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Abbreviation : AICAR
Long Form : 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
No. Year Title Co-occurring Abbreviation
2021 A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. AMP, pAmpkalpha
2021 A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner. AMPK
2021 AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1. AMP, AMPK, HMGB1, LKB1
2021 Blockade of mTORC1-NOX signaling pathway inhibits TGF-β1-mediated senescence-like structural alterations of the retinal pigment epithelium. AMD, EMT, mTORC1, NOX, ROS, RPE, TGF-beta1
2021 Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion. AMP, AMPK, UPS
2021 Effect of Deer Antler Extract on Muscle Differentiation and 5-Aminoimidazole-4-Carboxamide Ribonucleoside (AICAR)-Induced Muscle Atrophy in C2C12 Cells. AMPK, CON, FOXO3a, MuRF1, Myf5, MYOD1
2021 Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1α signaling pathway in 3T3-L1 preadipocytes. AP2, CEBPalpha, FAS, HS, HSP70, PPARgamma
2021 Identification and function prediction of novel microRNAs in adenosine monophosphate activated protein kinase-activated Sertoli cells of immature boar. AMPK, miRNAs, SCs
2021 Impairment of AMPK-α2 augments detrusor contractions in bladder ischemia. AMPK-alpha2
10  2021 In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium. PAICS, PFK-1
11  2021 Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome. AMPK, FGF21
12  2021 Metformin Reduces Vascular Assembly in High Glucose-Treated Human Microvascular Endothelial Cells in An AMPK-Independent Manner. AMPK, HG, HMECs
13  2021 MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in mice via AMPK signaling pathway. ---
14  2021 Obesity increases neuropathic pain via the AMPK-ERK-NOX4 pathway in rats. AMPK, CCD, DRG, ERK, NOX4, PA, PWMT
15  2020 Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness. AKI, CLP, HMGB1, IM, LPS, OXPHOS, TEC
16  2020 AICAR and Decitabine Enhance the Sensitivity of K562 Cells to Imatinib by Promoting Mitochondrial Activity. CML, LSCs, TKIs
17  2020 AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells. MSC, NAM, ROS, SIRT1
18  2020 AICAR Stimulates the Pluripotency Transcriptional Complex in Embryonic Stem Cells Mediated by PI3K, GSK3beta, and beta-Catenin. AMPK, mESCs
19  2020 Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway. CREB, Drp1, LBD, PD, SIRT3
20  2020 AMP-Activated Protein Kinase Restricts Zika Virus Replication in Endothelial Cells by Potentiating Innate Antiviral Responses and Inhibiting Glycolysis. AMPK, ZIKV
21  2020 AMPK Activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside Attenuates Alkali Injury-Induced Corneal Fibrosis. alpha-SMA, AMPK, ECM, OCT
22  2020 AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer. AMPK, CET, CRC, EGFR, Mcl-1, MET, mTOR, Pab
23  2020 AMPK activation suppresses mTOR/S6K1 phosphorylation and induces leucine resistance in rats with sepsis. CLP, PKB, TPN
24  2020 Aspirin and 5-Aminoimidazole-4-carboxamide Riboside Attenuate Bovine Ephemeral Fever Virus Replication by Inhibiting BEFV-Induced Autophagy. ---
25  2020 Atorvastatin inhibits endoplasmic reticulum stress through AMPK signaling pathway in atherosclerosis in mice. HUVECs, oxLDL, p-eIF2alpha, p-PERK, phospho-PERK, sXBP-1
26  2020 Autophagy modulation in animal models of corneal diseases: a systematic review. DED, FECD, GCD2, SR
27  2020 Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies. HSA
28  2020 CCAL1 enhances osteoarthritis through the NF-κB/AMPK signaling pathway. CAPE, HC-OA, OA, TNFRSF11B
29  2020 Dysregulation of Lipid Metabolism in Macrophages Is Responsible for Severe Endotoxin Tolerance in FcgRIIB-Deficient Lupus Mice. AMPKp, mtDNA, PC, PE, PEMT
30  2020 Effects of tannase-converted green tea extract on skeletal muscle development. AMPKalpha, EC, EGC, GA, MuRF1
31  2020 Effects of treadmill exercise on the regulation of tight junction proteins in aged mice. LPS, ZO-1
32  2020 Expression and purification of the 5'-nucleotidase YitU from Bacillus species: its enzymatic properties and possible applications in biotechnology. AICAR-P, FMN, HADSF, RF
33  2020 Impact of Facultative Bacteria on the Metabolic Function of an Obligate Insect-Bacterial Symbiosis. ---
