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Abbreviation : BMMs
Long Form : bone marrow macrophages
No. Year Title Co-occurring Abbreviation
2019 Ablation of Stabilin-1 Enhances Bone-Resorbing Activity in Osteoclasts In Vitro. Stab1 KO, WT
2019 Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of kappaB Kinase and Inflammasome-Mediated Interleukin-1beta Secretion. BMDMs, IKK, IL-1beta
2019 Bergapten suppresses RANKL-induced osteoclastogenesis and ovariectomy-induced osteoporosis via suppression of NF-kappaB and JNK signaling pathways. BP, RANKL
2019 Breast cancer cell-derived exosomal miR-20a-5p promotes the proliferation and differentiation of osteoclasts by targeting SRCIN1. ---
2019 C-Cbl negatively regulates TRAF6-mediated NF-kappaB activation by promoting K48-linked polyubiquitination of TRAF6. IFN-gamma, IKK, IL-1beta, NF-kappaB, RANKL, TNF-alpha, TRAF6
2019 CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages. ---
2019 Effect of local application of biphosphonates on improving peri-implant osseointegration in type-2 diabetic osteoporosis. BMSCs, BPs, T2DM
2019 Effect of ProRoot MTA and Biodentine on osteoclastic differentiation and activity of mouse bone marrow macrophages. ALD, BIOD, PMTA, TRAP
2019 High mobility group box 1 protein regulates osteoclastogenesis through direct actions on osteocytes and osteoclasts in vitro. CM, HMGB1, RAGE, TLR4
10  2019 Icariin inhibits RANKL-induced osteoclastogenesis via modulation of the NF-kappaB and MAPK signaling pathways. MAPK, NF-kappaB
11  2019 Inhibition of Osteoclastogenesis by Thioredoxin-Interacting Protein-Derived Peptide (TN13). HSCs, NFATc1, RANKL, TRAP
12  2019 Interleukin‑17A facilitates osteoclast differentiation and bone resorption via activation of autophagy in mouse bone marrow macrophages. TRAP
13  2019 Interval running training improves age-related skeletal muscle wasting and bone loss: Experiments with ovariectomized rats. BMPs, CR, IR, MAPKs, p-mTOR, RANKL, SIRTs
14  2019 Isorhamnetin attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through modulating reactive oxygen species homeostasis. ACLT, ISO, MAPK, NF-kappaB, OA, RANKL, ROS
15  2019 Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells. cKO, OC, Unc5b
16  2019 MiR-377 inhibits wear particle-induced osteolysis via targeting RANKL. CTSK, IL-6, PIO, RANKL, Ti, TNF-alpha, TRAP
17  2019 MOTS-c inhibits Osteolysis in the Mouse Calvaria by affecting osteocyte-osteoclast crosstalk and inhibiting inflammation. AMP, AMPK, OPG, PPARgamma, RANKL, UHMWPE
18  2019 MSU Crystals Enhance TDB-Mediated Inflammatory Macrophage IL-1beta Secretion. MSU, TDB
19  2019 Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment. HTRA1, OPG, RANKL
20  2019 Nirogacestat suppresses RANKL-Induced osteoclast formation in vitro and attenuates LPS-Induced bone resorption in vivo. CTR, CTSK, DC-STAMP, LPS, NFATc1, OCs, RANKL, TRAP
21  2019 Oleanolic acid exerts inhibitory effects on the late stage of osteoclastogenesis and prevents bone loss in osteoprotegerin knockout mice. CTSK, MMP9, NFATc1, OA, OPG, RANKL, TRAP
22  2019 Proanthocyanidins inhibit osteoclast formation and function by inhibiting the NF-kappaB and JNK signaling pathways during osteoporosis treatment. MAPK, PACs
23  2019 Role of ANTXR1 in the regulation of RANKL-induced osteoclast differentiation and function. ANTXR1, IkappaB, JNK, MMP-9, NFATc1, PLCgamma2, RANKL, VEGF-A
24  2019 Specific RANK Cytoplasmic Motifs Drive Osteoclastogenesis. CPPs, KI, M-CSF, Pg, RANKL, TNF
25  2019 Staphylococcus aureus Infects Osteoclasts and Replicates Intracellularly. OCs, OM, RANKL
