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Abbreviation : 12-HETE
Long Form : 12-hydroxy-5,8,10,14-eicosatetraenoic acid
No. Year Title Co-occurring Abbreviation
2016 A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway. 12-LOX
2012 JJK694, a synthesized obovatol derivative, inhibits platelet activation by suppressing cyclooxygenase and lipoxygenase activities. COX, LOX
2012 Metabolomic investigation of the anti-platelet aggregation activity of ginsenoside Rk₁ reveals attenuated 12-HETE production. AA, COX, OPLS-DA, PLS
2011 Ultra-pressure liquid chromatography/tandem mass spectrometry targeted profiling of arachidonic acid and eicosanoids in human colorectal cancer. AA, CRC, MRM
2007 Antiplatelet effect of NQ12: a possible mechanism through the arachidonic acid cascade. AA, TX
2005 Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism. ---
2003 12(S)-Hydroxyeicosatetraenoic acid induces cAMP production via increasing intracellular calcium concentration. AC
2000 Quantitation of arachidonic acid metabolites in small tissue biopsies by reversed-phase high-performance liquid chromatography. 15-HETE, LTB4, PGE2
2000 The effect of hypoxia on endogenous corneal epithelial eicosanoids. 12-HETrE, AA, COX, LOX, PG
10  1999 12-hydroxy-5Z, 8Z, 10E, 14Z, eicosatetraenoic acid (12-HETE) stimulates cAMP production in normal human fibroblasts. PLC
11  1999 Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes. 8-HETE, 9-HODE, LOX
12  1999 Enzyme self-inactivation is a main limitation of the preparation of eicosanoids. Enzymatic synthesis of thromboxane and 12(S)-hydroxytetraenoic acid. 12-LO, EPA, PG, TX
13  1999 Metabolic suppression of platelet-type 12-lipoxygenase in human uterine cervix with invasive carcinoma. ---
14  1999 Sphingomyelin inhibits platelet 12-lipoxygenase activity. HHT
15  1998 Comparison of the effects of nitric oxide and peroxynitrite on the 12-lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. HHT, NO, TX
16  1998 Eicosanoids in sickle cell disease: potential relevance of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid to the pathophysiology of vaso-occlusion. VCAM-1, VOC
17  1997 Aspirin enhances platelet-derived growth factor-induced vascular smooth muscle cell proliferation. cpm, PDGF, PGE2, SMC
18  1997 Effects of nonanal, trans-2-nonenal and 4-hydroxy-2,3-trans-nonenal on cyclooxygenase and 12-lipoxygenase metabolism of arachidonic acid in rabbit platelets. HHT, TXB2
19  1997 Expression of arachidonate platelet-type 12-lipoxygenase in human rheumatoid arthritis type B synoviocytes. 12-LOX, IL-1beta, RA, RT-PCR
20  1996 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. 15-HPEPE, EPA, HHT, TX
21  1996 Chiral analysis of 12-hydroxyeicosatetraenoic acid formed by calf corneal epithelial microsomes. ---
22  1996 Inhibition of adenylyl cyclases by 12(S)-hydroxyeicosatetraenoic acid. AC, HL-60, NRK-49F
23  1995 Effects of oxo and dihydro metabolites of 12-hydroxy-5,8,10,14-eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils. LTB4
24  1994 Decreased arachidonic acid metabolism in human platelets by autologous neutrophils: possible role of cell adhesion. 12,20-DHETE, HHT
25  1994 Effect of 12-hydroxyeicosatetraenoic acid on cytosolic calcium in human neutrophils. ---
26  1994 Effect of 13-hydroperoxy-9,11-octadecadienoic acid (13-HPODE) on arachidonic acid metabolism in rabbit platelets. 13-HPODE, HHT, TX
27  1994 Effect of metabolic inhibitors on arachidonic acid metabolism in the corneal epithelium: evidence for cytochrome P450-mediated reactions. 12-HETrE, NSAIDs
28  1994 Effects of sulfonylurea agents on platelet arachidonic acid metabolism; study on platelet homogenates. HHT, TXB2
29  1994 High density lipoprotein inhibits platelet 12-lipoxygenase activity. HDL, HHT, LDL, TX
30  1994 Metabolism of leukotriene B4 (LTB4) and 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) in human keratinocytes. LTB4
