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■ Abbreviation / Long Form : Trk / tropomyosin-related kinase

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Total Number of Papers: 85
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Abbreviation:   Trk  (>> Co-occurring Abbreviation)
Long Form:   tropomyosin-related kinase
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No. Year Title Co-occurring Abbreviation
2019 A phase 1, open-label, dose-escalation trial of oral TSR-011 in patients with advanced solid tumours and lymphomas. ALK, NSCLC, RP2D
2019 Investigating Trk Protein Expression between Oropharyngeal and Non-oropharyngeal Squamous Cell Carcinoma: Clinical Implications and Possible Roles of Human Papillomavirus Infection. HNSCC, HPV, RFS, SCC
2019 Trk inhibitor GNF‑5837 suppresses the tumor growth, survival and migration of renal cell carcinoma. ERK, RCC
2019 TrkB Agonist LM22A-4 Increases Oligodendroglial Populations During Myelin Repair in the Corpus Callosum. BDNF, CNS, TDP6
2019 Tropomyosin-Related Kinase Receptor and Neurotrophin Expression in Cutaneous Melanoma Is Associated with a Poor Prognosis and Decreased Survival. BDNF, NGF, NTs, OS, RFS
2018 Bioactivity-Guided Isolation of Neuritogenic Factor from the Seeds of the Gac Plant (Momordica cochinchinensis). CNS, NGF, TI, TIPTOPs
2018 Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration. BDNF, NGF, NT-3
2018 Corticotropin-releasing hormone-binding proteinis up-regulated by brain-derived neurotrophic factor and is secreted in an activity-dependent manner in rat cerebral cortical neurons. BDNF, CRH, CRH-BP, CTX, PLCgamma, RT-qPCR
2018 Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models. LS, NGF, UV
10  2018 Dramatic bone remodeling following larotrectinib administration for bone metastasis in a patient with TRK fusion congenital mesoblastic nephroma. ---
11  2018 Emerging Targeted Therapy for Tumors with NTRK Fusion Proteins. NTRK
12  2018 Expression of brain-derived neurotrophic factor in kidneys from normal and cyclosporine-treated rats. AQP2, BDNF, CsA
13  2018 Neurotrophic Factors: An Overview. p75NTR
14  2017 Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy. EGR3, NGF, NTs, SM
15  2017 Brain-derived neurotrophic factor/tropomyosin-related kinase B signaling pathway contributes to the aggressive behavior of lung squamous cell carcinoma. BDNF, MMP-2, rhBDNF, SCC
16  2016 Down-regulation of brain-derived neurotrophic factor and its signaling components in the brain tissues of scrapie experimental animals. BDNF, IFA, IHC
17  2016 Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101. IFS
18  2016 Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk. GGTase I, sGTPases
19  2016 Potentiation of Methylmercury-Induced Death in Rat Cerebellar Granular Neurons Occurs by Further Decrease of Total Intracellular GSH with BDNF via TrkB in Vitro. BDNF, BSO, CGNs, DEM
20  2016 Prognostic value of tropomyosin-related kinases A, B, and C in gastric cancer. CI, DSS, HR, RFS
21  2016 The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. BDNF, mAb, NGF, NT-3, NT4
22  2015 BDNF, via truncated TrkB receptor, modulates GlyT1 and GlyT2 in astrocytes. BDNF, GlyT, TrkB-FL
23  2015 Congenital absence of corticospinal tract does not severely affect plastic changes of the developing postnatal spinal cord. BDNF, CNTF, CST, GDNF, NT-3, PKCgamma
24  2015 Establishment of a cellular model to study TrkC-dependent neuritogenesis. Dox, NGF, NT-3
25  2015 Neural progenitor cell transplantation promotes neuroprotection, enhances hippocampal neurogenesis, and improves cognitive outcomes after traumatic brain injury. MNTS1-NPCs, MWM, NPCs, TBI
26  2015 Neuroprotection elicited by nerve growth factor and brain-derived neurotrophic factor released from astrocytes in response to methylmercury. BDNF, MCM, NGF
27  2015 Secreted herpes simplex virus-2 glycoprotein G modifies NGF-TrkA signaling to attract free nerve endings to the site of infection. gG, HSV-1, NGF
28  2015 The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells. NGF
29  2015 TrkB is involved in the mechanism by which BDNF accelerates the glutamate-induced death of rat neuroblastoma B35 cells. BDNF, MAPK
30  2014 Dynamic nature of the p75 neurotrophin receptor in response to injury and disease. ---
31  2014 Mapping of neurotrophins and their receptors in the adult mouse brain and their role in the pathogenesis of a transgenic murine model of bovine spongiform encephalopathy. BDNF, BSE, GFAP, NGF, NT
32  2014 Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player. BDNF, NGF, SOCS, SOCS2
33  2014 TrkB kinase activity is critical for recovery of respiratory function after cervical spinal cord hemisection. BDNF
34  2013 A novel uHPLC-MS/MS method for the quantitation of AZD7451 (AZ12607092) in human plasma. ---
35  2013 Brain-derived neurotrophic factor in cigarette smoke-induced airway hyperreactivity. ASM, BDNF, CSE, si
36  2013 BRET Biosensor Analysis of Receptor Tyrosine Kinase Functionality. BRET, FGFR, GHR, GPCR, IGFR, IR, p75NTR, PDGFR, RTK, VEGFR
37  2013 Differential effects of dehydroepiandrosterone and testosterone in prostate and colon cancer cell apoptosis: the role of nerve growth factor (NGF) receptors. DHEA, NGF
