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■ Abbreviation / Long Form : TTX-S / tetrodotoxin-sensitive

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Total Number of Papers: 118
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Abbreviation:   TTX-S  (>> Co-occurring Abbreviation)
Long Form:   tetrodotoxin-sensitive
 Abbreviation Variation
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No. Year Title Co-occurring Abbreviation
2019 Brucine alleviates neuropathic pain in mice via reducing the current of the sodium channel. AP, CCI, TTX-R
2019 Extracellular signal-regulated kinases mediate the enhancing effects of inflammatory mediators on resurgent currents in dorsal root ganglion neurons. DRG, ERK, PKC, TTX-R
2018 Conditional knockout of NaV1.6 in adult mice ameliorates neuropathic pain. AAV, DRG, SNI
2018 CRMP2 is necessary for Neurofibromatosis type 1 related pain. CRMP2, NF1
2018 CRMP2-Neurofibromin Interface Drives NF1-related Pain. CGRP, CRMP2, NF1
2018 Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V. DRG, TTX-R
2018 Puerarin Relieves Paclitaxel-Induced Neuropathic Pain: The Role of Nav1.8 beta1 Subunit of Sensory Neurons. DRG, TTX-R
2018 Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain. JZTX-34
2018 Tanshinone IIA Improves Painful Diabetic Neuropathy by Suppressing the Expression and Activity of Voltage-Gated Sodium Channel in Rat Dorsal Root Ganglia. DRG, i.p, PDN, STZ, TIIA, VGSCs
10  2018 Tetrodotoxin-sensitive voltage-gated sodium channels regulate bladder afferent responses to distension. DRG, IC/BPS, TTX-R
11  2017 Bulleyaconitine A preferably reduces tetrodotoxin-sensitive sodium current in uninjured dorsal root ganglion neurons of neuropathic rats probably via inhibition of protein kinase C. BLA, DRG, L5 SNL, SNI, VGSCs
12  2017 HYP-17, a novel voltage-gated sodium channel blocker, relieves inflammatory and neuropathic pain in rats. DRG, SCI, TTX-R, VGSCs
13  2017 Urothelial Tight Junction Barrier Dysfunction Sensitizes Bladder Afferents. CLDN2, IC/BPS, TJ
14  2016 Acid modulation of tetrodotoxin-sensitive Na+ channels in large-sized trigeminal ganglion neurons. TG, TTX-R
15  2016 Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels. NMR, RP-HPLC, SC, TLC, TTX-R
16  2016 Roles of Voltage-Gated Tetrodotoxin-Sensitive Sodium Channels NaV1.3 and NaV1.7 in Diabetes and Painful Diabetic Neuropathy. DM, DRG, PDN, VGSCs
17  2016 Voltage-gated sodium channel function and expression in injured and uninjured rat dorsal root ganglia neurons. DRG, Nav, Nav1.8, SNL, TTX-R
18  2015 An efficient strategy for heterologous expression and purification of active peptide hainantoxin-IV. DRG, GST, HNTX-IV, ICK, MALDI-TOF MS, RF, rHNTX-IV, SUMO, TCA
19  2015 De novo expression of Nav1.7 in injured putative proprioceptive afferents: Multiple tetrodotoxin-sensitive sodium channels are retained in the rat dorsal root after spinal nerve ligation. DRG, SNL
20  2015 Natural mutations change the affinity of mu-theraphotoxin-Hhn2a to voltage-gated sodium channels. VGSCs
21  2015 Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors. hPSCs
22  2014 Analgesic effects of Huwentoxin-IV on animal models of inflammatory and neuropathic pain. HWTX-IV
23  2014 Regulation/modulation of sensory neuron sodium channels. DRG, TTX-R
24  2014 Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators. DRG, TTX-R
25  2014 Up-regulation of NaV1.7 sodium channels expression by tumor necrosis factor-alpha in cultured bovine adrenal chromaffin cells and rat dorsal root ganglion neurons. DRG, TNF-alpha
26  2013 Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel. HWTX-IV, mHWTX-IV
27  2013 Synthesis and biological characterization of synthetic analogs of Huwentoxin-IV (Mu-theraphotoxin-Hh2a), a neuronal tetrodotoxin-sensitive sodium channel inhibitor. DRG
28  2013 The scorpion toxin Amm VIII induces pain hypersensitivity through gain-of-function of TTX-sensitive Na⁺ channels. DRG
29  2012 A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels. DRG, HNTX-IV
30  2012 Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine. DRG, TTX-R
31  2012 Ethanolic extract of Aconiti Brachypodi Radix attenuates nociceptive pain probably via inhibition of voltage-dependent Na⁺ channel. DRG, EABR