31  1994 [The effect of leukotrienes B4, C4, 12-hydroxyeicosatetraenoic acid and of the threo- and erythro-epimers of hepoxilin B3 on the plasticity of the neuronal cholinoreceptors in the snail]. ---
32  1993 Effects of reactive oxygen species on arachidonic acid metabolism in rabbit platelets. HHT, ROS, TX
33  1992 Effect of tert-butyl hydroperoxide on cyclooxygenase and lipoxygenase metabolism of arachidonic acid in rabbit platelets. 12-HPETE, AA, HHT, t-BOOH, TX
34  1992 Enhancement of platelet 12-HETE production in the presence of polymorphonuclear leukocytes during calcium ionophore stimulation. 5-HETE, PMNs
35  1992 In vivo transformation of arachidonic acid into 12-hydroxy-5,8,10,14-eicosatetraenoic acid by human nasal mucosa. GC-MS
36  1991 12-HETE inhibits the binding of PGH2/TXA2 receptor ligands in human platelets. ---
37  1991 Effects of 12-HETE on isolated dog renal arcuate arteries. ---
38  1991 Regeneration of vitamin E in human platelets. ETYA, HHT, NDGA
39  1990 Isomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid reduce renin activity and increase water and electrolyte excretion. ---
40  1990 [Effect of 2-naphthyl-3- (3,4-dimethoxy) phenyl-propenoic acid on the metabolism of arachidonic acid in rabbit platelets]. HHT, IMI, IND, NM-PA, TXB2
41  1989 12-Hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) does not stimulate proliferation of human neonatal keratinocytes. ---
42  1989 Arachidonic acid metabolism in isolated pancreatic islets. V. The enantiomeric composition of 12-hydroxy-5,8,10,14-eicosatetraenoic acid indicates synthesis by a 12-lipoxygenase rather than a monooxygenase. ---
43  1989 Correlation of intracellular and extracellular calcium ion concentrations with synergy between 1,2-dioctanoyl-sn-glycerol and ionomycin in platelet arachidonic acid mobilization. HHT
44  1989 Formation and action of 8-hydroxy-11,12-epoxy-5,9,14-icosatrienoic acid in Aplysia: a possible second messenger in neurons. 12-HPETE
45  1989 Hydrogen peroxide and methyl mercury are primary stimuli of eicosanoid release in human platelets. HHT, PGD2, PGE2, PGF2 alpha, PGH2, TXA2, TXB2
46  1989 Stimulation of 12-HETE production in human platelets by an immunomodulator, LF 1695. Evidence for activation of arachidonate liberation coupled to cyclo-oxygenase inhibition. HHT
47  1988 Platelet-neutrophil interactions. (12S)-hydroxyeicosatetraen-1,20-dioic acid: a new eicosanoid synthesized by unstimulated neutrophils from (12S)-20-dihydroxyeicosatetraenoic acid. ---
48  1988 Quantitative stereochemical analysis of subnanogram amounts of 12-hydroxy-(5,8,10,14)-eicosatetraenoic acid by sequential chiral phase liquid chromatography and stable isotope dilution mass spectrometry. ---
49  1988 The stimulation of arachidonic acid metabolism in human platelets by hydrodynamic stresses. HHT
50  1987 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid is a chemoattractant for human polymorphonuclear leucocytes in vitro. ---
51  1987 Brain 12-HETE formation in different species, brain regions, and in brain microvessels. ---
52  1987 Cutaneous responses to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and 5,12-dihydroxyeicosatetraenoic acid (leukotriene B4) in psoriasis and normal human skin. ---
53  1987 Interactions of arterial cells. Studies on the mechanisms of endothelial cell modulation of cholesterol metabolism in co-cultured smooth muscle cells. CE, EC, PDGF, SMC
54  1986 Effects of phenolic constituents from the mulberry tree on arachidonate metabolism in rat platelets. HHT
55  1986 Incorporation of platelet and leukocyte lipoxygenase metabolites by cultured vascular cells. ---
56  1986 Topical steroid treatment reduces arachidonic acid and leukotriene B4 in lesional skin of psoriasis. AA, LTB4, PGE2
57  1986 [Metabolism of arachidonic acid in the thrombocytes of patients with periodic disease]. AA, FMF, HHT
