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Abbreviation : 5-LO
Long Form : 5-lipoxygenase
No. Year Title Co-occurring Abbreviation
2020 A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4-Thiazolidinedione-Based Molecules as New Dual mPGES-1/5-LO Inhibitors. mPGES-1
2020 Analysis of proximal ALOX5 promoter binding proteins by quantitative proteomics. ---
2020 Arachidonic acid promotes the binding of 5-lipoxygenase on nanodiscs containing 5-lipoxygenase activating protein in the absence of calcium-ions. AA, TEM
2020 Concurrent Control of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: a New Prospect for the Therapeutic Potential of Lipoxin A4. AhR, AMPK, COX-2, hh, hh, KSHV, LXA4, MCM, PD-L1, RTA
2020 Development of a highly sensitive liquid chromatography-mass spectrometry method to quantify plasma leukotriene E4 and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man. LTE4, MS/MS, SPE, UPLC
2020 Effects of 5-lipoxygenase gene disruption on inflammation, osteoclastogenesis and bone resorption in polymicrobial apical periodontitis. HE, TRAP
2020 Formulation and Characterization of Solid Lipid Nanoparticles Loading RF22-c, a Potent and Selective 5-LO Inhibitor, in a Monocrotaline-Induced Model of Pulmonary Hypertension. LTs, MCT, mPAP, PAH, R-pre, SLN
2020 Improved Bioactivity of the Natural Product 5-Lipoxygenase Inhibitor Hyperforin by Encapsulation into Polymeric Nanoparticles. Ac-DEX, HSA, NPs
2020 Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase pathways. AD
10  2020 Lipid Mediator Profiles Predict Response to Therapy with an Oral Frankincense Extract in Relapsing-Remitting Multiple Sclerosis. EDA, LMs, NEDA, RRMS, SFE
11  2020 Lipoxin A4 impairs effective bacterial control and potentiates joint inflammation and damage caused by Staphylococcus aureus infection. LXA4
12  2020 LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells. MM-1
13  2020 Parasitic load determination by differential expressions of 5-lipoxygenase and PGE2 synthases in visceral leishmaniasis. ---
14  2020 Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors. delta-GA, LT
15  2020 Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors. LT
16  2020 Targeting the OXE receptor as a potential novel therapy for asthma. 5-oxo-ETE, 5S-HETE
17  2020 The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka. GC-MS, NO
18  2020 The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer. NF-kappaB, NFAs, PPARgamma, PTM, sEH
19  2020 The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis. LTB4
20  2020 The role of the LTB4-BLT1 axis in health and disease. LTA4H, LTB4
21  2020 Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils. cPLA2, dSTORM, LT
22  2020 Zileuton ameliorates depressive-like behaviors, hippocampal neuroinflammation, apoptosis and synapse dysfunction in mice exposed to chronic mild stress. CMS
23  2019 5-Lipoxagenase deficiency attenuates L-NAME-induced hypertension and vascular remodeling. 5-LO-KO, LTs, VSMCs, WT
24  2019 A Hydroquinone-Based Derivative Elicits Apoptosis and Autophagy via Activating a ROS-Dependent Unfolded Protein Response in Human Glioblastoma. GBM
25  2019 Anti-Allergic and Anti-Inflammatory Effects of Kuwanon G and Morusin on MC/9 Mast Cells and HaCaT Keratinocytes. AD, ELISA, IFN-gamma, NF-kappaB, STAT1, TNF-alpha
26  2019 Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase. CLP, SPM
27  2019 Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells. LTs, PMNL, RCC, VHL
28  2019 HMGB1 enhances AGE-mediated VSMC proliferation via an increase in 5-LO-linked RAGE expression. HMGB1, RAGE, VSMCs
29  2019 Human cytomegalovirus infection is correlated with enhanced cyclooxygenase-2 and 5-lipoxygenase protein expression in breast cancer. BC, COX-2, HCMV, IE, LA
30  2019 Identification of Peracetylated Quercetin as a Selective 12-Lipoxygenase Pathway Inhibitor in Human Platelets. 12-LO, COX, HEK293, PMNLs
31  2019 Inhibition of 5-lipoxygenase decreases renal fibrosis and progression of chronic kidney disease. LTA4H, LTC4S, LTs, UUO
32  2019 Inhibitory effect of taxifolin on mast cell activation and mast cell-mediated allergic inflammatory response. BMMCs, COX-2, cPLA2, IgE, IL-6, LTC4, MAPKs, PCA, PLCgamma, RBL
33  2019 Lens cholesterol biosynthesis inhibition: A common mechanism of cataract formation in laboratory animals by pharmaceutical products. LCB
34  2019 Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma. IHC, LTA4H, LTs
35  2019 Lipoxygenase inhibitors as cancer chemopreventives: discovery, recent developments, and future perspectives. 12-LO, 15-LO, LO, LTs, PUFA
36  2019 Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159. ---
37  2019 Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease. LTB4
38  2019 Paradoxical Effect of LTB4 on the Regulation of Stress-Induced Corticosterone Production. CUS, HPA, LTB4
39  2019 Parainfluenza virus infection enhances NSAIDs-induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells. 15-HETE, 15-LO, AA, COX-1, COX-2, ECs, NSAIDs, PGE2, PIV3
40  2019 Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5-lipoxygenase and stability in human blood and HepaRG cells. CAPE
41  2019 Phenotypically Silent Bone Morphogenetic Protein Receptor 2 Mutations Predispose Rats to Inflammation-Induced Pulmonary Arterial Hypertension by Enhancing the Risk for Neointimal Transformation. NF-kappaB, PAH, TGF-beta
42  2019 Potent stimulation of eosinopoiesis in murine bone-marrow by myriadenolide is mediated by cysteinyl-leukotriene signaling. IL, Myr, PGE2
43  2019 Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity. LTs, S1P
44  2019 The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses. ---
