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Abbreviation : 3alpha-HSD
Long Form : 3alpha-hydroxysteroid dehydrogenase
No. Year Title Co-occurring Abbreviation
2022 Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone. iPR, mPR, Sig-1R
2021 Combined MD and QM/MM Investigations of Hydride Reduction of 5alpha-Dihydrotestosterone Catalyzed by Human 3alpha-Hydroxysteroid Dehydrogenase Type 3: Importance of Noncovalent Interactions. 5 alpha-DHT, MD, NADPH, NCI, QM/MM
2020 Epigenetic regulation of steroidogenic enzymes expressed in peripheral blood mononuclear cells from healthy individuals and from patients with chronic lymphocytic leukemia. 17beta-HSD, 3beta-HSD, 5alpha-R, CLL, P450scc, PBMCs
2019 Developing an Enzyme-Assisted Derivatization Method for Analysis of C27 Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry. EADSA
2018 A novel electrochemical biosensor for ultrasensitive detection of serum total bile acids based on enzymatic reaction combined with the double oxidation circular amplification strategy. POCT, SPCE, TBA
2018 PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma. CSF, EFP, MLP, PTSD
2018 Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD. CSF, DHEA, GABA, GC-MS, NMDA, PTSD
2017 Effects of Fungicides on Rat's Neurosteroid Synthetic Enzymes. RDH2
2017 Effects of Refined Xiaoyaosan on Depressive-Like Behaviors in Rats with Chronic Unpredictable Mild Stress through Neurosteroids, Their Synthesis and Metabolic Enzymes. 3beta-HSD, 5AR, ALLO, CUMS, PREG, PROG, XYS
10  2016 Indirect electrochemical detection for total bile acids in human serum. IED, SPCE, TBA
11  2016 Progesterone treatment modulates mRNA OF neurosteroidogenic enzymes in a murine model of multiple sclerosis. 3beta-HSD, EAE, StAR, TSPO, VDAC
12  2015 Environmental enrichment attenuates the age-related decline in the mRNA expression of steroidogenic enzymes and reduces the methylation state of the steroid 5alpha-reductase type 1 gene in the rat hippocampus. ---
13  2015 Expression, purification and functional characterization of a novel 3alpha-hydroxysteroid dehydrogenase from Pseudomonas aeruginosa. ORF, SBAs
14  2015 One step affinity recovery of 3alpha-hydroxysteroid dehydrogenase from cloned Escherichia coli. hsdA
15  2014 5alpha-reductase type I expression is downregulated in the prefrontal cortex/Brodmann's area 9 (BA9) of depressed patients. 5alpha-RI, ALLO, BA9, CSF, mRNA, NPS, NSE, PTSD, SBSSs
16  2014 Enabling multi-enzyme biocatalysis using coaxial-electrospun hollow nanofibers: redesign of artificial cells. DP
17  2014 Expression levels of mRNA for neurosteroidogenic enzymes 17beta-HSD, 5alpha-reductase, 3alpha-HSD and cytochrome P450 aromatase in the fetal wild type and SF-1 knockout mouse brain. 17beta-HSD, SF-1
18  2014 Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo-keto reductase. AKR
19  2014 Selective inhibition of steroidogenic enzymes by ketoconazole in rat ovary cells. 20alpha-HSD, KCZ, TLC
20  2014 Ultrasensitive enzyme-linked immunosorbent assay (ELISA) of proteins by combination with the thio-NAD cycling method. ELISA, thio-NAD
21  2014 Understanding androgen action in adipose tissue. 17beta-HSD, AR, DHT, s.c
22  2013 A highly sensitive electrically driven electrochemiluminescent assay for quantification of bile acids in human serum. ECL
23  2012 Enzyme biosensor for androsterone based on 3alpha-hydroxysteroid dehydrogenase immobilized onto a carbon nanotubes/ionic liquid/NAD+ composite electrode. MWCNTs
24  2011 Variation in genes encoding the neuroactive steroid synthetic enzymes 5alpha-reductase type 1 and 3alpha-reductase type 2 is associated with alcohol dependence. 5alpha-R, AD
25  2010 Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors. 5alpha,3alpha-THSs
