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Abbreviation : 15-HETE
Long Form : 15-hydroxyeicosatetraenoic acid
No. Year Title Co-occurring Abbreviation
2020 Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell-Dependent Endothelial Cell Apoptosis. PAH
2019 Altered Lipid Metabolism in Blood Mononuclear Cells of Psoriatic Patients Indicates Differential Changes in Psoriasis Vulgaris and Psoriatic Arthritis. 13HODE, 4-HNE, 8-iso-PGF2alpha, COX-1, COX-2, LTB4, PGE1, TXB2
2019 Arachidonic Acid and Docosahexaenoic Acid Metabolites in the Airways of Adults With Cystic Fibrosis: Effect of Docosahexaenoic Acid Supplementation. AA, CF, COPD, DHA, LTB4, PGE2
2019 Effect of zinc, copper and resveratrol supplementation on the urinary level of 15-hydroxyeicosatetraenoic acid at the early stage of breast cancer in rats. ELISA
2019 Parainfluenza virus infection enhances NSAIDs-induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells. 15-LO, 5-LO, AA, COX-1, COX-2, ECs, NSAIDs, PGE2, PIV3
2019 Skin metabolome reveals immune responses in yellow drum Nibea albiflora to Cryptocaryon irritans infection. KEGG, PCA
2019 Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy. 15-LO, GPX4
2018 15-HETE protects pulmonary artery smooth muscle cells against apoptosis via SIRT1 regulation during hypoxia. PASM, PASMCs, SIRT1, TdT
2018 Hypoxic cardiac fibroblasts from failing human hearts decrease cardiomyocyte beating frequency in an ALOX15 dependent manner. ALOX15
10  2018 MMP-2 and MMP-9 contribute to the angiogenic effect produced by hypoxia/15-HETE in pulmonary endothelial cells. MMP-2, MMP-9, PAECs, PAH, RVSP
11  2018 Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis. 12-HETE, AA, ALS, HO-1, LOX, NFA
12  2017 Deletion of 12/15-lipoxygenase accelerates the development of aging-associated and instability-induced osteoarthritis. 13-HODE, DMM, iNOS, LXA4, MMP-13, NO, OA, PGE2, WT
13  2017 Plasma 15-Hydroxyeicosatetraenoic Acid Predicts Treatment Outcomes in Aspirin-Exacerbated Respiratory Disease. AERD
14  2017 Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. 13-HODE, 15-HETE-PE, FOXA3, HAECs
15  2017 The 15-LO-1/15-HETE system promotes angiogenesis by upregulating VEGF in ischemic brains. 15-LO, MCAO, OGD/R, VEGF
16  2016 15-oxo-ETE-induced internal carotid artery constriction in hypoxic rats is mediated by potassium channels. 15-LO, AA, CASMCs, ICA, RT-PCR
17  2016 Activation of ERK pathway is required for 15-HETE-induced angiogenesis in human umbilical vascular endothelial cells. ERK, HUVECs
18  2016 Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease. CD, EGCs, IEB, PUFA
19  2016 Grape Seed Procyanidin Extract Mediates Antineoplastic Effects against Lung Cancer via Modulations of Prostacyclin and 15-HETE Eicosanoid Pathways. BAL, COX-2, GSE, PGE2
20  2016 Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension. 15-LO, BrdU, EC, HPH, NOX4, PA, PASMC, PH, PVR, ROS
21  2016 The Arachidonate 15-Lipoxygenase Enzyme Product 15-HETE Is Present in Heart Tissue from Patients with Ischemic Heart Disease and Enhances Clot Formation. ALOX15
22  2016 The role of 12/15-lipoxygenase in production of selected eicosanoids in allergic airway inflammation. BAL, COX-2, CysLT, Dp, LOX, LXA4, PGE2
23  2015 12/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models. 13-HODE, AA, CRC, LA
