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Abbreviation : AURKA
Long Form : Aurora kinase A
No. Year Title Co-occurring Abbreviation
2020 A kinase-independent function for AURORA-A in replisome assembly during DNA replication initiation. ---
2020 AURKA rs2273535 T>A Polymorphism Associated With Cancer Risk: A Systematic Review With Meta-Analysis. CIs, ORs
2020 Aurora kinases and DNA damage response. AURKB
2020 Bioinformatics Analysis of Global Proteomic and Phosphoproteomic Data Sets Revealed Activation of NEK2 and AURKA in Cancers. ccRCC, CPTAC, LUAD, MS, UCEC
2020 CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation. CEP41, EC, PTMs
2020 Cinobufagin Triggers Defects in Spindle Formation and Cap-Dependent Translation in Liver Cancer Cells by Inhibiting the AURKA-mTOR-eIF4E Axis. ATP1A1, eIF4E, ERK, HCC, mTOR, NKA, TMT
2020 Differential expression of AURKA/PLK4 in quiescence and senescence of osteosarcoma U2OS cells. DEGs, OS
2020 Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition. AURKB
2020 Higher AURKA and PLK1 expression are associated with inferior overall survival in patients with myelofibrosis. JAK2, Plk1
10  2020 ID1 overexpression promotes HCC progression by amplifying the AURKA/Myc signaling pathway. HCC, Id1
11  2020 Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma. DCCT, MM
12  2020 Identification of lung adenocarcinoma biomarkers based on bioinformatic analysis and human samples. DEGs, GEO, GO, KEGG, PPI
13  2020 Impact of Aurora Kinase A Polymorphism and Epithelial Growth Factor Receptor Mutations on the Clinicopathological Characteristics of Lung Adenocarcinoma. EGFR, LADC, SNPs
14  2020 Inhibition of Aurora Kinase A by Alisertib Reduces Cell Proliferation and Induces Apoptosis and Autophagy in HuH-6 Human Hepatoblastoma Cells. ALS, COG, HB, TEM
15  2020 Integrated Bioinformatic Analysis Identifies Networks and Promising Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma. ASPM, CCNB1, CCNB2, CDK1, CENPF, DEGs, GEO, HBV, HCC, KIF2C, NDC80, PBK, PPI, TPX2
16  2020 Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA. cyt c, DeltaPsim, PAL, ROS
17  2020 Pan Aurora Kinase Inhibitor: A Promising Targeted-Therapy in Dedifferentiated Liposarcomas With Differential Efficiency Depending on Sarcoma Molecular Profile. LPS, STS
18  2020 Phase II Multicenter, Open-Label Study of Oral ENMD-2076 for the Treatment of Patients with Advanced Fibrolamellar Carcinoma. FLC, OS, PFS, PR, SD, TTP
19  2020 Polo-like kinase 1 as a therapeutic target for malignant peripheral nerve sheath tumors (MPNST) and schwannomas. MPNST, NF1, NF2, Plk1
20  2020 Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase. PP6
21  2020 PUF60/AURKA Axis Contributes to Tumor Progression and Malignant Phenotypes in Bladder Cancer. PUF60
22  2020 Reversine exerts cytotoxic effects through multiple cell death mechanisms in acute lymphoblastic leukemia. ALL
23  2020 Role of AURKA in the hypothalamus-pituitary-testicular axis in Tibetan sheep from Tianzhu. HPT
24  2020 Screening and Identification of Key Biomarkers in Inflammatory Breast Cancer Through Integrated Bioinformatic Analyses. BUB1B, CDC20, Cdc45, DEGs, GO, IBC, KEGG, MAD2L1, Plk1, PPI
25  2020 Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells. ---
26  2020 Structural basis for the design of allosteric inhibitors of the Aurora kinase A enzyme in the cancer chemotherapy. TPX2
27  2020 Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics. ---
28  2020 Tanshinone Inhibits NSCLC by Downregulating AURKA Through Let-7a-5p. NSCLC
29  2020 Targeting aurora kinase B alleviates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury. CCI
30  2020 Therapeutic Rationale to Target Highly Expressed Aurora kinase A Conferring Poor Prognosis in Cholangiocarcinoma. Plk1, TPX2
31  2020 Upregulation of aurora kinase A promotes vascular smooth muscle cell proliferation and migration by activating the GSK-3beta/beta-catenin pathway in aortic-dissecting aneurysms. ADA, Ang II, RT-qPCR, VSMCs
32  2020 Wwc2 Is a Novel Cell Division Regulator During Preimplantation Mouse Embryo Lineage Formation and Oogenesis. MII
