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■ Abbreviation / Long Form : VGSCs / voltage-gated sodium channels

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Total Number of Papers: 245
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Abbreviation:   VGSCs  (>> Co-occurring Abbreviation)
Long Form:   voltage-gated sodium channels
 Abbreviation Variation
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No. Year Title Co-occurring Abbreviation
2019 -TRTX-Ca1a: a novel neurotoxin from Cyriopagopus albostriatus with analgesic effects. Ca1a
2019 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels. 3MOD, CCI, DAI, GEN
2019 Biocatalytic Detoxification of Paralytic Shellfish Toxins. PSTs
2019 BmK AEP, an Anti-Epileptic Peptide Distinctly Affects the Gating of Brain Subtypes of Voltage-Gated Sodium Channels. APs
2019 BmK NT1-induced neurotoxicity is mediated by PKC/CaMKⅡ-dependent ERK1/2 and p38 activation in primary cultured cerebellar granule cells. BmK, CaMKK, CGCs, DIVs, JNK
2019 Changes in the neurotransmitter profile in the central nervous system of marine medaka (Oryzias melastigma) after exposure to brevetoxin PbTx-1 - A multivariate approach to establish exposure biomarkers. CNS, NMDARs, OPLS-DA, PCA, PLS-DA, SUS-plot
2019 Convergent and parallel evolution in a voltage-gated sodium channel underlies TTX-resistance in the Greater Blue-ringed Octopus: Hapalochlaena lunulata. TTX
2019 Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies. PAMPA, SCGE
2019 Distribution and Functional Characteristics of Voltage-Gated Sodium Channels in Immature Cochlear Hair Cells. IHCs
10  2019 Evaluation of the anticancer and anti-metastasis effects of novel synthetic sodium channel blockers in prostate cancer cells in vitro and in vivo. SCBs
11  2019 Natural Voltage-Gated Sodium Channel Ligands: Biosynthesis and Biology. ---
12  2019 SCN9A Epileptic Encephalopathy Mutations Display a Gain-of-function Phenotype and Distinct Sensitivity to Oxcarbazepine. OXC, WT
13  2019 The Emerging Role of Voltage-Gated Sodium Channels in Tumor Biology. ---
14  2019 The influence of voltage-gated sodium channels on human gastrointestinal nociception. ---
15  2019 The Role of Voltage-Gated Sodium Channels in Pain Signaling. ---
16  2019 Understanding Genotypes and Phenotypes of the Mutations in Voltage- Gated Sodium Channel alpha Subunits in Epilepsy. ---
17  2019 Voltage-Gated Sodium Channels Are Involved in Cognitive Impairments in Parkinson's Disease- like Rats. 6-OHDA, PD
18  2019 Voltage-gated Sodium Channels in Sensory Information Processing. ---
19  2019 Voltage-gated sodium channels: structures, functions, and molecular modeling. CADD
20  2018 Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma. CaM, CaMKII
21  2018 Differential roles of NaV1.2 and NaV1.6 in regulating neuronal excitability at febrile temperature and distinct contributions to febrile seizures. FS, PTx3
22  2018 Evaluation of the antinociceptive activities of several sodium channel blockers using veratrine test in mice. ---
23  2018 Functional Modulation of Nav1.2 Voltage-Gated Sodium Channels Induced by Escitalopram. SSRI
24  2018 Inhibition of lncRNA X inactivate-specific transcript ameliorates inflammatory pain by suppressing satellite glial cell activation and inflammation by acting as a sponge of miR-146a to inhibit Nav 1.7. CFA, DRG, GFAP, lncRNA, XIST
25  2018 Posttranslational Modification of Sodium Channels. ---
26  2018 Re-expression of voltage-gated sodium channel subtype Nav1.3 in the substantia nigra after dopamine depletion. BG, PD
27  2018 Reduced cooperativity of voltage-gated sodium channels in the hippocampal interneurons of an aged mouse model of Alzheimer's disease. AD, APdE9, APs, HH, NTG
28  2018 Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated with Pain. ---
29  2018 Selective lysis of breast carcinomas by simultaneous stimulation of sodium channels and blockade of sodium pumps. ---
30  2018 Strong G-Protein-Mediated Inhibition of Sodium Channels. CaSR, GDP
31  2018 Tanshinone IIA Improves Painful Diabetic Neuropathy by Suppressing the Expression and Activity of Voltage-Gated Sodium Channel in Rat Dorsal Root Ganglia. DRG, i.p, PDN, STZ, TIIA, TTX-S