24  2015 15-Hydroxyeicosatetraenoic Acid Inhibits Phorbol-12-Myristate-13-Acetate-Induced MUC5AC Expression in NCI-H292 Respiratory Epithelial Cells. ERK, MEK, MMP-9, NF-kappaB, PMA, PPARgamma, PTEN, Sp1
25  2015 15-Lipoxygenase and 15-hydroxyeicosatetraenoic acid regulate intravascular thrombosis in pulmonary hypertension. 15-LO, MCP-1, NDGA, PAH
26  2015 15-Lipoxygenase promotes chronic hypoxia-induced phenotype changes of PASMCs via positive feedback-loop of BMP4. 15-LO, PAH, PASMCs
27  2015 Cytomegalovirus Infection Triggers the Secretion of the PPARgamma Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures. 13-HODE, HCMV, PPARgamma
28  2015 Glycoxidized HDL, HDL enriched with oxidized phospholipids and HDL from diabetic patients inhibit platelet function. AA, HDL, PC, SR-BI, T2D
29  2015 IgE-mediated 15-hydroxyeicosatetraenoic acid (15-HETE) generation by peripheral blood leukocytes: its association with basophil activation. ---
30  2015 Low-grade inflammation in symptomatic knee osteoarthritis: prognostic value of inflammatory plasma lipids and peripheral blood leukocyte biomarkers. AUC, COX-2, IL-1beta, JSN, OA, PBLs, PGE2
31  2015 Modulation of Pulmonary Vascular Remodeling in Hypoxia: Role of 15-LOX-2/15-HETE-MAPKs Pathway. HE, MAPKs, p-ERK, p-p38 MAPK, PASMCs, PH, TUNEL
32  2015 On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells. EXC4, GST
33  2015 PGC-1alpha plays a major role in the anti-apoptotic effect of 15-HETE in pulmonary artery endothelial cells. PAECs, PGC-1alpha
34  2014 Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains. 5-HETE, AA, DDC, NAFLD, PGD2, SAMe
35  2014 Enhancement of the HIF-1alpha/15-LO/15-HETE axis promotes hypoxia-induced endothelial proliferation in preeclamptic pregnancy. HIF-1alpha, HUVECs, PE
36  2014 Inhibition of 15-lipoxygenase (15-LOX) reverses hypoxia-induced down-regulation of potassium channels Kv1.5 and Kv2.1Inhibition of 15-lipoxygenase (15-LOX) reverses hypoxia-induced down-regulation of potassium channels Kv1.5 and Kv2.1. 15-LOX, CASMCs
37  2014 NFATc3 pathway participates in the process that 15-LO/15-HETE protects pulmonary artery smooth muscle cells against apoptosis during hypoxia. 15-LO, NDGA, NFATc3, PAs, PASMCs, PH
38  2014 Phospholipase A2 regulates eicosanoid class switching during inflammasome activation. LX, TLR4
39  2013 15-Lipoxygenase promotes chronic hypoxia-induced pulmonary artery inflammation via positive interaction with nuclear factor-kappaB. 15-LO
40  2013 15-lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation. PI3K
41  2013 Heme oxygenase-1 induces 15-lipoxygenase expression during hypoxia-induced pulmonary hypertension. 15-LO, AA, HO-1, HPH, PAs, PASMCs
42  2013 Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease. 12-HETE, 17,18-diHETE, 17,18-EpETE, 19,20-diHDoPE, 19,20-EpDPE, AD, APP, ChE, PGD2, SMs
43  2013 Placenta growth factor mediates angiogenesis in hypoxic pulmonary hypertension. 15-LO, PlGF
44  2013 Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension. 15-LO, PH, RVSP, TERT
45  2013 Role of 15-hydroxyeicosatetraenoic acid in hemozoin-induced lysozyme release from human adherent monocytes. 4-HNE, NF, nHZ
46  2013 The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma. 15-LO, 5-LO, AIA, EXC4, HV, LT, MA, SA
47  2012 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells from apoptosis via inducible nitric oxide synthase (iNOS) pathway. AA, iNOS, PASMCs
48  2012 Cellular mechanisms and intracellular signaling pathways for the modulation of eNOS in pulmonary arteries by 15-HETE. eNOS, NO, PAECs, PAs, SMCs
