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■ Abbreviation / Long Form : eIF4E / eukaryotic initiation factor 4E

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Total Number of Papers: 348
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Abbreviation:   eIF4E  (>> Co-occurring Abbreviation)
Long Form:   eukaryotic initiation factor 4E
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2019 A Yeast System for Discovering Optogenetic Inhibitors of Eukaryotic Translation Initiation. ---
2019 Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold. ---
2019 Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction oftranslation initiation factors eIF4E/eIF4G as multifunctional agentsfor cancer treatment. ---
2019 Effect of all-trans retinoic acid on casein and fatty acid synthesis in MAC-T cells. ATRA, ELF5, JAK2, mTOR, MUFA, PI3K, PPARgamma, PUFA, S6K1, SCD, SFA, SREBP1, STAT5-beta
2019 Eukaryotic Initiation Factor 4E (eIF4E) sequestration mediates 4E-BP1 response to rapamycin. ---
2019 Eukaryotic initiation factor 4E (eIF4E): A recap of the cap-binding protein. mRNA
2019 Ferulic acid ameliorates cerebral infarction by activating Akt/mTOR/4E‑BP1/Bcl‑2 anti‑apoptotic signaling in the penumbral cortex following permanent cerebral ischemia in rats. Akt, FerA, MCAO
2019 Functional characterization of the translation initiation factor eIF4E of Echinococcus granulosus. TMGcap
2019 Microplitis bicoloratus bracovirus modulates innate immune suppression through the eIF4E-eIF4A axis in the insect Spodoptera litura. MbBV
10  2019 O-GlcNAc transferase activates stem-like cell potential in hepatocarcinoma through O-GlcNAcylation of eukaryotic initiation factor 4E. OGT
11  2019 The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis. EMT, MAPK, TNBC
12  2018 A blood pact: the significance and implications of eIF4E on lymphocytic leukemia. ---
13  2018 A widespread alternate form of cap-dependent mRNA translation initiation. ---
14  2018 Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis. 4E-BPs, HSV-1, HSV1, ICP0
15  2018 Association of eIF4E and SPARC Expression with Lymphangiogenesis and Lymph Node Metastasis in Hypopharyngeal Cancer. HNSCC, LVD, LYVE-1, SPARC
16  2018 Bufadienolides from Venenum Bufonis Inhibit mTOR-Mediated Cyclin D1 and Retinoblastoma Protein Leading to Arrest of Cell Cycle in Cancer Cells. mTOR, Rb, S6K1
17  2018 Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation. eIF4G1, TISU
18  2018 Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer. MNKs
19  2018 Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells. NP, STAT3
20  2018 Loss of eIF4E Phosphorylation Engenders Depression-like Behaviors via Selective mRNA Translation. MAPK
21  2018 RACK1 Specifically Regulates Translation through Its Binding to Ribosomes. PKC
22  2018 Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells. ---
23  2018 The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer. ---
24  2018 The retinamide VNLG-152 inhibits f-AR/AR-V7 and MNK-eIF4E signaling pathways to suppress EMT and castration-resistant prostate cancer xenograft growth. AR-V7, CRPC, f-AR, NR
25  2018 Total Saponins of Rubus Parvifolius L. Exhibited Anti-Leukemia Effect in vivo through STAT3 and eIF4E Signaling Pathways. Bcl-2, HE, STAT3, TdT
26  2017 Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1alpha via the mTOR/p70S6K/4E-BP1 and MAPK pathways. HIF-1, mTOR, RT-PCR, topo I
27  2017 miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer. NSCLC
28  2017 Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice. CYFIP1, FMRP, FXS, LTD, mGluR, PAK
29  2017 Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases. ---
30  2017 Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery. m7G, mRNA, RNPs
31  2017 The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer. CRPC, mTOR, PCa
32  2017 Translational control of mRNAs by 3'-Untranslated region binding proteins. UTRs
