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Abbreviation : ADAM17
Long Form : disintegrin and metalloproteinase 17
No. Year Title Co-occurring Abbreviation
2023 Periostin derived from cancer-associated fibroblasts promotes esophageal squamous cell carcinoma progression via ADAM17 activation. CAFs, ESCC, POSTN
2023 Phosphate, calcium, and vitamin D signaling, transport, and metabolism in the endometria of cyclic ewes. ATP2B4, CYP24, FGFR2, KL, PTHrP, S100g, sGE, TRPV6, VDR
2022 Acute Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy Is Associated with Placental Angiotensin-Converting Enzyme 2 Shedding. ACE, COVID, SARS-CoV-2
2022 ADAM17 regulates the proliferation and extracellular matrix of keloid fibroblasts by mediating the EGFR/ERK signaling pathway. alpha-SMA, CTGF, ECM, EGFR, ERK, KFs, qRT-PCR, TGF-beta1
2022 An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model. ACE2
2022 An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infection. ACE2, ASGR1, CLEC4M, GLCE, GPR78, GWO, IHC, KREMEN1, MS, NDST2, NRG1, PVR, SARS-CoV-2, TMPRSS2
2022 Analysis of A Disintegrin and Metalloprotease 17 (ADAM17) Expression as a Prognostic Marker in Ovarian Cancer Patients Undergoing First-Line Treatment Plus Bevacizumab. ---
2022 Blockade of the protease ADAM17 ameliorates experimental pancreatitis. A17pro, IL, NNK, TNF-alpha, WT
2022 Blocking postsynaptic density-93 binding to C-X3-C motif chemokine ligand 1 promotes microglial phenotypic transformation during acute ischemic stroke. CX3CL1
10  2022 Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice. ACE2, DCM, HIF-1alpha, NRCMs
11  2022 Downregulation of ADAM17 in pediatric immune thrombocytopenia impairs proplatelet formation. GPIbalpha, ITP, p-MLC
12  2022 Endothelial ADAM17 Expression in the Progression of Kidney Injury in an Obese Mouse Model of Pre-Diabetes. HFD, TGF-alpha, TNF-alpha
13  2022 Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells. ADCC, NK
14  2022 Galectin-1 orchestrates an inflammatory tumor-stroma crosstalk in hepatoma by enhancing TNFR1 protein stability and signaling in carcinoma-associated fibroblasts. CAFs, Gal-1, HCC, HSCs, PAI-2, sh, TNFR1
15  2022 Host Cell Receptors Implicated in the Cellular Tropism of BVDV. BVDV, HS, LDL
16  2022 Immune Responses to IAV Infection and the Roles of L-Selectin and ADAM17 in Lymphocyte Homing. HEVs, IAV
17  2022 Implications of Sm22alpha-Cre expression in keratinocytes and unanticipated inflammatory skin lesion in a model of atherosclerosis. HFD, LDLR, SMC
18  2022 Involvement of shedding induced by ADAM17 on the nitric oxide pathway in hypertension. ACE2, MasR, NO
19  2022 PM2.5 induce the defective efferocytosis and promote atherosclerosis via HIF-1alpha activation in macrophage. BMDMs, CIMT, HIF-1alpha, MerTK, sMer, VHL
20  2022 Regulation of autoimmune disease progression by Pik3ip1 through metabolic reprogramming in T cells and therapeutic implications. EAE, HIF1alpha, Pik3ip1
21  2022 Repurposing of drugs for combined treatment of COVID-19 cytokine storm using machine learning. AT1R, JAK1, ML, STAT3
22  2022 Shuttle Transfer of mRNA Transcripts via Extracellular Vesicles From Male Reproductive Tract Cells to the Cumulus-Oocyte Complex in Rabbits (Oryctolagus cuniculus). COCs, COX2, EVs, IVM, MDK, mRNA, PB, RT-qPCR, VEGFA
23  2022 The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10. ADAM10, ASD, pCG, PCS
24  2022 The Role of ADAM17 in Inflammation-Related Atherosclerosis. ---
25  2022 TNF or EGFR inhibition equally block AKI-to-CKD transition: opportunities for etanercept treatment. EGFR, PTC, TNF, UUO
26  2021 A New Inhibitor of ADAM17 Composed of a Zinc-Binding Dithiol Moiety and a Specificity Pocket-Binding Appendage. TNF-alpha
27  2021 Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma. alpha-SMA, COA, CTGF, si
28  2021 Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation. IL-15, NK
29  2021 ADAM17 and NF-kappaB p65 form a positive feedback loop that facilitates human esophageal squamous cell carcinoma cell viability. ESCC
30  2021 ADAM17 Inhibition Increases the Impact of Cisplatin Treatment in Ovarian Cancer Spheroids. OvCa
31  2021 ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium. sVLDLR, VLDLR
32  2021 ADAM17, A Key Player of Cardiac Inflammation and Fibrosis in Heart Failure Development During Chronic Catecholamine Stress. AREG, beta-ARs, ERKs, p38 MAPKs, sIL-6R, TNF-alpha
