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■ Abbreviation / Long Form : sigma1R / sigma-1 receptor

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Total Number of Papers: 79
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Abbreviation:   sigma1R  (>> Co-occurring Abbreviation)
Long Form:   sigma-1 receptor
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No. Year Title Co-occurring Abbreviation
2019 Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors. ---
2019 Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS. BBB
2019 May a sigma-1 antagonist improve neuropathic signs induced by cisplatin and vincristine in rats? ---
2019 Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress. AD, DHEA, ER, MAMs, NOX, ROS, SOD
2019 Sigma-1 Receptor Expression in DRG Neurons during a Carrageenan-Provoked Inflammation. DRG
2018 Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review. NMDA, SARs, sigma2R
2018 Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. CBD, NMDAR
2018 Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice. KO, NR2B-NMDA, SCI, WT
2018 Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats. A2AR, AUD, D2R, NAc
10  2018 Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. 5HT2R, CaM, NMDAR
11  2018 Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease. 5-LOX, AChE, AD, DFHs, MAOs
12  2018 Overexpression of sigma-1 receptor in MCF-7 cells enhances proliferation via the classic protein kinase C subtype signaling pathway. ---
13  2018 Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays. BRET, ER
14  2018 Pridopidine Reverses Phencyclidine-Induced Memory Impairment. D2R
15  2018 Sigma 1 receptor mediated HMGB1 expression in spinal cord is involved in the development of diabetic neuropathic pain. DRG, HMGB1, STZ
16  2018 Sigma-1 receptor (sigma1R) is downregulated in hepatic malignant tumors and regulates HepG2 cell proliferation, migration and apoptosis. HCC, HMTs
17  2018 Small molecule modulators of sigma2R/Tmem97 reduce alcohol withdrawal-induced behaviors. ---
18  2018 The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9. MCAO, MMP-9, NMDAR, pMCAO
19  2018 The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction. DAT, METH
20  2017 Activation of Sigma-1 Receptor Alleviates Postpartum Estrogen Withdrawal-Induced "Depression" Through Restoring Hippocampal nNOS-NO-CREB Activities in Mice. BDNF, cAMP, HSP, NMDA, nNOS, NO
21  2017 Blockade of sigma 1 receptors alleviates sensory signs of diabetic neuropathy in rats. ZDF
22  2017 Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain. ---
23  2017 Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel. sigma2-R
24  2017 Pyrazolo[3,4-d]pyrimidines as sigma-1 receptor ligands for the treatment of pain. Part 1: 4-acylamino derivatives. ---
25  2017 Pyrazolo[3,4-d]pyrimidines as sigma-1 receptor ligands for the treatment of pain. Part 2: Introduction of cyclic substituents in position 4. ---
26  2017 Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice. DRG, i.t, SNI, TMEM97
27  2017 sigma Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration. BZT, DAT
28  2017 Sigma-1 Receptor and Pain. DRG
29  2017 Sigma-1 receptor knockout increases alpha-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra. alpha-Syn
30  2017 Sigma-1 Receptor Regulates Mitochondrial Function in Glucose- and Oxygen-Deprived Retinal Ganglion Cells. OGD, RGCs
31  2017 The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. DA, DAT
32  2017 The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission. DAT
33  2017 The sigma1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes. GM1
34  2017 [Clinical significance of sigma1 receptor over-expression in cervical cancer and the effect of its synthetic ligands on the growth of cervical cancer cells]. AC, HSIL, mOS, MTT, NDP, SCC
35  2016 (+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury. ---
36  2016 Aberrant Subcellular Dynamics of Sigma-1 Receptor Mutants Underlying Neuromuscular Diseases. ---
37  2016 Computer-assisted design, synthesis, binding and cytotoxicity assessments of new 1-(4-(aryl(methyl)amino)butyl)-heterocyclic sigma 1 ligands. ---
38  2016 Corticosteroids Mediate Heart Failure-Induced Depression through Reduced sigma1-Receptor Expression. TAC
39  2016 Haloperidol aggravates transverse aortic constriction-induced heart failure via mitochondrial dysfunction. TAC
40  2016 Molecular Mechanisms Involving Sigma-1 Receptor in Cell Apoptosis of BV-2 Microglial Cells Induced by Methamphetamine. ---
41  2016 New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with sigma-1 agonism and beta-secretase inhibition. AChE, AD, BACE1
42  2016 Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments. AD, CI