45  2019 Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation. Erg, HUVECs, IbTX, NO, VEGF
46  2018 5-Lipoxygenase Knockout Aggravated Apical Periodontitis in a Murine Model. AP
47  2018 5-lipoxygenase-dependent biosynthesis of novel 20:4 n-3 metabolites with anti-inflammatory activity. AA
48  2018 An allosteric inhibitor of Mycobacterium tuberculosis ArgJ: Implications to a novel combinatorial therapy. Mtb, PRK
49  2018 Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice. BDNF, CREB, FST, LPS, NSFT, TST
50  2018 Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice. ---
51  2018 Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages. TAMs
52  2018 Association between 5-lipoxygenase expression, and malignant behaviors and poor prognosis in esophageal squamous cell carcinoma. ESCC
53  2018 BLTR1 in Monocytes Emerges as a Therapeutic Target For Vascular Inflammation With a Subsequent Intimal Hyperplasia in a Murine Wire-Injured Femoral Artery. BMDCs, cysLTRs, HMGB1, LTB4, MMD
54  2018 Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice. ---
55  2018 Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways. ---
56  2018 Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation. LM, LTs, mPGES-1, PG
57  2018 Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer's Disease Pathology. AD, HHcy
58  2018 Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy. LT, NO
59  2018 Evaluation on Analgesic and Anti-Inflammatory Activities of Total Flavonoids from Juniperus sabina. COX-2
60  2018 Further studies about Coactosin-like protein-1 affecting the migration of mouse neocortical neurons. ABM, Cotl1, F-actin
61  2018 Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7. LTs, PG
62  2018 Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1. LTB4, mTOR, TNF-alpha
63  2018 Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout. GC-MS, XO
64  2018 Lipopolysaccharide and cytokines modulate leukotriene (LT)B4 and LTC4 production by porcine endometrial endothelial cells. IL, LPS, LT, LTs, TNF
65  2018 Machine intelligence decrypts beta-lapachone as an allosteric 5-lipoxygenase inhibitor. ---
66  2018 Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice. LTB4, MRSA
67  2018 miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells. AA, LTB4, LTs, miRNAs, PGs, UTR
68  2018 Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy. AD
69  2018 Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155. AKBA, DEX, i.p, LPS, miR-155, P-IkappaB-alpha, SOCS-1
70  2018 Simulation Study of Interactions Between Two Bioactive Components from Zingiber cassumunar and 5-Lipoxygenase. MD
71  2018 Sinapic acid phenethyl ester as a potent selective 5-lipoxygenase inhibitor: Synthesis and structure-activity relationship. 12-LO, CAPE, COX-1
72  2018 Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation. AA, LTs, mPGES-1, PGs
73  2018 The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing. CysLT, CysLTs, LTB4
74  2018 Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G. BAs
75  2018 Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice. COX-2, LT, PGE2, PHP, TNF-alpha, TUNEL, ZFL
76  2017 5-Lipoxygenase in monocytes emerges as a therapeutic target for intimal hyperplasia in a murine wire-injured femoral artery. HMGB1, WT
77  2017 5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes. CysLTs, LTB4, PA
78  2017 Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males. LTs
79  2017 Anti-inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions. CA, CS, mPGES-1
80  2017 Cysteinyl leukotrienes as novel host factors facilitating Cryptococcus neoformans penetration into the brain. CNS, cPLA2alpha, CysLT1, LTs
81  2017 Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase. 5-HEDH, 5-HETE, 5-oxo-ETE, AA
82  2017 Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. AA, diHETEs, EETs, LTs, sEH
83  2017 Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid. AA, PG
84  2017 Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology. Hcy
85  2017 Homocysteine modulates 5-lipoxygenase expression level via DNA methylation. AD, Hcy, SAH
86  2017 Host-Derived Leukotriene B4 Is Critical for Resistance against Invasive Pulmonary Aspergillosis. LTB4
87  2017 Inhibition of 5-lipoxygenase alleviates graft-versus-host disease. GVHD, LTB4
88  2017 Interfacial Enzymes: Membrane Binding, Orientation, Membrane Insertion, and Activity. ATR-FTIR, FRET, LO, PLA2
89  2017 Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for invitro growth of CD34+CD38- stem and progenitor cells in chronic myeloid leukemia. BM, CML, LSC, LTC-IC
90  2017 Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418. NFA, TQ
91  2017 Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents. LTs
92  2017 Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase. ---
93  2017 Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads from Enzyme-Mediated Fragmentation of Natural Products. DFOB, HDACs
94  2017 Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases. CysLTs
95  2017 Short-Term Regulation of FcgammaR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products. AMs, BMDMs, IgG-sRBC, LTs, PMs
96  2017 Structure-activity relationship of caffeic acid phenethyl ester analogs as new 5-lipoxygenase inhibitors. CAPE, LTs, PMNL
97  2017 Structure-activity relationship study of beta-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists. 5-HETE, 5-oxo-ETE, OXE-R
98  2017 Substituted Caffeic and Ferulic Acid Phenethyl Esters: Synthesis, Leukotrienes Biosynthesis Inhibition, and Cytotoxic Activity. GBM
99  2017 TGFbeta/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation. MLL, TGF-beta
100  2017 The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy. AD