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Abbreviation : 12-LO
Long Form : 12-lipoxygenase
No. Year Title Co-occurring Abbreviation
2021 Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2. AMPK, Ang II, DDAH-1, ET-1, SHR, Sulf1, SULF2, TGF-beta1, VSMCs
2021 Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production. 5-LO, BALF, HDMs, LTB4, OVA
2019 12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages. 12-HETE, COX, MT, NF, p38 MAPK, PG, PKC, sPLA2
2019 Lipoxygenase Inhibitors as Cancer Chemopreventives: Discovery, Recent Developments and Future Perspectives. 15-LO, 5-LO, LO, LTs, PUFA
2019 Roles of 12-Lipoxygenase and Its Interaction with Angiotensin II on p21 and p27 Expression in Diabetic Nephropathy. 12-LOKO, Ang II, MCs
2018 Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice. AT, HETE, SVF
2018 Altered expression of cyclooxygenase-2, 12-lipoxygenase, inducible nitric oxide synthase-2 and surfactant protein D in lungs of patients with pulmonary injury caused by sulfur mustard. COX-2, iNOS2, SFTPD, SM
2018 Identification of Peracetylated Quercetin as a Selective 12-Lipoxygenase Pathway Inhibitor in Human Platelets. 5-LO, COX, HEK293, PMNLs
2018 Sinapic acid phenethyl ester as a potent selective 5-lipoxygenase inhibitor: Synthesis and structure-activity relationship. 5-LO, CAPE, COX-1
10  2018 Sulfatase 1 mediates the attenuation of Ang II-induced hypertensive effects by CCL5 in vascular smooth muscle cells from spontaneously hypertensive rats. Ang II, DDAH-1, ET-1, mRNA, SHR, siRNA, Sulf1, SULF2, VSMCs
11  2017 12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets. OCR, T2D
12  2017 ITRAQ-Based Proteomics Analysis of Acute Lung Injury Induced by Oleic Acid in Mice. ALI, DEPs, DOCK2, ELISA, iTRAQ, OA, p-MLC
13  2017 The Four-Way Stop Sign: Viruses, 12-Lipoxygenase, Islets, and Natural Killer Cells in Type 1 Diabetes Progression. NK, NOD, T1D
14  2016 12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance. AMPK, Ang II, AT1R, DN, IR, MAPK, MAU, T2DN
15  2016 Effect of angiotensin II type 1 receptor blocker on 12-lipoxygenase activity and slit diaphragm protein expression in type 2 diabetic rat glomeruli. Ang II, AT1, DN, LG, SG
16  2016 Host Factors Alter Effects of Angiopoietin-Like Protein 8 on Glucose Homeostasis in Diabetic Mice. ANGPTL8, NOD
17  2015 p16ink4a Expression Is Increased through 12-Lipoxygenase in High Glucose-Stimulated Glomerular Mesangial Cells and Type 2 Diabetic Glomeruli. CDC, CKIs, DN, HG, MCs
18  2015 Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA. EVs, MPs, sPLA2-IIA
19  2014 12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets. ---
20  2014 CCL5 upregulates activation of AMP-activated protein kinases in vascular smooth muscle cells of spontaneously hypertensive rats. AMPK, Ang II, DDAH, ET, SHR
21  2014 Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes. nPOD, PP
22  2013 12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival. AAV, VSMC
23  2013 ATP antagonizes thrombin-induced signal transduction through 12(S)-HETE and cAMP. AC, ADA, NDGA, TIPA
24  2013 Effect of CCL5 on dimethylarginine dimethylaminohydrolase-1 production in vascular smooth muscle cells from spontaneously hypertensive rats. ADMA, DDAH, ET-1, SHR, VSMCs, WKY
25  2012 Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. 12-HETE, Nox1, ROS
26  2011 Angiotensin II inhibits chemokine CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats. Ang II, ERK, HETE, MAP, SHR, VSMCs, WKY
27  2011 Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats. Ang II, CDC, DN
28  2011 The inhibition effect of anti-GPIIIa49-66 antibody on megakaryocyte differentiation. MK, ROS, TPO
29  2010 12-Lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca2+ channels. LTP
30  2010 Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils. ---
31  2009 Role of the low-affinity leukotriene B4 receptor BLT2 in VEGF-induced angiogenesis. HETE, HUVECs, VEGF
32  2008 Angiotensin II type 1 receptor expression is increased via 12-lipoxygenase in high glucose-stimulated glomerular cells and type 2 diabetic glomeruli. AT1, CDC, DN, HG, MCs
33  2008 Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. ACR
34  2008 Lipoxygenase-derived metabolites are regulators of peroxisome proliferator-activated receptor gamma-2 expression in human vascular smooth muscle cells. 12- and 15-LO, 13-HODE, 15-HETE, 15-LO, mRNA, PPARgamma, VSMCs
35  2007 Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase. Ab, DEX, PMA, ROS
36  2006 An aldosterone-related system in the ventrolateral medulla oblongata of spontaneously hypertensive and Wistar-Kyoto rats. SHR, VLM, WKY
37  2006 Disparate effects of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid in vascular endothelial and smooth muscle cells and in cardiomyocytes. 12-HETE
38  2006 Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice. ---
