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Abbreviation : APN
Long Form : aminopeptidase N
No. Year Title Co-occurring Abbreviation
2020 Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA. DPP-IV, IL-10, LPS, MSC-CM, NO, PMA
2020 Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying. IGS, T/N
2020 Aminopeptidase N Expression, Not Interferon Responses, Determines the Intestinal Segmental Tropism of Porcine Deltacoronavirus. IFN, PDCoV
2020 Bacillus thuringiensis Cry1Ab domain III beta-22 mutants with enhanced toxicity to Spodoptera frugiperda (J. E. Smith). ALP, Bt, CAD
2020 Bestatin and bacitracin inhibit porcine kidney cortex dipeptidyl peptidase IV activity and reduce human melanoma MeWo cell viability. pDPP-IV
2020 Combination of metronomic administration and target delivery strategies to improve the anti-angiogenic and anti-tumor effects of triptolide. cEPCs, HUVECs, MTD, TP, TSP-1
2020 Combinatorial inhibition of Angiotensin converting enzyme, Neutral endopeptidase and Aminopeptidase N by N-methylated peptides alleviates blood pressure and fibrosis in rat model of dexamethasone-induced hypertension. ACE, Me, NEP, SBP
2020 Designed Three-in-One Peptides with Anchoring, Antifouling, and Recognizing Capabilities for Highly Sensitive and Low-Fouling Electrochemical Sensing in Complex Biological Media. PEDOT
2020 Digestive abilities, amino acid transporter expression, and metabolism in the intestines of piglets fed with spermine. ---
10  2020 Digestive enzyme expression in the large intestine of children with short bowel syndrome in a late stage of adaptation. IEM, LPH, SBS, SI
11  2020 Evaluating single-domain antibodies as carriers for targeted vaccine delivery to the small intestinal epithelium. APCs, Fc, pAPN
12  2020 Exploring the structural aspects of ureido-amino acid-based APN inhibitors: a validated comparative multi-QSAR modelling study. ---
13  2020 Identification and Characterization of Aminopeptidase-N as a Binding Protein for Cry3Aa in the Midgut of Monochamus alternatus (Coleoptera: Cerambycidae). BBMVs
14  2020 Identification and Validation of VEGFR2 Kinase as a Target of Voacangine by a Systematic Combination of DARTS and MSI. DARTS, MSI, VEGFR2
15  2020 Identification of Cry1Ah-binding proteins through pull down and gene expression analysis in Cry1Ah-resistant and susceptible strains of Ostrinia furnacalis. ACB, ALP, BBMV, CAD, proPO, Spi
16  2020 In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy. CPG2, Cys, LDEPT
17  2020 iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin-angiotensin system-mediated congenital ureteropelvic junction obstruction. ACE, UPJO
18  2020 MicroRNA-125a attenuates the chemoresistance against ubenimex in non-small cell lung carcinoma via targeting the aminopeptidase N signaling pathway. lncRNAs, NSCLC
19  2020 Role of Porcine Aminopeptidase N and Sialic Acids in Porcine Coronavirus Infections in Primary Porcine Enterocytes. NA, PEDV, SAs, TGEV
20  2020 The use of cells from ANPEP knockout pigs to evaluate the role of aminopeptidase N (APN) as a receptor for porcine deltacoronavirus (PDCoV). KO, PAMs, PDCoV, PEDV, TGEV
21  2020 Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling. ISCs, TGEV
22  2019 A comprehensive analysis of amino-peptidase N1 protein (APN) from Anopheles culicifacies for epitope design using Immuno-informatics models. TBV
23  2019 Activity-Based Sensing and Theranostic Probes Based on Photoinduced Electron Transfer. FRET, ICT, PET
24  2019 Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virus. PEDV, TGEV
25  2019 Chemically synthesized LYRM03 could inhibit the metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo. ---
26  2019 Correlation Between Proteolytic Enzymes and Microangiogenesis in Degenerative Intervertebral Disc Nucleus. LAP, VEGF
27  2019 CTLGA9 Interacts with ALP1 and APN Receptors To Modulate Cry11Aa Toxicity in Aedes aegypti. ALP, BBMVs, Bt, CHIKV, DENVs, YFV, ZIKV
28  2019 Differential Effects of Doxazosin on Renin-Angiotensin-System- Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells. APA, APB, ASAP, IRAP, RAS
29  2019 Expression of amino acid and sugar transporters, aminopeptidase, and the di- and tri-peptide transporter PepT1; differences between modern fast growing broilers and broilers not selected for rapid growth. FCR, ph, Ross
30  2019 In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe. ICT, NIR