58  1985 Biosynthesis of prostaglandins and hydroxy fatty acids in primary squamous carcinomas of head and neck in humans. ---
59  1985 Cutaneous responses to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE). 9-HODD
60  1985 Endogenous hydroxyeicosatetraenoic acids stimulate the human polymorphonuclear leukocyte 15-lipoxygenase pathway. PMNs
61  1985 Glucose increases the synthesis of lipoxygenase-mediated metabolites of arachidonic acid in intact rat islets. ---
62  1985 Increase in 12-lipoxygenase activity in platelets of spontaneously hypertensive rats. ---
63  1985 Influence of dietary partially hydrogenated vegetable and marine oils on membrane composition and function of liver microsomes and platelets in the rat. HHO, HHT, HLRSO, OO, TE
64  1985 Inhibition of platelet and neutrophil phospholipase A2 by hydroxyeicosatetraenoic acids (HETES). A novel pharmacological mechanism for regulating free fatty acid release. 15-HETE, 5-HETE, HETEs, PLA2
65  1985 Lipoxygenase metabolism of arachidonic acid in brain. ---
66  1985 Stimulatory effect of insulin on aortic smooth muscle cell migration induced by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid and its modulation by elevated extracellular glucose levels. ---
67  1985 Temporal changes in 12-HETE formation in two models of canine myocardial infarction. AA, GC-MS, HETEs, PMNs, RP-HPLC
68  1984 Age-related increase in the migration of aortic smooth muscle cells induced by 12-L-hydroxy-5,8,10,14-eicosatetranoic acid. HPF
69  1984 Biosynthesis of lipoxygenase products by enzyme preparations from normal and psoriatic skin. ETYA, NDGA
70  1984 Inhibitory action of soluble elastin on thromboxane B2 formation in blood platelets. ---
71  1984 Synthesis of two hydroxy fatty acids from 7,10,13,16,19-docosapentaenoic acid by human platelets. TXB2
72  1983 Anthralin inhibition of mouse epidermal arachidonic acid lipoxygenase in vitro. CDNQ, DHAQ
73  1983 Biosynthesis of cyclooxygenase and lipoxygenase metabolites of arachidonic acid by rabbit renal microsomes. 5-HETE, AA, LT, RP-HPLC, UV
74  1983 Calcium dependency of aortic smooth muscle cell migration induced by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid. Effects of A23187, nicardipine and trifluoperazine. ---
75  1983 Lipoxygenase activity in human uterine and intrauterine tissues: new prospects for control of prostacyclin production in pre-eclampsia. 12-HPETE, AA, NDGA
76  1983 Modulation of insulin secretion by lipoxygenase products of arachidonic acid. Relation to lipoxygenase activity of pancreatic islets. 15-HETE, 15-HPETE, 5-HETE, BHT, NDGA
77  1983 Preferential utilization of endogenous arachidonate by cyclo-oxygenase in incubations of human platelets. SIM, TXB2
78  1983 The effect of prenatal dexamethasone on fetal rat lung prostaglandin synthesis. 6-keto-PGF1 alpha, HHT, PGD2, PGE2, PGF2 alpha, TXB2
79  1983 The effects of aspirin and dipyridamole on the metabolism of arachidonic acid in human platelets. 12-HPETE, HHT, TXB2
80  1982 6,9-deepoxy-6,9,-(phenylimino)-delta 6,8-prostaglandin I1, (U-60,257), a new inhibitor of leukotriene C and D synthesis: in vitro studies. LT's, TXB2
81  1982 Arachidonic acid metabolism in rat pancreatic acinar cells: calcium-mediated stimulation of the lipoxygenase system. ---
82  1982 Effect of fasting on production from exogenous arachidonic acid of thromboxane and 12-hydroxy 5, 8, 10, 14-Eicosatetraenoic acid (12-HETE) by washed platelets of normal and streptozotocin diabetic mice. TXB2
83  1982 Formation of arachidonate lipoxygenase metabolites by human fetal membranes, uterine decidua vera and placenta. NDGA
84  1981 A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases. THETEs
85  1980 Monohydroxyeicosatetraenoic acids (HETEs) induce degranulation of human neutrophils. 5-HETE
86  1979 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid, a chemotactic fatty acid, is incorporated into neutrophil phospholipids and triglyceride. ---