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Abbreviation : BZR
Long Form : benzodiazepine receptor
No. Year Title Co-occurring Abbreviation
2018 Functional neuroimaging in Rasmussen syndrome. CBF, EEG, FDG-PET, IOAE, MRI, RS
2017 Dual Isotope SPECT Study With Epilepsy Patients Using Semiconductor SPECT System. ---
2017 I-123 iomazenil single photon emission computed tomography for detecting loss of neuronal integrity in patients with traumatic brain injury. BPND, FMZ, IMZ, LPR, PET, SPECT, TBI
2014 In vivo pharmacological characterization of AC-3933, a benzodiazepine receptor partial inverse agonist for the treatment of Alzheimer's disease. EEG
2014 Pharmacological properties of AC-3933, a novel benzodiazepine receptor partial inverse agonist. ACh
2013 Cortical neuron loss in post-traumatic higher brain dysfunction using (123)I-iomazenil SPECT. ACG, HBD, IMZ, MFG, mTBI, SEE
2013 Search for alpha3beta₂/₃gamma2 subtype selective ligands that are stable on human liver microsomes. ---
2012 From the pharmacophore to the homology model of the benzodiazepine receptor: the indolyglyoxylamides affair. ---
2012 Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein. TSPO
10  2009 Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. GABAA
11  2008 Classification of drug molecules considering their IC50 values using mixed-integer linear programming based hyper-boxes method. AChE, COX-2, DHFR
12  2008 Quantitative structure-activity relationship studies of a series of non-benzodiazepine structural ligands binding to benzodiazepine receptor. HM, RBFNN
13  2008 Residual effect of a 7-amino metabolite of clonazepam on GABAA receptor function in the nucleus reticularis thalami of the rat. ACZP, CZP, NRT
14  2007 5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists. ARs
15  2007 Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands. ---
16  2007 Selective neuronal damage and chronic hemodynamic cerebral ischemia. MCA, OEF
17  2007 Use of a novel mouse genotype to model acute benzodiazepine withdrawal. ---
18  2006 Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides. ---
19  2005 Benzodiazepine effect of (125)I-iomazenil-benzodiazepine receptor binding and serum corticosterone level in a rat model. SUV
20  2005 High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives. PTBTs
21  2005 Preparation of highly specific radioactivity [18F]flumazenil and its evaluation in cynomolgus monkey by positron emission tomography. NCA
22  2005 Selective neuronal damage and borderzone infarction in carotid artery occlusive disease: a 11C-flumazenil PET study. BP, ICA
23  2004 Benzodiazepine receptor distribution in severe intractable tinnitus. GABA, SPECT
24  2004 Comparative quantitative structure-activity relationship studies (QSAR) on non-benzodiazepine compounds binding to benzodiazepine receptor (BzR). QSAR
25  2003 Geometrically constrained analogues of N-benzylindolylglyoxylylamides: [1, 2, 4]triazino[4, 3-a]benzimidazol-4(10H)-one derivatives as potential new ligands at the benzodiazepine receptor. ---
26  2003 High affinity central benzodiazepine receptor ligands. Part 3: insights into the pharmacophore and pattern recognition study of intrinsic activities of pyrazolo[4,3-c]quinolin-3-ones. k-NN, LDA, PQs
27  2003 Increased regional cerebral blood flow but normal distribution of GABAA receptor in the visual cortex of subjects with early-onset blindness. ---
28  2003 Sensitivities of benzodiazepine receptor binding and muscarinic acetylcholine receptor binding for the detection of neural cell death caused by sodium nitroprusside microinjection in rat brain. mAChR, SNP
29  2003 Spline-fitting with a genetic algorithm: a method for developing classification structure-activity relationships. COX-2, DHFR, ER, MAO, RP, SIMCA
30  2002 125I-iomazenil-benzodiazepine receptor binding during psychological stress in rats. 125I-IMZ
31  2002 Impaired benzodiazepine receptor binding in peri-lesional cortex of patients with symptomatic epilepsies studied by [(11)C]-flumazenil PET. MRI, ROIs
32  2002 The correlation between cerebral glucose metabolism and benzodiazepine receptor density in the acute vegetative state. FDG, FMZ, PET
33  2001 3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists. A1AR, ATBI
34  2001 Decreased benzodiazepine receptor density in the cerebellum of early blind human subjects. ---
35  2001 Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. ---
36  2000 3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: tricyclic heteroaromatic derivatives as a new class of benzodiazepine receptor ligands. ---