33  2021 ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19. ACE2, COVID-19, NLR, RBD-S
34  2021 Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17. WSS
35  2021 Aryl Hydrocarbon Receptor Defect Attenuates Mitogen-Activated Signaling through Leucine-Rich Repeats and Immunoglobulin-like Domains 1 (LRIG1)-Dependent EGFR Degradation. AhR, COPD, EGF, EGFR, LRIG1
36  2021 Defective Efferocytosis in a Murine Model of Sjogren's Syndrome Is Mediated by Dysfunctional Mer Tyrosine Kinase Receptor. ANA, MerKO, SjS, SjSs, sMer, SMG
37  2021 Diminazen Aceturate Protects Pulmonary Ischemia-Reperfusion Injury via Inhibition of ADAM17-Mediated Angiotensin-Converting Enzyme 2 Shedding. ACE2, DIZE, IR
38  2021 Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1. NISBD1, TNF-alpha
39  2021 Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway. AP-1, ERK, HIF-1alpha, OVA, PEA3, Pref-1, si
40  2021 Identification of novel substrates of a disintegrin and metalloprotease 17 by specific labeling of surface proteins. 2-DE
41  2021 Implications of ADAM17 activation for hyperglycaemia, obesity and type 2 diabetes. TNF-alpha
42  2021 Interactions of renin-angiotensin system and COVID-19: the importance of daily rhythms in ACE2, ADAM17 and TMPRSS2 expression. ACE2, Ang II, SARS-CoV-2, TMPRSS2
43  2021 iRhom1 rescues cognitive dysfunction in multiple sclerosis via preventing myelin injury. MS, OL
44  2021 KIM-1-mediated anti-inflammatory activity is preserved by MUC1 induction in the proximal tubule during ischemia-reperfusion injury. IRI, KIM-1, KO, MUC1, PT, WT
45  2021 MicroRNA-146a-5p enhances T helper 17 cell differentiation via decreasing a disintegrin and metalloprotease 17 level in primary sjogren's syndrome. mIL-23R, miR, PBMCs, pSS, Th17
46  2021 MicroRNA‑28‑3p inhibits angiotensin‑converting enzyme2 ectodomain shedding in 293T cells treated with the spike protein of severe acute respiratory syndrome coronavirus2 by targeting A disintegrin and metalloproteinase 17. ACE2, miR
47  2021 OM-85 Broncho-Vaxom, a Bacterial Lysate, Reduces SARS-CoV-2 Binding Proteins on Human Bronchial Epithelial Cells. ACE2, DPP4, S protein, TMPRSS2
48  2021 Redefining the Role of ADAM17 in Renal Proximal Tubular Cells and Its Implications in an Obese Mouse Model of Pre-Diabetes. HFD
49  2021 Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage. DMM, EGFR, Mmp13, OA, PMA, TACE
50  2021 Regulation of Platelet-Derived ADAM17: A Biomarker Approach for Breast Cancer? pADAM17
51  2021 Restoration of renal TIMP3 levels via genetics and pharmacological approach prevents experimental diabetic nephropathy. DN, NOX4
52  2021 Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells. TACE
53  2021 Rosmarinic acid inhibits proliferation and migration, promotes apoptosis and enhances cisplatin sensitivity of melanoma cells through inhibiting ADAM17/EGFR/AKT/GSK3beta axis. CIS, EGFR, RA
54  2021 Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2. AD, ADAM10, APP, BACE1, TREM2
55  2021 Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL‑6/STAT3 signaling pathway. eIF2alpha, ROS, SKN, STAT3
56  2021 Strategies to Target ADAM17 in Disease: From its Discovery to the iRhom Revolution. TNF
57  2021 Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype. EGFR, IL-6R, TNF-alpha
58  2021 The -172 A-to-G variation in ADAM17 gene promoter region affects EGR1/ADAM17 pathway and confers susceptibility to septic mortality with sepsis-3.0 criteria. ChIP, Egr-1
59  2021 The Downregulation of ADAM17 Exerts Protective Effects against Cardiac Fibrosis by Regulating Endoplasmic Reticulum Stress and Mitophagy. ER, mCFs
60  2021 The Synergy of ADAM17-Induced Myocardial Inflammation and Metabolic Lipids Dysregulation During Acute Stress: New Pathophysiologic Insights Into Takotsubo Cardiomyopathy. AHA, beta-ARs, TTC
61  2021 Titanium dioxide nanoparticles impair the inner blood-retinal barrier and retinal electrophysiology through rapid ADAM17 activation and claudin-5 degradation. HRECs
62  2021 [Effect of active component compound of Epimedii Folium,Astragali Radix,and Puerariae Lobatae Radix on expression of ADAM17 in HT22 cells by mediating hepcidin]. AD, APP, siRNA
