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Abbreviation : AA
Long Form : aristolochic acid
No. Year Title Co-occurring Abbreviation
2020 Aristolochic acid induces renal fibrosis by arresting proximal tubular cells in G2/M phase mediated by HIF-1alpha. HIF-1alpha, PTCs, TIF, WT
2020 Aristolochic Acid-Induced Genotoxicity and Toxicogenomic Changes in Rodents. BMD
2020 Aristolochic Acid-Induced Nephrotoxicity: Molecular Mechanisms and Potential Protective Approaches. UUC
2020 Assessment of nephrotoxicity of herbal medicine containing aristolochic acid in mice. HM, NGAL, TUNEL
2020 Blockade of the mTOR signaling pathway with rapamycin ameliorates aristolochic acid nephropathy. CAAN
2020 Chemotaxonomy of the ethnic antidote Aristolochia indica for aristolochic acid content: Implications of anti-phospholipase activity and genotoxicity study. AAN, HPTLC, LOD, LOQ, PLA2
2020 Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry. GLO1, TPI
2020 Hirsutella sinensis inhibits NLRP3 inflammasome activation to block aristolochic acid-induced renal tubular epithelial cell transdifferentiation. AAN, HS
2020 Human umbilical cord mesenchymal stem cell attenuates renal fibrosis via TGF-beta/Smad signaling pathways in vivo and in vitro. BUN, EMT, SCr, UC-MSCs
10  2020 In Vivo Metabolism of Aristolochic Acid I and II in Rats Is Influenced by Their Coexposure. AAI
11  2020 Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus. ccRCC, ccRCC-TT
12  2020 Integrative microRNA and mRNA expression profiling in acute aristolochic acid nephropathy in mice. AAN, DE, KEGG
13  2020 Isolation and structural characterization of bioactive compound from Aristolochia sprucei aqueous extract with anti-myotoxic activity. HPLC, NMR
14  2020 Local and Systemic Oxidative Stress in Balkan Endemic Nephropathy Is Not Associated with Xanthine Oxidase Activity. AOPPs, BEN, ROS, TBARS, XO
15  2020 Macroscopic somatic clonal expansion in morphologically normal human urothelium. MNU
16  2020 Mesenchymal Stem Cell Derived Extracellular Vesicles Ameliorate Kidney Injury in Aristolochic Acid Nephropathy. AAN, BUN, CKD
17  2020 Mitochondrial dysfunction is involved in aristolochic acid I-induced apoptosis in renal proximal tubular epithelial cells. AAI, AAN, ATP, MMP, mtDNA, NRK-52E, PTEC, ROS
18  2020 Pig-a gene mutation assay study design: critical assessment of 3- versus 28-day repeat-dose treatment schedules. BMD, OECD
19  2020 Protective effect of panaxydol against repeated administration of aristolochic acid on renal function and lipid peroxidation products via activating Keap1-Nrf2/ARE pathway in rat kidney. IHC, PX
20  2020 The Mutational Features of Aristolochic Acid-Induced Mouse and Human Liver Cancers. AAI, HCC, PTEN
21  2020 The protective role of Nrf2 against aristolochic acid-induced renal tubular epithelial cell injury. Nrf2, ROS
22  2020 Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma. UTUC
23  2020 Upregulation of miR-101a Suppresses Chronic Renal Fibrosis by Regulating KDM3A via Blockade of the YAP-TGF-beta-Smad Signaling Pathway. alpha-SMA, FISH, qRT-PCR, UUO
24  2020 Upregulation of miR-382 contributes to renal fibrosis secondary to aristolochic acid-induced kidney injury via PTEN signaling pathway. AKI, CKD
25  2019 Aristolochic Acid Affects Upper Tract Urothelial Cancer Behavior through the MAPK Pathway. ERK, MAPK, MCA, UTUC
26  2019 Aristolochic Acid and Immunotherapy for Urothelial Carcinoma: Directions for unmet Needs. UCB
27  2019 Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid. ---
28  2019 Bardoxolone ameliorates TGF-beta1-associated renal fibrosis through Nrf2/Smad7 elevation. alpha-SMA, BARD, ECM, Keap1, Smurf1, TbetaR1, TGF-beta
29  2019 Comparison of Aristolochic acid I derived DNA adduct levels in human renal toxicity models. AAI, pHKC
30  2019 Developed a novel sensor based on fluorescent graft conjugated polymer for the determination of aristolochic acid in traditional Chinese medicine. LOD
31  2019 Effects of Human Placental Amnion Derived Mesenchymal Stem Cells on Proliferation and Apoptosis Mechanisms in Chronic Kidney Disease in the Rat. CKF, hAMSCs, MSCs
32  2019 Electromembrane extraction of aristolochic acids: New insights in separation of bioactive ingredients of traditional Chinese medicines. ALA, EME, RA, TCMs
