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■ Abbreviation / Long Form : mGluR5 / metabotropic glutamate receptor 5

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Total Number of Papers: 637
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Abbreviation:   mGluR5  (>> Co-occurring Abbreviation)
Long Form:   metabotropic glutamate receptor 5
 Abbreviation Variation
 Long Form Variation
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No. Year Title Co-occurring Abbreviation
2020 Activation of mGluR5 and NMDA Receptor Pathways in the Rostral Ventrolateral Medulla as a Central Mechanism for Methamphetamine-Induced Pressor Effect in Rats. Fos, i.c.v, MA, MAP, pGluN1-ser 896, PKC, RVLM
2020 Alterations in sleep, sleep spindle, and EEG power in mGluR5 knockout mice. EEG, KO, WT
2020 Analysis of the Gut Microbiota and Inflammatory Factors in mGluR5-Knockout Mice. ELISAs, EPM, FST, OF, PFC, TST
2020 Association between human gray matter metabotropic glutamate receptor-5 availability in vivo and white matter properties: a [11C]ABP688 PET and diffusion tensor imaging study. BPND, DTI, FA, FDT, GM, PET, ROI, TBSS, WM
2020 Astrocyte Signaling Gates Long-Term Depression at Corticostriatal Synapses of the Direct Pathway. A1R, DLS, DREADDs, HFS, LTD
2020 Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling. FMRP, FXS
2020 Attenuation of Acute Intracerebral Hemorrhage-Induced Microglial Activation and Neuronal Death Mediated by the Blockade of Metabotropic Glutamate Receptor 5 In Vivo. ICH
2020 Bi-Directional Communication Between Neurons and Astrocytes Modulates Spinal Motor Circuits. CPG
2020 Disabling phosphorylation at the homer ligand of the metabotropic glutamate receptor 5 alleviates complete Freund's adjuvant-induced inflammatory pain. ---
10  2020 Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats. DG, IGF-1R
11  2020 Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance. dlPFC
12  2020 Effects of sevoflurane anaesthesia on radioligand binding to monoamine oxidase-B invivo. MAO-B, NHPs, PET
13  2020 Electroacupuncture Regulates Pain Transition by Inhibiting the mGluR5-PKCepsilon Signaling Pathway in the Dorsal Root Ganglia. DRG, EA, MWT, PGE2
14  2020 Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior. 2-AG, eCB, LTD, MSNs, NAc
15  2020 Essential and sex-specific effects of mGluR5 in ventromedial hypothalamus regulating estrogen signaling and glucose balance. BDNF, VMH
16  2020 Excitatory amino acid transporter (EAAT)1 and EAAT2 mRNA levels are altered in the prefrontal cortex of subjects with schizophrenia. BA, EAAT, EAAT1, SKP1A, TFB1M
17  2020 In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS. KO, MRS, NMDA, SUVs, WT
18  2020 Inhibiting MLL1-WDR5 interaction ameliorates neuropathic allodynia via attenuating histone H3 lysine 4 trimethylation-dependent spinal mGluR5 transcription. MLL1, SNL
19  2020 Isolation of rat hepatocytes for pharmacological studies on metabotropic glutamate receptor (mGluR) subtype 5: a comparison between collagenase I versus collagenase IV. IP-1, mGluR
20  2020 Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET. ---
21  2020 mGluR5 receptor availability is associated with lower levels of negative symptoms and better cognition in male patients with chronic schizophrenia. BPND
22  2020 mGluR5 regulates REST/NRSF signaling through N-cadherin/beta-catenin complex in Huntington's disease. HD, REST/NRSF
23  2020 Midbrain D3 Receptor Availability Predicts Escalation in Cocaine Self-administration. ---
24  2020 Neurotransmitters and Endothelins Acting on Radial Glial G-Protein-Coupled Receptors Are, Through Proteolytic NRG/ErbB4 Activation, Able to Modify the Migratory Behavior of Neocortical Cells and Mediate Bipolar-to-Multipolar Transition. GPCRs, MMPs, NRGs, TRPC3
25  2020 Oxidative stress and glutamate excretion in alcoholic steatosis: Metabolic synapse between hepatocyte and stellate cell. CB1R, CYP2E1, HSCs, ROS
26  2020 Persistent Activity of Metabotropic Glutamate Receptor 5 in the Periaqueductal Gray Constrains Emergence of Chronic Neuropathic Pain. PAG
27  2020 PET imaging of mGluR5 in Alzheimer's disease. AD, CN, MCI, PET
28  2020 Profiling the Structural Determinants of Aryl Benzamide Derivatives as Negative Allosteric Modulators of mGluR5 by In Silico Study. CoMFA, CoMSIA, MD, NAMs
29  2020 Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [11C]ABP688 PET study. BPND, KO, OCD, Sapap3, SPM, SRTM
30  2020 Recovery of Decreased Metabotropic Glutamate Receptor 5 Availability in Abstinent Alcohol-Dependent Patients. 18F-FPEB