32  2018 The Effect of Ca2+, Lobe-Specificity, and CaMKII on CaM Binding to NaV1.1. CaM, CaMKII
33  2018 The effect of ethanol extract of Glycyrrhiza uralensis on the voltage-gated sodium channel subtype 1.4. G. uralensis
34  2018 Toxins That Affect Voltage-Gated Sodium Channels. ---
35  2018 Voltage-gated sodium channel beta subunits: The power outside the pore in brain development and disease. ---
36  2018 [Voltage-gated sodium channels regulate the biological functions of macrophages]. ---
37  2017 A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms. HH
38  2017 Activation of sodium channel by a novel alpha-scorpion toxin, BmK NT2, stimulates ERK1/2 and CERB phosphorylation through a Ca2+ dependent pathway in neocortical neurons. CREB, ERK
39  2017 Activation of sodium channels by alpha-scorpion toxin, BmK NT1, produced neurotoxicity in cerebellar granule cells: an association with intracellular Ca2+ overloading. CGCs
40  2017 Bulleyaconitine A preferably reduces tetrodotoxin-sensitive sodium current in uninjured dorsal root ganglion neurons of neuropathic rats probably via inhibition of protein kinase C. BLA, DRG, L5 SNL, SNI, TTX-S
41  2017 C2-Modified Sparteine Derivatives Are a New Class of Potentially Long-Acting Sodium Channel Blockers. ---
42  2017 Cytokine cascades induced by mechanical trauma injury alter voltage-gated sodium channel activity in intact cortical neurons. BDNF, IL, TBI
43  2017 Deltamethrin affects the expression of voltage-gated calcium channel alpha1 subunits and the locomotion, egg-laying, foraging behavior of Caenorhabditis elegans. C. elegans, VGCCs
44  2017 Distribution and function of voltage-gated sodium channels in the nervous system. ---
45  2017 FGF14 is a regulator of KCNQ2/3 channels. AIS, FGF14
46  2017 HYP-17, a novel voltage-gated sodium channel blocker, relieves inflammatory and neuropathic pain in rats. DRG, SCI, TTX-R, TTX-S
47  2017 Investigation of Binding Modes and Functional Surface of Scorpion Toxins ANEP to Sodium Channels 1.7. ANEP
48  2017 Local knockdown of Nav1.6 relieves pain behaviors induced by BmK I. BmK
49  2017 Modification of distinct ion channels differentially modulates Ca2+ dynamics in primary cultured rat ventricular cardiomyocytes. RyRs
50  2017 Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate. ---
51  2017 Molecular Mechanism of Action and Selectivity of Sodium Ch annel Blocker Insecticides. SCBIs
52  2017 New Anti-Seizure (Arylalkyl)azole Derivatives: Synthesis, In Vivo and In Silico Studies. GABA, LRZ
53  2017 Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel beta4 subunit explain its role in cell-cell adhesion. ---
54  2017 Peptide-rich venom from the spider Heteropoda venatoria potently inhibits insect voltage-gated sodium channels. DUM
55  2017 The efficacy of lacosamide as monotherapy and adjunctive therapy in focal epilepsy and its use in status epilepticus: clinical trial evidence and experience. AEDs, AEs, LCM, SE
56  2017 The role of REST and HDAC2 in epigenetic dysregulation of Nav1.5 and nNav1.5 expression in breast cancer. HDACs, REST, TSA
57  2017 Zn2+ reduction induces neuronal death with changes in voltage-gated potassium and sodium channel currents. TPEN
58  2016 Anti-angiogenic activities of CRBGP from buccal glands of lampreys (Lampetra japonica). CAM, CRISPs, HUVECs, MMP-2, MMP-9, VEGF-A
59  2016 Changes in the expression of voltage-gated sodium channels Nav1.3, Nav1.7, Nav1.8, and Nav1.9 in rat trigeminal ganglia following chronic constriction injury. TN
60  2016 Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin. ATX, FLIPR
61  2016 Differential effects of lacosamide, phenytoin and topiramate on peripheral nerve excitability: An ex vivo electrophysiological study. AEDs, CAP, LCM, PHT, PNS, TPM
62  2016 Effects of Hedera helix L. extracts on rat prostate cancer cell proliferation and motility. ---
63  2016 Effects of Na+ Current and Mechanogated Channels in Myofibroblasts on Myocyte Excitability and Repolarization. APD, Mfb-M, MGCs
64  2016 Functional up-regulation of Nav1.8 sodium channel on dorsal root ganglia neurons contributes to the induction of scorpion sting pain. ASODN, BmK, CFA, DRG
