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Abbreviation : CAVD
Long Form : Calcific aortic valve disease
No. Year Title Co-occurring Abbreviation
2020 AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-beta1 and BMPR2 signaling. AGEs, ALP, alpha-SMA, EndMT, TGF-beta1, VE-cadherin
2020 Aldo-keto reductase family 1 member B induces aortic valve calcification by activating hippo signaling in valvular interstitial cells. Akr1B1, RNA-Seq
2020 AntagomiR-29b inhibits vascular and valvular calcification and improves heart function in rats. ALP
2020 Antibody microarray analysis of serum inflammatory cytokines in patients with calcific aortic valve disease. BLC, CAD, IL, MIG, MIP
2020 Bench to bedside defining calcific aortic valve disease: osteocardiology. ---
2020 Caffeic Acid Phenethyl Ester Ameliorates Calcification by Inhibiting Activation of the AKT/NF-kappaB/NLRP3 Inflammasome Pathway in Human Aortic Valve Interstitial Cells. AVICs, CAPE, DEGs, OM
2020 Calcific Aortic Valve Disease-Natural History and Future Therapeutic Strategies. ---
2020 Celastrol Alleviates Aortic Valve Calcification Via Inhibition of NADPH Oxidase 2 in Valvular Interstitial Cells. AVICs, NOX2, ROS
2020 Cell-Type Transcriptome Atlas of Human Aortic Valves Reveal Cell Heterogeneity and Endothelial to Mesenchymal Transition Involved in Calcific Aortic Valve Disease. ---
10  2020 CircRNA TGFBR2/MiR-25-3p/TWIST1 axis regulates osteoblast differentiation of human aortic valve interstitial cells. ALP, VICs
11  2020 Correlations between lipoprotein(a) gene polymorphisms and calcific aortic valve disease and coronary heart disease in Han Chinese. CHD, LPA
12  2020 Curcumin inhibits calcification of human aortic valve interstitial cells by interfering NF-kappaB, AKT, and ERK pathways. CCM, hVICs, OM
13  2020 Endothelial-to-Mesenchymal Transition in Calcific Aortic Valve Disease. EndMT, VECs
14  2020 Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017. DALYs, DMVD, GBD, NRVDs, UI
15  2020 Identification of a peripheral blood gene signature predicting aortic valve calcification. ---
16  2020 Identification of key genes in calcific aortic valve disease by integrated bioinformatics analysis. DEGs, ECM, MCC, PPI
17  2020 Inhibition of PP2A enhances the osteogenic differentiation of human aortic valvular interstitial cells via ERK and p38 MAPK pathways. RT-PCR, VICs
18  2020 Inorganic phosphate-osteogenic induction medium promotes osteogenic differentiation of valvular interstitial cells via the BMP-2/Smad1/5/9 and RhoA/ROCK-1 signaling pathways. IP-OIM, OIM, VICs
19  2020 Integrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like Deposits. A2M, ApoA1, APP, HBB, IGKC, ITIH3, LBP, miRNA, SERPINA1, Tf, TGFBI, TTR
20  2020 Interleukin 37 Suppresses M1 Macrophage Polarization Through Inhibition of the Notch1 and Nuclear Factor Kappa B Pathways. IFN-gamma, IL-37, iNOS, LPS, MCP-1, NF-kappaB, PMA
21  2020 Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression. TPEF, VICs
22  2020 Lipoprotein(a): Expanding Our Knowledge of Aortic Valve Narrowing. AS, ASCVD
23  2020 Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells. AVICs, ECM, PKR, TLR
24  2020 Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells. DPP4, HCD
25  2020 MicroRNA-34c Inhibits Osteogenic Differentiation and Valvular Interstitial Cell Calcification via STC1-Mediated JNK Pathway in Calcific Aortic Valve Disease. ALP, BMP2, JNK, VICs
26  2020 Molecular mechanisms involved in high glucose-induced valve calcification in a 3D valve model with human valvular cells. BMP, ECM, HG, MMPs, NG, VEC, VIC
27  2020 Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level. AVICs, TLRs
28  2020 Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells. sh, VIC
29  2020 NFkappaB (Nuclear Factor kappa-Light-Chain Enhancer of Activated B Cells) Activity Regulates Cell-Type-Specific and Context-Specific Susceptibility to Calcification in the Aortic Valve. ---
30  2020 Nucleotide ecto-enzyme metabolic pattern and spatial distribution in calcific aortic valve disease; its relation to pathological changes and clinical presentation. ---