26  2019 STAT3 controls osteoclast differentiation and bone homeostasis by regulating NFATc1 transcription. Ctsk-Cre, NFATc1, STAT3
27  2018 A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages. PTPN11, SHP2
28  2018 Alendronate induces osteoclast precursor apoptosis via peroxisomal dysfunction mediated ER stress. ALN, Bcl-2, CHOP, ER, FDPS, GRP, PDGF-BB, POC
29  2018 Binding of PICK1 PDZ domain with calcineurin B regulates osteoclast differentiation. NFAT
30  2018 Bisphosphonates hinder osteoblastic/osteoclastic differentiation in the maxillary sinus mucosa-derived stem cells. ALN, ALP, BPs, HMSMCs, RANKL, ZOL
31  2018 Comparative Characterization of Osteoclasts Derived From Murine Bone Marrow Macrophages and RAW 264.7 Cells Using Quantitative Proteomics. M-CSF, RANKL
32  2018 Desoxyrhapontigenin inhibits RANKL‑induced osteoclast formation and prevents inflammation‑mediated bone loss. DRG, LPS, NFATc1, RANKL
33  2018 Estrogen Deficiency-Mediated M2 Macrophage Osteoclastogenesis Contributes to M1/M2 Ratio Alteration in Ovariectomized Osteoporotic Mice. ERalpha, IFN-gamma, IL-4, LPS, RANKL
34  2018 Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation. CDK9
35  2018 FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-kappaB Activation and CXCL10 Expression. GEO
36  2018 Gentiopicroside inhibits RANKL-induced osteoclastogenesis by regulating NF-kappaB and JNK signaling pathways. RANKL
37  2018 Gypenoside inhibits RANKL-induced osteoclastogenesis by regulating NF-kappaB, AKT, and MAPK signaling pathways. GP, RANKL
38  2018 Histone Demethylase Jmjd7 Negatively Regulates Differentiation of Osteoclast. ChIP, Jmjd7, M-CSF, qRT-PCR
39  2018 Inhibitory activity of linarin on osteoclastogenesis through receptor activator of nuclear factor kappaB ligand-induced NF-kappaB pathway. NF-kappaB, NFATc1, OSCAR, RANKL, TRAP
40  2018 Inhibitory Effect of Purpurogallin on Osteoclast Differentiation in Vitro through the Downregulation of c-Fos and NFATc1. BCL6, Blimp-1, CTSK, IRF8, RANKL, TRAP
41  2018 Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype. IL, UHMWPE
42  2018 Monocrotaline Suppresses RANKL-Induced Osteoclastogenesis In Vitro and Prevents LPS-Induced Bone Loss In Vivo. Mon, TRAP
43  2018 Naringenin inhibits osteoclastogenesis through modulation of helper T cells-secreted IL-4. NAR
44  2018 Oleanolic acid exerts bone protective effects in ovariectomized mice by inhibiting osteoclastogenesis. CTSK, LPS, MMP9, NFATc1, OA, POP, RANKL, TRAP
45  2018 PoligoniMultiflori Radix enhances osteoblast formation and reduces osteoclast differentiation. ALP, LPS, PMR, RANKL, TRAP
46  2018 Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-kappaB pathway. c-Fos, CTSK, MMP-9, NFATc1, RBM
47  2018 Silencing LAIR-1 in human THP-1 macrophage increases foam cell formation by modulating PPARgamma and M2 polarization. CREB, LAIR-1, oxLDL, PPARgamma
48  2018 The inhibition of malignant melanoma cell invasion of bone by the TLR7 agonist R848 is dependent upon pro-inflammatory cytokines produced by bone marrow macrophages. TLRs
49  2018 The naturally derived small compound Osthole inhibits osteoclastogenesis to prevent ovariectomy-induced bone loss in mice. CTSK, MMP9, NFATc1, OT, RANKL, TRAP
50  2018 The systemic bone protective effects of Gushukang granules in ovariectomized mice by inhibiting osteoclastogenesis and stimulating osteoblastogenesis. ALP, CTSK, GSK, MMP9, MSCs, NFATc1, POP, RANKL, TCM
51  2018 Titanium particle‑mediated osteoclastogenesis may be attenuated via bidirectional ephrin‑B2/eph‑B4 signaling invitro. MMP9, NFATc1, Ti, TRAP