31  2019 Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II. 5-FU, HUVECs
32  2019 Poly(ethylene glycol)-poly(lysine) block copolymer-ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells. HCC, ROS
33  2019 Synthesis and 4D-QSAR Studies of Alanine Hydroxamic Acid Derivatives as Aminopeptidase N Inhibitors. ---
34  2019 Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway. CCK-8, ROS
35  2018 Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma. MPM
36  2018 Analysis of Homologs of Cry-toxin Receptor-Related Proteins in the Midgut of a Non-Bt Target, Nilaparvata lugens (Stal) (Hemiptera: Delphacidae). ALP, BPH, Bt, CBPs
37  2018 Anti-Inflammatory and Antitumor Effects of Hydroxytyrosol but Not Oleuropein on Experimental Glioma In Vivo. A Putative Role for the Renin-Angiotensin System. APA, APB, ASAP, IRAP, RAS
38  2018 Binding determinants in the interplay between porcine aminopeptidase N and enterotoxigenic Escherichia coli F4 fimbriae. ETEC
39  2018 Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility. PDCoV
40  2018 Cell lines as models for the study of Cry toxins from Bacillus thuringiensis. ABCC2, ALP, CAD, GPI
41  2018 Correlation between adiponectin polymorphism and atherosclerotic plaque compositions under intravascular ultrasound (IVUS). FIN, IL-1beta, IVUS, LDL-C, TG, TNF-alpha
42  2018 Cytotoxicity and binding profiles of activated Cry1Ac and Cry2Ab to three insect cell lines. ALP
43  2018 Design of Aminopeptidase N Inhibitors as Anti-cancer Agents. ---
44  2018 Design, Synthesis, and Biological Evaluation of Pyrazoline-Based Hydroxamic Acid Derivatives as Aminopeptidase N (APN) Inhibitors. HUVECs
45  2018 Differential mRNA expression of nutrient transporters in male and female chickens. doh
46  2018 Effect of Aminopeptidase N on functions and fertility of mouse spermatozoa invitro. ---
47  2018 Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicity. ALP, CAD
48  2018 Enhancement of Bacillus thuringiensis Cry1Ab and Cry1Fa Toxicity to Spodoptera frugiperda by Domain III Mutations Indicates There Are Two Limiting Steps in Toxicity as Defined by Receptor Binding and Protein Stability. ALP
49  2018 Epidermal growth factor receptor is a co-factor for transmissible gastroenteritis virus entry. TGEV
50  2018 Fate of egg proteins during the development of Columba livia domestica embryo. YSM
51  2018 Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N. ADAM17, PED, PEDV
52  2018 Morphofunctional properties of a differentiated Caco2/HT-29 co-culture as an in vitro model of human intestinal epithelium. ALP, DPP-IV, LY, TEER
53  2018 Role of ubenimex as an anticancer drug and its synergistic effect with Akt inhibitor in human A375 and A2058 cells. MM
54  2018 Spodoptera frugiperda (J. E. Smith) Aminopeptidase N1 Is a Functional Receptor of the Bacillus thuringiensis Cry1Ca Toxin. APN1, BBMV, dsRNA, SfAPN1
55  2018 Synthesis and molecular simulation study of furoic peptidomimetic derivatives as potent aminopeptodase N inhibitors. ---
56  2018 The C-terminal protoxin region of Bacillus thuringiensis Cry1Ab toxin has a functional role in binding to GPI-anchored receptors in the insect midgut. ALP
57  2018 Ubenimex, an APN inhibitor, could serve as an anti‑tumor drug in RT112 and 5637 cells by operating in an Akt‑associated manner. ---
58  2018 Upregulation of genes encoding digestive enzymes and nutrient transporters in the digestive system of broiler chickens by dietary supplementation of fiber and inclusion of coarse particle size corn. ASCT1, CAT1, CC, FCR, PEPT2, SB
59  2017 27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation. Ang IV, IRAP
60  2017 Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection. ---
61  2017 Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry. HCoV-229E, PEDV, ST, TGEV
62  2017 Angiotensin-III is Increased in Alzheimer's Disease in Association with Amyloid-beta and Tau Pathology. ACE-1, AD, Ang II, Ang-III, APA, AT1R, AT2R, RAS
63  2017 Bacillus subtilis and surfactin inhibit the transmissible gastroenteritis virus from entering the intestinal epithelial cells. EGFR, TGE, TLR
64  2017 Biochemical characterization of aminopeptidase N2 from Toxoplasma gondii. rTgAPN2
65  2017 CD13/aminopeptidase N mRNA expression and enzyme activity in Systemic Lupus Erythematosus. SLE
66  2017 Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN). pAPA, ZBG