63  2020 A Bispecific Inhibitor of the EGFR/ADAM17 Axis Decreases Cell Proliferation and Migration of EGFR-Dependent Cancer Cells. DARPin, EGFR
64  2020 ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19. ACE2, COVID-19, RAS
65  2020 Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons. ACE2, ADAM, B1R, LDABK
66  2020 ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma. AKT1, BMECs, CX3CL1, CXCR3, HCC, MAPK, PIK3CA, PTK2, RhoA, ROCK2
67  2020 Alpha-1-antitrypsin: A possible host protective factor against Covid-19. A1AT, NE, TMPRSS2
68  2020 Decreased ADAM17 expression in the lungs of alpha-Klotho reduced mouse. SMP30
69  2020 Distance dependent shedding of IL-6R. PS
70  2020 Excessive ADAM17 activation occurs in uremic patients and may contribute to their immunocompromised status. FGF23, HD, HS
71  2020 IL-33 promotes type 1 cytokine expression via p38 MAPK in human NK cells. ---
72  2020 Influences of miR-708 on cerebral ischemia-reperfusion injury through targeted regulation of ADAM17. MCAO, miR, siRNA
73  2020 Long noncoding RNA SBF2-AS1 contributes to the growth and metastatic phenotypes of NSCLC via regulating miR-338-3p/ADAM17 axis. lncRNA, NSCLC, RIP, SBF2-AS1
74  2020 Novel Evidence of Acute Kidney Injury in COVID-19. AKI, SARS-CoV-2, TMPRSS2
75  2020 Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17/EGFR. CAG, H. pylori, HB-EGF, IL-8, Pal
76  2020 Role of iRhoms 1 and 2 in Endochondral Ossification. iRhom1, 2
77  2020 Shedding Light on COVID-19: ADAM17 the Missing Link? COVID-19
78  2020 TGF-beta Induced CTGF Expression in Human Lung Epithelial Cells through ERK, ADAM17, RSK1, and C/EBPbeta Pathways. ADAM17-siRNA, CTGF, EMT, ERK, FN, RSK1, TGF-beta
79  2019 ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury. SCI
80  2019 ADAM17-Mediated Reduction in CD14++CD16+ Monocytes ex vivo and Reduction in Intermediate Monocytes With Immune Paresis in Acute Pancreatitis and Acute Alcoholic Hepatitis. AAH, AP, LPS, PBMCs, TLR
81  2019 ADAM17: An Emerging Therapeutic Target for Lung Cancer. EGFR, LAC, NSCLC, SCLC, sIL-6R, TNF-alpha
82  2019 Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through the AT1R/ROS/p38 MAPK/ADAM17 pathway. ACS, AT1R, MerTK, NAC, ROS, sMer
83  2019 Circadian Expression of TIMP3 Is Disrupted by UVB Irradiation and Recovered by Green Tea Extracts. AQP3, TNF-alpha, UVB, UVR
84  2019 Feedback loop in miR-449b-3p/ADAM17/NF-kappaB promotes metastasis in nasopharyngeal carcinoma. miRNAs, NPC
85  2019 KDEL Receptor 1 Contributes to Cell Surface Association of Protein Disulfide Isomerases. ER, KDELRs, PDIs
86  2019 L-selectin shedding affects bacterial clearance in the lung: a new regulatory pathway for integrin outside-in signaling. ---
87  2019 Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1alpha-ADAM17 pathway✰. CBA, ChIP, ELISA, HIF-1alpha
88  2019 Potential role of a disintegrin and metalloproteinase-17 (ADAM17) in age-associated ventricular remodeling of rats. TNF-alpha
89  2019 Proximal Tubule-Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis. EGFR, YAP1
90  2019 Rapid and sensitive detection of the activity of ADAM17 using a graphene oxide-based fluorescence sensor. CGO
91  2019 Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy. ADCC
92  2019 Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway. AAC, Ang II, ERK, NOX4, ROS
93  2019 Sema4D expression and secretion are increased by HIF-1alpha and inhibit osteogenesis in bone metastases of lung cancer. Sema4D
94  2019 Soluble delta-like 1 homolog decreases in patients with acromegaly following pituitary surgery: A potential mediator of adipogenesis suppression by growth hormone? sDlk1, sKlotho
95  2019 The metalloprotease ADAM17 in inflammation and cancer. EGFR, IL-6R, TNF-alpha
96  2019 TMEM16F inhibition limits pain-associated behavior and improves motor function by promoting microglia M2 polarization in mice. SCI, TMEM16F
97  2018 A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo. EMT
98  2018 A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity. DTA, EGFR, LC, SLE, UVR
99  2018 A Reduction in ADAM17 Expression Is Involved in the Protective Effect of the PPAR-alpha Activator Fenofibrate on Pressure Overload-Induced Cardiac Hypertrophy. HW/BW, LVAW, LVPW, LVW/BW, PPAR-alpha
100  2018 ADAM17 inhibition enhances platinum efficiency in ovarian cancer. AREG, EGFR, ERK, PMA