31  2020 Repeated nicotine exposure increases the intracellular interaction between ERK-mGluR5 in the nucleus accumbens more in adult than adolescent rats. ERK, GABA, NAc
32  2020 Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction. FXS
33  2020 Selective inhibition of glycogen synthase kinase 3alpha corrects pathophysiology in a mouse model of fragile X syndrome. FMRP, GSK-3, LTD
34  2020 Targeting VGLUT Machinery: Implications on mGluR5 Signaling and Behavior. VGLUT3, VGLUTs
35  2020 The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids. MOR, NP, SNI
36  2020 The fluctuations of metabotropic glutamate receptor subtype 5 (mGluR5) in the amygdala in fear conditioning model of male Wistar rats following sleep deprivation, reverse circadian and napping. RC, SD
37  2020 The negative allosteric modulator of mGluR5, MPEP, potentiates the rewarding properties of cocaine in priming-induced reinstatement of CPP. ---
38  2020 The pro-psychotic metabotropic glutamate receptor compounds fenobam and AZD9272 share binding sites with monoamine oxidase-B inhibitors in humans. MAO-B, NHPs
39  2020 The role of the metabotropic glutamate receptor 5 in nicotine addiction. ---
40  2019 18F-FPEB PET/CT Shows mGluR5 Upregulation in Parkinson's Disease. BPND, DAT, HVs, PD
41  2019 Age dependency of mGluR5 availability in 5xFAD mice measured by PET. AD
42  2019 Allosteric activation of metabotropic glutamate receptor 5. GPCR
43  2019 Allosteric Modulation Mechanism of the mGluR5 Transmembrane Domain. GPCR, PAMs
44  2019 Assessment of mGluR5 KO mice under conditions of low stress using a rodent touchscreen apparatus reveals impaired behavioural flexibility driven by perseverative responses. ERC, EXT, KO, PR, VDR, WT
45  2019 Association of antibodies against myelin and neuronal antigens with neuroinflammation in systemic lupus erythematosus. AQP4, CASPR2, GAD65, GlyR, LGI1, MOG, NF186, NS
46  2019 Astrocyte Receptor Rebirth. ---
47  2019 Brain mGluR5 in Shank3B-/- Mice Studied With in vivo [18F]FPEB PET Imaging and ex vivo Immunoblotting. ASD, BPND
48  2019 Cholinergic Neurons of the Medial Septum Are Crucial for Sensorimotor Gating. KO, PPI, PV
49  2019 Chronic Nicotine Exposure Alters Metabotropic Glutamate Receptor 5: Longitudinal PET Study and Behavioural Assessment in Rats. PET
50  2019 Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake. TLE
51  2019 Decoding neuropathic pain severity using distinct patterns of corticolimbic metabotropic glutamate receptor 5. SNL
52  2019 Differential Aggregation and Phosphorylation of Alpha Synuclein in Membrane Compartments Associated With Parkinson Disease. APP, iPD, LR, NR, PD, PS, PUFA
53  2019 Downregulation of RTN1-C attenuates MPP+-induced neuronal injury through inhibition of mGluR5 pathway in SN4741 cells. ER, PD, RTNs
54  2019 Dynamic changes in cerebral and peripheral markers of glutamatergic signaling across the human sleep-wake cycle. BDNF, BG, FMRP, GABA, Glu
55  2019 Effects of the presence and absence of amino acids on translation, signaling, and long-term depression in hippocampal slices from Fmr1 knockout mice. FMRP, FXS, LTD
56  2019 Endogenous TRPC channels mediate Ca2+ signals and trigeminal synaptic plasticity induced by mGluR5. SG, TRPC
57  2019 Expression of type I mGluRs predicts plasticity in the hippocampal stratum radiatum interneurons. eCB, LTD, STD
58  2019 Fragile X and APP: a Decade in Review, a Vision for the Future. APP, FXS
59  2019 Genetic Knockdown of mGluR5 in Striatal D1R-Containing Neurons Attenuates L-DOPA-Induced Dyskinesia in Aphakia Mice. ---
60  2019 Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis. 2-AG, ALD, CB1R, HSC
61  2019 Homer1/mGluR1-mediated ER stress contributes to lysophosphatidic acid-induced neurotoxicity in cortical neurons. 4-PBA, ER, LDH, LPA, mGluR1
62  2019 Homer1a Is Required for Establishment of Contralateral Bias and Maintenance of Ocular Dominance in Mouse Visual Cortex. H1a, KO, MD, OD
63  2019 In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. HC, SI
64  2019 In vivo metabotropic glutamate receptor 5 availability-associated functional connectivity alterations in drug-naive young adults with major depression. beta, BPND, PET, ROI, rs-fMRI
65  2019 In vivo metabotropic glutamate receptor type 5 abnormalities localize the epileptogenic zone in mesial temporal lobe epilepsy. BPND, EZ, FDG, MTLE, PET
66  2019 Inhibiting mGluR5 activity by AFQ056/Mavoglurant rescues circuit-specific functional connectivity in Fmr1 knockout mice. DWI, FXS, rs-fMRI