33  2019 Exposure to aristolochic acid I compromises the maturational competency of porcine oocytes via oxidative stress-induced DNA damage. ---
34  2019 Genome-wide somatic mutation analysis via Hawk-Seq™ reveals mutation profiles associated with chemical mutagens. BP, DEN, ENU, MNU
35  2019 Herbal Medicine Containing Aristolochic Acid and the Risk of Primary Liver Cancer in Patients with Hepatitis C Virus Infection. CI, HCV, HM, PLC
36  2019 Inhibition of 4E-BP1 phosphorylation promotes tubular cell escaping from G2/M arrest and ameliorates kidney fibrosis. ---
37  2019 Prevalence, clinicopathological features, and prognosis in upper tract urinary carcinoma patients with severe preoperative chronic kidney disease. CKD, CSS, eGFR, IVR, MDRD, OS, RNU, UTUC
38  2019 Protective Effects of Melatonin Against Aristolochic Acid-Induced Nephropathy in Mice. ---
39  2019 Protective role of relaxin in a mouse model of aristolochic acid nephropathy. AAN, RLX
40  2019 Recognition of the toxicity of aristolochic acid. AAN, HCC
41  2019 Reply. AAI, HCC
42  2019 The Disturbance of Hepatic and Serous Lipids in Aristolochic Acid Iota Induced Rats for Hepatotoxicity Using Lipidomics Approach. AAI, AAN
43  2019 The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo. AAI, BW
44  2019 The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro. BW, GC-MS, MEFs, NMR
45  2018 A comparison between the effects of ochratoxin A and aristolochic acid on the inflammation and oxidative stress in the liver and kidney of weanling piglets. CAT, GPx, IFN, IL, OTA, SOD, TNF
46  2018 Aristolochic acid containing herbs induce gender-related oncological differences in upper tract urothelial carcinoma patients. BR, CSS, CUTR, UTUC
47  2018 Carcinogens that induce the A:T > T:A nucleotide substitutions in the genome. HCC
48  2018 Cooking methods employing natural anti-oxidant food additives effectively reduced concentration of nephrotoxic and carcinogenic aristolochic acids in contaminated food grains. ---
49  2018 Deregulation of Hippo-TAZ pathway during renal injury confers a fibrotic maladaptive phenotype. CKD, CTGF, HK, SMAD, TAZ, YAP
50  2018 Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) amazonensis. BEL, MAFP, PLA2
51  2018 Glucofucogalactan, a heterogeneous low-sulfated polysaccharide from Saccharina japonica and its bioactivity. ---
52  2018 Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes. AAI, GNMT
53  2018 Human Liver Stem Cell-Derived Extracellular Vesicles Prevent Aristolochic Acid-Induced Kidney Fibrosis. CKD, HLSC-EVs, miRNAs
54  2018 Inhibition of phospholipases influences the metabolism of wound-induced benzylisoquinoline alkaloids in Papaver somniferum L. BIAs, FIPI, PLD
55  2018 Proteomics analysis of altered proteins in kidney of mice with aristolochic acid nephropathy using the fluorogenic derivatization-liquid chromatography-tandem mass spectrometry method. AAN, GPR87, TSP1
56  2018 Update of aristolochic acid nephropathy in Korea. AAN, ESRD
57  2018 Vitamin E (alpha‑tocopherol) ameliorates aristolochic acid‑induced renal tubular epithelial cell death by attenuating oxidative stress and caspase‑3 activation. ---
58  2017 A systematic review of the possible carcinogenic role of the aristolochic acid. UTUC
59  2017 An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature. AAN
60  2017 Aristolochic acid and its derivatives as inhibitors of snake venom L-amino acid oxidase. LAAO, ROS
61  2017 Aristolochic Acid-Induced Autophagy Promotes Epithelial-to-Myofibroblast Transition in Human Renal Proximal Tubule Epithelial Cells. EMT
62  2017 DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer. AAI, AAN, BEN, UUC
63  2017 Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial? SGLT2
64  2017 Impact of aristolochic acid exposure on oncologic outcomes of upper tract urothelial carcinoma after radical nephroureterectomy. HR, IVR, RNU, UTUC
65  2017 Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone. 3-NBA, AAI, AAII, AAN, BEN, SULT1A1, WT
66  2017 Prescribed Renoprotective Chinese Herbal Medicines Were Associated with a Lower Risk of All-Cause and Disease-Specific Mortality among Patients with Chronic Kidney Disease: A Population-Based Follow-Up Study in Taiwan. aHR, CHMs, CKD, RPCHM