33  2019 A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish. HCC
34  2019 Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. EGFR
35  2019 Aurora kinase A induces chemotherapy resistance through revival of dormant cells in laryngeal squamous cell carcinoma. LSCC
36  2019 Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma. ATAD, CDK, DEGs, GEO, GO, KEGG, KIF, KNTC, NPC, PPI, SMC
37  2019 Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck. HNSCC, HPV
38  2019 Design, synthesis, and biological evaluation of polyphenols with 4,6-diphenylpyrimidin-2-amine derivatives for inhibition of Aurora kinase A. QSAR
39  2019 Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian Cancer. EOC, FGF18, MAL, SDC, VCAN
40  2019 DNA hypermethylation of aurora kinase A in hepatitisC virus‑positive hepatocellular carcinoma. CDKN3, FOS, HCC, HCV, HPA, PPI, UBE2C
41  2019 Effects of AURKA-mediated degradation of SOD2 on mitochondrial dysfunction and cartilage homeostasis in osteoarthritis. DEGs, IL-1beta, MMP-13, OA, SOD2, Sox9
42  2019 Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers. UGC
43  2019 Evaluation of the Association between Androgen Receptor and AURKA and Its Prognostic Value in Gastric Cancer. AR, GC
44  2019 Expression profile‑driven discovery of AURKA as a treatment target for liposarcoma. DD, IL, LPS, STS, WD
45  2019 Failure to reabsorb the primary cilium induces cellular senescence. ---
46  2019 Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro. BAP1, DDB2, HR, MPM
47  2019 Gossypin inhibits gastric cancer growth by direct targeting of AURKA and RSK2. ---
48  2019 High aurora kinase expression identifies patients with muscle-invasive bladder cancer who have poor survival after neoadjuvant chemotherapy. AURKB, MIBC, NAC, OS, RFS, ROC, TURBT
49  2019 Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors. CML, IM, LSC, RT, TCF/LEF, TK, WB
50  2019 Identification of hub genes and pathways in glioblastoma by bioinformatics analysis. BUB1, CDC20, CDK1, DEGs, GBM
51  2019 Identification of key candidate genes involved in melanoma metastasis. ADCY1, ASXL1, BAP1, BUB1, CENPM, DEGs, KEGG, LAMA1, NDC80, PCNA, PIK3R3, PPI, PRKCA, UBC
52  2019 Impacts of AURKA Genetic Polymorphism on Urothelial Cell Carcinoma Development. SNPs, UCC
53  2019 Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1. RPS6KB1
54  2019 Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma. AIF, NHL
55  2019 Interactive effects of AURKA polymorphisms with smoking on the susceptibility of oral cancer. ORs, PCR-RFLP
56  2019 Linc00299/miR-490-3p/AURKA axis regulates cell growth and migration in atherosclerosis. lncRNA, VSMCs
57  2019 Long noncoding RNA AURKAPS1 potentiates malignant hepatocellular carcinoma progression by regulating miR-142, miR-155 and miR-182. HCC, lncRNA
58  2019 MiR-154 inhibits cells proliferation and metastasis in melanoma by targeting AURKA and serves as a novel prognostic indicator. CCK-8, RT-PCR
59  2019 Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients. MTC
60  2019 Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma. PDC, TKI
61  2019 Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer. DLT, mFOLFOX, MTD
62  2019 Prediction of a miRNA-mRNA functional synergistic network for cervical squamous cell carcinoma. CDK1, CIN, CSCC, DEGs, DEmiRNAs
63  2019 PRL-3 Promotes Ubiquitination and Degradation of AURKA and Colorectal Cancer Progression via Dephosphorylation of FZR1. CIN
64  2019 The anticancer effects of cinobufagin on hepatocellular carcinoma Huh‑7cells are associated with activation of the p73 signaling pathway. HCC
65  2019 The chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) controls cellular quiescence by hyperpolarizing the cell membrane during diapause in the crustacean Artemia. CFTR, RNA-Seq
66  2019 Up-regulated HIF-2alpha contributes to the Osteoarthritis development through mediating the primary cilia loss. DMM, OA
67  2018 AURKA contributes to the progression of oral squamous cell carcinoma (OSCC) through modulating epithelial-to-mesenchymal transition (EMT) and apoptosis via the regulation of ROS. CCK-8, EMT, NAC, OSCC, ROS