39  2005 Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome. IR, LSF, p-STAT4, ZR
40  2005 AMPA receptor phosphorylation is selectively regulated by constitutive phospholipase A(2) and 5-lipoxygenase activities. 5-LO, AMPA, BEL, iPLA2, NMDA
41  2005 Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway. 15-LO, AII, LOX-1, oxLDL, VSMC
42  2005 C-terminus of p47(phox) is required for interaction with leukocyte type rat 12-lipoxygenase. ---
43  2005 Delayed autoregulation of glucose transport in vascular endothelial cells. 12-HETE
44  2005 Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation. SMCs
45  2004 Acute aspirin treatment abolishes, whereas acute ibuprofen treatment enhances morphine-induced cardioprotection: role of 12-lipoxygenase. NSAIDs
46  2004 Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway. ROS
47  2003 12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses. IPC, SNC
48  2003 Anti-inflammatory activity of Chinese medicinal vine plants. 5-LO, COX-1, COX-2
49  2003 Evidence that increased 12-lipoxygenase expression impairs pancreatic beta cell function and viability. AAV, GSIS, MAPK
50  2003 Overexpression of 12-lipoxygenase and cardiac fibroblast hypertrophy. 12-HETE, Ang II, CHO
51  2003 Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes. CDC, ECM, GAPDH, HG
52  2002 Induction of cyclooxygenase-2 gene in pancreatic beta-cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid. COX-2, HETE, PGE2
53  2002 Key role of P38 mitogen-activated protein kinase and the lipoxygenase pathway in angiotensin II actions in H295R adrenocortical cells. 12-HETE, Ang II, MAPKs
54  2002 Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model. 12-HETE, HLHG, HLNG, LO, NLHG, NLNG
55  2001 12-lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy. MCs, RT-PCR
56  2001 Increased levels of 12(S)-HETE in patients with essential hypertension. ---
57  2001 Overexpression of 12-lipoxygenase causes cardiac fibroblast cell growth. ---
58  2001 Partial purification and characterization of 12-lipoxygenase in bullfrog erythrocytes. 13-HpODE, AA, Hb, LA
59  2001 Ribozyme-mediated inhibition of rat leukocyte-type 12-lipoxygenase prevents intimal hyperplasia in balloon-injured rat carotid arteries. MRz, Rz
60  2000 Enzyme self-inactivation is a main limitation of the preparation of eicosanoids. Enzymatic synthesis of thromboxane and 12(S)-hydroxytetraenoic acid. 12-HETE, EPA, PG, TX
61  2000 Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3. apoA-I, HDL, LDL, PAPC
62  1999 Lipoxygenase metabolism of arachidonic acid in ischemic preconditioning and PKC-induced protection in heart. DOG, LVDP, PC, PKC
63  1999 Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells. HAECs, VLA-4
64  1999 Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni. 5-LO
65  1999 Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice. 12-HETE, 12-LOKO
66  1998 The role of 12-lipoxygenase in pancreatic -cells (Review). 12-HPETE, 13-HPODE, AA, LA
67  1997 Effect of 2,4-disubstituted thiazol-5yl-aminoketones on inflammation. In vitro and in vivo biological studies: a structure-activity approach. DPPH
68  1997 Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells. 12-HETE, Ang II, PSMC, VEGF, VSMC
69  1997 Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives. 5-LO, DPE, PMNL
70  1996 (Carboxyalkyl)benzyl propargyl ethers as selective inhibitors of leukocyte-type 12-lipoxygenases. ---
71  1996 Inactivation of mouse epidermal 12-lipoxygenase by anthralin--implications for the role of oxygen radicals. BHT, SOD
72  1996 Mechanisms of ANG II-induced mitogenic responses: role of 12-lipoxygenase and biphasic MAP kinase. 12-HETE, Ang II, MAP, PTX
73  1996 Platelet-derived growth factor BB mediated regulation of 12-lipoxygenase in porcine aortic smooth muscle cells. 12-HETE, PDGF, PVSMC, VSMC
74  1995 Interleukin-1 beta regulates the expression of a leukocyte type of 12-lipoxygenase in rat islets and RIN m5F cells. IL-1beta, mRNA
75  1995 Novel 10-substituted antipsoriatic anthrones as inhibitors of epidermal 12-lipoxygenase and lipid peroxidation in membranes. 5-LO
76  1995 Ribozyme-mediated inhibition of expression of leukocyte-type 12-lipoxygenase in porcine aortic vascular smooth muscle cells. ---
77  1994 Expression of porcine leukocyte 12-lipoxygenase in a baculovirus/insect cell system and its characterization. ---
78  1993 Lipoxin synthase activity of human platelet 12-lipoxygenase. LTA4, LXA4, LXB4
79  1989 Inhibitory activities and inhibition specificities of caffeic acid derivatives and related compounds toward 5-lipoxygenase. 5-LO, PG
80  1989 Selective inhibition of angiotensin-II-mediated aldosterone secretion by 5-hydroxyeicosatetraenoic acid. 5-HETE, AII
81  1989 Tumor necrosis factor and interleukin-1 are potent inhibitors of angiotensin-II-induced aldosterone synthesis. 12-HETE, AII, IL-1, TNF