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Abbreviation : ASIC
Long Form : acid-sensing ion channel
No. Year Title Co-occurring Abbreviation
2020 Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways. CF, MUC5B
2020 Acid-sensing ion channel 3 blockade inhibits durovascular and nitric oxide-mediated trigeminal pain. ---
2020 Epigenetic upregulation of acid-sensing ion channel 1 contributes to gastric hypersensitivity in adult offspring rats with prenatal maternal stress. DRG, GHS, NF-kappaB, PMS
2020 Heterologous expression of biologically active Mambalgin-1 peptide as a new potential anticancer, using a PVX-based viral vector in Nicotiana benthamiana. PVX
2020 Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels. ---
2020 Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by stomatin. STOM
2020 Machaerium hirtum (Vell.) Stellfeld Alleviates Acute Pain and Inflammation: Potential Mechanisms of Action. HEMh, PGE2
2020 Stability of extemporaneously compounded amiloride nasal spray. AD, HPLC, USP
2019 Amiloride does not protect retinal nerve fibre layer thickness in optic neuritis in a phase 2 randomised controlled trial. ITT, MS, OCT, ON, VEP
10  2019 Chondroitin sulfate attenuates acid-induced augmentation of the mechanical response in rat thin-fiber muscle afferents in vitro. CS, EPR, TRPV1
11  2019 Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3). ---
12  2019 Inhibition on acid-sensing ion channels and analgesic activities of flavonoids isolated from dragon's blood resin. CFA, DRG
13  2019 Inhibitory ASIC2-mediated calcineurin/NFAT against colorectal cancer by triterpenoids extracted from Rhus chinensis Mill. CRC, NFAT, TER
14  2019 Involvement of the epithelial sodium channel in initiation of mechanically evoked swallows in anaesthetized rats. ENaC
15  2019 Ion Channel Pharmacology for Pain Modulation. TRP, VGCC
16  2019 Multiple modes of action of hydrophobic amines and their guanidine analogues on ASIC1a. CHO
17  2019 Opioid-Mediated Modulation of Acid-Sensing Ion Channel Currents in Adult Rat Sensory Neurons. DRG, PAD
18  2019 Sa12b Peptide from Solitary Wasp Inhibits ASIC Currents in Rat Dorsal Root Ganglion Neurons. DRG
19  2019 The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. ---
20  2019 Thin-fibre receptors expressing acid-sensing ion channel 3 contribute to muscular mechanical hypersensitivity after exercise. 2.2muM, DOMS, LC
21  2019 [New horizons for acute and prophylactic treatments of migraine]. CGRP, NPY, PACAP
22  2018 Acid Sensing Ion Channel 1a (ASIC1a) Mediates Activity-induced Pain by Modulation of Heteromeric ASIC Channel Kinetics. ASIC1a
23  2018 Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection? ---
24  2018 Effects of creatine supplementation on nociception in young male and female mice. ---
25  2018 Neuroprotective Effects of Psalmotoxin-1, an Acid-Sensing Ion Channel (ASIC) Inhibitor, in Ischemia Reperfusion in Mouse Eyes. GPX4, HSP70, PERG, RBPMS, RGCs, SOD1
26  2018 PhcrTx2, a New Crab-Paralyzing Peptide Toxin from the Sea Anemone Phymanthus crucifer. DRG
27  2018 Protons as Messengers of Intercellular Communication in the Nervous System. CNS
28  2017 Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms. ASICs
29  2017 Acidity and Acid-Sensing Ion Channels in the Normal and Alzheimer's Disease Brain. ---
30  2017 Biological Behavior of Human Nucleus Pulposus Mesenchymal Stem Cells in Response to Changes in the Acidic Environment During Intervertebral Disc Degeneration. IVDD, NPMSCs
31  2017 Endomorphins potentiate acid-sensing ion channel currents and enhance the lactic acid-mediated increase in arterial blood pressure: effects amplified in hindlimb ischaemia. ASICs, DRG, MOR, PAD
32  2017 Enhanced maximal exercise capacity, vasodilation to electrical muscle contraction, and hind limb vascular density in ASIC1a null mice. FVC
33  2017 Involvement of Opioid System, TRPM8, and ASIC Receptors in Antinociceptive Effect of Arrabidaea brachypoda (DC) Bureau. DEAB, TRPA1, TRPM8, TRPV1
34  2017 Modulation of the FMRFamide-gated Na+ channel by external Ca2. FaNaC
35  2017 Proton and non-proton activation of ASIC channels. ---
36  2017 The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis. CRC, CsA
37  2016 Acid-sensing ion channel 3 or P2X2/3 is involved in the pain-like behavior under a high bone turnover state in ovariectomized mice. TRPV1
38  2016 Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target. IVD
39  2016 ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease. MPTP
40  2016 Characterization of cutaneous and articular sensory neurons. HPD, TRPA1, TRPM8, TRPV1
41  2016 Combination of Ambiguous and Unambiguous Data in the Restraint-driven Docking of Flexible Peptides with HADDOCK: The Binding of the Spider Toxin PcTx1 to the Acid Sensing Ion Channel (ASIC) 1a. ---
42  2016 Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development. ENaC
43  2016 Therapeutic Effect Analysis of Sinomenine on Rat Cerebral Ischemia-Reperfusion Injury. BBB, IR, LD, LDH, MCAO, NSS, SIN
44  2016 TRPV1, ASICs and P2X2/3 expressed in bone cells simultaneously regulate bone metabolic markers in ovariectomized mice. ---
45  2015 Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression. ASICs
46  2015 Acid-sensing ion channel 2 (ASIC2) is selectively localized in the cilia of the non-sensory olfactory epithelium of adult zebrafish. ASIC2
47  2015 Acid-sensing ion channels: a novel therapeutic target for pain and anxiety. ---
48  2015 Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety. CNS, CR, NG2, VIP