68  2018 AURKA Suppresses Leukemic THP-1 Cell Differentiation through Inhibition of the KDM6B Pathway. AML, MLL, PMA
69  2018 Aurora kinase A (AURKA) interaction with Wnt and Ras-MAPK signalling pathways in colorectal cancer. CRC, DEA, PPI
70  2018 Aurora-A-mediated phosphorylation of LKB1 compromises LKB1/AMPK signaling axis to facilitate NSCLC growth and migration. NSCLCs
71  2018 Bexarotene - a novel modulator of AURKA and the primary cilium in VHL-deficient cells. HTS, RCC, RXR, VHL
72  2018 Biological and Genetic Features of Neuroblastoma and Their Clinical Importance. BDNF, LOH, NGF, NT-3
73  2018 c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer. ---
74  2018 Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models. PDOX, pGBM
75  2018 Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus. ---
76  2018 Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase. EGFR, SAR
77  2018 Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma. BRD4
78  2018 EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis. CDK4, circMMP9, circRNAs, eIF4A3, GBM
79  2018 Exploring the molecular mechanisms of osteosarcoma by the integrated analysis of mRNAs and miRNA microarrays. DEGs, DEmiRNAs, ESR1, FOSL1, GO, OS, PPI, STAT3, TF
80  2018 GNAS, GNAQ, and GNA11 alterations in patients with diverse cancers. CBL, GNAS, LYN
81  2018 Identification of Novel Aurora Kinase A (AURKA) Inhibitors via Hierarchical Ligand-Based Virtual Screening. ---
82  2018 Identification of target gene and prognostic evaluation for lung adenocarcinoma using gene expression meta-analysis, network analysis and neural network algorithms. CDK1, DEGs, Egr-1, ES, HNF4A, LUAD, NSCLC, TFs
83  2018 Identifying genes as potential prognostic indicators in patients with serous ovarian cancer resistant to carboplatin using integrated bioinformatics analysis. EZH2, MMP9, SOC
84  2018 Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer. BC
85  2018 LncRNA TUG1 promotes cells proliferation and inhibits cells apoptosis through regulating AURKA in epithelial ovarian cancer cells. AV, EOC, lncRNAs, NC, PI, qPCR, SKOV3, TUG1
86  2018 Long non-coding RNA taurine-upregulated gene 1 correlates with poor prognosis, induces cell proliferation, and represses cell apoptosis via targeting aurora kinase A in adult acute myeloid leukemia. AML, lncRNA, TUG1
87  2018 Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA. si
88  2018 Methylation of Aurora kinase A by MMSET reduces p53 stability and regulates cell proliferation and apoptosis. ---
89  2018 MicroRNA-26-5p functions as a new inhibitor of hepatoblastoma by repressing lin-28 homolog B and aurora kinase a expression. HB, LIN28B, miR-26a-5p, Ran
90  2018 NOTCH3 expression is linked to breast cancer seeding and distant metastasis. MAPK, TNBC
91  2018 p21 Activated kinase 1: Nuclear activity and its role during DNA damage repair. DDR, ERalpha, FKHR, PAK1, Plk1
92  2018 Phase I trial to evaluate the addition of alisertib to fulvestrant in women with endocrine-resistant, ER+ metastatic breast cancer. MBC
93  2018 Polymer Nanovesicle-Mediated Delivery of MLN8237 Preferentially Inhibits Aurora Kinase A To Target RalA and Anchorage-Independent Growth in Breast Cancer Cells. ---
94  2018 Polymorphisms in AURKA and AURKB are associated with the survival of triple-negative breast cancer patients treated with taxane-based adjuvant chemotherapy. AURKB, DFS, OS, SNPs, TNBC, UK
95  2018 Protein Kinase D2 Modulates Cell Cycle By Stabilizing Aurora A Kinase at Centrosomes. PKD
96  2018 Role of PLK1 signaling pathway genes in gastrointestinal stromal tumors. Cdc25C, GISTs, IHC, Plk1, RFS, TPX2
97  2018 Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells. CRC
98  2018 Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2. ---
99  2018 The Association Between AURKA Gene rs2273535 Polymorphism and Gastric Cancer Risk in a Chinese Population. GC, SNP
100  2018 Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma. HCC, SNPs