49  2012 Identification of novel markers of alternative activation and potential endogenous PPARgamma ligand production mechanisms in human IL-4 stimulated differentiating macrophages. 13-HODE, LPA
50  2012 Neuroprotection of hydroxysafflor yellow A in the transient focal ischemia: inhibition of protein oxidation/nitration, 12/15-lipoxygenase and blood-brain barrier disruption. BBB, HSYA, I/R
51  2012 Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition. 15-LO, PASMCs, PDGF
52  2012 Preeclampsia activates 15-lipoxygenase and its metabolite 15-hydroxyeicosatetraenoic acid enhances constriction in umbilical arteries. 15-LO, 2-APB, HUA, PE
53  2012 Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension. 15-LO, PAH
54  2011 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. MEK, PE, PEBP1
55  2011 A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm. 14,15-EET, 5-LOX, Ang II, COX, mPGES-1
56  2011 Acetylsalicylic acid-triggered 15-HETE generation by peripheral leukocytes for identifying ASA sensitivity. ASA
57  2011 Key role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in pulmonary vascular remodeling and vascular angiogenesis associated with hypoxic pulmonary hypertension. ---
58  2011 Lack of association between aspirin-triggered 15-hydroxyeicosatetraenoic acid release and mast cell/eosinophil activation in nasal polyps from aspirin-sensitive patients. ECP, LT, NPDCs
59  2011 The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells. 15-LO, PASMCs, TUNEL
60  2010 15-HETE mediates sub-acute hypoxia-induced TRPC1 expression and enhanced capacitative calcium entry in rat distal pulmonary arterial myocytes. 15-LO, HPV, PASMCs
61  2010 15-HETE protects rat pulmonary arterial smooth muscle cells from apoptosis via the PI3K/Akt pathway. AA, PASMCs
62  2010 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90. 15-LO
63  2010 15-hydroxyeicosatetraenoic acid is a preferential peroxisome proliferator-activated receptor beta/delta agonist. AA, PPARs
64  2010 Hypoxia-induced 15-HETE enhances the constriction of internal carotid arteries by down-regulating potassium channels. 15-LOX, ICA
65  2010 Increased expression and altered subcellular distribution of PKC-delta and PKC-ɛ in pulmonary arteries exposed to hypoxia and 15-HETE. 15-LOX, AA, HPV, NDGA, PA, PASMCs, PKC
66  2010 ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat. 15-LO, AA, NDGA, PA, PAECs, PASMCs, PVR, SD
67  2010 Role of the G-protein and tyrosine kinase--Rho/ROK pathways in 15-hydroxyeicosatetraenoic acid induced pulmonary vasoconstriction in hypoxic rats. 15-LO, PA, PASMCs, ROK
68  2009 15-HETE suppresses K(+) channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells. AA, PASMCs
69  2009 Association analysis of peroxisome proliferator-activated receptors gamma gene polymorphisms with asprin hypersensitivity in asthmatics. AIA, PPARs, SNP
70  2009 Concentration of 14,15-leukotriene C4 (eoxin C4) in bronchoalveolar lavage fluid. BALF, CysLTs
71  2009 Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids. AA, GC, LO, OA, RA, SF
72  2009 Free Fatty Acids and Methyl Jasmonate Trigger Defense Reactions in Laminaria digitata. 13-HOTE, 15-HEPE, DPI, MeJA
73  2009 Role of protein kinase C in 15-HETE-induced hypoxic pulmonary vasoconstriction. PA, PKC
74  2009 TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. 13-HODE, CD, ChIP, EMSA, PUFAs, TR4, TZD
