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■ Abbreviation / Long Form : eIF2 / eukaryotic initiation factor 2

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Total Number of Papers: 244
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Abbreviation:   eIF2  (>> Co-occurring Abbreviation)
Long Form:   eukaryotic initiation factor 2
 Abbreviation Variation
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No. Year Title Co-occurring Abbreviation
2020 Clinical and Proteomic Correlates of Plasma ACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure. ACE2, COVID-19, PHFS
2020 EIF2alpha phosphorylation is regulated in intracellular amastigotes for the generation of infective Trypanosoma cruzi trypomastigote forms. ---
2020 Inbuilt tendency of the eIF2 regulatory system to counteract uncertainties. ---
2020 Inhibition of protein kinase R by C16 protects the retinal ganglion cells from hypoxia-induced oxidative stress, inflammation, and apoptosis. IL-6, LDH, NAC, NF-kappaB, PKR, RGCs, ROS, ssDNA, TNF-alpha
2020 Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association. ISR, p-eIF2
2020 Interleukin-27 Gene Delivery Targeting IL-6Ralpha-Expressing Cells as a Stress Response Therapy. BH, eIF2alpha, IFN, IL-27, IPA, IRF, JAK/STAT, p-eIF2alpha
2020 M. tuberculosis infection of human iPSDM reveals complex membrane dynamics during xenophagy evasion. iPSDM, LC3-TVS, Mtb
2020 System-Wide Analysis of Protein Acetylation and Ubiquitination Reveals a Diversified Regulation in Human Cancer Cells. ---
2020 Translation Regulation by eIF2alpha Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs). COPD, ISR, mTORC1, NCDs
10  2019 Cellular eIF2B subunit localization: implications for the integrated stress response and its control by small molecule drugs. eIF2B, ISR
11  2019 Dietary Sulfur Amino Acid Restriction and the Integrated Stress Response: Mechanistic Insights. ATF4, ISR, SAAR
12  2019 Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups. cAMP, CD, NKT
13  2019 Involvement of the eIF2alpha Kinase GCN2 in UV-B Responses. CHS, FADox, GCN2, GPX7, MKP1, RAD51
14  2019 Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells. Bcl-2, ER
15  2018 Arabidopsis ILITHYIA protein is necessary for proper chloroplast biogenesis and root development independent of eIF2alpha phosphorylation. ILA
16  2018 Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2alpha and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats. CBP, PP1, WIN
17  2018 DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation. DENR, MCTS1, ORF
18  2018 eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex. Met-tRNAi, PIC, TC
19  2018 Eukaryotic Initiation Factor 5B (eIF5B) Cooperates with eIF1A and eIF5 to Facilitate uORF2-Mediated Repression of ATF4 Translation. ATF4, eIF5B, uORF
20  2018 Identification of differentially expressed genes and pathways in mice exposed to mixed field neutron/photon radiation. ---
21  2018 Modeling and Dynamic Behavior of eIF2 Dependent Regulatory System With Disturbances. ---
22  2018 PEP-1-glutaredoxin-1 induces dedifferentiation of rabbit articular chondrocytes by the endoplasmic reticulum stress-dependent ERK-1/2 pathway and the endoplasmic reticulum stress-independent p38 kinase and PI-3 kinase pathways. ER, ERK, GRP, GRX-1
23  2018 Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling. AML, CML, EGF, HGF, IL-6, MEME, MSI2, PAR-CLIP, pB-ALL, RRE, STAT3
24  2017 Crystal Structure of the C-terminal Domain of Human eIF2D and Its Implications on Eukaryotic Translation Initiation. ---
25  2017 Human Keratinocyte Differentiation Requires Translational Control by the eIF2alphaKinase GCN2. GCN2
26  2017 Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment. ER, PKR, UPR
27  2017 Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice. apoB100, ATF4, ISR, mTORC1, PERK
28  2017 Proteomic analysis reveals changes in carbohydrate and protein metabolism associated with broiler breast myopathy. IPA, mTOR, WB, WS
29  2017 Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in eukaryotic initiation factor 2B (eIF2B)-mediated translation control and stress response. eIF2B, Sup-II
30  2017 Salubrinal protects human skin fibroblasts against UVB-induced cell death by blocking endoplasmic reticulum (ER) stress and regulating calcium homeostasis. ER
31  2017 Smad7 positively regulates keratinocyte proliferation in psoriasis. AS, TGF
32  2017 The effects of administration of the Lactobacillus gasseri strain CP2305 on quality of life, clinical symptoms and changes in gene expression in patients with irritable bowel syndrome. IBS
33  2017 Translational Control in the Latency of Apicomplexan Parasites. ---
34  2016 An RNA trapping mechanism in Alphavirus mRNA promotes ribosome stalling and translation initiation. CDS
35  2016 eIF2alpha phosphorylation controls thermal nociception. ---
36  2016 General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice. ER, FGF21, GCN2, Hspa5, Pap, PERK, sXbp1
37  2016 Human Cytomegalovirus pTRS1 and pIRS1 Antagonize Protein Kinase R To Facilitate Virus Replication. HCMV, PKR
38  2016 OLA1, a Translational Regulator of p21, Maintains Optimal Cell Proliferation Necessary for Developmental Progression. MEFs
39  2016 Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction. EAAs, ER, GCN2, ISR, MR
40  2016 Temporal proteomic profiling of Chlamydia trachomatis-infected HeLa-229 human cervical epithelial cells. iTRAQ, mTOR
41  2015 ABC50 mutants modify translation start codon selection. ABC50
42  2015 Bufalin Reverses Resistance to Sorafenib by Inhibiting Akt Activation in Hepatocellular Carcinoma: The Role of Endoplasmic Reticulum Stress. CHOP, ER, HCC, IRE1
43  2015 Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features. ---
44  2015 Fexofenadine regulates nuclear factor-kappaB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in mice. DSS, ER, IL, PCR, TNF
45  2015 GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. AAR, FGF21, GCN2
