
69  2012 Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes. AMPK, CaMKKbeta, LKB1, mTOR
70  2012 Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. MCAO, mTOR, OGD
71  2012 Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway. IL, TAM
72  2012 mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo. AMPK, mTORC1, NDGA
73  2012 Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage. EBs, ECs, EEs, ISCs
74  2012 Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation. AFS, EBs, mTOR, PRAS40
75  2012 Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase. mTOR, TORC1
76  2012 Uterine angiosarcoma associated with lymphangioleiomyomatosis in a patient with tuberous sclerosis complex: an autopsy case report with immunohistochemical and genetic analysis. ---
77  2011 AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor. AMPK, CaMKK, PI3K, PTEN, S6K
78  2011 Doxycycline inhibits matrix metalloproteinase-2 secretion from TSC2-null mouse embryonic fibroblasts and lymphangioleiomyomatosis cells. FBS, LAM, MEFs, MMPs
79  2011 ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling. ERK, GAP, mTOR, mTORC1
80  2011 GSK-3beta at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways. GSK-3beta, IPC, MPG, mTOR, PPC, ROS
81  2011 Increased expression of tuberin in human uterine leiomyoma. ---
82  2011 mTORC2 is required for proliferation and survival of TSC2-null cells. LAM, siRNA, TS
83  2011 Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR. mTOR, S6Ks
84  2011 The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. mTOR
85  2011 ULK1 inhibits the kinase activity of mTORC1 and cell proliferation. mTORC1
86  2010 AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. AMPK, CKI
87  2010 Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR. ADPKD, CP1, CP1, ESRF, PC1
88  2010 Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication. HSV-1
89  2010 Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. AMPK, EDL, mTOR, p70S6K
90  2010 Herpes Simplex Virus is Akt-ing in translational control. mTORC1
91  2010 Interferons modulate mitogen-induced protein synthesis in airway smooth muscle. ASM, mTOR, S6K1
92  2010 Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves. CNS, DRGs, mTOR, PNS
93  2010 The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. HPV-16, mTOR, S6K
94  2010 Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition. EMT, mTOR
95  2010 Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. PI3K
96  2009 Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR. G protein, GAP, GTPase, mTOR, NMR
97  2009 Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles. mTORC1, POF
98  2009 Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. mTOR, PPARgamma
99  2009 REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch. mTOR, si
100  2009 Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway. Bhd, FLCN