75  2008 Histopathology and bronchoalveolar lavage. alpha-SMA, BAL, BALF, CTGF, SSc-ILD
76  2008 Involvement of 15-lipoxygenase and prostaglandin EP receptors in aspirin-triggered 15-hydroxyeicosatetraenoic acid generation in aspirin-sensitive asthmatics. AS, AT, CA, PBLs
77  2008 Lipoxygenase-derived metabolites are regulators of peroxisome proliferator-activated receptor gamma-2 expression in human vascular smooth muscle cells. 12- and 15-LO, 12-LO, 13-HODE, 15-LO, mRNA, PPARgamma, VSMCs
78  2008 Source of the elevation Ca2+ evoked by 15-HETE in pulmonary arterial myocytes. 2-APB, TRPC
79  2007 Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase. LOX, PE
80  2007 Alternative splicing of cyclooxygenase-1 gene: altered expression in leucocytes from patients with bronchial asthma and association with aspirin-induced 15-HETE release. ASA, ATA, COX-1, COX-1 AS index, HS, PBL
81  2007 Expression of 15-lipoxygenase type-1 in human mast cells. CBMC, IL-4, MS/MS
82  2007 Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. 13-OH-14,15-EET, 15-HPETE, 15-KETE, TXAS
83  2006 Monitoring eicosanoid biosynthesis via lipoxygenase and cyclooxygenase pathways in human whole blood by single HPLC run. 12-HETE, 12-HHT, 5-HETE, LTB4
84  2006 Oxymetazoline inhibits proinflammatory reactions: effect on arachidonic acid-derived metabolites. 15-LO, 5-LO, AMs, UCPs
85  2006 Role of 15-hydroxyeicosatetraenoic acid in phosphorylation of ERK1/2 and caldesmon in pulmonary arterial smooth muscle cells. CDC, PA, PASMCs
86  2006 [Kv3.4 channel is involved in rat pulmonary vasoconstriction induced by 15-hydroxyeicosatetraenoic acid]. 15-LO, AA, PAs, PASMCs
87  2005 15-hydroxyeicosatetraenoic acid depressed endothelial nitric oxide synthase activity in pulmonary artery. 15-LO, BPAECs, eNOS, IP, NO, PA
88  2005 Aspirin-triggered 15-HETE generation in peripheral blood leukocytes is a specific and sensitive Aspirin-Sensitive Patients Identification Test (ASPITest). AS, ASPITest, AT, HC, PBL, ROC
89  2005 Cyclooxygenase- and lipoxygenase-dependent relaxation to arachidonic acid in rabbit small mesenteric arteries. AA, CDC, COX, HEETAs, NDGA, THETA
90  2005 Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: an imbalance between proinflammatory and antiinflammatory lipid mediators. 5-LOX, BAL, COX, SLD, SSc
91  2005 ERK1/2 signaling pathway is involved in 15-hydroxyeicosatetraenoic acid-induced hypoxic pulmonary vasoconstriction. PA, PASMCs
92  2004 Effect of 15-HETE on potassium channels of rabbit pulmonary arterial smooth muscles during hypoxia. PASMCs
93  2004 Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase. 13-HODE, 5-LO, EAE, LTs, PPARgamma
94  2004 The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase. LC-UV-MS-MS, LOXa
95  2003 Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. PBLs, PG
96  2002 Arachidonic acid metabolism in growth control of A549 human lung adenocarcinoma cells. AA, bFGF, FCS, PGE2
97  2001 Alterations in lipoxygenase and cyclooxygenase-2 catalytic activity and mRNA expression in prostate carcinoma. AA, COX-2, LOX, PCa
98  2001 Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. DHA, EPA
99  2000 Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. ASA, ASARS, ATRS, dsDNA, ECs
100  2000 Significance of lipoxygenase-derived monohydroxy fatty acids in cutaneous biology. 13-HODE, 15-HETrE, AA, DGLA, LA, PGE2, PUFA