52  2018 Toll-like receptor 2 activation primes and upregulates osteoclastogenesis via lox-1. BMCs, FACS, LOX-1, LPS, MAPK, MyD88, OCs, oxLDL, PCR, RANKL, TLR, TRAP
53  2018 Various roles of heme oxygenase-1 in response of bone marrow macrophages to RANKL and in the early stage of osteoclastogenesis. CoPPIX, HO-1, OCLs
54  2017 25-hydroxycholesterol promotes RANKL-induced osteoclastogenesis through coordinating NFATc1 and Sp1 complex in the transcription of miR-139-5p. 25-HC, M-CSF, NFATc1, RANKL
55  2017 Afatinib ameliorates osteoclast differentiation and function through downregulation of RANK signaling pathways. EGF-TK, NSCLC, RANK
56  2017 AG490 suppresses interleukin-34-mediated osteoclastogenesis in mice bone marrow macrophages. IL-34, M-CSF, RANKL
57  2017 alpha-Linolenic Acid Inhibits Receptor Activator of NF-kappaB Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible Nitric Oxide Synthases (NF-kappaB-iNOS) Signaling Pathways. ALA, NF-kappaB-iNOS, RANKL-Induced
58  2017 Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis via induction of Nrf2 and suppression of NF-kappaB and MAPK signalling. BMC, BMD, CA, LPS, Nrf2, RANKL, Tb.Sp, Tb.Th, TRAP
59  2017 Catabolic Effects of Human PTH (1-34) on Bone: Requirement of Monocyte Chemoattractant Protein-1 in Murine Model of Hyperparathyroidism. MCP-1, PTH, WT
60  2017 Clinically Relevant Concentrations of Ketamine Inhibit Osteoclast Formation In Vitro in Mouse Bone Marrow Cultures. BMs, M-CSF, NFATc1, NMDARs, OCs, RANKL
61  2017 DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation. OC, RANKL, ROS
62  2017 Fluvastatin Inhibits Osteoclast Differentiation and Porphyromonas gingivalis Lipopolysaccharide-Induced Alveolar Bone Erosion in Mice. LPS, Pg, RANKL
63  2017 Fullerenol nanoparticles suppress RANKL-induced osteoclastogenesis by inhibiting differentiation and maturation. M-CSF, MAPK, NF
64  2017 Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors. OSM, RANKL, TRAP
65  2017 Kaempferide Prevents Titanium Particle Induced Osteolysis by Suppressing JNK Activation during Osteoclast Formation. CTR, KF
66  2017 NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-kappaB Signaling During Osteoclastogenesis. NUMBL, WT
67  2017 Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. PI, TRAP
68  2017 Sappanone A inhibits RANKL-induced osteoclastogenesis in BMMs and prevents inflammation-mediated bone loss. DC-STAMP, GSK-3beta, LPS, MAPKs, NFATc1, OSCAR, RANKL, SPNA
69  2017 Sophorae Flos extract inhibits RANKL-induced osteoclast differentiation by suppressing the NF-kappaB/NFATc1 pathway in mouse bone marrow cells. NFATc1, RANKL, SF, SFE, TRAP
70  2017 The Mincle ligand trehalose dibehenate differentially modulates M1-like and M2-like macrophage phenotype and function via Syk signaling. TDB
71  2016 Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing. FACS, INF-gamma, LPS
72  2016 Deficiency of Lipocalin-2 Promotes Proliferation and Differentiation of Osteoclast Precursors via Regulation of c-Fms Expression and Nuclear Factor-kappa B Activation. BrdU, ELISA, LCN2, M-CSF, NFATc1, RANKL, TRAP
73  2016 Dual effect of WIN-34B on osteogenesis and osteoclastogenesis in cytokine-induced mesenchymal stem cells and bone marrow cells. ALP, ERK, GAPDH, hMSCs, IkappaBalpha, IL, JNK, M-CSF, MAPK, NF-kappaB, OPG, RANKL, RT-PCR, TRAP
74  2016 Echinocystic acid inhibits RANKL-induced osteoclastogenesis by regulating NF-kappaB and ERK signaling pathways. EA, RANKL
75  2016 Enhanced M2 macrophage polarization in high n-3 polyunsaturated fatty acid transgenic mice fed a high-fat diet. HFD, WT