67  2017 Elevated aminopeptidase N affects sperm motility and early embryo development. ---
68  2017 Extracellular functions of 14-3-3 adaptor proteins. ---
69  2017 Functional characterization of Aedes aegypti alkaline phosphatase ALP1 involved in the toxicity of Cry toxins from Bacillus thuringiensis subsp. israelensis and jegathesan. ALP
70  2017 Functional roles of cadherin, aminopeptidase-N and alkaline phosphatase from Helicoverpa armigera (Hubner) in the action mechanism of Bacillus thuringiensis Cry2Aa. ALP, CAD
71  2017 Identification and Characterization of Hyphantria cunea Aminopeptidase N as a Binding Protein of Bacillus thuringiensis Cry1Ab35 Toxin. Cry, dsRNA, RNAi
72  2017 Influence of Ephestia kuehniella stage larvae on the potency of Bacillus thuringiensis Cry1Aa delta-endotoxin. BBM
73  2017 Mesoporous Silica Nanocarriers with Cyclic Peptide Gatekeeper: Specific Targeting of Aminopeptidase N and Triggered Drug Release by Stimuli-Responsive Conformational Transformation. ---
74  2017 Modulation of digestive enzyme activities in the avian digestive tract in relation to diet composition and quality. ---
75  2017 NGR-peptide-drug conjugates with dual targeting properties. ---
76  2017 Receptor-binding loops in alphacoronavirus adaptation and evolution. RBD
77  2017 RNAi in the striped stem borer, Chilo suppressalis, establishes a functional role for aminopeptidase N in Cry1Ab intoxication. Bt, CsAPNs, RNAi
78  2017 Sex differences in the aging pattern of renin-angiotensin system serum peptidases. ACE, ACE2, APA, NEP, RAS
79  2017 Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain. NEP, UHP
80  2017 SYNTHESIS AND AMINOPEPTIDASE N INHIBITING ACTIVITY OF 3-(NITROPHENOXYMETHYL)-[1,3,2]DIOXABOROLAN-2-OLS AND THEIR OPEN ANALOGUES. ---
81  2017 Systemic Administration of Sialorphin Attenuates Experimental Colitis in Mice via Interaction With Mu and Kappa Opioid Receptors. DSS, IBD, MPO, NEP
82  2017 The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach. ---
83  2017 Trypsin and N-aminopeptidase (APN) activities in the hepatopancreas of an intertidal euryhaline crab: Biochemical characteristics and differential modulation by histamine and salinity. ---
84  2017 Ultrasensitive Detection of Aminopeptidase N Activity in Urine and Cells with a Ratiometric Fluorescence Probe. ---
85  2017 [Interaction of aminopeptidase (BmAPN5) and parasporal crystal (PC) toxin isolated from Bacillus bombysepticus]. Bb, PC
86  2016 A high-throughput, in-vitro assay for Bacillus thuringiensis insecticidal proteins. ALP, BBMV, Bt, Cad
87  2016 Activity profiling of aminopeptidases in cell lysates using a fluorogenic substrate library. ---
88  2016 Design of a Hyperpolarized Molecular Probe for Detection of Aminopeptidase N Activity. ---
89  2016 Exploring ligand dissociation pathways from aminopeptidase N using random acceleration molecular dynamics simulation. RAMD
90  2016 Expression of small intestinal nutrient transporters in embryonic and posthatch turkeys. DOH
91  2016 LJNK, an indoline-2,3-dione-based aminopeptidase N inhibitor with promising antitumor potency. ---
92  2016 Molecular characterization and dietary regulation of aminopeptidase N (APN) in the grass carp (Ctenopharyngodon idella). CP
93  2016 Opiorphin causes a panicolytic-like effect in rat panic models mediated by mu-opioid receptors in the dorsal periaqueductal gray. dPAG, MORs, NEP
94  2016 Paracrine regulation of matrix metalloproteinases contributes to cancer cell invasion by hepatocellular carcinoma-secreted 14-3-3sigma. HCC, MMPs, PMA, r14-3-3sigma
95  2016 Porcine aminopeptidase N binds to F4+ enterotoxigenic Escherichia coli fimbriae. ETEC
96  2016 Silencing of CYP6 and APN Genes Affects the Growth and Development of Rice Yellow Stem Borer, Scirpophaga incertulas. YSB
97  2016 Targeted antitumor prodrug therapy using CNGRC-yCD fusion protein in combination with 5-fluorocytosine. 5-FC, 5-FU, yCD
98  2016 Three toxins, two receptors, one mechanism: Mode of action of Cry1A toxins from Bacillus thuringiensis in Heliothis virescens. ALP, Bt, Cry
99  2016 Two galactose-alpha-1,3-galactose carrying peptidases from pork kidney mediate anaphylactogenic responses in delayed meat allergy. ACEI, alpha-gal
100  2016 Ubenimex inhibits cell proliferation, migration and invasion by inhibiting the expression of APN and inducing autophagic cell death in prostate cancer cells. AO/EB, LDH