37  2000 Atrophy of the corpus callosum associated with a decrease in cortical benzodiazepine receptor in large cerebral arterial occlusive diseases. IMZ
38  2000 Attenuation of the bidirectional effects of chlordiazepoxide and FG 7142 on conditioned response suppression and associated cardiovascular reactivity by loss of cortical cholinergic inputs. CDP, CS
39  2000 Benzodiazepine receptor distribution and cerebral blood flow in early blindness--a PET study. EB, SC
40  2000 Effect of chronic (-)-nicotine treatment on rat cerebral benzodiazepine receptors. ---
41  2000 Interictal hippocampal benzodiazepine receptors in temporal lobe epilepsy: comparison with coregistered hippocampal metabolism and volumetry. FMZ, MRI, PET, TLE, VOI
42  2000 Intrasubject correlation between static scan and distribution volume images for [11C]flumazenil PET. DV, FMZ
43  2000 Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones: a new class of GABA(A) brain receptor ligands. ---
44  1999 Basal forebrain afferent projections modulating cortical acetylcholine, attention, and implications for neuropsychiatric disorders. ACh, DA, NAc
45  1999 Benzodiazepine receptor imaging with iomazenil SPECT in aphasic patients with cerebral infarction. CBF, IMP, ROIs
46  1999 Benzodiazepine receptor ligands. 4. Synthesis and pharmacological evaluation of 3-heteroaryl-8-chloropyrazolo[5,1-c][1,2,4] benzotriazine 5-oxides. ---
47  1999 Benzodiazepine receptor ligands. III. Synthesis and biological evaluation of 2- and/or 3-substituted pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides. ---
48  1999 Cerebellar reorganization following cortical injury in humans: effects of lesion size and age. CCD, FDG, FMZ
49  1999 Preserved benzodiazepine receptors in Alzheimer's disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF. AD, CBF, FMZ, IMZ, MMS
50  1999 Studies of molecular pharmacophore/receptor models for GABAA/benzodiazepine receptor subtypes: binding affinities of substituted beta-carbolines at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis. CoMFA
51  1999 Synthesis and evaluation of [123I]labelled analogues of the partial inverse agonist Ro 15-4513 for the study of diazepam-insensitive benzodiazepine receptors. DI, DS
52  1998 3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists. AMPA, SAR
53  1998 Antineophobic effect of the neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one in male rats. ---
54  1998 Antiproliferative and differentiating effects of benzodiazepine receptor ligands on B16 melanoma cells. ---
55  1998 Binding profiles and physical dependence liabilities of selected benzodiazepine receptor ligands. ---
56  1998 Cardiovascular and somatic startle and defense: concordant and discordant actions of benzodiazepine receptor agonists and inverse agonists. ---
57  1998 Characterization of neuronal damage by iomazenil binding and cerebral blood flow in an ischemic rat model. CBF, HE, TTC
58  1998 Effects of benzodiazepine receptor ligands on the ingestion of sucrose, intralipid, and maltodextrin: an investigation using a microstructural analysis of licking behavior in a brief contact test. ---
59  1998 Food intake in Prader-Willi syndrome and controls with obesity after administration of a benzodiazepine receptor agonist. PWS
60  1998 Permanent cortical damage detected by flumazenil positron emission tomography in acute stroke. FMZ, OEF
61  1997 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. AMPA, NMDA
62  1997 Alterations of benzodiazepine receptor binding potential in anxiety and somatoform disorders measured by 123I-iomazenil SPECT. BP, IMZ
63  1997 Assessment of benzodiazepine receptors using iodine-123-labeled iomazenil single-photon emission computed tomography in patients with ischemic cerebrovascular disease. A comparison with PET study. CBF, CMRglc, IMZ, SPECT
64  1997 Cerebral benzodiazepine receptor binding in vivo in patients with recurrent hepatic encephalopathy. FMZ, HE, PET
65  1997 Presurgical identification of epileptic foci with iodine-123 iomazenil SPET: comparison with brain perfusion SPET and FDG PET. BP, FDG, IMZ, PET, SPET
66  1997 The cardiovascular startle response: anxiety and the benzodiazepine receptor complex. ---
67  1997 Trans-synaptic stimulation of cortical acetylcholine and enhancement of attentional functions: a rational approach for the development of cognition enhancers. ---
68  1997 Tricyclic heteroaromatic systems. 1,2,4-triazolo[4,3-a]quinoxalines and 1,2,4-Triazino[4,3-a]quinoxalines: synthesis and central benzodiazepine receptor activity. ---
