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Abbreviation : AA
Long Form : asiatic acid
No. Year Title Co-occurring Abbreviation
2020 Asiatic Acid Glucosamine Salt Alleviates Ultraviolet B-induced Photoaging of Human Dermal Fibroblasts and Nude Mouse Skin. ---
2020 Preparation and evaluation of PEGylated asiatic acid nanostructured lipid carriers on anti-fibrosis effects. ALB, ALT, AST, DSC, P-AA-NLCs, TEM, XRD
2019 An aligned porous electrospun fibrous scaffold with embedded asiatic acid for accelerating diabetic wound healing. PLLA
2019 Anti-Cancer Effects of Asiatic Acid, A Triterpene From Centilla Asiatica L: A Literature Review. ---
2019 Antiobesity efficacy of asiatic acid: down-regulation of adipogenic and inflammatory processes in high fat diet induced obese rats. aP2, FAS, IR, PPARgamma, TNF, UCP2
2019 Asiatic Acid Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress and Apoptosis Via AKT/GSK-3beta Signaling Pathway in Wistar Rats. AChE, AD
2019 Asiatic Acid Attenuates Bone Loss by Regulating Osteoclastic Differentiation. NF-kappaB, TGF-beta
2019 Asiatic acid enhances intratumor delivery and the antitumor effect of pegylated liposomal doxorubicin by reducing tumor-stroma collagen. IHC, PLD, Tt-DDSs
2019 Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-beta1/Smads signaling pathways in spontaneous hypertension rats. CFs, MDA, Nrf2, ROS, SHRs, SOD
10  2019 Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-gamma. CKD, nSREBP-1, UUO
11  2019 Asiaticoside but not its aglycone exhibits neuritogenicity through TrkA receptor signaling: a bridge between ERK1/2-CREB and Akt-GSK3beta/RhoA. AS, GSK3beta, RhoA, TrkA
12  2019 Combination of carnosine and asiatic acid provided greater anti-inflammatory protection for HUVE cells and diabetic mice than individual treatments of carnosine or asiatic acid alone. ROS, TNF
13  2019 Effect of asiatic acid on epithelial-mesenchymal transition of human alveolar epithelium A549 cells induced by TGF-beta1. EMT, TGF-beta1
14  2019 Protective effects of Asiatic acid against pelvic inflammatory disease in rats. MPO, NF-kappaB, NLRP3, PID
15  2019 Strategies for Improving Healing of the Gastric Epithelium Using Oral Solid Dispersions Loaded with Pentacyclic Triterpene-Rich Centella Extract. AS, MA, MS, PRE, PRE-ESD
16  2019 Synthesis and discovery of asiatic acid based 1,2,3-triazole derivatives as antitumor agents blocking NF-kappaB activation and cell migration. ---
17  2018 Antiangiogenic effects of AA-PMe on HUVECs in vitro and zebrafish in vivo. AA-PMe, HUVECs, VEGF, VEGFR2
18  2018 Asiatic Acid (AA) Sensitizes Multidrug-Resistant Human Lung Adenocarcinoma A549/DDP Cells to Cisplatin (DDP) via Downregulation of P-Glycoprotein (MDR1) and Its Targets. DDP, MDR, NF, RT-PCR, YB1
19  2018 Asiatic acid ameliorates CCl4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-kappaB/IkappaBalpha, and JAK1/STAT3 signaling pathways. NF-kappaB, STAT3
20  2018 Asiatic Acid Ameliorates Doxorubicin-Induced Cardiac and Hepato-Renal Toxicities with Nrf2 Transcriptional Factor Activation in Rats. DXR
21  2018 Asiatic acid ameliorates hepatic ischemia/reperfusion injury in rats via mitochondria-targeted protective mechanism. A/R, AST, I/R, MMP
22  2018 Asiatic acid and maslinic acid attenuated kainic acid-induced seizure through decreasing hippocampal inflammatory and oxidative stress. IL, KA, MA, NGF
23  2018 Asiatic acid attenuates CCl4-induced liver fibrosis in rats by regulating the PI3K/AKT/mTOR and Bcl-2/Bax signaling pathways. ECM
24  2018 Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis. HFD
25  2018 Asiatic acid attenuates lipopolysaccharide-induced injury by suppressing activation of the Notch signaling pathway. IL-1beta
26  2018 Asiatic acid inhibits proliferation, migration and induces apoptosis by regulating Pdcd4 via the PI3K/Akt/mTOR/p70S6K signaling pathway in human colon carcinoma cells. EMT, mTOR, PI3K
27  2018 Asiatic acid nullified aluminium toxicity in in vitro model of Alzheimer's disease. AD, Al, ROS
28  2018 Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of alpha-Synuclein Into Mitochondria. PD
29  2018 Asiatic Acid Prevents Retinal Ganglion Cell Apoptosis in a Rat Model of Glaucoma. IOP, PhNR, RGCs
30  2018 Asiatic acid prevents the development of interstitial lung disease in a hypochlorous acid-induced mouse model of scleroderma. HOCl, PF, SSc, TGF-beta1
31  2018 Asiatic acid protects against cisplatin-induced acute kidney injury via anti-apoptosis and anti-inflammation. CIS, CON, KIM-1