32  2012 Thermal sensitivity of voltage-gated Na+ channels and A-type K+ channels contributes to somatosensory neuron excitability at cooling temperatures. DRG, IA, IK, TTX-R
33  2011 Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin. COX-2, r-anntoxin, TNF-alpha, VGSC
34  2011 Capsaicin indirectly suppresses voltage-gated Na+ currents through TRPV1 in rat dorsal root ganglion neurons. TRPV1
35  2011 Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo. DRG
36  2011 Single-cell analysis of sodium channel expression in dorsal root ganglion neurons. DRG, TTX-R
37  2010 Altered expression of sodium channel distribution in the dorsal root ganglion after gradual elongation of rat sciatic nerves. TTX-R
38  2010 Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. TTX-R
39  2010 Excitability parameters and sensitivity to anemone toxin ATX-II in rat small diameter primary sensory neurones discriminated by Griffonia simplicifolia isolectin IB4. TTX-R
40  2010 Pharmacological effect of deoxypodophyllotoxin: a medicinal agent of plant origin, on mammalian neurons. APs, DOP, DRG, TTX-R
41  2009 Expression and characterization of jingzhaotoxin-34, a novel neurotoxin from the venom of the tarantula Chilobrachys jingzhao. JZTX-34, TTX-R
42  2009 The first gene-encoded amphibian neurotoxin. VGSC
43  2008 Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain. DRG, FB, FCA, TTX-R
44  2008 Differing alterations of sodium currents in small dorsal root ganglion neurons after ganglion compression and peripheral nerve injury. CCD, CCI, DRG, TTX-R
45  2008 Effects of a polyacetylene from Panax ginseng on Na+ currents in rat dorsal root ganglion neurons. TTX-R
46  2008 Effects of eugenol on Na+ currents in rat dorsal root ganglion neurons. TTX-R
47  2008 Jingzhaotoxin-II, a novel tarantula toxin preferentially targets rat cardiac sodium channel. JZTX-II, TTX-R, VGSCs
48  2008 JZTX-IV, a unique acidic sodium channel toxin isolated from the spider Chilobrachys jingzhao. JZTX-IV, TTX-R
49  2008 The effect of recombinant neurotoxins from the sea anemone Anthopleura sp. on sodium currents of rat cerebral cortical neurons. ---
50  2007 Celecoxib inhibits Na+ currents in rat dorsal root ganglion neurons. COX-2, TTX-R
51  2007 CgNa, a type I toxin from the giant Caribbean sea anemone Condylactis gigantea shows structural similarities to both type I and II toxins, as well as distinctive structural and functional properties(1). DRG
52  2007 Characterization of the excitatory mechanism induced by Jingzhaotoxin-I inhibiting sodium channel inactivation. JZTX-I
53  2007 Inactivation properties of sodium channel Nav1.8 maintain action potential amplitude in small DRG neurons in the context of depolarization. AP, DRG, TTX-R, WT
54  2007 Inhibitory effects of artemisinin on voltage-gated ion channels in intact nodose ganglion neurones of adult rats. CTX, TTX-R
55  2007 Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels. TTX
56  2007 Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain). NGF
57  2007 [Synthesis and oxidative refolding of an N-terminal truncate of jingzhaotoxin-V and characterization of its activities of sodium channels]. RP-HPLC, TTX-R
58  2006 Effects of ApC, a sea anemone toxin, on sodium currents of mammalian neurons. TTX-R
59  2006 Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. DRG, TTX-R
60  2006 The anti-nociceptive effect of BmK AS, a scorpion active polypeptide, and the possible mechanism on specifically modulating voltage-gated Na+ currents in primary afferent neurons. APs, TTX-R
61  2006 The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels. ---
62  2005 Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons. TTX-R
63  2005 Effects of lysophosphatidic acid on sodium currents in rat dorsal root ganglion neurons. DRG, LPA, TTX-R
64  2005 Loureirin B: An Effective Component in Dragon's Blood Modulating Sodium Currents in TG Neurons. TCM, TG, TTX-R
65  2005 Modulation of nano-selenium on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons. ---
66  2005 Resveratrol inhibits Na+ currents in rat dorsal root ganglion neurons. DRG, TTX-R
