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Abbreviation : BAD
Long Form : Bcl-2-associated death promoter
No. Year Title Co-occurring Abbreviation
2020 BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis. ---
2020 Cranberry extract initiates intrinsic apoptosis in HL-60 cells by increasing BAD activity through inhibition of AKT phosphorylation. AKT, Bcl-2, CB
2020 Ethanol extract from Gynostemma pentaphyllum ameliorates dopaminergic neuronal cell death in transgenic mice expressing mutant A53T human alpha-synuclein. A53T, PD
2020 MYDGF attenuates podocyte injury and proteinuria by activating Akt/BAD signal pathway in mice with diabetic kidney disease. DKD, MYDGF
2019 1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells. Bax, HTHQ, MAPK
2019 Differential Apoptotic and Mitogenic Effects of Lectins in Zebrafish. Akt, Bcl-2, CDK4, G6PD, GLUD, PNA, Rb, SBA, TOR
2019 Effects of Grape Seed Extract and Proanthocyanidin B2 on In Vitro Proliferation, Viability, Steroidogenesis, Oxidative Stress, and Cell Signaling in Human Granulosa Cells. CCK-8, GSE, GSPB2, ROS
2019 Egg White Ovotransferrin Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption. Bcl-2, Bcl-xL, MAPK, NF-kappaB, RANKL
2019 Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways. Bax, Bcl-2, Bcl-XL, Bid, GFX, MTP, PS, SFs
10  2019 Genome-wide CRISPR-Cas9 viability screen reveals genes involved in TNF-alpha-induced apoptosis of human umbilical vein endothelial cells. Bcl-2, HUVECs, NLRX1, TNF-alpha, TNFRSF1A
11  2019 Luteal granulosa cells from natural cycles are more capable of maintaining their viability, steroidogenic activity and LH receptor expression than those of stimulated IVF cycles. Bax, BCL2-L2, CASP3, GC, KUTTAM, VEGF
12  2019 PCAT1 is a poor prognostic factor in endometrial carcinoma and associated with cancer cell proliferation, migration and invasion. Bcl-2, EC, lncRNAs, PCAT-1, RT-qPCR, siRNA
13  2019 Suberoylanilide Hydroxamic Acid Can Re-sensitize a Cisplatin-Resistant Human Bladder Cancer. Bcl-2, CCK, CI, FDA, PD-L1, SAHA
14  2018 Bufalin induces apoptosis in human esophageal carcinoma ECA109 cells by inhibiting the activation of the mTOR/p70S6K pathway. cIAP-1, mTOR, p70S6K, wtmTOR
15  2018 CDK5RAP1 targeting NF-kappaB signaling pathway in human malignant melanoma A375 cell apoptosis. Bcl-2, Bcl-xl, CDK5RAP1, NF-kappaB, p-JNK, PDTC, ROS, siRNA
16  2018 Combined effects of 17beta-estradiol and exercise training on cardiac apoptosis in ovariectomized rats. Bax, Bcl-2, Bcl-xL, ERalpha, ERbeta, FADD, IGF-1, IGF-1R, OVX-E2, p-PI3K, pBad, SHAM, tBid, TNF-alpha
17  2018 Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats. AT, Bax, Bcl-2, GFAP, IL-1beta, MCA, SIRT1, TNF-alpha
18  2018 Red pepper seed water extract inhibits preadipocyte differentiation and induces mature adipocyte apoptosis in 3T3-L1 cells. ACC, AMPK, Bak, Bcl-2, FAS, ORO, PPARgamma, RPS, SREBP-1c
19  2018 Salidroside induces apoptosis in human ovarian cancer SKOV3 and A2780 cells through the p53 signaling pathway. ---
20  2017 Acai Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice. AOM, Bcl-2, COX-2, DSS, IL, MPO, PCNA, TNF-alpha
21  2017 Actein induces apoptosis in leukemia cells through suppressing RhoA/ROCK1 signaling pathway. Bcl-2, cyto c, Mcl-1, PARP
22  2017 Knockdown of GluA2 induces apoptosis in non-small-cell lung cancer A549 cells through the p53 signaling pathway. AMPA, GluA2
23  2017 Neuroprotective Mechanisms of Lycium barbarum Polysaccharides Against Ischemic Insults by Regulating NR2B and NR2A Containing NMDA Receptor Signaling Pathways. Cyt C, LBP, OGD
24  2017 Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity. BiP, CHOP, ER, PHB2, S1P
25  2017 Piezo1 protein induces the apoptosis of human osteoarthritis-derived chondrocytes by activating caspase-12, the signaling marker of ER stress. Bax, Bcl-2, LDH, MA, OA
26  2017 PM2.5 obtained from urban areas in Beijing induces apoptosis by activating nuclear factor-kappa B. CHO, NF-kappaB, PM
27  2017 Post-ischemic treatment with azithromycin protects ganglion cells against retinal ischemia/reperfusion injury in the rat. ERK, MMP-2, RGCs
28  2017 Riparsaponin isolated from Homonoia riparia Lour induces apoptosis of oral cancer cells. Bax, Bcl-2, E-cad, MMP, RSP