26  2010 [Measurement of the transport activities of bile salt export pump using chemiluminescence detection method]. hBSEP, PFIC2, RI, TCA
27  2009 Determination of total bile acid levels using a thick-film screen-printed Ir/C sensor for the detection of liver disease. ---
28  2008 3alpha-Hydroxysteroid dehydrogenase type III deficiency: a novel mechanism for hirsutism. 3alpha-diol, DHT
29  2008 Androgen biosynthetic pathways in the human prostate. 3alpha-diol, DHEA, DHEAS, DHT
30  2008 Evaluation of a fluorometric-enzymatic method based on 3alpha-hydroxysteroid dehydrogenase for the mycotoxin zearalenone determination in corn. ZEN
31  2008 Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. 5alpha-RI, AAS, SBSS
32  2007 Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. 5alpha-RI, ALLO, SI
33  2007 Effects of swim stress on mRNA and protein levels of steroid 5alpha-reductase isozymes in prefrontal cortex of adult male rats. 5alpha-R, LIF-CE
34  2007 Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3alpha-hydroxysteroid dehydrogenase. ---
35  2007 Steroid metabolism and profile of steroidogenic gene expression in Episkin: high similarity with human epidermis. 17beta-HSD, 20alpha-HSD, ADT, DHEAS, DHT
36  2006 Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. 5alpha-R, ALLO, THDOC
37  2006 Chiral inversion of RS-8359: a selective and reversible MAO-A inhibitor via oxido-reduction of keto-alcohol. ---
38  2006 Crystallization and preliminary X-ray analysis of the complex of NADH and 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831. ---
39  2006 Discrete analysis of bile acid in serum and bile with 3 alpha-hydroxysteroid dehydrogenase and diaphorase immobilized onto alkylamine glass beads. CV, NBT
40  2006 Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. 3alpha-diol, AKR, PG
41  2006 Leydig cell function in mice lacking connexin43. 17beta-HSD, 5alpha-R, Cx43
42  2005 Arginine 276 controls the directional preference of AKR1C9 (rat liver 3alpha-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells. ---
43  2005 Influence of mirtazapine on plasma concentrations of neuroactive steroids in major depression and on 3alpha-hydroxysteroid dehydrogenase activity. SSRIs
44  2005 Inhibition of 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) activity of human lung microsomes by genistein, daidzein, coumestrol and C(18)-, C(19)- and C(21)-hydroxysteroids and ketosteroids. 17beta-HSD
45  2005 [Isolation and identification of Comamonas testosteroni: cloning and overexpression of 3alpha-hydroxysteroid dehydrogenase in E.coli]. IPTG
46  2004 5alpha-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats. 3alpha-diol, DHT
47  2004 Kinetic study of the enzymatic cycling reaction conducted with 3alpha-hydroxysteroid dehydrogenase in the presence of excessive thio-NAD(+) and NADH. ---
48  2004 New tools for molecular imaging of redox metabolism: development of a fluorogenic probe for 3 alpha-hydroxysteroid dehydrogenases. ---
49  2004 Testosterone's metabolism in the hippocampus may mediate its anti-anxiety effects in male rats. 3alpha-diol, DHT
50  2004 Transient-phase kinetic studies on the nucleotide binding to 3alpha-hydroxysteroid dehydrogenase from Pseudomonas sp. B-0831 using fluorescence stopped-flow procedures. AKR, cat, SDR
51  2004 [Expression analysis of mouse homologous proteins with human aldose reductase like-1]. ARL-1, CHO-Red, LeAR, MVDP, RaK-c, rARLP
52  2003 Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes. ---
53  2003 Characterization and modulation of sex steroid metabolizing activity in normal human keratinocytes in primary culture and HaCaT cells. 17beta-HSD, 3beta-HSD, DEX, DHT, IL-4