67  2005 State-dependent block of rat Nav1.4 sodium channels expressed in xenopus oocytes by pyrazoline-type insecticides. DRG, TTX-R
68  2005 Tetrodotoxin-resistant Na+ channels in human neuroblastoma cells are encoded by new variants of Nav1.5/SCN5A. TTX-R
69  2005 The modulation effects of BmK I, an alpha-like scorpion neurotoxin, on voltage-gated Na(+) currents in rat dorsal root ganglion neurons. BmK, DRG, TTX-R
70  2004 Block of tetrodotoxin-resistant Na+ channel pore by multivalent cations: gating modification and Na+ flow dependence. TTX-R
71  2004 Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury. DRG, RMP, SNL
72  2004 Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons. DRG
73  2004 Modulation of sodium currents in rat dorsal root ganglion neurons by sulfur dioxide derivatives. DRG, TTX-R
74  2004 Tetrodotoxin-sensitive and -resistant Na+ channel currents in subsets of small sensory neurons of rats. DRG, IB4
75  2003 Arylacetamide kappa-opioid receptor agonists produce a tonic- and use-dependent block of tetrodotoxin-sensitive and -resistant sodium currents in colon sensory neurons. kappa-ORAs
76  2003 ATP modulation of sodium currents in rat dorsal root ganglion neurons. TTX-R
77  2003 Diclofenac inhibition of sodium currents in rat dorsal root ganglion neurons. NSAID, TTX-R
78  2003 Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana. ---
79  2003 Purification and characterization of Hainantoxin-V, a tetrodotoxin-sensitive sodium channel inhibitor from the venom of the spider Selenocosmia hainana. HNTX-V, TTX-R
80  2003 Voltage-dependent block of sodium channels in mammalian neurons by the oxadiazine insecticide indoxacarb and its metabolite DCJW. TTX-R
81  2002 Changes in Na(+) channel currents of rat dorsal root ganglion neurons following axotomy and axotomy-induced autotomy. DRG, TTX-R
82  2002 Changes in three subtypes of tetrodotoxin sensitive sodium channel expression in the axotomized dorsal root ganglion in the rat. DRG, EDs
83  2002 Effects of arachidonic acid on sodium currents in rat dorsal root ganglion neurons. TTX-R
84  2002 Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena. TTX, TTX-R
85  2002 Kinetic properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channel currents in neonatal rat trigeminal ganglion neurons. TTX-R
86  2002 Modulation of sodium channels in primary afferent neurons. HSV, PGE2, TTX-R
87  2002 The sea anemone toxins BgII and BgIII prolong the inactivation time course of the tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons. ATX-II, TTX-R
88  2001 Buthus martensi Karsch agonist of skeletal-muscle RyR-1, a scorpion active polypeptide: antinociceptive effect on rat peripheral nervous system and spinal cord, and inhibition of voltage-gated Na(+) currents in dorsal root ganglion neurons. BmK AS-1, DRG, TTX-R
89  2001 Effects of ATP on TTX-sensitive and TTX-resistant sodium currents in rat sensory neurons. TTX-R
90  2001 Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons. DRG, TTX-R, TTX-RP
91  2001 The inhibitory effects of BmK IT2, a scorpion neurotoxin on rat nociceptive flexion reflex and a possible mechanism for modulating voltage-gated Na(+) channels. BmK IT2, TTX-R
92  2000 An analysis of the variations in potency of grayanotoxin analogs in modifying frog sodium channels of differing subtypes. DRG, GTX
93  2000 ATP evokes different currents in TTX-sensitive and TTX-resistant cells of dorsal root ganglia. TTX-R
94  2000 Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine. DRG, TTX-R
95  2000 Characteristics of ropivacaine block of Na+ channels in rat dorsal root ganglion neurons. DRG, TTX-R
96  2000 Ethanol modulates the ionic permeability of sodium channels in rat sensory neurons. TTX-R
97  2000 Inhibitory action of thimerosal, a sulfhydryl oxidant, on sodium channels in rat sensory neurons. TTX-R
98  2000 N-Ethylmaleimide modulation of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. DRG, NEM, TTX-R
99  2000 Nitric oxide is an autocrine regulator of Na(+) currents in axotomized C-type DRG neurons. DRG, L-NAME, NO, NOS, TTX-R
100  2000 [Effects of phoxim and fenvalerate on TTX-S and TTX-R sodium channels in the DRG neurons of adult rat]. DRG, Fen, Pho, TTX-R