49  2015 Ionic homeostasis in brain conditioning. NHE
50  2015 Mechanotransduction of trigeminal ganglion neurons innervating inner walls of rat anterior eye chambers. MS, TG, TRPA1, TRPV4
51  2015 Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. cASIC1, MD
52  2015 Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. DRG
53  2015 Physical and functional interactions between a glioma cation channel and integrin-beta1 require alpha-actinin. ENaC
54  2015 Sensory nerves contribute to cutaneous vasodilator response to cathodal stimulation in healthy rats. CGRP, CIV, NK-1, SP, TRPV1
55  2015 Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. ---
56  2014 A novel sea anemone peptide that inhibits acid-sensing ion channels. DRG, ICK
57  2014 Acid-sensing ion channel (ASIC) 1a/2a heteromers have a flexible 2:1/1:2 stoichiometry. ASICs
58  2014 Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice. ASIC1a, MNTs
59  2014 Effects of acid on vagal nociceptive afferent subtypes in guinea pig esophagus. AP
60  2014 Evidence for role of acid-sensing ion channels in nucleus ambiguus neurons: essential differences in anesthetized versus awake rats. ---
61  2014 Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. DRG, STOML1
62  2014 The expression profile of acid-sensing ion channel (ASIC) subunits ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3 in the esophageal vagal afferent nerve subtypes. ASICs
63  2013 2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type gamma-aminobutyric acid receptors. fEPSPs, GABAARs, GMQ
64  2013 A rapid facilitation of acid-sensing ion channels current by corticosterone in cultured hippocampal neurons. CORT, PKC
65  2013 Coupling of proton binding in extracellular domain to channel gating in acid-sensing ion channel. DTT, ECD, MTSET, TCEP
66  2013 Cyclophosphamide-induced cystitis reduces ASIC channel but enhances TRPV1 receptor function in rat bladder sensory neurons. CYP, DRG, TRPV1
67  2013 Mechanisms involved in the nociception triggered by the venom of the armed spider Phoneutria nigriventer. ArAv, PNV
68  2012 ENaCs and ASICs as therapeutic targets. ENaC
69  2012 Eosinophil peroxidase induces the expression and function of acid-sensing ion channel-3 in allergic rhinitis: in vitro evidence in cultured epithelial cells. AR, EPO
70  2012 Ginsenoside-Rd attenuates TRPM7 and ASIC1a but promotes ASIC2a expression in rats after focal cerebral ischemia. GS, MCAO, NMDA, TRPM
71  2012 Lignan from thyme possesses inhibitory effect on ASIC3 channel current. ---
72  2012 Modulation of ionotropic glutamate receptors and Acid-sensing ion channels by nitric oxide. iGluR, NO
73  2012 Molecules to selectively target receptors for treatment of pain and neurogenic inflammation. TRP
74  2012 Muscle afferent receptors engaged in augmented sympathetic responsiveness in peripheral artery disease. BP, EPR, PAD, SNA, TRPV1
75  2012 Putative binding sites, and pathways to them, for amidine and guanidine current inhibitors on acid-sensing ion channels (ASIC). A theoretical approach with hASIC1a homology model. ---
76  2012 Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. ASICs, GMQ
77  2011 Blockade of acid sensing ion channels attenuates the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. ---
78  2011 Chronic hypoxia-induced acid-sensitive ion channel expression in chemoafferent neurons contributes to chemoreceptor hypersensitivity. CH, CSN, PG, SCG
79  2011 Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death. ASICs
80  2011 Human odontoblasts express transient receptor protein and acid-sensing ion channel mechanosensor proteins. TRP
81  2011 Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes. Deg, ENaC, GBM, TIRFM, YFP
82  2010 Acid-sensing ion channel (ASIC) 1a undergoes a height transition in response to acidification. ---
83  2010 ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis. ---
84  2010 Demonstration of a direct interaction between sigma-1 receptors and acid-sensing ion channels. ---
85  2010 Expression and response of acid-sensing ion channels in urinary bladder to cyclophosphamide-induced cystitis. CYP
86  2010 Extracellular acidosis activates ASIC-like channels in freshly isolated cerebral artery smooth muscle cells. VSMCs
87  2010 Increased response of muscle sensory neurons to decreases in pH after muscle inflammation. DiI, DRG
88  2010 Regulation of acid signaling in rat pulmonary sensory neurons by protease-activated receptor-2. TRPV1
89  2010 Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567. SAR
90  2009 Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models. ASICs
91  2009 Acid-evoked Ca2+ signalling in rat sensory neurones: effects of anoxia and aglycaemia. ---
92  2009 Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis. CGRP, DRG
93  2009 Acid-sensing ionic-channel functional expression in the vestibular endorgans. ASA
94  2009 Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes. NHE
95  2009 ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca(2+) entry. VSM
96  2009 Functional TRP and ASIC-like channels in cultured urothelial cells from the rat. TRP
97  2009 Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration. ENaC
98  2009 Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test. ASICs, CFA
99  2009 The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. ---
100  2009 [Expression of acid-sensing ion channels in neurons of trapezoid body and lateral paragigantocellular nuclei in rat brain, and effects of intermittent hypoxia on their expression]. IH