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Abbreviation : 5AR
Long Form : 5alpha-reductase
No. Year Title Co-occurring Abbreviation
2022 Comparison of oral minoxidil, finasteride, and dutasteride for treating androgenetic alopecia. AGA, CVS
2022 Phytosterols in hull-less pumpkin seed oil, rich in ∆7-phytosterols, ameliorate benign prostatic hyperplasia by lowing 5α-reductase and regulating balance between cell proliferation and apoptosis in rats. AR, BPH, GC/MS, HPLC, NMR, SRC-1, TPS
2022 Preliminary Reference Interval for 5-Alpha Reductase in Normal Male Children and Its Association with Hypospadias. DHT, ELISA, RI
2022 Target Specific Uptake of a Newly Synthesized Radiolabeled 5α-Reductase Inhibitor "Tc-99m-17-Oxo-17a-Aza-D-Homo-5-Androsten-3β-yl Phenoxyacetate (Tc-99m-17a-Aza Steroid)" in Rat Prostatic Neoplastic Lesions. ---
2021 A new combination of molecules for the treatment of androgenetic alopecia and telogen effluvium: a double-blind randomized, monocentric, placebo-controlled study. AGA, TE
2021 An appraisal of laboratory models of androgenetic alopecia: A systematic review. AGA, DHT
2021 Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for the Screening of Steroid 5-alpha Reductase in Human and Fish Cell Lines. AOP, DHT, EDCs
2021 Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. 3 beta-HSDH, LCA
2020 5-Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety. 5ARI, AGA, DHT
10  2020 Curcuma oil ameliorates benign prostatic hyperplasia through suppression of the nuclear factor-kappa B signaling pathway in rats. BPH, CO, DHT, IHC, IL, SD, TNF, TP
11  2020 Differential effects of testosterone on circulating neutrophils, monocytes, and platelets in men: Findings from two trials. TE
12  2020 In vivo and in silico evaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats. ---
13  2019 Aconiti Lateralis Radix Preparata, the Dried Root of Aconitum carmichaelii Debx., Improves Benign Prostatic Hyperplasia via Suppressing 5-Alpha Reductase and Inducing Prostate Cell Apoptosis. AR, BPH
14  2019 Effect of Paecilomyces tenuipes Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Sprague-Dawley Rats. AR, BPH, DHT, Fi, P. tenuipes, PE, PSA, Saw, SRC-1, TP
15  2019 Exploration of Novel 5alpha-Reductase Inhibitors for Benign Prostatic Hyperplasia by 2D/3D QSAR, Cytotoxicity Pre-ADME and Docking Studies. 5ARI, DHT
16  2019 In Vitro and In Vivo Assessment of Metabolic Drug Interaction Potential of Dutasteride with Ketoconazole. DUT, H-DUT, HPLC-FL, KET
17  2019 The role of 5alpha-reductase inhibitors in gastro-oesophageal cancer risk: A nested case-control study. ORs
18  2018 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction. D1R, DUTA, ERK, FIN, LID, PD
19  2018 Berberine Improves Benign Prostatic Hyperplasia via Suppression of 5 Alpha Reductase and Extracellular Signal-Regulated Kinase in Vivo and in Vitro. AR, BBR, BPH, ERK, JNK, PSA, SRC-1, TP
20  2018 Synthesis, 17alpha-hydroxylase-C17,20-lyase Inhibitory and 5AR Reductase Activity of Novel Pregnenolone Derivatives. ---
21  2017 Effects of Refined Xiaoyaosan on Depressive-Like Behaviors in Rats with Chronic Unpredictable Mild Stress through Neurosteroids, Their Synthesis and Metabolic Enzymes. 3alpha-HSD, 3beta-HSD, ALLO, CUMS, PREG, PROG, XYS
22  2017 Effects of testosterone administration (and its 5-alpha-reduction) on parenchymal organ volumes in healthy young men: findings from a dose-response trial. TT
23  2017 Muscles of the trunk and pelvis are responsive to testosterone administration: data from testosterone dose-response study in young healthy men. ---
24  2017 The 5-alpha reductase inhibitor finasteride reduces dyskinesia in a rat model of Parkinson's disease. FIN, LID, PD
25  2017 The Genomic Alterations of 5alpha-Reductases and Their Inhibitor Finasteride's Effect in Bladder Cancer. 5ARI, UBC
