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Abbreviation : AA
Long Form : acetoacetate
No. Year Title Co-occurring Abbreviation
2020 The contribution of ketone bodies to glycolytic inhibition for the treatment of adult and pediatric glioblastoma. 2-DG, beta-HB, GBM, GSCs, UCP2
2017 Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows. NAC, Nrf2, ROS
2016 Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice. ---
2016 Acetoacetate promotes the formation of fluorescent advanced glycation end products (AGEs). AGEs, CD, GHSA, HSA, ROS
2016 Monitoring for compliance with a ketogenic diet: what is the best time of day to test for urinary ketosis? BHB, KD
2015 Effect of hyperketonemia (Acetoacetate) on nuclear factor-kappaB and p38 mitogen-activated protein kinase activation mediated intercellular adhesion molecule 1 upregulation in endothelial cells. BHB, HUVECs, ICAM-1, KPD, MAPK, NAC, NF-kappaB, ROS
2014 L-Cysteine supplementation reduces high-glucose and ketone-induced adhesion of monocytes to endothelial cells by inhibiting ROS. BHB, CVD, HG, LC, T1D
2014 Roles and regulation of ketogenesis in cultured astroglia and neurons under hypoxia and hypoglycemia. BHB, KBs, LC, PAL
2012 Elevated acetoacetate and monocyte chemotactic protein-1 levels in cord blood of infants of diabetic mothers. BHB, IDMs, MCP-1
10  2012 Hyperketonemia induces upregulation of LFA-1 in monocytes, which is mediated by ROS and P38 MAPK activation. BHB, NAC, ROS
11  2011 Effects of high glucose and ketosis (acetoacetate, ss-hydroxybutyrate) on PAI-1 secretion in human umbilical vascular endothelial cells. BHB, CVD, HG, HUVEC, PAI-1
12  2011 Hyperketonemia decreases mitochondrial membrane potential and its normalization with chromium (III) supplementation in monocytes. BHB, MMP
13  2011 Hyperketonemia increases monocyte adhesion to endothelial cells and is mediated by LFA-1 expression in monocytes and ICAM-1 expression in endothelial cells. BHB, EC, HUVECs, ICAM-1, LFA-1
14  2011 Ketogenic diet-induced peroxisome proliferator-activated receptor-gamma activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures. COX, KD, mPGES-1, NF, PPAR, TNF-alpha
15  2011 Myoglobin-H2O2 catalyzes the oxidation of beta-ketoacids to alpha-dicarbonyls: mechanism and implications in ketosis. MAA, Mb
16  2007 Automated determination of blood metabolic acidosis, total acid phosphatase, angiotensin converting enzyme, fructosamine and urinary oxalate and citrate on the ABX Pentra 400. ACE, BOHB, Cit, FRUCT, Oxal, Pyr, TAP
17  2007 High glucose and ketosis (acetoacetate) increases, and chromium niacinate decreases, IL-6, IL-8, and MCP-1 secretion and oxidative stress in U937 monocytes. Cr-N, CrP, CVD, HG, IL-6, IL-8, MCP-1
18  2006 Acetoacetate protects neuronal cells from oxidative glutamate toxicity. beta-OHB, CNS, KD
19  2006 Hyperketonemia (ketosis), oxidative stress and type 1 diabetes. ---
20  2005 Acetoacetate induces CYP2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes. p70S6K, PI3K, PKC
21  2004 Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: role of oxidative stress. 3HB, MAPK, NAC, PKC, ROS
22  2003 Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes. BHB, HK, IL-6, NAC, NK, ROS
23  2002 Accuracy of serum beta-hydroxybutyrate measurements for the diagnosis of diabetic ketoacidosis in 116 dogs. beta-OHB, DKA, IT, ROC, SUN
24  2002 Hyperketonemia increases tumor necrosis factor-alpha secretion in cultured U937 monocytes and Type 1 diabetic patients and is apparently mediated by oxidative stress and cAMP deficiency. BHB, NAC, NF, TNF
25  2002 Identification of an acetoacetyl coenzyme A synthetase-dependent pathway for utilization of L-(+)-3-hydroxybutyrate in Sinorhizobium meliloti. acetoacetyl-CoA, DHB, LHB, PHB
26  2000 Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission. beta-HB
27  1999 Effect of hyperketonemia on blood monocytes in type-I diabetic patients and apoptosis in cultured U937 monocytes. BHB
28  1999 Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients. ACE, BHB, NAC, RBCs
29  1998 Hyperketonemia (acetoacetate) increases the oxidizability of LDL + VLDL in Type-I diabetic patients. BHB, HK, LDL, NK, VLDL
30  1996 Alterations of remnant liver carnitine and serum carnitine concentrations after partial hepatectomy in rats. BB, FFA
31  1992 L-Tyrosine oxidative metabolism byStreptomyces aureofaciens. HGA, p-HPPA
32  1992 [Effects of temperature and pH on hydrolysis of monoacetoacetin in an aqueous phase]. Acet, Glyc, MAA
33  1990 Effect of intravenous L-carnitine on growth parameters and fat metabolism during parenteral nutrition in neonates. BOB, FFA, TGY
34  1990 Metabolic balance and reproductive performance in Finnish dairy cows. HB
35  1988 Solventogenesis in Clostridium acetobutylicum fermentations related to carboxylic acid and proton concentrations. UBA
36  1985 Renal hydroxybutyrate and acetoacetate reabsorption and utilization in the rat. HB
37  1983 Ketone bodies in cold-acclimated rats. BOH
38  1980 Ketonuria in pregnancy--with special reference to calorie-restricted food intake in obese diabetics. BB
39  1977 Tubular reabsorption and urinary excretion of acetoacetate and 3-hydroxybutyrate in normal subjects and juvenile diabetics. 3HB
40  1975 The concentration of ketone bodies, free fatty acids, and glycerol in the blood of obese perons after injection of insulin and glucose. Studies before and during absolute fasting. 3HB