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Total Number of Papers: 81
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| Abbreviation |
: 12-LO |
| Long Form |
: 12-lipoxygenase |
|
| No. |
Year |
Title |
Co-occurring Abbreviation |
| 1 |
2021 |
Hypertensive effects of transforming growth factor-β1 in vascular smooth muscles cells from spontaneously hypertensive rats are mediated by sulfatase 2. |
AMPK, Ang II, DDAH-1, ET-1, SHR, Sulf1, SULF2, TGF-beta1, VSMCs |
| 2 |
2021 |
Leukotriene B4 receptors contribute to house dust mite-induced eosinophilic airway inflammation via TH2 cytokine production. |
5-LO, BALF, HDMs, LTB4, OVA |
| 3 |
2019 |
12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages. |
12-HETE, COX, MT, NF, p38 MAPK, PG, PKC, sPLA2 |
| 4 |
2019 |
Lipoxygenase Inhibitors as Cancer Chemopreventives: Discovery, Recent Developments and Future Perspectives. |
15-LO, 5-LO, LO, LTs, PUFA |
| 5 |
2019 |
Roles of 12-Lipoxygenase and Its Interaction with Angiotensin II on p21 and p27 Expression in Diabetic Nephropathy. |
12-LOKO, Ang II, MCs |
| 6 |
2018 |
Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice. |
AT, HETE, SVF |
| 7 |
2018 |
Altered expression of cyclooxygenase-2, 12-lipoxygenase, inducible nitric oxide synthase-2 and surfactant protein D in lungs of patients with pulmonary injury caused by sulfur mustard. |
COX-2, iNOS2, SFTPD, SM |
| 8 |
2018 |
Identification of Peracetylated Quercetin as a Selective 12-Lipoxygenase Pathway Inhibitor in Human Platelets. |
5-LO, COX, HEK293, PMNLs |
| 9 |
2018 |
Sinapic acid phenethyl ester as a potent selective 5-lipoxygenase inhibitor: Synthesis and structure-activity relationship. |
5-LO, CAPE, COX-1 |
| 10 |
2018 |
Sulfatase 1 mediates the attenuation of Ang II-induced hypertensive effects by CCL5 in vascular smooth muscle cells from spontaneously hypertensive rats. |
Ang II, DDAH-1, ET-1, mRNA, SHR, siRNA, Sulf1, SULF2, VSMCs |
| 11 |
2017 |
12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets. |
OCR, T2D |
| 12 |
2017 |
ITRAQ-Based Proteomics Analysis of Acute Lung Injury Induced by Oleic Acid in Mice. |
ALI, DEPs, DOCK2, ELISA, iTRAQ, OA, p-MLC |
| 13 |
2017 |
The Four-Way Stop Sign: Viruses, 12-Lipoxygenase, Islets, and Natural Killer Cells in Type 1 Diabetes Progression. |
NK, NOD, T1D |
| 14 |
2016 |
12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance. |
AMPK, Ang II, AT1R, DN, IR, MAPK, MAU, T2DN |
| 15 |
2016 |
Effect of angiotensin II type 1 receptor blocker on 12-lipoxygenase activity and slit diaphragm protein expression in type 2 diabetic rat glomeruli. |
Ang II, AT1, DN, LG, SG |
| 16 |
2016 |
Host Factors Alter Effects of Angiopoietin-Like Protein 8 on Glucose Homeostasis in Diabetic Mice. |
ANGPTL8, NOD |
| 17 |
2015 |
p16ink4a Expression Is Increased through 12-Lipoxygenase in High Glucose-Stimulated Glomerular Mesangial Cells and Type 2 Diabetic Glomeruli. |
CDC, CKIs, DN, HG, MCs |
| 18 |
2015 |
Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA. |
EVs, MPs, sPLA2-IIA |
| 19 |
2014 |
12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets. |
--- |
| 20 |
2014 |
CCL5 upregulates activation of AMP-activated protein kinases in vascular smooth muscle cells of spontaneously hypertensive rats. |
AMPK, Ang II, DDAH, ET, SHR |
| 21 |
2014 |
Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes. |
nPOD, PP |
| 22 |
2013 |
12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival. |
AAV, VSMC |
| 23 |
2013 |
ATP antagonizes thrombin-induced signal transduction through 12(S)-HETE and cAMP. |
AC, ADA, NDGA, TIPA |
| 24 |
2013 |
Effect of CCL5 on dimethylarginine dimethylaminohydrolase-1 production in vascular smooth muscle cells from spontaneously hypertensive rats. |
