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â–  Abbreviation / Long Form : sIL-6R / soluble IL-6R

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Abbreviation:   sIL-6R  (>> Co-occurring Abbreviation)
Long Form:   soluble IL-6R
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No. Year Title Co-occurring Abbreviation
2020 Antinociceptive effects of IL-6R vs. glucocorticoid receptors during rat hind paw inflammatory pain. GR, IL-6R
2020 Soluble IL-6R promotes chondrogenic differentiation of mesenchymal stem cells to enhance the repair of articular cartilage defects using a rat model for rheumatoid arthritis. AIA, HLA, MSCs, PLGA, RA, SO
2019 Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling. ERK, IL-6, PBMCs, TLR2
2019 Molecular characterization of grass carp interleukin-6 receptor and the agonistic activity of its soluble form in head kidney leucocytes. gcIl-6r, HKLs, IL, rgcIl-6, rgcsIl-6r, SOCS3
2018 Differential profiling of lacrimal cytokines in patients suffering from thyroid-associated orbitopathy. CAS, TAO
2018 Dissecting Interleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer. ---
2018 IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy. cis, IL-6, IL-6R
2018 Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension. CH, IL-6, mIL-6R, PASMCs, PH
2018 The balance of interleukin (IL)-6, IL-6soluble IL-6 receptor (sIL-6R), and IL-6sIL-6Rsgp130 complexes allows simultaneous classic and trans-signaling. gp130, IL, IL-6R, sgp130
10  2018 The classic signalling and trans-signalling of interleukin-6 are both injurious in podocyte under high glucose exposure. DKD, HG, IL-6, mIL-6R, sgp130
11  2018 The combination of IL-6 and its soluble receptor is associated with the response of rheumatoid arthritis patients to tocilizumab. DAS, EULAR, RA
12  2017 IL-6 signaling in diabetic nephropathy: From pathophysiology to therapeutic perspectives. CKD, DN, IL-6
13  2017 IL-6 trans-signaling is another pathway to upregulate Osteopontin. ADAM17, IL, OPN, PMA
14  2017 The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation. IL
15  2016 Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17. ADAM10, IL-6R
16  2016 IL-6 Trans-Signaling Drives Murine Crescentic GN. IL-6R
17  2016 Interleukin-6 receptor alpha blockade improves skin lesions in a murine model of systemic lupus erythematosus. ANA, IL, IL-6Ralpha, SLE
18  2016 Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway. ---
19  2015 Contribution of the Interleukin-6/STAT-3 Signaling Pathway to Chondrogenic Differentiation of Human Mesenchymal Stem Cells. IL-6, IL-6R, MSCs
20  2015 Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of interleukin-6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3. ADAM17, IL-6R, sFRP3
21  2014 The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. ADAM, CRP, IL-6R, SNP
22  2013 Alterations of IL-6, IL-6R and gp130 in early and late onset severe preeclampsia. GP, IL-6, IL-6R, PE, sgp130
23  2013 An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. IL-6R
24  2013 Enhancement of gingival inflammation induced by synergism of IL-1beta and IL-6. HGFs, IL-1
25  2013 Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases. AAA, AF, CHD, IL-6, PBMCs, RA, T1D
26  2013 Pharmacokinetics and pharmacodynamics of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, following single-dose administration by subcutaneous and intravenous routes to healthy subjects. Cmax, CRP, i.v, IL-6R, PD, PK, s.c
27  2013 The regenerative activity of interleukin-6. IL-6, IL-6R
28  2012 Anti-inflammatory effect of IL-6 receptor blockade in corneal alkali burn. PBS
29  2012 Blockade of interleukin-6 receptor suppresses the proliferation of H460 lung cancer stem cells. CSCs, IL-6R, mAb, MTX, NSCLC, siRNA
30  2012 Hitting a complex target: an update on interleukin-6 trans-signalling. IL-6, IL-6R
31  2012 Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis. IL-6, IL-6R, Mtb, sgp130, TB, TNF
32  2011 Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients. IL-6, IL-6R