69  1997 Tricyclic heteroaromatic systems. Pyrazolo[3,4-c]quinolin-4-ones and pyrazolo[3,4-c]quinoline-1,4-diones: synthesis and benzodiazepine receptor activity. ---
70  1997 Widespread functional deficits in perception-related networks demonstrated by PET in a case with simple visual seizures. FDG, MRI, PET
71  1997 [Functional MRI employing diazepam; a proposal of neuropharmacological fMRI]. GABA
72  1997 [Intrathecal midazolam attenuates renal sympathetic nerve activity in rabbits]. HR, i.t, IRSNA, MAP, RSNA
73  1996 A central cholinergic link in the cardiovascular effects of the benzodiazepine receptor partial inverse agonist FG 7142. i.c.v
74  1996 Benzodiazepine antagonists reduce epileptiform discharges in rat hippocampal slices. beta-CCP, DMCM
75  1996 Effects of benzodiazepine receptor inverse agonists and nicotine on behavioral vigilance in senescent rats. ---
76  1996 Heterogeneous distribution of benzodiazepine receptors among rat neostriatal neurones. ---
77  1996 Neuronal mechanisms mediating drug-induced cognition enhancement: cognitive activity as a necessary intervening variable. ACh
78  1996 Reduction of 123I-iomazenil uptake in haemodynamically and metabolically impaired brain areas in patients with cerebrovascular disease. CBF, CVD, OEF, PET, SPET
79  1996 Structure-activity relationship studies of novel pyrazolo[1,5-c][1,3]benzoxazines: synthesis and benzodiazepine receptor affinity. ---
80  1996 Structure-activity relationships of 2-aryl-2,5-dihydropyridazino [4,3-b]indol-3(3H)-ones at the benzodiazepine receptor. PQ
81  1996 Synthesis, structure-activity relationships, and molecular modeling studies of N-(indol-3-ylglyoxylyl)benzylamine derivatives acting at the benzodiazepine receptor. ---
82  1996 Trans-synaptic stimulation of cortical acetylcholine release after partial 192 IgG-saporin-induced loss of cortical cholinergic afferents. ACh
83  1996 Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. beta-CCM, GABA
84  1996 [A phase 3 clinical trial of 123I-iomazenil, a new central-type benzodiazepine receptor imaging agent (Part 1)--report on clinical usefulness in diagnosis of various brain diseases]. IMZ
85  1996 [A phase 3 clinical trial of 123I-iomazenil, a new central-type benzodiazepine receptor imaging agent (Part 2)--Report on clinical usefulness in diagnosis of degenerative neurological diseases and mental disorders]. CBF, IMZ
86  1996 [A phase 3 clinical trial of 123I-iomazenil, a new central-type benzodiazepine receptor imaging agent (Part 3)--Report on clinical usefulness in epilepsy]. CBF, IMZ
87  1996 [Benzodiazepine receptor and cerebral blood flow in early Alzheimer's disease--SPECT study using 123I-iomazenil and 123I-IMP]. CBF, IMZ
88  1996 [Impairment of benzodiazepine receptor in Parkinson's disease evaluated by 123I-iomazenil SPECT]. BPI, PD
89  1996 [Phase 2 clinical study of 123I-iomazenil in various cerebral diseases: part 1--examination of injection dose and clinical indications]. CVD, IMZ, rCBF
90  1995 Behavioral vigilance in rats: task validation and effects of age, amphetamine, and benzodiazepine receptor ligands. CDP
91  1995 Bidirectional modulation of cortical acetylcholine efflux by infusion of benzodiazepine receptor ligands into the basal forebrain. ACh
92  1995 Comparison of benzodiazepine receptor ligands with partial agonistic, antagonistic or partial inverse agonistic properties in precipitating withdrawal in squirrel monkeys. ---
93  1995 Computer-aided molecular modeling, synthesis, and biological evaluation of 8-(benzyloxy)-2-phenylpyrazolo[4,3-c]quinoline as a novel benzodiazepine receptor agonist ligand. ---
94  1995 Contribution of "diazepam-insensitive" GABAA receptors to the alcohol antagonist properties of Ro 15-4513 and related imidazobenzodiazepines. DI, DS
95  1995 Development of a comprehensive pharmacophore model for the benzodiazepine receptor. ---
96  1995 Differential effects of flumazenil in alcoholic and nonalcoholic cirrhotic patients. ---
97  1995 Dissociation between the attentional effects of infusions of a benzodiazepine receptor agonist and an inverse agonist into the basal forebrain. ACh, CDP
98  1995 Double dissociation between the effects of muscarinic antagonists and benzodiazepine receptor agonists on the acquisition and retention of passive avoidance. ---
99  1995 Effects of benzodiazepine receptor partial inverse agonists in the elevated plus maze test of anxiety in the rat. PTZ
100  1995 Effects of chlordiazepoxide and scopolamine, but not aging, on the detection and identification of conditional visual stimuli. CDP