31  2020 Plasma lipoprotein(a) concentration as an independent predictor of hemodynamic progression of aortic valve stenosis. ---
32  2020 Potential role of full-length and nonfull-length progranulin in affecting aortic valve calcification. AV, hVICs, OM, PGRN, pVICs, WT
33  2020 Quantifying Apolipoprotein(a) in the era of Proteoforms and Precision Medicine. ASCVD
34  2020 Sex-differences in echocardiographic assessment of aortic valve in young adult LDLr-/-/ApoB100/100/IGF-II+/- mice. ---
35  2020 Sex-Specific Features of Calcific Aortic Valve Disease. AS
36  2020 Statin treatment of patients with calcific aortic valve disease modulates extracellular adenosine metabolism on the cell surface of the aortic valve. E-ADA
37  2020 The dedicated "Lp(a) clinic": A concept whose time has arrived? CVD
38  2020 The impact of altered mechanobiology on aortic valve pathophysiology. ---
39  2020 The natural compound andrographolide inhibits human aortic valve interstitial cell calcification via the NF-kappa B/Akt/ERK pathway. AGP, DEGs, hVICs, OM, VICs
40  2020 The role of stress concentration in calcified bicuspid aortic valve. ATC, BAV, FE
41  2020 The Ryanodine Receptor Contributes to the Lysophosphatidylcholine-Induced Mineralization in Valvular Interstitial Cells. VICs
42  2020 TLR4 Stimulation Promotes Human AVIC Fibrogenic Activity through Upregulation of Neurotrophin 3 Production. AVIC, ECM, MMP-9, NT-3, Trk
43  2020 Transforming growth factor-beta1 promotes fibrosis but attenuates calcification of valvular tissue applied as three-dimensional calcific aortic valve disease model. VICs
44  2020 Ultrastructural Pathology of Atherosclerosis, Calcific Aortic Valve Disease, and Bioprosthetic Heart Valve Degeneration: Commonalities and Differences. ECM
45  2020 Upregulation of microRNA-195 ameliorates calcific aortic valve disease by inhibiting VWF via suppression of the p38-MAPK signaling pathway. AVICs, DEGs, miRNAs
46  2019 Activation of the calcium-sensing receptor in human valvular interstitial cells promotes calcification. CaSR, hVICs
47  2019 Adaptive immune cells in calcific aortic valve disease. ---
48  2019 Association Between Serum Leptin Level and Calcific Aortic Valve Disease. ---
49  2019 Autotaxin and Lipoprotein Metabolism in Calcific Aortic Valve Disease. ATX, GWA, lysoPA, MR, OxPLs, PLPP3, VICs
50  2019 Biomechanical modeling of transcatheter aortic valve replacement in a stenotic bicuspid aortic valve: deployments and paravalvular leakage. BAV, PVL, TAVR
51  2019 Calcification and extracellular matrix dysregulation in human postmortem and surgical aortic valves. AoV, AS, ECM
52  2019 Cardiovascular Effects and Molecular Mechanisms of Bisphenol A and Its Metabolite MBP in Zebrafish. BPA, ECM, ERE
53  2019 CC chemokine receptor 2 functions in osteoblastic transformation of valvular interstitial cells. AVICs, CCRs
54  2019 Characterizing valve dynamics in mice by high-resolution cine-MRI. EF, WD
55  2019 Development of calcific aortic valve disease: Do we know enough for new clinical trials? VECM, VICs
56  2019 Elastin-Dependent Aortic Heart Valve Leaflet Curvature Changes During Cyclic Flexure. ECM
57  2019 Genetic variants in cardiac calcification in Northern Sweden. ABCC6, CCAD, NT5E, Pi
58  2019 H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice. ---
59  2019 Heat shock protein 90 is downregulated in calcific aortic valve disease. ANXA2, IPA, PDIA3
60  2019 Heterogeneous multi-laminar tissue constructs as a platform to evaluate aortic valve matrix-dependent pathogenicity. VICs
61  2019 Hyperphosphatemia is required for initiation but not propagation of kidney failure-induced calcific aortic valve disease. ---
62  2019 Identification of key genes and pathways in calcific aortic valve disease by bioinformatics analysis. CAMs, DEGs, GEO, GO, PPI
63  2019 Increased mesenchymal podoplanin expression is associated with calcification in aortic valves. AS, RT-PCR
64  2019 Knockdown of CD44 expression decreases valve interstitial cell calcification in vitro. ECM, HA, PAAm, RHAMM, VICs