33  2011 Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation. HGF, IL-6, PH
34  2011 IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes. AF, IAI, IL-6R, PPROM, sgp130
35  2011 Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. IL, MSLN, NF-kappaB, PC, siRNA
36  2011 Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing. MCP-1, mIL-6R, STAT3, VEGF
37  2011 Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. CLP, gp130, IL, IL-6R, sgp130
38  2010 Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule. HUVEC, PBMC
39  2010 Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration. IL-6, IL-6R
40  2010 Increased interleukin-6 activity associated with painful chemotherapy-induced peripheral neuropathy in women after breast cancer treatment. IL
41  2010 Regulation of adenosine system at the onset of peritonitis. ADA, AK, sgp130-Fc
42  2010 Role of IL-6 trans-signaling in CClâ‚„induced liver damage. IL-6
43  2010 The expression of osteoclastogenesis-associated factors and osteoblast response to osteolytic prostate cancer cells. CM, PCa
44  2009 The effect of interleukin-6 and the interleukin-6 receptor on glucose transport in mouse skeletal muscle. AMPK, IL-6
45  2008 Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia. IL-6, IL-6R, PE, sgp130, SOCS-3
46  2008 Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. ---
47  2008 IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier. EAE, IL-6, IL-6R, MBP
48  2008 Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease. CRP, IL-6, IL-6Rs, RA
49  2008 Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis. CIA, IL-6R, PIP
50  2007 Cytokines are a therapeutic target for the prevention of inflammation-induced cancers. IL-6, IL-6R
51  2006 Interleukin-6 and its receptor: from bench to bedside. IL-6, IL-6R
52  2006 Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas. IL-6, IL-6R, MM, MRA, STAT3, VEGF
53  2006 Sleep enhances IL-6 trans-signaling in humans. DS, IL-6, mIL-6R, PC
54  2005 Interleukin-6/soluble interleukin-6 receptor complex reduces infarct size via inhibiting myocardial apoptosis. IL-6, IL-6R
55  2005 Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family. CNTF, IL-11, IL-6R, LIF, mIL-6R, OSM
56  2004 Novel therapy for Crohn's disease targeting IL-6 signalling. CD, mAb
57  2003 Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study. AD, IL-6, IL-6prom, IL-6vntr
58  2002 Characterization of anti-mouse interleukin-6 receptor antibody. IL-6R
59  2002 Proteolysis of interleukin-6 receptor (IL-6R) by Porphyromonas gingivalis cysteine proteinases (gingipains) inhibits interleukin-6-mediated cell activation. IL-6, IL-6R
60  2002 Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. OSM
61  2001 Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus. GP, hIL-6, IL-6R, mAbs, sgp130, vIL-6
62  2001 Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. IL-6, LIF, OSM, sgp130
63  2000 Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. CD, IL, IL-6R
64  2000 Human myeloma cells promote the recruitment of osteoblast precursors: mediation by interleukin-6 and soluble interleukin-6 receptor. IL-6R
65  1999 Interleukin-6 receptor signaling. I. gp80 and gp130 receptor interaction in the absence of interleukin-6. IL-6
66  1999 Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression. CNS, H-IL-6, IL-6, IL-6R, NGF, NTs
67  1999 [Cord blood transplantation and ex vivo expansion of hematopoietic stem cells]. AGM, dpc, IL-6R
68  1998 Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells. IL-6, IL-6Rs, MAP
69  1997 I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion. ---
70  1997 Oncostatin M stimulates the expression and release of the IL-6 receptor in human hepatoma HepG2 cells. ---
71  1997 Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice. ---
72  1996 Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. IL, IL-6
73  1995 Detection of membrane and soluble interleukin-6 receptor in lymphoid malignancies. CLL, IL-6R, MG, NHL
74  1992 Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130. ELISA, sgp130