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■ Abbreviation / Long Form : VCN / vector copy number

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Total Number of Papers: 19
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Abbreviation:   VCN  (>> Co-occurring Abbreviation)
Long Form:   vector copy number
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No. Year Title Co-occurring Abbreviation
2021 A Novel Branched DNA-Based Flowcytometric Method for Single-Cell Characterization of Gene Therapy Products and Expression of Therapeutic Genes. GT
2021 Combination of lentiviral and genome editing technologies for the treatment of sickle cell disease. HSPCs, LVs, SCD
2021 Droplet digital PCR allows vector copy number assessment and monitoring of experimental CAR T cells in murine xenograft models or approved CD19 CAR T cell-treated patients. AML, axi-cel, CAR, FC, MM, tisa-cel
2021 Gene delivery using AAV8 in vivo for disease stabilization in a bimodal gene therapy approach for the treatment of ADA-deficient SCID. AAV, ADA, ERT, LV
2021 Reference standards for accurate validation and optimization of assays that determine integrated lentiviral vector copy number in transduced cells. LV
2020 betaT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for ExVivo Anti-sickling Activity in Human Erythroid Cells. SCD, sHUDEP-2
2020 Busulfan Pharmacokinetics in Adenosine Deaminase-Deficient Severe Combined Immunodeficiency Gene Therapy. ABW, AUC, BSA, BU, gamma-RV, GT, HSPCs, LV, TDM
2020 Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy. HSC, LVs
2020 Vector Copy Distribution at a Single-Cell Level Enhances Analytical Characterization of Gene-Modified Cell Therapies. ---
10  2019 PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a beta-Globin Lentiviral Vector. HSPC, LV
11  2018 Efficient Transduction and Expansion of Ovine Macrophages for Gene Therapy Implementations. ---
12  2018 Staurosporine Increases Lentiviral Vector Transduction Efficiency of Human Hematopoietic Stem and Progenitor Cells. HSPCs, LVV, MPB, PGE2
13  2017 Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency. ADA-deficient, ERT, HSCT, MND-ADA, PBMC, RIC
14  2017 Long-term effects of systemic gene therapy in a canine model of myotubular myopathy. AAV, XLMTM
15  2016 Application of Droplet Digital PCR for Estimating Vector Copy Number States in Stem Cell Gene Therapy. ddPCR, iPSCs, SCGT
16  2015 Plerixafor+G-CSF-mobilized CD34+ cells represent an optimal graft source for thalassemia gene therapy. ---
17  2014 Dose response and clonal variability of lentiviral tetracycline-regulated vectors in murine hematopoietic cells. tetPs
18  2013 Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number. GFP, HSC, SIN-LTR, YFP
19  2010 Quantification of lentiviral vector copy numbers in individual hematopoietic colony-forming cells shows vector dose-dependent effects on the frequency and level of transduction. CFC, qPCR