43  2016 Sigma receptor type 1 knockout mice show a mild deficit in plasticity but no significant change in synaptic transmission in the CA1 region of the hippocampus. ER, WT
44  2016 Synthesis and biological evaluation of novel 6,7-dihydro-5H-cyclopenta[d]pyrimidine and 5,6,7,8-tetrahydroquinazoline derivatives as sigma-1 (sigma1) receptor antagonists for the treatment of pain. ---
45  2015 Cocaine enhances HIV-1 gp120-induced lymphatic endothelial dysfunction in the lung. D4R, FN, L-LECs
46  2015 Dehydroepiandrosterone administration improves memory deficits following transient brain ischemia through sigma-1 receptor stimulation. ATP, BCCAO, CaMKII, DHEA, ERK
47  2015 Investigational sigma-1 receptor antagonists for the treatment of pain. ---
48  2015 Involvement of sigma-1 receptor in astrocyte activation induced by methamphetamine via up-regulation of its own expression. ChIP, CREB, GFAP, KO, RT-PCR, WT
49  2015 Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. CRF, CRF1R, OX1R, VTA
50  2015 QSAR Approaches Applied to Antidepressants Induced Neurogenesis--in vivo and in silico Applications. 5-HT, SAR
51  2015 Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes. GFAP, HMGB1, LV-RFP
52  2015 Sigma-1 (sigma₁) receptor deficiency reduces beta-amyloid(25-35)-induced hippocampal neuronal cell death and cognitive deficits through suppressing phosphorylation of the NMDA receptor NR2B. AD, INMDA
53  2015 Sigma-1 and N-Methyl-d-Aspartate Receptors: A Partnership with Beneficial Outcomes. NMDARs, nNOS
54  2015 Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons. DAT, MPTP, NMDAR, VMAT2
55  2015 Synthesis and structure-activity relationship study of a new series of selective sigma(1) receptor ligands for the treatment of pain: 4-aminotriazoles. ---
56  2015 The sigma1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control. HINT1, MOR, NMDARs, NO
57  2014 Fluvoxamine rescues mitochondrial Ca2+ transport and ATP production through sigma(1)-receptor in hypertrophic cardiomyocytes. IP3R, RyRs, SR
58  2014 Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice. WT
59  2014 Mitochondrial protection by the mixed muscarinic/sigma1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Abeta25-35 peptide-injected mice, a nontransgenic Alzheimer's disease model. Abeta25-35, AD, ER, i.c.v
60  2014 S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. Carr, CFA
61  2014 Selective sigma-1 receptor antagonists for the treatment of pain. ---
62  2014 Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. DRG, ICa, SNL, VGCC
63  2014 Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic. ---
64  2014 Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. ---
65  2014 The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. CB1, NMDA
66  2013 Diverse regulation of IP3 and ryanodine receptors by pentazocine through sigma1-receptor in cardiomyocytes. IP3R, PO, RyR, SR
67  2013 Sigma-1 receptor expression in sensory neurons and the effect of painful peripheral nerve injury. CGRP, DRG, IB4, IHC, NF200, SNL
68  2013 Stimulation of sigma1-receptor restores abnormal mitochondrial Ca⁺ mobilization and ATP production following cardiac hypertrophy. Ang II, PE, SR, TAC
69  2013 Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selective sigma1 receptor ligands. sigma2R
70  2013 Vascular endothelial sigma1-receptor stimulation with SA4503 rescues aortic relaxation via Akt/eNOS signaling in ovariectomized rats with aortic banding. ACh, eNOS, ET-1, PE, PO
71  2012 Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice. BW, NMDAR
72  2012 Overexpression of sigma1 receptor and its positive associations with pathologic TNM classification in esophageal squamous cell carcinoma. ESCC, pTNM
73  2012 Sigma-1R agonist improves motor function and motoneuron survival in ALS mice. ALS, MNs, NMDA
74  2011 Pregnenolone sulfate enhances survival of adult-generated hippocampal granule cells via sustained presynaptic potentiation. aCSF, alpha7nAChR, BrdU, DG, NMDAR, nNOS, PREGS
75  2010 Stimulation of Sigma-1 receptor by dehydroepiandrosterone ameliorates hypertension-induced kidney hypertrophy in ovariectomized rats. BW, DHEA, eNOS, LK, MABP, PO, RK
76  2008 Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells. aa, ANK 220, BDK, IP3R3
77  2006 A feasibility study of [11C]SA4503-PET for evaluating sigmal receptor occupancy by neuroleptics: the binding of haloperidol to sigma1 and dopamine D2-like receptors. BP, D2R, PET
78  2005 Spreading depression expands traumatic injury in neocortical brain slices. LT, SD, TBI, tSD
79  2004 Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution. EGF, EGFR, ERKs, sigma-1R OE cells