ADMA, DDAH, ET-1, SHR, VSMCs, WKY |
| 25 |
2012 |
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. |
12-HETE, Nox1, ROS |
| 26 |
2011 |
Angiotensin II inhibits chemokine CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats. |
Ang II, ERK, HETE, MAP, SHR, VSMCs, WKY |
| 27 |
2011 |
Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats. |
Ang II, CDC, DN |
| 28 |
2011 |
The inhibition effect of anti-GPIIIa49-66 antibody on megakaryocyte differentiation. |
MK, ROS, TPO |
| 29 |
2010 |
12-Lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca2+ channels. |
LTP |
| 30 |
2010 |
Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils. |
--- |
| 31 |
2009 |
Role of the low-affinity leukotriene B4 receptor BLT2 in VEGF-induced angiogenesis. |
HETE, HUVECs, VEGF |
| 32 |
2008 |
Angiotensin II type 1 receptor expression is increased via 12-lipoxygenase in high glucose-stimulated glomerular cells and type 2 diabetic glomeruli. |
AT1, CDC, DN, HG, MCs |
| 33 |
2008 |
Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. |
ACR |
| 34 |
2008 |
Lipoxygenase-derived metabolites are regulators of peroxisome proliferator-activated receptor gamma-2 expression in human vascular smooth muscle cells. |
12- and 15-LO, 13-HODE, 15-HETE, 15-LO, mRNA, PPARgamma, VSMCs |
| 35 |
2007 |
Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase. |
Ab, DEX, PMA, ROS |
| 36 |
2006 |
An aldosterone-related system in the ventrolateral medulla oblongata of spontaneously hypertensive and Wistar-Kyoto rats. |
SHR, VLM, WKY |
| 37 |
2006 |
Disparate effects of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid in vascular endothelial and smooth muscle cells and in cardiomyocytes. |
12-HETE |
| 38 |
2006 |
Role of 12-lipoxygenase in volatile anesthetic-induced delayed preconditioning in mice. |
--- |
| 39 |
2005 |
Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome. |
IR, LSF, p-STAT4, ZR |
| 40 |
2005 |
AMPA receptor phosphorylation is selectively regulated by constitutive phospholipase A(2) and 5-lipoxygenase activities. |
5-LO, AMPA, BEL, iPLA2, NMDA |
| 41 |
2005 |
Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway. |
15-LO, AII, LOX-1, oxLDL, VSMC |
| 42 |
2005 |
C-terminus of p47(phox) is required for interaction with leukocyte type rat 12-lipoxygenase. |
--- |
| 43 |
2005 |
Delayed autoregulation of glucose transport in vascular endothelial cells. |
12-HETE |
| 44 |
2005 |
Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation. |
SMCs |
| 45 |
2004 |
Acute aspirin treatment abolishes, whereas acute ibuprofen treatment enhances morphine-induced cardioprotection: role of 12-lipoxygenase. |
NSAIDs |
| 46 |
2004 |
Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway. |
ROS |
| 47 |
2003 |
12-lipoxygenase in opioid-induced delayed cardioprotection: gene array, mass spectrometric, and pharmacological analyses. |
IPC, SNC |
| 48 |
2003 |
Anti-inflammatory activity of Chinese medicinal vine plants. |
5-LO, COX-1, COX-2 |
| 49 |
2003 |
Evidence that increased 12-lipoxygenase expression impairs pancreatic beta cell function and viability. |
AAV, GSIS, MAPK |
| 50 |
2003 |
Overexpression of 12-lipoxygenase and cardiac fibroblast hypertrophy. |
12-HETE, Ang II, CHO |
| 51 |
2003 |
Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes. |
CDC, ECM, GAPDH, HG |
| 52 |
2002 |
Induction of cyclooxygenase-2 gene in pancreatic beta-cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid. |
COX-2, HETE, PGE2 |
| 53 |
2002 |
Key role of P38 mitogen-activated protein kinase and the lipoxygenase pathway in angiotensin II actions in H295R adrenocortical cells. |
12-HETE, Ang II, MAPKs |
| 54 |
2002 |
Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model. |
12-HETE, HLHG, HLNG, LO, NLHG, NLNG |
| 55 |
2001 |
12-lipoxygenase is increased in glucose-stimulated mesangial cells and in experimental diabetic nephropathy. |
MCs, RT-PCR |
| 56 |
2001 |
Increased levels of 12(S)-HETE in patients with essential hypertension. |
--- |
| 57 |
2001 |
Overexpression of 12-lipoxygenase causes cardiac fibroblast cell growth. |
--- |
| 58 |
2001 |
Partial purification and characterization of 12-lipoxygenase in bullfrog erythrocytes. |
13-HpODE, AA, Hb, LA |
| 59 |
2001 |
Ribozyme-mediated inhibition of rat leukocyte-type 12-lipoxygenase prevents intimal hyperplasia in balloon-injured rat carotid arteries. |
MRz, Rz |
| 60 |
2000 |
Enzyme self-inactivation is a main limitation of the preparation of eicosanoids. Enzymatic synthesis of thromboxane and 12(S)-hydroxytetraenoic acid. |
12-HETE, EPA, PG, TX |
| 61 |
2000 |
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3. |
apoA-I, HDL, LDL, PAPC |
| 62 |
1999 |
Lipoxygenase metabolism of arachidonic acid in ischemic preconditioning and PKC-induced protection in heart. |
DOG, LVDP, PC, PKC |
| 63 |
1999 |
Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells. |
HAECs, VLA-4 |
| 64 |
1999 |
Mice deficient for 5-lipoxygenase, but not leukocyte-type 12-lipoxygenase, display altered immune responses during infection with Schistosoma mansoni. |
5-LO |
| 65 |
1999 |
Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice. |
12-HETE, 12-LOKO |
| 66 |
1998 |
The role of 12-lipoxygenase in pancreatic -cells (Review). |
12-HPETE, 13-HPODE, AA, LA |
| 67 |
1997 |
Effect of 2,4-disubstituted thiazol-5yl-aminoketones on inflammation. In vitro and in vivo biological studies: a structure-activity approach. |
DPPH |
| 68 |
1997 |
Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells. |
12-HETE, Ang II, PSMC, VEGF, VSMC |
| 69 |
1997 |
Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives. |
5-LO, DPE, PMNL |
| 70 |
1996 |
(Carboxyalkyl)benzyl propargyl ethers as selective inhibitors of leukocyte-type 12-lipoxygenases. |
--- |
| 71 |
1996 |
Inactivation of mouse epidermal 12-lipoxygenase by anthralin--implications for the role of oxygen radicals. |
BHT, SOD |
| 72 |
1996 |
Mechanisms of ANG II-induced mitogenic responses: role of 12-lipoxygenase and biphasic MAP kinase. |
12-HETE, Ang II, MAP, PTX |
| 73 |
1996 |
Platelet-derived growth factor BB mediated regulation of 12-lipoxygenase in porcine aortic smooth muscle cells. |
12-HETE, PDGF, PVSMC, VSMC |
| 74 |
1995 |
Interleukin-1 beta regulates the expression of a leukocyte type of 12-lipoxygenase in rat islets and RIN m5F cells. |
IL-1beta, mRNA |
| 75 |
1995 |
Novel 10-substituted antipsoriatic anthrones as inhibitors of epidermal 12-lipoxygenase and lipid peroxidation in membranes. |
5-LO |
| 76 |
1995 |
Ribozyme-mediated inhibition of expression of leukocyte-type 12-lipoxygenase in porcine aortic vascular smooth muscle cells. |
--- |
| 77 |
1994 |
Expression of porcine leukocyte 12-lipoxygenase in a baculovirus/insect cell system and its characterization. |
--- |
| 78 |
1993 |
Lipoxin synthase activity of human platelet 12-lipoxygenase. |
LTA4, LXA4, LXB4 |
| 79 |
1989 |
Inhibitory activities and inhibition specificities of caffeic acid derivatives and related compounds toward 5-lipoxygenase. |
5-LO, PG |
| 80 |
1989 |
Selective inhibition of angiotensin-II-mediated aldosterone secretion by 5-hydroxyeicosatetraenoic acid. |
5-HETE, AII |
| 81 |
1989 |
Tumor necrosis factor and interleukin-1 are potent inhibitors of angiotensin-II-induced aldosterone synthesis. |
12-HETE, AII, IL-1, TNF |
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