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Abbreviation : CADs
Long Form : cationic amphiphilic drugs
No. Year Title Co-occurring Abbreviation
2019 Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone. PLD
2018 Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs. PFASs, PFBS, PFHxA, PFOA
2018 Derivatization of common antidepressant drugs increases inhibition of acid sphingomyelinase and reduces induction of phospholipidosis. ASM, FIASMAs, MDD, PLD
2018 Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone. DIPL
2018 Lysosomotropic cationic amphiphilic drugs inhibit adipocyte differentiation in 3T3-L1K cells via accumulation in cells and phospholipid membranes, and inhibition of autophagy. ---
2018 Repurposing cationic amphiphilic drugs as adjuvants to induce lysosomal siRNA escape in nanogel transfected cells. NPs
2017 Antiviral activity of cationic amphiphilic drugs. ---
2017 From the Cover: Potentiation of Drug-Induced Phospholipidosis In Vitro through PEGlyated Graphene Oxide as the Nanocarrier. DIP, LAMP2, PEG-GO, PLD
2017 Hydrophilic interaction chromatography with a focus on the drug-phosphate interaction in drug screening to determine the phospholipidosis induction risk. HILIC
10  2017 New insights into the intracellular distribution pattern of cationic amphiphilic drugs. ---
11  2017 Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium. FDA, SERMs
12  2016 Detachment of surface membrane invagination systems by cationic amphiphilic drugs. DMS
13  2016 Discovery of Small Molecules That Induce Lysosomal Cell Death in Cancer Cell Lines Using an Image-Based Screening Platform. Gal-3, HT, LCD
14  2015 Cationic amphiphilic drugs enhance entry of lentiviral particles pseudotyped with rabies virus glycoprotein into non-neuronal cells. RABV
15  2015 Evaluating the risk of phospholipidosis using a new multidisciplinary pipeline approach. PLD
16  2014 Determination of the cationic amphiphilic drug-DNA binding mode and DNA-assisted fluorescence resonance energy transfer amplification. AMT, EB, FRET, IMP, PMT
17  2014 Maintenance of luminal pH and protease activity in lysosomes/late endosomes by vacuolar ATPase in chlorpromazine-treated RAW264 cells accumulating phospholipids. CPZ, vATPase
18  2013 Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs. ---
19  2013 pH-gradient PAMPA-based in vitro model assay for drug-induced phospholipidosis in early stage of drug discovery. PLD
20  2011 Cellular responses associated with dibucaine-induced phospholipidosis. ---
21  2011 In Silico Studies of the Relationship Between Chemical Structure and Drug Induced Phospholipidosis. PLD
22  2011 Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization. LMP, ROS
23  2010 Phospholipidosis in healthy subjects participating in clinical studies: ultrastructural findings in white blood cells. FDA
24  2010 Prediction of phospholipidosis-inducing potential of drugs by in vitro biochemical and physicochemical assays followed by multivariate analysis. ---
25  2009 Characterization of the phospholipidogenic potential of 4(1H)-pyridone antimalarial derivatives. PLD
26  2008 Drug-induced phospholipidosis is caused by blockade of mannose 6-phosphate receptor-mediated targeting of lysosomal enzymes. PLD
27  2008 Monitoring the accumulation of fluorescently labeled phospholipids in cell cultures provides an accurate screen for drugs that induce phospholipidosis. PLD
28  2008 Proteomic analysis of phospholipidosis in citalopram treated U937 cells--support for the cholesterol biosynthesis hypothesis. HMGCS1, PL, TEM
29  2007 A role for lysosomal phospholipase A2 in drug induced phospholipidosis. ---
30  2006 Degradative transport of cationic amphiphilic drugs across phospholipid bilayers. ---
31  2005 Induction of apoptosis by cationic amphiphilic drugs amiodarone and imipramine. ---
32  2004 Alpha-tocopherol influences the lipid membrane affinity of desipramine in a pH-dependent manner. alpha-TocAc, PhC, PhI, PMC
33  2003 A cell-based approach for the early assessment of the phospholipidogenic potential in pharmaceutical research and drug development. EM
34  2001 Drug-induced phospholipidosis: are there functional consequences? ---
35  1997 Amiodarone induces two different types of disorders in mouse alveolar macrophages. ---
36  1997 Cationic amphiphilic drug-induced phospholipidosis. ---
37  1996 Inhibition by vitamin E of drug accumulation and of phospholipidosis induced by desipramine and other cationic amphiphilic drugs in human cultured cells. alpha-Toc, PL
38  1995 Biochemical and functional analysis of rat bronchoalveolar macrophages containing chemically induced phospholipid inclusions. AM, PL, SC
39  1995 Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP. CT, Rh
40  1995 Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance. ASMase, DOX, MDR, Rho-123, VBL
41  1991 Effects of drugs on cholesterol esterification in normal and Niemann-Pick type C fibroblasts: AY-9944, other cationic amphiphilic drugs and DMSO. NPC
42  1981 Alterations of phospholipid metabolism in rat cerebral cortex mince induced by cationic amphiphilic drugs. ---