38  2013 Motor activity affects adult skeletal muscle re-innervation acting via tyrosine kinase receptors. BDNF
39  2013 Novel small molecule activators of the Trk family of receptor tyrosine kinases. ---
40  2012 Antitumor activity of AZ64 via G2/M arrest in non-small cell lung cancer. NSCLC
41  2012 BDNF-dependent accumulation of palmitoleic acid in CNS neurons. BDNF, PLO
42  2012 The neurotrophin family of neurotrophic factors: an overview. ---
43  2012 Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells. hES
44  2011 DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma. HCC
45  2011 Expression of neurotrophin and its tropomyosin-related kinase receptors (Trks) during axonal regeneration following spinal cord injury in larval lamprey. NT, Trks
46  2011 Leukemias induced by altered TRK-signaling are sensitive to mTOR inhibitors in preclinical models. ---
47  2011 Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development. GC, GDF9
48  2011 Positive feedback regulation between gamma-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons. BDNF, ERK, GABA, PI3K, PKC
49  2010 Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development. BDNF, NT4
50  2010 Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons. Co-IP, Dok, GST, NT-3, PTB
51  2010 Functional interactions between steroid hormones and neurotrophin BDNF. BDNF, CNS
52  2010 Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development. ---
53  2010 Neurotrophin receptors TrkB.T1 and p75NTR cooperate in modulating both functional and structural plasticity in mature hippocampal neurons. ---
54  2010 RanBPM contributes to TrkB signaling and regulates brain-derived neurotrophic factor-induced neuronal morphogenesis and survival. BDNF, RanBPM
55  2010 TrkC plays an essential role in breast tumor growth and metastasis. PI3K
56  2009 Axonal targeting of Trk receptors via transcytosis regulates sensitivity to neurotrophin responses. NGF
57  2009 Brain-derived neurotrophic factor (BDNF) has proliferative effects on neural stem cells through the truncated TRK-B receptor, MAP kinase, AKT, and STAT-3 signaling pathways. BDNF, EGF, fl-TRK-B, NSCs, NT, TRK-B, TRK-C
58  2009 Complex formation of a brain-derived neurotrophic factor and glycosaminoglycans. BDNF, GAGs, NTR
59  2009 High-affinity neurotrophin receptors and ligands promote leukemogenesis. NTs, RT-PCR
60  2009 Triggering neurotrophic factor actions through adenosine A2A receptor activation: implications for neuroprotection. ---
61  2008 Activity-dependent regulation of neuronal apoptosis in neonatal mouse cerebral cortex. ---
62  2008 Neurotrophic factors in Alzheimer's disease: role of axonal transport. AD, BDNF, NGF, NTF
63  2008 The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors. NGF
64  2007 A cell-biological model of p75NTR signaling. ---
65  2007 Expression of angiogenic and neurotrophic factors in the progenitor cell niche of adult monkey subventricular zone. FLT-1, SVZa
66  2007 Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: potential implications for Rett syndrome. BDNF, MR, RTT, TRPC
67  2007 TrkC binds to the bone morphogenetic protein type II receptor to suppress bone morphogenetic protein signaling. BMP-2, BMPRII, NT-3
68  2006 Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation. BDNF, NGF
69  2006 Cyclic-AMP response element-based signaling assays for characterization of Trk family tyrosine kinases modulators. BDNF, CRE, NTs
70  2006 Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation. ---
71  2006 Expression of neurotrophins and their receptors tropomyosin-related kinases (Trk) under tension-stress during distraction osteogenesis. ---
72  2006 Immunohistochemical analysis of acid-sensing ion channel 2 expression in rat dorsal root ganglion and effects of axotomy. ASIC2, NF200
73  2006 Neurotrophin-regulated signalling pathways. NF-kappaB, p75NTR, PI3
74  2006 Neurotrophins mediate human embryonic stem cell survival. hES
75  2006 Polysialic acid limits choline acetyltransferase activity induced by brain-derived neurotrophic factor. BDNF, ChAT, PSA
76  2006 The dark side of the NGF family: neurotrophins in neoplasias. NGF
77  2005 Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinases. ---
78  2005 Neurotrophins protect against cytosine arabinoside-induced apoptosis of immature rat cerebellar neurons. BDNF, CGC, MAPK, MEK, NT-3, NT-4, PI
79  2003 Inhibitors of neuronal regeneration: mediators and signaling mechanisms. CNS, MAP, PI 3-kinase
80  2003 Neurotrophins in cultured cells from periodontal tissues. BDNF, IL, NGF, NT-3
81  2002 Trk Neurotrophin Receptor Activators. ---
82  1996 Dissociation of p75 receptors and nerve growth factor neurotrophic effects: lack of p75 immunoreactivity in striatum following physical trauma, excitotoxicity and NGF administration. ChAT, CNS, NGF
83  1996 TRK and p75 neurotrophin receptor systems in the developing human brain. p75NTR, p75NTR-ir, trk-ir
84  1995 Time-resolved signaling pathways of nerve growth factor diverge downstream of the p140trk receptor activation between chick sympathetic and dorsal root ganglion sensory neurons. DRG, MAP, NGF
85  1994 trk-immunoreactivity in the monkey central nervous system: forebrain. ChAT, NGF