32  2018 Asiatic acid protects differentiated PC12 cells from Abeta25-35-induced apoptosis and tau hyperphosphorylation via regulating PI3K/Akt/GSK-3beta signaling. AD, MMP
33  2018 Assessment of Toxicity and Absorption of the Novel AA Derivative AA-Pme in SGC7901 Cancer Cells In Vitro and in Zebrafish In Vivo. AA-PMe
34  2018 Differences in Neuritogenic Activity and Signaling Activation of Madecassoside, Asiaticoside, and Their Aglycones in Neuro-2a cells. AS, CREB, MA, MS
35  2018 Fabrication of peptide-linked albumin nanoconstructs for receptor-mediated delivery of asiatic acid to the brain as a preventive measure in cognitive impairment: optimization, in-vitro and in-vivo evaluation. DTE, EE, GU, QbD
36  2018 Neuroprotective Properties of Asiatic Acid against 5-Fluorouracil Chemotherapy in the Hippocampus in an Adult Rat Model. MDA, Nrf2, SGZ, SOX2
37  2018 Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer's disease. AD
38  2018 Obesity-alleviating potential of asiatic acid and its effects on ACC1, UCP2, and CPT1 mRNA expression in high fat diet-induced obese Sprague-Dawley rats. ACC, BW, CPT-1, HFD, UCP2
39  2018 Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise. ---
40  2018 Pharmacological Review on Asiatic Acid and Its Derivatives: A Potential Compound. ---
41  2018 The protective effect of asiatic acid on podocytes in the kidney of diabetic rats. ---
42  2017 A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway. AA-PMe, MMP, STAT3
43  2017 Antifibrotic effect of Centella asiatica Linn and asiatic acid on arecoline-induced fibrosis in human buccal fibroblasts. CA, HBF, HPTLC
44  2017 Asiatic acid abridges pre-neoplastic lesions, inflammation, cell proliferation and induces apoptosis in a rat model of colon carcinogenesis. ACF, AgNORs, DMH, PCNA
45  2017 Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways. BALF, BLM, NLRP3, TGF-beta1
46  2017 Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis pathway. ERK, METH, NF-kappaB, STAT, TNFR
47  2017 Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis. ACF, DMH, LPO
48  2017 Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation. ARE, GCLC, HO-1, Nrf2, ROS, TBHP
49  2017 Asiatic acid enhances survival of human AC16 cardiomyocytes under hypoxia by upregulating miR-1290. ---
50  2017 Asiatic Acid Exhibits Anti-inflammatory and Antioxidant Activities against Lipopolysaccharide and d-Galactosamine-Induced Fulminant Hepatic Failure. AMPK, FHF, GalN, GSK3beta, IL, LPS, MAPK, NF-kappaB, NQO1, Nrf2, PDCD4
51  2017 Asiatic acid inhibits lung cancer cell growth in vitro and in vivo by destroying mitochondria. LC3, PCNA, ROS
52  2017 Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy. 5-FU, NOL, SGZ, VPA
53  2017 Asiatic acid protects against hepatic ischemia/reperfusion injury by inactivation of Kupffer cells via PPARgamma/NLRP3 inflammasome signaling pathway. I/R, KCs, LPS, NLR, NPCs, PPARgamma
54  2017 Effect of Asiatic Acid on the Treatment of Spinal Cord Injury: An Experimental Study in Rats. SCI
55  2017 Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells. PD
56  2017 Neurotrophic Effect of Asiatic acid, a Triterpene of Centella asiatica Against Chronic 1-Methyl 4-Phenyl 1, 2, 3, 6-Tetrahydropyridine Hydrochloride/Probenecid Mouse Model of Parkinson's disease: The Role of MAPK, PI3K-Akt-GSK3beta and mTOR Signalling Pathways. NTFs, PD
57  2017 Pharmacological effects of asiatic acid in glioblastoma cells under hypoxia. ---
58  2017 Protective effect of asiatic acid in an experimental cerulein-induced model of acute pancreatitis in mice. AP, CCK, IL, NF, TNF
59  2017 Protective effects of asiatic acid in a spontaneous type2 diabetic mouse model. PH, PI3K
60  2017 The anti-inflammatory effects of asiatic acid in lipopolysaccharide-stimulated human corneal epithelial cells. CCK-8, HCECs, IL-1beta, IL-6, IL-8, LPS, qRT-PCR, ROS, TGF-beta, TNF-alpha
61  2017 [Oral absorption of asiatic acid nanoparticles modified with PEG]. ---
62  2016 AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells. AA-PMe
63  2016 Anti-glioma activity and the mechanism of cellular uptake of asiatic acid-loaded solid lipid nanoparticles. AA-MS-SLNs, BBB, DS, MS, SLNs, TS
64  2016 Asiatic acid attenuated apoptotic and inflammatory stress in the striatum of MPTP-treated mice. IL, MPTP, TLR
65  2016 Asiatic acid inhibits lactate-induced cardiomyocyte apoptosis through the regulation of the lactate signaling cascade. CCK-8, MCT1, ROS