33  2017 TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis. mTOR, NSCLC, TRIM59
34  2017 Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding. DAZL, PABP
35  2016 Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP. 4E-BP
36  2016 Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells. ELONA, MNKs
37  2016 Coordinated Regulation of Cap-Dependent Translation and MicroRNA Function by Convergent Signaling Pathways. PI3K-Akt-mTOR, RISC
38  2016 Covalent Chemical 5'-Functionalization of RNA with Diazo Reagents. ---
39  2016 Diversity of genetic backgrounds modulating the durability of a major resistance gene. Analysis of a core collection of pepper landraces resistant to Potato virus Y. ---
40  2016 eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. ---
41  2016 Expression of phosphorylated eIF4E-binding protein 1, but not of eIF4E itself, predicts survival in male breast cancer. DFS, p-4E-BP1
42  2016 Inhibition of eukaryotic initiation factor 4E phosphorylation by cercosporamide selectively suppresses angiogenesis, growth and survival of human hepatocellular carcinoma. HCC, HCC-EC
43  2016 mTOR downstream effectors, 4EBP1 and eIF4E, are overexpressed and associated with HPV status in precancerous lesions and carcinomas of the uterine cervix. HPV, HR-HPV, mTOR, P-4EBP1
44  2016 N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells. ERK, mTOR, mTORC2, NHPI
45  2016 Perillyl alcohol efficiently scavenges activity of cellular ROS and inhibits the translational expression of hypoxia-inducible factor-1alpha via mTOR/4E-BP1 signaling pathways. HIF-1alpha, mTOR, POH, ROS
46  2016 Prognostic significance of eukaryotic initiation factor 4E in hepatocellular carcinoma. HCC
47  2016 Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis. mTORC1
48  2016 The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. mTOR, S6Ks
49  2016 The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E (eIF4E) and inhibits protein synthesis in MG63 osteosarcoma cells. 2-ME
50  2016 The MNK-1/eIF4E pathway as a new therapeutic pathway to target inflammation and remodelling in asthma. MNK
51  2016 Toward the mechanism of eIF4F-mediated ribosomal attachment to mammalian capped mRNAs. Met
52  2015 An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis. Mnks
53  2015 Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion. 4E-BP1
54  2015 CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. CDC20, Cdh1, MCV sT, mTOR
55  2015 Dihydrotanshinone I inhibits the translational expression of hypoxia-inducible factor-1alpha. DHTS, HIF-1, mTOR
56  2015 Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation. MAPK
57  2015 Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis. ---
58  2015 Extracellular signal-regulated kinase (ERK) activity during sleep consolidates cortical plasticity in vivo. ERK, MD, Mnk1, ODP
59  2015 Gemin5: A Multitasking RNA-Binding Protein Involved in Translation Control. IRES, RBP, SMN, snRNAs, snRNPs
60  2015 GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy. miR
61  2015 Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2. Mnks
62  2015 Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. ASDs, LTD, mGluRs
63  2015 Integrin beta6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy. siRNA
64  2015 Knockdown of eIF4E suppresses cell proliferation, invasion and enhances cisplatin cytotoxicity in human ovarian cancer cells. ---
65  2015 Nutritional plane of twin-bearing ewes alters fetal mammary gland biochemical composition and mTOR/MAPK pathway signaling. MAPK, mTOR, rpS6
66  2015 P70S6K and Elf4E dual inhibition is essential to control bladder tumor growth and progression in orthotopic mouse non-muscle invasive bladder tumor model. BLI, mTOR, NMIBT, P70S6K, UC
67  2015 Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations. ---