29  2017 Saikosaponin a Induces Apoptosis through Mitochondria-Dependent Pathway in Hepatic Stellate Cells. HSC, SSa
30  2016 Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K/AKT signaling. BDNF, CB1, CCH, CREB, FAAH, FoxO, GAP, GSK, MAP, MGL, NAPE-PLD, PI3K, WIN
31  2016 Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells. Bak, Bax, Bcl-2, HCC
32  2016 Epstein-Barr Virus MicroRNA miR-BART20-5p Suppresses Lytic Induction by Inhibiting BAD-Mediated caspase-3-Dependent Apoptosis. EBV
33  2016 Glucagon-like peptide-1 protects cardiomyocytes from advanced oxidation protein product-induced apoptosis via the PI3K/Akt/Bad signaling pathway. AOPPs, Bax, Bcl, GLP-1, PI3K
34  2016 Injection of Abeta1-40 into hippocampus induced cognitive lesion associated with neuronal apoptosis and multiple gene expressions in the tree shrew. Abeta1-40, AD, cyt c, HE, i.c.v, IAP, MRI, NFTs, TNFR1, TS
35  2016 Maspin mediates the gemcitabine sensitivity of hormone-independent prostate cancer. Bax, Bcl-2, HIPC, Mcl-1, PI
36  2016 MiR-1180 promotes apoptotic resistance to human hepatocellular carcinoma via activation of NF-kappaB signaling pathway. HCC, miRNAs, NF
37  2016 MiR-15a/16 Regulates Apoptosis of Lung Epithelial Cells after Oxidative Stress. BALF, ROS
38  2016 The pro-inflammatory role of high-mobility group box 1 protein (HMGB-1) in photoreceptors and retinal explants exposed to elevated pressure. Bcl-2, HMGB-1, IL, RAGE, rHMGB-1, TLR2, TLR4, TNF-alpha, VEGF
39  2016 Upregulation of Akt/NF-kappaB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle. CA
40  2015 Decrease of Bcl-xL/Bcl-2-associated death promoter in hepatocellular carcinoma indicates poor prognosis. HCC, TMA
41  2015 Elevated Pressure Enhanced Trail-Induced Apoptosis in Hepatocellular Carcinoma Cells Via Erk1/2-Inactivation. TRAIL
42  2015 Elevation of cAMP Levels Inhibits Doxorubicin-Induced Apoptosis in Pre- B ALL NALM- 6 Cells Through Induction of BAD Phosphorylation and Inhibition of P53 Accumulation. IBMX, pre-B ALL
43  2015 Epstein-Barr virus miR-BART20-5p regulates cell proliferation and apoptosis by targeting BAD. 3'-UTR, BART, EBV, miRNAs
44  2015 Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status. ERK
45  2015 Melatonin Counteracts at a Transcriptional Level the Inflammatory and Apoptotic Response Secondary to Ischemic Brain Injury Induced by Middle Cerebral Artery Blockade in Aging Rats. Bax, Bcl-2, GFAP, IL-1beta, MCA, TNF-alpha
46  2014 Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line. Bax, Bcl-2, FADDR, IGF, IGF1R, PARP, PI3K, XIAP
47  2014 Curcumin induces apoptosis in human neuroblastoma cells via inhibition of AKT and Foxo3a nuclear translocation. HSP, NB
48  2014 Porphyromonas gingivalis modulates Pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the STAT3 signaling pathway. bcl-2, STAT3
49  2014 RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. Bax, Mcl-1
50  2014 The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function. Bak, Bax, Bcl-2, BH, Bim
51  2014 Xiaoji Decoction inhibited cell proliferation and induced apoptosis through Akt signaling pathway in human lung cancer A549 cells. MTT
52  2014 [Construction and expression of recombinant lentiviral vectors of AKT2,PDK1 and BAD]. PDK1
53  2013 Behavioral stress accelerates prostate cancer development in mice. ADRB2, PKI, PTEN-deficient
54  2013 Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer. MCL-1, PI3K, PSMA
55  2013 Comparison between axonal and retinal ganglion cell gene expression in various optic nerve injuries including glaucoma. Bax, Bcl-2, IAP, NMDA, ON, Thy-1, XIAP
56  2013 Phospho-GSK-3beta is involved in the high-glucose-mediated lipid deposition in renal tubular cells in diabetes. GSK-3beta, SREBP-1
57  2013 Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147. HUVECs, IHs, sh
58  2013 Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: early target in the anticancer strategy. COX-1, DMH, IL-1beta, JAK3, STAT3
59  2013 Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia. AR, Bcl-2, ERK, JNK, LNCaPH, PI3K, siRNA
60  2012 Mesenchymal stem cell transplantation improves regional cardiac remodeling following ovine infarction. ERK, MI, MSCs, pERK, PI3Kalpha, PLB, SERCA2a