66  2016 Asiatic acid inhibits left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction. MI
67  2016 Asiatic Acid Inhibits Lipopolysaccharide-Induced Acute Lung Injury in Mice. ALI, BALF, LPS, MPO
68  2016 Asiatic acid inhibits pulmonary inflammation induced by cigarette smoke. BALF, COPD, CS, TECA
69  2016 Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKalpha Signalling Pathway. AMPKalpha, ERK, mTOR
70  2016 Asiatic acid-pectin hydrogel matrix patch transdermal delivery system influences parasitaemia suppression and inflammation reduction in P.berghei murine malaria infected Sprague-Dawley rats. CHQ
71  2016 Neuroprotective effect of asiatic acid against spinal cord injury in rats. HO, NLRP, Nrf, ROS, SCI
72  2016 Protective Effects of Asiatic Acid Against Spinal Cord Injury-Induced Acute Lung Injury in Rats. ALI, CAT, MDA, MPO, PPI, ROS, SCI, SOD
73  2016 Synthesis and anticancer activity of novel fluorinated asiatic acid derivatives. ---
74  2016 [Response surface method for optimization of asiatic acid nanoparticles modified with PEG and its enhancing effects on intestinal absorption]. AA-NLC, Peff
75  2015 Anti-apoptotic and anti-glycative effects of asiatic acid in the brain of D-galactose treated mice. AGE, BDNF, DG, GFAP, IL, RAGE, TNF
76  2015 Antioxidative and antiinflammatory activities of asiatic acid, glycyrrhizic acid, and oleanolic acid in human bronchial epithelial cells. COX-2, GA, NF-kappaB, OA
77  2015 Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway. Bcl-2, ERK, JNK, Mcl-1
78  2015 Asiatic acid and maslinic acid protected heart via anti-glycative and anti-coagulatory activities in diabetic mice. MA, NF-kappaB
79  2015 Asiatic Acid Attenuates the Progression of Left Ventricular Hypertrophy and Heart Failure Induced by Pressure Overload by Inhibiting Myocardial Remodeling in Mice. TAC
80  2015 Asiatic acid inhibits cardiac hypertrophy by blocking interleukin-1beta-activated nuclear factor-kappaB signaling in vitro and in vivo. ANP, EMSA, IL, NF, qPCR, TAC
81  2015 Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model. GK
82  2015 Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat. EPM, FST, GABAA, MANOVA
83  2015 Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats. GLUT4, IR, IRS, PI3K
84  2015 Pentacyclic triterpenes combined with ciprofloxacin help to eradicate the biofilm formed in vitro by Escherichia coli. UA
85  2015 Pentacyclic Triterpenoids Inhibit IKKbeta Mediated Activation of NF-kappaB Pathway: In Silico and In Vitro Evidences. CA, IFN-gamma, IKKbeta, NF-kappaB, PTs, UA
86  2015 Structural analysis of metabolites of asiatic acid and its analogue madecassic acid in zebrafish using LC/IT-MSn. MA
87  2015 Synthesis, anti-tumor and anti-angiogenic activity evaluations of asiatic Acid amino Acid derivatives. ---
88  2015 Treatment of renal fibrosis by rebalancing TGF-beta/Smad signaling with the combination of asiatic acid and naringenin. NG
89  2015 [Protective effect of asiatic acid from Potentilla chinensis on alcohol hepatic injury in rats]. ---
90  2014 Anti-glycative effects of asiatic acid in human keratinocyte cells. AGE, BSA, HaCaT, IL, MMP, RAGE
91  2014 Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, role of HMG CoA: in vivo and in silico approaches. HMG-CoA, STZ
92  2014 Asiatic acid ameliorates hepatic lipid accumulation and insulin resistance in mice consuming a high-fat diet. FAS, HFD, IL, NF-kappa, SCD, SREBP
93  2014 Asiatic acid attenuates cardiac hypertrophy by blocking transforming growth factor-beta1-mediated hypertrophic signaling in vitro and in vivo. ANP, ERK, NF-kappaB, TGF-beta1
94  2014 Asiatic acid inhibits adipogenic differentiation of bone marrow stromal cells. ap, BMSCs, PPAR
95  2014 Asiatic acid reduces blood pressure by enhancing nitric oxide bioavailability with modulation of eNOS and p47phox expression in L-NAME-induced hypertensive rats. eNOS, L-NAME, NADPH
96  2014 Inhibition of human enterovirus 71 replication by pentacyclic triterpenes and their novel synthetic derivatives. EV71, GA, OA, UA
97  2014 Neuroprotective effect of asiatic acid in rat model of focal embolic stroke. AIF, cyto c, tPA
98  2014 Synthesis and biological evaluation of novel aniline-derived asiatic acid derivatives as potential anticancer agents. 5-FU
99  2013 Antiproliferative, cell-cycle dysregulation effects of novel asiatic acid derivatives on human non-small cell lung cancer cells. ---
100  2013 Asiatic acid ameliorates tubulointerstitial fibrosis in mice with ureteral obstruction. ECM, SH, SMA, TGF, UUO