46  2015 OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation. ISR, TC, tRNAi
47  2015 p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways. dnp300
48  2015 Somatostatin, neuronal vulnerability and behavioral emotionality. SST
49  2015 Systems biology surveillance decrypts pathological transcriptome remodeling. ER, WT
50  2015 Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. ORFs, uORF
51  2014 A functional role for Smad7 in sustaining colon cancer cell growth and survival. CDK, CRC, TGF
52  2014 Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 S preinitiation complex. PIC, TC
53  2014 Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease. LRRK2, PBMC, PD
54  2013 ApoE epsilon4 is associated with eIF2alpha phosphorylation and impaired learning in young mice. APOE, SAD
55  2013 Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis. CHOP, ER, PERK, VacA
56  2013 Maternal overweight induced by a diet with high content of saturated fat activates placental mTOR and eIF2alpha signaling and increases fetal growth in rats. eIF2alpha, HF, LPL, mTOR, mTORC1
57  2013 The eIF2alpha kinases: their structures and functions. ATF4, GCN2, HRI, ISR, PERK, PKR
58  2013 The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment. AAR, GCN2
59  2013 The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control. ER, UPR
60  2013 Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2). Cdc123
61  2013 Unfolded protein response pathways regulate Hepatitis C virus replication via modulation of autophagy. 3-MA, ER, HCV, UPR, XBP1
62  2012 AIMP3/p18 controls translational initiation by mediating the delivery of charged initiator tRNA to initiation complex. AIMPs, Met, Met, MRS, MSC
63  2012 Conformational transitions of the catalytic domain of heme-regulated eukaryotic initiation factor 2alpha kinase, a key translational regulatory molecule. CD, GdnHCl, HRI, KD, KI
64  2012 Dephosphorylation of eIF2alpha is essential for protein synthesis increase and cell cycle progression after sea urchin fertilization. ---
65  2012 Eukaryotic initiation factor 2 (eIF2) signaling regulates proinflammatory cytokine expression and bacterial invasion. ---
66  2012 New insights into translational regulation in the endoplasmic reticulum unfolded protein response. ER, IRE1, UPR, XBP1
67  2012 Potential contribution of translational factors to triiodo-L-thyronine-induced insulin synthesis by pancreatic beta cells. 4E-BP, eEF1A, THs
68  2011 An inhibitor of eIF2 activity in the sRNA pool of eukaryotic cells. met-tRNAi, TCI
69  2011 Development of transgenic mice expressing a conditionally active form of the eIF2alpha kinase PKR. GyrB, KD
70  2011 Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. ISR, uORF
71  2010 The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. ASNase, GCN2
72  2010 The ribosome-bound initiation factor 2 recruits initiator tRNA to the 30S initiation complex. fMet, IF2
73  2009 ABC50 promotes translation initiation in mammalian cells. ABC
74  2009 Crystal structure of the alpha subunit of human translation initiation factor 2B. eIF2B
75  2009 Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast. GCN, HTS
76  2009 Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p. ---
77  2009 The role of translational regulation in ultraviolet C light-induced cyclooxygenase-2 expression. COX-2, S51A, UV-C
78  2009 Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a review. ---
79  2008 Acute and chronic ethanol consumption differentially impact pathways limiting hepatic protein synthesis. ---
80  2008 Alanyl-glutamine consumption modifies the suppressive effect of L-asparaginase on lymphocyte populations in mice. ---
81  2008 Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by beta-hydroxy-beta-methylbutyrate. Ang II, HMB, IFN-gamma, LPS, mTOR, PKR, TNF-alpha
82  2008 Intersubunit and interprotein interactions of alpha- and beta-subunits of human eIF2: Effect of phosphorylation. ---
83  2008 Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. uORFs
84  2008 Role of the dsRNA-dependent protein kinase (PKR) in the attenuation of protein loss from muscle by insulin and insulin-like growth factor-I (IGF-I). IGF-I, PIF, PKR
85  2007 Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2. IFN, PKR, Tyr
86  2007 Mechanism of attenuation of angiotensin-II-induced protein degradation by insulin-like growth factor-I (IGF-I). I-kappaB, IGF-I, NF-kappaB, PKCalpha, PKR
87  2007 Nck-1 selectively modulates eIF2alphaSer51 phosphorylation by a subset of eIF2alpha-kinases. GCN2, HRI, PERK, PKR
88  2007 Requirement for protein kinase R in interleukin-1alpha-stimulated effects in cartilage. IL-1
89  2007 The eukaryotic initiation factor-2 kinase pathway facilitates differential GADD45a expression in response to environmental stress. ---
90  2006 Characterization of the eIF2-associated protein p67 during brain ischemia and reperfusion. ---
91  2006 Expression and purification of the subunits of human translational initiation factor 2 (eIF2): phosphorylation of eIF2 alpha and beta. ---
92  2006 Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. ER, SH
93  2006 The N-terminal lysine residue-rich domain II and the 340-430 amino acid segment of eukaryotic initiation factor 2-associated glycoprotein p67 are the binding sites for the gamma-subunit of eIF2. ---
94  2006 Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase. PKR
95  2006 Yeast initiator tRNA identity elements cooperate to influence multiple steps of translation initiation. ---
96  2005 eIF2alpha phosphorylation, stress perception, and the shutdown of global protein synthesis in cultured CHO cells. ---
97  2005 Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases. ---
98  2005 PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia. PERK
99  2005 Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition. ER, MEF
100  2005 The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo. TC