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Abbreviation : AC
Long Form : aconitine
No. Year Title Co-occurring Abbreviation
2020 A proton-coupled organic cation antiporter is involved in the blood-brain barrier transport of Aconitum alkaloids. BBB, HA, MA
2020 Circadian clock regulates metabolism and toxicity of Fuzi(lateral root of Aconitum carmichaeli Debx) in mice. HA, MA
2020 Pharmacokinetic effects of ginsenoside Rg1 on aconitine, benzoylaconine and aconine by UHPLC-MS/MS. ACN, BAC
2019 Aconitum alkaloids induce cardiotoxicity and apoptosis in embryonic zebrafish by influencing the expression of cardiovascular relative genes. HPLC, MA
2019 Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade. BAC, OXPHOS
2019 Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish. BAC, BHAC, BMAC, DAs, DDAs, HAC, MAC, MDAs
2019 Effects of liquorice on pharmacokinetics of aconitine in rats. AUC, HA, MA, P-gp
2019 Optimization of the traditional processing method for precision detoxification of CaoWu through biomimetic linking kinetics and human toxicokinetics of aconitine as toxic target marker. Cop, HPLC, LPS, Mes, NCA, QC, RA, TK
2019 Tissue Accumulations of Toxic Aconitum Alkaloids after Short-Term and Long-Term Oral Administrations of Clinically Used Radix Aconiti Lateralis Preparations in Rats. BAC, BHA, BMA, HA, MA
10  2019 [Aconitine ameliorates cardiomyocyte hypertrophy induced by angiotensin Ⅱ]. alpha-SMA, ANP
11  2018 Aconitum alkaloids, the major components of Aconitum species, affect expression of multidrug resistance-associated protein 2 and breast cancer resistance protein by activating the Nrf2-mediated signalling pathway. ARE, BAC, BCRP, ETs, HDIs, MRP2, Nrf2, P-gp
12  2018 Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms. Ber, CK, ECG, LDH
13  2017 Mdr1a plays a crucial role in regulating the analgesic effect and toxicity of aconitine by altering its pharmacokinetic characteristics. ---
14  2017 Simultaneous quantitation of six aconitum alkaloids and three flavonoids in the herb couple of radix aconiti lateralis-radix glycyrrhizae (Fuzi-Gancao) by UHPLC-ESI-MS/MS. BAC, BHA, BMA, Fuzi-Gancao, HA, LCA, MA
15  2017 The Effects of Rheum palmatum L. on the Pharmacokinetic of Major Diterpene Alkaloids of Aconitum carmichaelii Debx. in Rats. ACN, ADAs, AUClast, BAC, BHC, BMC, DDAs, HC, MC, MDAs, T max
16  2016 Biological activities and pharmacokinetics of aconitine, benzoylaconine, and aconine after oral administration in rats. ACN, BAC
17  2016 Induction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug-drug interactions. BAC, DDIs, P-gp
18  2016 Toxic Constituents Index: A Toxicity-Calibrated Quantitative Evaluation Approach for the Precise Toxicity Prediction of the Hypertoxic Phytomedicine-Aconite. DDAs, HA, MA, TCI, TP
19  2015 Encapsulation of Aconitine in Self-Assembled Licorice Protein Nanoparticles Reduces the Toxicity In Vivo. ---
20  2015 In vivo and in vitro metabolites from the main diester and monoester diterpenoid alkaloids in a traditional chinese herb, the aconitum species. DDAs, HA, MA, MDAs
21  2015 Multidrug resistance-associated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells. BAC, BCRP, BHA, BMA, ER, HA, MA, MRP2, P-gp
22  2015 Panax ginseng inhibits intestinal absorption of toxic Aconitum carmichaeli alkaloids in Vitro. BCRP, CM, HA, MA, MDR1, P-gp
23  2014 The influences of aconitine, an active/toxic alkaloid from aconitum, on the oral pharmacokinetics of CYP3A probe drug buspirone in rats. BP, TCM
24  2014 [Pharmacokinetic study of six aconitine alkaloids in aconiti lateralis radix praeparata in beagle dogs]. BAC, BHA, BMA, ESI, HA, MA, MRM, SPE
25  2013 Metabolite profile analysis of aconitine in rabbit stomach after oral administration by liquid chromatography/electrospray ionization/multiple-stage tandem mass spectrometry. ---
26  2013 P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: in vitro, in situ, in vivo and in silico studies. P-gp
27  2013 The effects of Rhizoma Zingiberis on pharmacokinetics of six Aconitum alkaloids in herb couple of Radix Aconiti Lateralis-Rhizoma Zingiberis. BAC, BHA, BMA, HA, MA
28  2013 The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone. DDI
29  2013 The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. BAC, BCRP, BHA, BMA, ER, HA, MA, MRP2, P-gp
30  2013 Transcellular transport of aconitine across human intestinal Caco-2 cells. MRP2, P-gp
31  2013 [Simultaneous determination of four trace aconitum alkaloids in urine using ultra performance liquid chromatography-mass spectrometry]. ESI, HA, MA, MRM, YA
32  2012 Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine. BAC, BHA, BMA, ESI, HA, MA, MRM
33  2012 Identification and determination of Aconitum alkaloids in Aconitum herbs and Xiaohuoluo pill using UPLC-ESI-MS. BAC, BHA, BMA, HA, LLOQs, MA, PCA, SIR, UPLC-ESI-MS
34  2012 Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model. app, HA, MA, P-gp
35  2011 CE-electrochemiluminescence with ionic liquid for the facile separation and determination of diester-diterpenoid aconitum alkaloids in traditional Chinese herbal medicine. CE-ECL, HA, MA
36  2011 Effect of (E)-2-isopropyl-5-methylcyclohexyl octadec-9-enoate on transdermal delivery of Aconitum alkaloids. ATR-FTIR, HA, IPM, IPP, M-OA, MA, SC, SEM
37  2011 Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes. HLMs
38  2010 An online coupled cell membrane chromatography with LC/MS method for screening compounds from Aconitum carmichaeli Debx. acting on VEGFR-2. AT, DX, HPC, LC/MS, MSC, MT, NF, SN, VEGF, VEGFR
39  2010 Determination of aconitine, hypaconitine and mesaconitine in urine using hollow fiber liquid-phase microextraction combined with high-performance liquid chromatography. HA, HF-LPME, MA
40  2009 Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk? DDAs, HA, MA, TCM
41  2009 Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the rapid simultaneous quantification of aconitine, mesaconitine, and hypaconitine in rat plasma after oral administration of Sini decoction. HA, IS, LC-ESI-MS-MS, MA, SND, SRM
42  2009 [Changes of DDAs content affected by different processing time and its relationship with safety of processed Fuzi]. DDAs, HA, MA
43  2008 Simultaneous quantitation of aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine in human plasma by liquid chromatography-tandem mass spectrometry and pharmacokinetics evaluation of "SHEN-FU" injectable powder. BAC, BHA, BMA, ESI, HA, IS, MA, MRM, SPE
44  2006 Facile separation and determination of Aconitine alkaloids in traditional Chinese medicines by CE with tris(2,2'-bipyridyl) ruthenium(II)-based electrochemiluminescence detection. HA, MA
45  2002 Comparison of aconitine-modified human heart (hH1) and rat skeletal (mu1) muscle Na+ channels: an important role for external Na+ ions. ---
46  2000 Modification of alpha subunit of RIIA sodium channels by aconitine. CHO