65  2016 Glycyrrhizic Acid Ameliorates Cognitive Impairment in a Rat Model of Vascular Dementia Associated with Oxidative Damage and Inhibition of Voltage-Gated Sodium Channels. GA, VD
66  2016 Inhibition of cystathionine beta-synthetase suppresses sodium channel activities of dorsal root ganglion neurons of rats with lumbar disc herniation. AOAA, CBS, DRG, LDH
67  2016 Inverse Association between Sodium Channel-Blocking Antiepileptic Drug Use and Cancer: Data Mining of Spontaneous Reporting and Claims Databases. AEDs, ASR, CI, ESSA, IC, ROR
68  2016 Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels. JZTX-I
69  2016 Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc. ---
70  2016 New (arylalkyl)azole derivatives showing anticonvulsant effects could have VGSC and/or GABAAR affinity according to molecular modeling studies. BZD, GABA, MES, scMet
71  2016 Parkinson's disease-like forelimb akinesia induced by BmK I, a sodium channel modulator. GP, PD, STN
72  2016 Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action. AIS
73  2016 Release of neuropeptides from a neuro-cutaneous co-culture model: A novel invitro model for studying sensory effects of ciguatoxins. CGRP, P-CTX-2, SP
74  2016 Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis. KA, PTZ, SE, TLE
75  2016 Role of Sodium Channels in Epilepsy. ---
76  2016 Roles of Voltage-Gated Tetrodotoxin-Sensitive Sodium Channels NaV1.3 and NaV1.7 in Diabetes and Painful Diabetic Neuropathy. DM, DRG, PDN, TTX-S
77  2016 Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines. nNav1.5
78  2016 Sodium Channels in Pain and Cancer: New Therapeutic Opportunities. ---
79  2016 Transient Receptor Potential Vanilloid 4-Induced Modulation of Voltage-Gated Sodium Channels in Hippocampal Neurons. i.c.v, PKA, TRPV4
80  2016 Venom from the spider Araneus ventricosus is lethal to insects but inactive in vertebrates. DUM
81  2016 Venom Peptides From Cone Snails: Pharmacological Probes for Voltage-Gated Sodium Channels. ---
82  2016 Voltage-Gated Na+ Channels: Not Just for Conduction. AP
83  2016 Voltage-gated sodium channel Nav 1.7 promotes gastric cancer progression through MACC1-mediated upregulation of NHE1. GC, HGF, MACC1, NHE1
84  2016 Voltage-gated sodium channels and pain-related disorders. ---
85  2015 Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons. IP3, PKC, PLC
86  2015 Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain. BmK
87  2015 Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference. ---
88  2015 Brivaracetam differentially affects voltage-gated sodium currents without impairing sustained repetitive firing in neurons. BRV, CBZ, SRF, SV2A
89  2015 Changes of voltage-gated sodium channels in sensory nerve regeneration and neuropathic pain models. SNI
90  2015 Comparative evaluation of in vitro and in vivo high glucose-induced alterations in voltage-gated tetrodotoxin-resistant sodium channel: Effects attenuated by sodium channel blockers. DRG, HG, INa, NG, TTX-R
91  2015 Effect of Homocysteine on Voltage-Gated Sodium Channel Currents in Primary Cultured Rat Caudate Nucleus Neurons and Its Modulation by 2-Arachidonylglycerol. 2-AG, AD, CN, CNS, Hcy
92  2015 Effects of curcumin on sodium currents of dorsal root ganglion neurons in type 2 diabetic neuropathic pain rats. DNP, DRG, T2DM
93  2015 Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain. DNP, DRG, T2DM
94  2015 Expression profiling of SCN8A and NDUFC2 genes in colorectal carcinoma. CI, CRC
95  2015 Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling. AISs, AnkG, APs
96  2015 Identification and functional characterization of voltage-gated sodium channels in lymphocytes. ALL
97  2015 Lipid bilayer modification alters the gating properties and pharmacological sensitivity of voltage-gated sodium channel. BmK, SMase D
98  2015 Mapping the interaction site for the tarantula toxin hainantoxin-IV (beta-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels. ---
99  2015 Modulation of Voltage-Gated Sodium Channels by Activation of Tumor Necrosis Factor Receptor-1 and Receptor-2 in Small DRG Neurons of Rats. TNFR-2, TNFR1
100  2015 Molecular basis of the inhibition of the fast inactivation of voltage-gated sodium channel Nav1.5 by tarantula toxin Jingzhaotoxin-II. DIV, JZTX-II, VSD