68  2015 Rapamycin-induced G1 cell cycle arrest employs both TGF-beta and Rb pathways. mTORC1, S6K, TGF-beta
69  2015 Single nucleoprotein residue modulates arenavirus replication complex formation. GP, LCMV, NP, RTC
70  2015 The expanding role of mTOR in cancer cell growth and proliferation. mTOR, mTORC1, S6Ks
71  2015 The unique Leishmania EIF4E4N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation. ---
72  2015 Viral Genome-Linked Protein (VPg) Is Essential for Translation Initiation of Rabbit Hemorrhagic Disease Virus (RHDV). RHDV, VPg
73  2015 [Clinical significance of the expression of eukaryotic initiation factor 4 E and mammalian target of rapamycin in esophageal squamous carcinoma tissues]. mTOR
74  2014 Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene. 4EBP, KS, KSHV, vGPCR
75  2014 Cancer cells exploit eIF4E2-directed synthesis of hypoxia response proteins to drive tumor progression. ---
76  2014 Celastrol inhibits the HIF-1alpha pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells. EPO, ERK, HIF-1, mTOR, VEGF
77  2014 Dual inhibition by S6K1 and Elf4E is essential for controlling cellular growth and invasion in bladder cancer. mTOR
78  2014 Evolution of plant eukaryotic initiation factor 4E (eIF4E) and potyvirus genome-linked protein (VPg): a game of mirrors impacting resistance spectrum and durability. ---
79  2014 Expression of eukaryotic initiation factor 4 E in hypopharyngeal carcinoma. IOD
80  2014 Functional protection of learning and memory abilities in rats with vascular dementia. mTOR, rTMS, VaD
81  2014 Inactivation of mTor arrests bovine oocytes in the metaphase-I stage, despite reversible inhibition of 4E-BP1 phosphorylation. CDKs, GV, MAPK, MII, mTOR
82  2014 Interaction patterns between potato virus Y and eIF4E-mediated recessive resistance in the Solanaceae. MA, PVY
83  2014 MAP kinase-interacting kinases--emerging targets against cancer. MAPK
84  2014 Mnk kinase pathway: Cellular functions and biological outcomes. MAPK
85  2014 Oncogenic activation of MEK/ERK primes melanoma cells for adaptation to endoplasmic reticulum stress. ATF6, ER, GRP78, IRE1, MEK/ERK, UPR
86  2014 Overexpression of eukaryotic initiation factor 4E is correlated with increased risk for systemic dissemination in node-positive breast cancer patients. ---
87  2014 Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes. FXS, MMP-9
88  2014 Phosphorylation dynamics of eukaryotic initiation factor 4E binding protein 1 (4E-BP1) is discordant with its potential to interact with eukaryotic initiation factor 4E (eIF4E). mTOR, S6K1
89  2014 Phosphorylation of mTOR and S6RP predicts the efficacy of everolimus in patients with metastatic renal cell carcinoma. CBR, CR, mRCC, mTOR, PD, PFS, PR, RCC, SD, VEGFR
90  2014 Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity. eEF1A, mTOR, Paip2
91  2014 Rapamycin-mediated CD36 translational suppression contributes to alleviation of hepatic steatosis. HFD, mTOR, NAFLD, p70S6K
92  2014 Regulation of protein degradation pathways by amino acids and insulin in skeletal muscle of neonatal pigs. LAMP 2, LC3, MuRF1, rpS6, UKL1
93  2014 SUMO-2 promotes mRNA translation by enhancing interaction between eIF4E and eIF4G. eIF4F, eIF4G, SUMO
94  2013 Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression. AMPK, AR, EGF, miR, mTOR, PDCD4, ROS, S6K
95  2013 Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2. CO, CORM-2, eEF2, eIF2alpha, PI3K-Akt-mTOR, PSCs, Rb
96  2013 eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells. CBC, NMD, PTCs
97  2013 eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. CHO, mTOR, POH, TERT
98  2013 eIF4F suppression in breast cancer affects maintenance and progression. MMP9, mTOR, VEGF
99  2013 Human eIF4E promotes mRNA restructuring by stimulating eIF4A helicase activity. eIF4A, eIF4G
100  2013 Identification of two novel inhibitors of mTOR signaling pathway based on high content screening. mTOR, S6K