67  2019 Inhibiting the LPS-induced enhancement of mEPSC frequency in superficial dorsal horn neurons may serve as an electrophysiological model for alleviating pain. ATP, LPS, mEPSCs, P2Y1R
68  2019 Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling. H1a, IEG, NMDARs
69  2019 MGluR5 activity is required for the induction of ethanol behavioral sensitization and associated changes in ERK MAP kinase phosphorylation in the nucleus accumbens shell and lateral habenula. AcbSh, IR, LHb
70  2019 mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor alpha1ins subunit in spinal dorsal horn of mice. ERK, GlyRs, IL, TM
71  2019 Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model of depression. mGluR1, PSD-95
72  2019 Positive modulation of mGluR5 attenuates seizures and reduces TNF-alpha+ macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy. IL, TMEV, TNF
73  2019 Potential Astrocytic Receptors and Transporters in the Pathogenesis of Alzheimer's Disease. A2AR, AD, alpha7-nAChR, CaSR, EAATs
74  2019 The effect of manganese exposure on GnRH secretion via Nrf2/mGluR5/COX-2/PGE2/signaling pathway. COX-2, DMSO, GnRH, Mn, MTEP, Nrf2, PGE2
75  2019 Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription. CDK9, Hes1, RNAPII, siRNA
76  2019 Transplantation with mGluR5 deficiency bone marrow displays antidepressant-like effect in C57BL/6J mice. KO
77  2019 [Role of mGluR5 in laterocapcular division of central nucleus of amygdala in fentanyl-induced hyperalgesia in rats]. CeLC, mEPSCs, OIH, PWMT, PWTL
78  2018 Acute Ketamine Infusion in Rat Does Not Affect In Vivo [11C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5. NMDA, PET
79  2018 Altered mGluR5 binding potential and glutamine concentration in the 6-OHDA rat model of acute Parkinson's disease and levodopa-induced dyskinesia. CP, L-dopa, LID, PD, PET
80  2018 Atom-based 3D-QSAR, induced fit docking, and molecular dynamics simulations study of thieno[2,3-b]pyridines negative allosteric modulators of mGluR5. ---
81  2018 Bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by selective positive and negative allosteric mGluR5 modulators. mPFC, PFC
82  2018 Cerebral dopaminergic and glutamatergic transmission relate to different subjective responses of acute alcohol intake: an in vivo multimodal imaging study. ACC, PFC
83  2018 Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in a ketamine-based animal model of schizophrenia. NOR
84  2018 Chronic Inflammatory Pain Impairs mGluR5-Mediated Depolarization-Induced Suppression of Excitation in the Anterior Cingulate Cortex. ACC, DSE
85  2018 Conditioned medium from overly excitatory primary astrocytes induced by La3+ increases apoptosis in primary neurons via upregulating the expression of NMDA receptors. CM, Cx43, Glu, La, NMDAR, PLC
86  2018 Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome. FXS
87  2018 Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results. ADAMS, FXS, NAMs
88  2018 Effects of mGluR5 Antagonists on Parkinson's Patients With L-Dopa-Induced Dyskinesia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. CIs, LID, PD, RCTs, WMD
89  2018 Encephalitis Associated to Metabotropic Glutamate Receptor 5 (mGluR5) Antibodies in Cerebrospinal Fluid. CSF
90  2018 Encephalitis with mGluR5 antibodies: Symptoms and antibody effects. IgG
91  2018 Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels. 2-AG, eCBs, TRPC3
92  2018 Glutamatergic Biomarkers for Cocaine Addiction: A Longitudinal Study Using MR Spectroscopy and mGluR5 PET in Self-Administering Rats. 18F-FPEB, rIGT
93  2018 In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5. IP, NAM
94  2018 Involvement of mGluR5 and TRPV1 in visceral nociception in a rat model of uterine cervical distension. TRPV1
95  2018 Ketamine and Ceftriaxone-Induced Alterations in Glutamate Levels Do Not Impact the Specific Binding of Metabotropic Glutamate Receptor Subtype 5 Radioligand [18F]PSS232 in the Rat Brain. DVRs
96  2018 L-DOPA-Induced Motor Impairment and Overexpression of Corticostriatal Synaptic Components Are Improved by the mGluR5 Antagonist MPEP in 6-OHDA-Lesioned Rats. L-dopa, LID, MPEP, PD
97  2018 Longitudinal Characterization of mGluR5 Using 11C-ABP688 PET Imaging in the Q175 Mouse Model of Huntington Disease. BPND, SPM, WT
98  2018 Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder. PET
99  2018 Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex as a Molecular Determinant of Pain and Ensuing Depression. mPFC
100  2018 Metabotropic glutamate receptor 5 tracer [18F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study. ABC, PET