76  2016 Ethanolic extract of Schizonepeta tenuifolia attenuates osteoclast formation and activation in vitro and protects against lipopolysaccharide-induced bone loss in vivo. EEST, F-actin, LPS, NFATc1, RANKL
77  2016 Gingival epithelial cells support osteoclastogenesis by producing receptor activator of nuclear factor kappa B ligand via protein kinase A signaling. GECs, RANKL
78  2016 HDAC2 regulates FoxO1 during RANKL-induced osteoclastogenesis. FOXO1, HDAC2, OC, RANKL
79  2016 Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation. HSCs
80  2016 Polycan suppresses osteoclast differentiation and titanium particle-induced osteolysis in mice. IL, M-CSF, RANKL, Ti
81  2016 Prostaglandin-mediated inhibition of PTH-stimulated beta-catenin signaling in osteoblasts by bone marrow macrophages. CM, COX-2, KO, PKA, POBs, SAA, WT
82  2016 Protocatechuic Acid Attenuates Osteoclastogenesis by Downregulating JNK/c-Fos/NFATc1 Signaling and Prevents Inflammatory Bone Loss in Mice. NFATc1, PCA, RANKL
83  2016 Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts. CM, FPR2, KO, POBs, PTH, PTX, RANKL
84  2016 Tatarinan O, a lignin-like compound from the roots of Acorus tatarinowii Schott inhibits osteoclast differentiation through suppressing the expression of c-Fos and NFATc1. OC, TO
85  2016 Thymus-expressed chemokine enhances Porphyromonas gingivalis LPS-induced osteoclast formation via NFATc1 activation. RTPCR
86  2016 Transcriptional Modulator Ifrd1 Regulates Osteoclast Differentiation through Enhancing the NF-kappaB/NFATc1 Pathway. Ifrd1, NF-kappaB, NFATc1
87  2016 Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-beta1 by Regulatory T Cells. RA
88  2016 Xanthotoxin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis. DCFH-DA, NFATc1, RANKL, ROS, TRAP, XAT
89  2015 17-Hydroxy-jolkinolide A inhibits osteoclast differentiation through suppressing the activation of NF-kappaB and MAPKs. CTSK, HJA, MNCs, OC, TRAP
90  2015 Berberine Sulfate Attenuates Osteoclast Differentiation through RANKL Induced NF-kappaB and NFAT Pathways. CTSK, NFATc1, V-ATPase d2
91  2015 Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-kappaB. CTSK, TRAP
92  2015 CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo. AMPK, NF-kappaB, OPG, TNF
93  2015 Diacylglycerol Kinase zeta (DGKzeta) Is a Critical Regulator of Bone Homeostasis Via Modulation of c-Fos Levels in Osteoclasts. DAG, DGKs, DGKzeta, M-CSF, OCs, RANK, RANKL
94  2015 Donepezil prevents RANK-induced bone loss via inhibition of osteoclast differentiation by downregulating acetylcholinesterase. AChE, RANKL, TRAP
95  2015 Effect of BioAggregate on osteoclast differentiation and inflammatory bone resorption in vivo. LPS, MTA, TRAP
96  2015 Eriodicyol inhibits osteoclast differentiation and ovariectomy-induced bone loss in vivo. NFAT, RANKL
97  2015 Harpagoside Inhibits RANKL-Induced Osteoclastogenesis via Syk-Btk-PLCgamma2-Ca(2+) Signaling Pathway and Prevents Inflammation-Mediated Bone Loss. ERK, F-actin, HAR, JNK, LPS, NFATc1, RANKL
98  2015 Inhibitory Effects of KP-A159, a Thiazolopyridine Derivative, on Osteoclast Differentiation, Function, and Inflammatory Bone Loss via Suppression of RANKL-Induced MAP Kinase Signaling Pathway. CTSK, ERK, JNK, LPS, M-CSF, Mmp9, Nfatc1, RANKL, TRAP
99  2015 Inhibitory effects of triptolide on titanium particle-induced osteolysis and receptor activator of nuclear factor-kappaB ligand-mediated osteoclast differentiation. RANKL, Ti
100  2015 Invitro anti-osteoclastogenic activity of p38 inhibitor doramapimod via inhibiting migration of pre-osteoclasts and NFATc1 activity. ---