61  2012 Sequential in-office vitreous aspirates demonstrate vitreous matrix metalloproteinase 9 levels correlate with the amount of subretinal fluid in eyes with wet age-related macular degeneration. AMD, IL, MMP-9, SRF
62  2012 The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain. Bcl-2, BDNF, CREB, FLX, OLZ
63  2012 Tounongsan extract induces apoptosis in cultured Raji cells. NF-kappaB, RT-PCR, TNSE
64  2011 Effect of growth hormone treatment on pancreatic inflammation, oxidative stress, and apoptosis related to aging in SAMP8 mice. Bax, Bcl-2, GH, IkappaB, IL-beta, iNOS, MCP-1, NOx, s.c, TNF-alpha, XIAP
65  2011 Major role of the PI3K/Akt pathway in ischemic tolerance induced by sublethal oxygen-glucose deprivation in cortical neurons in vitro. OGD
66  2011 Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. BH3, EPO, JNK1
67  2011 The Bcl-2 homology domain 3 (BH3) mimetic ABT-737 reveals the dynamic regulation of bad, a proapoptotic protein of the Bcl-2 family, by Bcl-xL. Bcl-2, Bcl-xL, BH3
68  2011 The Bcl-2-associated death promoter (BAD) lowers the threshold at which the Bcl-2-interacting domain death agonist (BID) triggers mitochondria disintegration. Bid
69  2008 17Beta-estradiol abrogates apoptosis in murine skeletal muscle cells through estrogen receptors: role of the phosphatidylinositol 3-kinase/Akt pathway. ER
70  2008 Cell death is associated with reduced base excision repair during chronic alcohol administration in adult rat brain. AIF, Bax, Bcl-2, NMDAR1, NMDAR2B, NMDAR2C, PARP-1, TdT
71  2008 Cell stress gives a red light to the mitochondrial cell death pathway. Bcl-2, IGFBP-1, PP1gamma
72  2008 Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart. I/R, PC
73  2008 Epidermal growth factor abrogates hypoxia-induced apoptosis in cultured human trophoblasts through phosphorylation of BAD Serine 112. EGF, GFP
74  2008 Mutant B-RAF mediates resistance to anoikis via Bad and Bim. Bim, MEK
75  2008 Overexpression of phospho-Akt correlates with phosphorylation of EGF receptor, FKHR and BAD in nasopharyngeal carcinoma. FKHR, NPC, pEGFR, PI3K
76  2008 P38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by Porphyromonas gingivalis conditioned medium. cyt c, P. gingivalis
77  2008 Selective induction of calcineurin activity and signaling by oligomeric amyloid beta. AD, CaN, CNS, CREB, pBAD
78  2007 Acute ethanol exposure inhibits insulin signaling in the liver. GSK3beta, IRS-1, PI3K
79  2007 Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling. ERK
80  2007 PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts. Chel, LY, PAR-2 AP, PAR2, PD, SP
81  2007 Reelin signals survival through Src-family kinases that inactivate BAD activity. S136A
82  2006 A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss. OHC
83  2006 Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways. bFGF, PI 3-kinase
84  2006 Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury. IR, MAPKs, PI3K, PKB, TUNEL, Z-Asp-cmk
85  2006 Role of calcineurin in Porphyromonas gingivalis-induced myocardial cell hypertrophy and apoptosis. NFAT, P. gingivalis
86  2006 The effect of phenotype on mechanical stretch-induced vascular smooth muscle cell apoptosis. VSMC
87  2005 Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection. AR, DHT, ERK, MAPK
88  2005 Inactivation of bad by site-specific phosphorylation: the checkpoint for ischemic astrocytes to initiate or resist apoptosis. MAPK/ERK
89  2005 Retinal ganglion cell death is delayed by activation of retinal intrinsic cell survival program. CREB, IOP
90  2004 Inactivating mutations of proapoptotic Bad gene in human colon cancers. ---
91  2003 Cytochalasin D disruption of actin filaments in 3T3 cells produces an anti-apoptotic response by activating gelatinase A extracellularly and initiating intracellular survival signals. CytoD, ERK, JNK, MMC, SAPK
92  2003 Interaction of 14-3-3 with Bid during seizure-induced neuronal death. Bid
93  2003 Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity. MAPK, PKC
94  2001 Lack of binding observed between human alpha-synuclein and Bcl-2 protein family. GST
95  1997 Expression and function of a proapoptotic Bcl-2 family member Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary. BH, mRNA