67  2017 Protective effects of cyclic helix B peptide on aristolochic acid induced acute kidney injury. CHBP
68  2017 Restored nitric oxide bioavailability reduces the severity of acute-to-chronic transition in a mouse model of aristolochic acid nephropathy. AKI, CKD, L-Arg, NO
69  2017 The proteasome inhibitor bortezomib attenuates renal fibrosis in mice via the suppression of TGF-beta1. AAN, BZM, CKD, MM
70  2017 TP53 mutations in p53-negative dysplastic urothelial cells from Belgian AAN patients: New evidence for aristolochic acid-induced molecular pathogenesis and carcinogenesis. AAN, IHC, UC
71  2017 Urinary Time- or Dose-Dependent Metabolic Biomarkers of Aristolochic Acid-Induced Nephrotoxicity in Rats. BUN, GC-MS
72  2016 Application of small RNA sequencing to identify microRNAs in acute kidney injury and fibrosis. miRNA
73  2016 Aristolochic acid exposure in Romania and implications for renal cell carcinoma. AAN, AL, RCC, UUTC
74  2016 Aristolochic Acid I Causes Testis Toxicity by Inhibiting Akt and ERK1/2 Phosphorylation. AAI, Bcl-2
75  2016 Aristolochic Acid in the Etiology of Renal Cell Carcinoma. AL, ccRCC
76  2016 Balkan endemic nephropathy: an update on its aetiology. BEN, UUC
77  2016 Evaluation for a mutagenicity of aristolochic acid by Pig-a and PIGRET assays in rats. IWGT, PIG-A
78  2016 Evaluation of nephrotoxic effects of aristolochic acid on zebrafish (Danio rerio) larvae. ---
79  2016 Expression of Renal Aquaporins in Aristolochic Acid I and Aristolactam I-Induced Nephrotoxicity. AL-I, AQPs
80  2016 Hirsutella sinensis Attenuates Aristolochic Acid-Induced Renal Tubular Epithelial-Mesenchymal Transition by Inhibiting TGF-beta1 and Snail Expression. alpha-SMA, Ccr, EMT, HS, TGF-beta1
81  2016 Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation and Matrix Deposition in Kidney Tissues after Injury. MIF, TECs
82  2016 Interplay between chronic kidney disease (CKD) and upper tract urothelial carcinomas (UUC): foe or friend? CKD
83  2016 Long-term Outcome of Kidney Recipients Transplanted for Aristolochic Acid Nephropathy. AAN
84  2016 Lynch syndrome and exposure to aristolochic acid in upper-tract urothelial carcinoma: its clinical impact? BNe, HNPCC, LS, UTUC
85  2016 New in vitro insights on a cell death pathway induced by magnolol and honokiol in aristolochic acid tubulotoxicity. ---
86  2016 Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity. AMK, OM
87  2016 Patients with urothelial carcinoma have poor renal outcome regardless of whether they receive nephrouretectomy. BUC, CI, HRs, UC, UTUC
88  2016 Preparation of a nitric oxide imaging agent from gelatin derivative micelles. LPS, NO
89  2016 Protective effect of nitric oxide in aristolochic acid-induced toxic acute kidney injury: an old friend with new assets. L-Arg, NO, NOX2
90  2016 Reduced rat plasma lysophosphatidylglycerol or lysophosphatidic acid level as a biomarker of aristolochic acid-induced renal and adipose dysfunctions. LPA, LPG, LPL
91  2016 Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N-hydroxyaristolactam I in human cells. AL-I-NOH, SULT
92  2016 Transforming growth factor-beta1 stimulates hedgehog signaling to promote epithelial-mesenchymal transition after kidney injury. ECM, EMT, TECs, TGF
93  2015 Analysis of potential risk factors for cancer incidence in patients with aristolochic acid nephropathy from Wenzhou, China. AAN, CYP1A1, ESRD
94  2015 Aristolochic acid nephropathy: epidemiology, clinical presentation, and treatment. AAN, ESRD
95  2015 Comparison of DNA and RNA Adduct Formation: Significantly Higher Levels of RNA than DNA Modifications in the Internal Organs of Aristolochic Acid-Dosed Rats. ---
96  2015 Differential microRNA expression in aristolochic acid-induced upper urothelial tract cancers ex vivo. CKD, UUC
97  2015 Human bone morphogenetic protein-7 does not counteract aristolochic acid-induced renal toxicity. rhBMP
98  2015 Impairment of the Cellular Distribution and Stability of the Erythropoietin Receptor Through the Direct Targeting of Aristolochic Acid. EpoR
99  2015 Integrated microRNA, mRNA, and protein expression profiling reveals microRNA regulatory networks in rat kidney treated with a carcinogenic dose of aristolochic acid. HCA, IPA, miRNAs, PCA
100  2015 Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid. LC-WES