34  2020 Insight into AMPK regulation mechanism in vivo and in vitro: Responses to low temperatures in the olive flounder Paralichthys olivaceus. AMPK
35  2020 Metabolic and transcriptome responses of RNAi-mediated AMPKα knockdown in Tribolium castaneum. AMPK, ChREBP, DEGs, IIS, RNAi, SREBP1, TG
36  2020 Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes. AMPK, DR
37  2020 Metformin Is Associated with Reduced Tissue Factor Procoagulant Activity in Patients with Poorly Controlled Diabetes. AMPK, LPS, TF, VCAM
38  2020 Metformin regulation of progesterone receptor isoform-B expression in human endometrial cancer cells is glucose-dependent. EC, MET, PgR
39  2020 Mitochondrial dysfunction in skeletal muscle of fukutin-deficient mice is resistant to exercise- and 5-aminoimidazole-4-carboxamide ribonucleotide-induced rescue. AMPK, DGC, Fktn KO, LM, PGC-1alpha
40  2020 Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator. AMP, CcO, OCR
41  2020 Phloretin Modulates Human Th17/Treg Cell Differentiation In Vitro via AMPK Signaling. AMPK, Com C
42  2020 Protective effect of MOTS-c on acute lung injury induced by lipopolysaccharide in mice. ALI, AMPK, BALF, CINC-1, ICAM-1, LPS, LTA
43  2020 Role of the AMPK/ACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation. ACC, AMPK, eIF2alpha, PERK, TRPP2
44  2020 Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at ∼65% V ̇ O 2 peak in endurance trained men. AMPK, ET, UT
45  2020 Targeting bioenergetics prevents CD4 T cell-mediated activation of synovial fibroblasts in rheumatoid arthritis. CD4CM, FLS
46  2020 The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin. AMPK
47  2020 The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport. EDL
48  2020 Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide-induced acute pneumonia in mice. AMPK, IL-1beta, LPS, TNF-alpha, VitB6
49  2020 Whether AICAR in Pregnancy or Lactation Prevents Hypertension Programmed by High Saturated Fat Diet: A Pilot Study. AMPK, HFD, NO
50  2020 [Effect of 5-aminoimidazole-4-formamide Ribonucleotide Combined with Interferon on Chronic Myeloid Leukemia K562 Cells]. ---
51  2019 Activation of adenosine monophosphate-activated protein kinase (AMPK) enhances energy metabolism, motility, and fertilizing ability of cryopreserved spermatozoa in domestic cat model. AMPK
52  2019 Activation of AMPK alleviates cardiopulmonary bypass-induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder. AMPK, AS160, AS160, CPB, GLUT4
53  2019 AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathway. AKI, AMPK, BUN, SD
54  2019 AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-kappaB Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats. BDL
55  2019 AMP-activated protein kinase activation reduces the transcriptional activity of the murine luteinizing hormone β-subunit gene. AMPK
56  2019 AMP-activated protein kinase signaling regulated expression of urea cycle enzymes in response to changes in dietary protein intake. AMPK, HP
57  2019 AMPK activation by AICAR sensitizes prostate cancer cells to radiotherapy. AMPK
58  2019 AMPK alleviates high uric acid-induced Na+-K+-ATPase signaling impairment and cell injury in renal tubules. AMP, HUA, IL-1beta, LKB1, mTOR, NKA, PTECs, UA
59  2019 Central Injection of Leptin Increases Sympathetic Nerve Outflows to the Stomach and Spleen in Anesthetized Rats. AMPK
60  2019 Chronic AICAR treatment prevents metabolic changes in cardiomyocytes exposed to free fatty acids. AMPK, FFA
61  2019 Deltamethrin promotes adipogenesis via AMPKalpha and ER stress-mediated pathway in 3T3- L1 adipocytes and Caenorhabditis elegans. 4-PBA, AMPKalpha, ER, FAS
62  2019 Experimental characterization of two archaeal inosine 5'-monophosphate cyclohydrolases. FAICAR, IMP
63  2019 Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats. AMPK, TEs
64  2019 Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway. CsA, HIE
65  2019 Glycogen Synthase Kinase-3 Regulates Sperm Motility and Acrosome Reaction via Affecting Energy Metabolism in Goats. ATP, GSK-3, LDH, MDH, SDH
66  2019 Hyperglycemia aggravates acute liver injury by promoting liver-resident macrophage NLRP3 inflammasome activation via the inhibition of AMPK/mTOR-mediated autophagy induction. AMPK, KCs, mTOR, NLRP3, TAA