54  2003 Differential recognition of the free versus bound retinol by human microsomal retinol/sterol dehydrogenases: characterization of the holo-CRBP dehydrogenase activity of RoDH-4. SDR
55  2003 Proposed mechanism for sperm chromatin condensation/decondensation in the male rat. 3alpha-diol, 5 alpha-DHT, ABP
56  2003 Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells. 3alpha-diol, 5 alpha-DHT, AKRs
57  2003 The 3alpha-hydroxy-steroid-dehydrogenase-mRNA and -protein are more prevalent in pericentral than in periportal hepatocytes. ---
58  2002 Pathogenesis of diabetic neuropathy--do hyperglycemia and aldose reductase inhibitors affect neuroactive steroid formation in the rat sciatic nerves? AR, DHP, THP
59  2002 Purification, crystallization and preliminary X-ray diffraction results of human 17beta-hydroxysteroid dehydrogenase type 5. 17beta-HSDs
60  2001 3alpha-Hydroxysteroid dehydrogenase in animal and human tissues. ---
61  2001 3alpha-hydroxysteroid dehydrogenase messenger RNA transcription in the immature rat ovary in response to an ovulatory dose of gonadotropin. PCR
62  2001 Characterization of the 5alpha-reductase-3alpha-hydroxysteroid dehydrogenase complex in the human brain. CX, SC
63  2001 Cloning of the human RoDH-related short chain dehydrogenase gene and analysis of its structure. ---
64  2001 Modulation of the androgenic response by recombinant human 11-cis retinol dehydrogenase. 11-cis-RoDH, 3alpha-diol, DHT, HEK293, pCMV-11-cisRoDH, PSA
65  2001 Proteome analysis of rat hepatomas: carcinogen-dependent tumor-associated protein variants. Rak-c, rARLP-1
66  2001 Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism. 5 alpha-DHT, 5alpha-R
67  2000 Feigrisolides A, B, C and D, new lactones with antibacterial activities from Streptomyces griseus. ---
68  2000 Functional expression, purification, and characterization of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. ---
69  2000 Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. 3alpha-androstanediol, AKR, cat
70  2000 Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase. 3alpha-diol, DHT
71  2000 Interactions between type 1 astrocytes and LHRH-secreting neurons (GT1-1 cells): modification of steroid metabolism and possible role of TGFbeta1. 5alpha-R, DHP, DHT, TGF-beta1, THP
72  2000 Mutation of nicotinamide pocket residues in rat liver 3 alpha-hydroxysteroid dehydrogenase reveals different modes of cofactor binding. ---
73  2000 New 1-O-acyl alpha-L-rhamnopyranosides and rhamnosylated lactones from Streptomyces sp., inhibitors of 3 alpha-hydroxysteroid-dehydrogenase (3alpha-HSD). ---
74  1999 Characterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile. 20alpha-HSD, AKR
75  1999 Metabolism of dihydrotestosterone in human liver: importance of 3alpha- and 3beta-hydroxysteroid dehydrogenase. 3alpha-diol, 3beta-HSD, DHT
76  1999 Opposing changes in 3alpha-hydroxysteroid dehydrogenase oxidative and reductive activities in rat leydig cells during pubertal development. 3alpha-diol, DHT
77  1999 Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. SSRIs
78  1998 Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution. 5 alpha-DHT, AR, HSD
79  1998 Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells. 17beta-HSD, 3alpha-diol, 5alpha-R, AO, mRNA
80  1997 Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate. 17beta-HSD, 3alpha-adiol, RoDH1
81  1996 Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence. ---
82  1994 Progesterone 5-alpha-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes. ---
83  1978 Electrophoretic and histochemical studies on hepatic 3 alpha-hydroxysteroid dehydrogenase in the rat. ---
84  1975 Effects of testosterone mediated or modulated by pituitary factors. TP