26  2016 Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays. AGA, BPH
27  2016 Boric Acid Is Reproductively Toxic to Adult Xenopus laevis, but Not Endocrine Active. BA, DHT, GSI, SVL
28  2016 Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5alpha-reductase. AR, BPH, CC, ERalpha, TP
29  2016 Opposing Effects of Cyclooxygenase-2 (COX-2) on Estrogen Receptor beta (ERbeta) Response to 5alpha-Reductase Inhibition in Prostate Epithelial Cells. BPH, COX-2, ERbeta
30  2016 Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5alpha-reductase inhibitors. HEK
31  2014 Differential expression of 5-alpha reductase isozymes in the prostate and its clinical implications. 5-ARI, BPH, DHT, PCa
32  2014 Molecular effects of bioactive fraction of Curcuma mangga (DLBS4847) as a downregulator of 5alpha-reductase activity pathways in prostatic epithelial cells. PC
33  2013 Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence. HO-1, Nrf2
34  2012 A multiscale, mechanism-driven, dynamic model for the effects of 5alpha-reductase inhibition on prostate maintenance. BPH, DHT
35  2011 Intraprostatic testosterone and dihydrotestosterone. Part II: concentrations after androgen hormonal manipulation in men with benign prostatic hyperplasia and prostate cancer. ADT, BPH, DHT
36  2011 Isolation rearing-induced reduction of brain 5alpha-reductase expression: relevance to dopaminergic impairments. DA, DOPAC, GABA, IR, mPFC, NAcc, SR
37  2011 Prostate diseases--role of sex steroids and their inhibitors. ADT, BPH, CRPC, DHT, PC
38  2010 New therapeutic approaches for epilepsies, focusing on reorganization of the GABAA receptor subunits by neurosteroids. 3aHSD, GABA
39  2009 High-grade prostate cancer and finasteride. PCPT
40  2009 Key targets of hormonal treatment of prostate cancer. Part 2: the androgen receptor and 5alpha-reductase. DHT
41  2009 Prostate cancer: a serious disease suitable for prevention. ---
42  2009 The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme? BPH, DHT
43  2008 An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males. AER, AX, DHT, ES, SPLE
44  2008 Antipsychotic-like properties of 5-alpha-reductase inhibitors. PPI
45  2008 Dutasteride: a review of its use in the management of prostate disorders. AUR, BPH, DHT, TPV
46  2008 Evaluation of MENT on primary cell cultures from benign prostatic hyperplasia and prostate carcinoma. BPH, DHT, MENT, MTT, PSA
47  2006 5alpha-reductase: history and clinical importance. BPH, DHT
48  2006 Comparison of clinical trials with finasteride and dutasteride. AUR, BPH, DHT
49  2005 Dutasteride: an evidence-based review of its clinical impact in the treatment of benign prostatic hyperplasia. AUR, BPH
50  2003 Comparative pharmacophore development for inhibitors of human and rat 5-alpha-reductase. ---
51  2002 A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. AGA, BPH, DHT, LSESr
52  2002 Comparative study of human steroid 5alpha-reductase isoforms in prostate and female breast skin tissues: sensitivity to inhibition by finasteride and epristeride. BPH, DHT
53  2001 Linear relationships between the ligand binding energy and the activation energy of time-dependent inhibition of steroid 5alpha-reductase by delta 1-4-azasteroids. ---
54  2001 Substrate interaction with 5alpha-reductase enzyme: influence of the 17beta-chain chirality in the mechanism of action of 4-azasteroid inhibitors. ---
55  2000 The novel drug CS-891 inhibits 5alpha-reductase activity in freshly isolated dermal papilla of human hair follicles. AGA, DHT, DP, HF
56  1999 Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalp. ---
57  1997 4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro]. hAR, PC
58  1997 Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro. 3beta-HSD, 4-MA, ALP, DHEA, DHEAS, DHT, HOCs, TGF-beta ab