67  2019 Identification of microRNAs for regulating adenosine monophosphate-activated protein kinase expression in immature boar Sertoli cells in vitro. AMPK, miRNAs, SC
68  2019 Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system. DGAT1, FFAs, PLIN2, TAG
69  2019 Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression. AMPK, BDNF, CREB, FST, NF-kappaB, PKCzeta, TST
70  2019 Metformin prevents the pathological browning of subcutaneous white adipose tissue. AMPK, PP2A, WAT
71  2019 Modular systems metabolic engineering enables balancing of relevant pathways for l-histidine production with Corynebacterium glutamicum. FBA, IMP, SMP
72  2019 NSAID-induced injury of gastric epithelial cells is reversible: roles of mitochondria, AMP kinase, NGF, and PGE2. AMPK, DFN, dmPGE2, GEPCs, INDO, NGF, NSAIDs
73  2019 Peptide YY (PYY) Is Expressed in Human Skeletal Muscle Tissue and Expanding Human Muscle Progenitor Cells. hMPCs, PYY, SkM, TNF-alpha
74  2019 Theaflavin 3,3'-digallate reverses the downregulation of connexin 43 and autophagy induced by high glucose via AMPK activation in cardiomyocytes. AMPK, Cx43, GJIC, NRCMs, siRNA, TF3
75  2019 [Advances on the anti-inflammatory and protective effect of AMPK activators]. AMPK
76  2018 Activation of AMPK in Human Placental Explants Impairs Mitochondrial Function and Cellular Metabolism. AMPK, ATP
77  2018 Aicar effect in early neuronal development. HPRT, LND, RA, SHH, TGF-beta
78  2018 AICAR inhibits NFkappaB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages. AMPK, IL, LPS, NF-kappaB, STAT3
79  2018 AICAR Prevents Acute Olanzapine-Induced Disturbances in Glucose Homeostasis. AMPK, OLZ
80  2018 AMP-activated kinase is a regulator of fibroblast growth factor 23 production. AMPK, FGF23, SOCE
81  2018 AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications. 2-ME, AMPK, COMT, GDM
82  2018 AMPK activation by A-769662 and 991 does not affect catecholamine-induced lipolysis in human adipocytes. AMPK, HSL
83  2018 AMPK blunts chronic heart failure by inhibiting autophagy. AMPK, mTOR, mTORC2
84  2018 Astragaloside IV Inhibits Triglyceride Accumulation in Insulin-Resistant HepG2 Cells via AMPK-Induced SREBP-1c Phosphorylation. AMPK, AST-IV, IR, NAFLD, NEFA, SREBP-1c, TG
85  2018 Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2. CSCs, MTHFD2
86  2018 Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells. AMPK, aNPC, CM, GPI, HPLC
87  2018 Digitoxin Suppresses Human Cytomegalovirus Replication via Na+, K+/ATPase alpha1 Subunit-Dependent AMP-Activated Protein Kinase and Autophagy Activation. AMPK, HCMV, mTOR, PI3K-CIII
88  2018 Evolutionary convergence in the biosyntheses of the imidazole moieties of histidine and purines. PRPP
89  2018 Exercise Improves Outcomes of Surgery on Fatty Liver in Mice: A Novel Effect Mediated by the AMPK Pathway. AMPK
90  2018 Flubendiamide Enhances Adipogenesis and Inhibits AMPKalpha in 3T3-L1 Adipocytes. AMP, CCAAT
91  2018 Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson's models. DA, PD
92  2018 Ginsenoside Rb1 Ameliorates Autophagy of Hypoxia Cardiomyocytes from Neonatal Rats via AMP-Activated Protein Kinase Pathway. AMPK, cTnI, DCFH-DA, ELISA, Gs-Rb1, LC3, MTT
93  2018 High Glucose Upregulated Vascular Smooth Muscle Endothelin Subtype B Receptors via Inhibition of Autophagy in Rat Superior Mesenteric Arteries. AMP, ETB, HG, mTOR, S6c, SMA, VSMCs
94  2018 High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans. AMPK, ATIC, atic-1, HG
95  2018 Hyaluronidase2 (Hyal2) modulates low shear stress-induced glycocalyx impairment via the LKB1/AMPK/NADPH oxidase-dependent pathway. ECL, HUVEC, HYAL2, LKB1, LSS, NADPH
96  2018 IL6 and LIF mRNA expression in skeletal muscle is regulated by AMPK and the transcription factors NFYC, ZBTB14, and SP1. AMPK, LIF, Nfyc, Sp1, Zbtb14
97  2018 Knockdown of Sestrin2 Increases Lipopolysaccharide-Induced Oxidative Stress, Apoptosis, and Fibrotic Reactions in H9c2 Cells and Heart Tissues of Mice via an AMPK-Dependent Mechanism. AMPK, LPS, MMP, ROS, Sesn2
98  2018 Metabolic perturbations of post-load hyperglycemia vs. fasting hyperglycemia. ELISA, FH, NC, OGTT, PH
99  2018 Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKalpha. AMPK, CE-MS, FBS, HCC, KO, MEF, TCA, WT
100  2018 Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and cancer cells. AMPK, MEMalpha