65  2019 Lipopolysaccharide and interferon-gamma team up to activate HIF-1alpha via STAT1 in normoxia and exhibit sex differences in human aortic valve interstitial cells. AVICs, HIF, IFN, JAK, LPS, STAT, TLR
66  2019 Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification. ---
67  2019 LncRNA OIP5-AS1 inhibits osteoblast differentiation of valve interstitial cells via miR-137/TWIST11 axis. lncRNA, qRT-PCR, RIP, TWIST1, VICs
68  2019 Meis2 represses the osteoblastic transdifferentiation of aortic valve interstitial cells through the Notch1/Twist1 pathway. EMT, NCCs, VICs
69  2019 MicroRNA-204 Deficiency in Human Aortic Valves Elevates Valvular Osteogenic Activity. ALP, AVICs, miR-204
70  2019 MicroRNA-214 promotes the calcification of human aortic valve interstitial cells through the acceleration of inflammatory reactions with activated MyD88/NF-kappaB signaling. AVICs, ELISA, LPS, miRs
71  2019 MicroRNA-638 inhibits human aortic valve interstitial cell calcification by targeting Sp7. HAVICs, SP7
72  2019 MMP-12-Induced Pro-osteogenic Responses in Human Aortic Valve Interstitial Cells. ALP, AVICs, BMP-2, LRP-6, MAPK, MMP-12
73  2019 Native aortic valve derived extracellular matrix hydrogel for three dimensional culture analyses with improved biomimetic properties. AVdH, ECM
74  2019 New Frontiers in Lp(a)-Targeted Therapies. ASCVD
75  2019 Oxidized HDL, as a Novel Biomarker for Calcific Aortic Valve Disease, Promotes the Calcification of Aortic Valve Interstitial Cells. ALP, AVICs, CAD, oxHDL
76  2019 Oxidized phospholipids as a unifying theory for lipoprotein(a) and cardiovascular disease. ASCVD
77  2019 Predictive Roles of Neutrophil-to-Lymphocyte Ratio and C-Reactive Protein in Patients with Calcific Aortic Valve Disease. AVR, CPB, CRP, NLR
78  2019 Spatiotemporal Complexity of the Aortic Sinus Vortex as a Function of Leaflet Calcification. ---
79  2019 Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification. OM, PM, TNAP, VICs
80  2019 The methylation of Notch1 promoter mediates the osteogenesis differentiation in human aortic valve interstitial cells through Wnt/beta-catenin signaling. AVICs, hAVICs, PCR
81  2018 A New Growth Model for Aortic Valve Calcification. CT, RCT
82  2018 Advances in Pathophysiology of Calcific Aortic Valve Disease Propose Novel Molecular Therapeutic Targets. ---
83  2018 Association between homocysteine levels and calcific aortic valve disease: a systematic review and meta-analysis. Hcy, SMD
84  2018 Calcific Aortic Valve Disease: a Developmental Biology Perspective. BMP, TGF-beta
85  2018 CD39 and CD73 in the aortic valve-biochemical and immunohistochemical analysis in valve cell populations and its changes in valve mineralization. ---
86  2018 Comparing the Role of Mechanical Forces in Vascular and Valvular Calcification Progression. ECM
87  2018 Creation of disease-inspired biomaterial environments to mimic pathological events in early calcific aortic valve disease. CS, GAG, HA, oxLDL, VEGF, VICs
88  2018 Crystallinity of hydroxyapatite drives myofibroblastic activation and calcification in aortic valves. HA
89  2018 Deletion of calponin 2 attenuates the development of calcific aortic valve disease in ApoE-/- mice. KO, SMA, WT
90  2018 DNA methylation of a PLPP3 MIR transposon-based enhancer promotes an osteogenic programme in calcific aortic valve disease. 5-MeC, AV, dCas9-DNMT, lysoPA, MIR, PLPPs, VICs
91  2018 Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. AV, OM, VICs
92  2018 Exploiting novel valve interstitial cell lines to study calcific aortic valve disease. MGP, VICs
93  2018 In-vitro analysis of early calcification in aortic valvular interstitial cells using Laser-Induced Breakdown Spectroscopy (LIBS). LIBS, VICs
94  2018 Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLr-/-ApoB100/100 mouse model. AS, DB diet, NC, VIC
95  2018 Inflammatory and metabolic mechanisms underlying the calcific aortic valve disease. ---
96  2018 Involvement of inflammatory responses in the early development of calcific aortic valve disease: lessons from statin therapy. ---
97  2018 LncRNA TUG1 sponges miR-204-5p to promote osteoblast differentiation through upregulating Runx2 in aortic valve calcification. lncRNAs, shRNA, VICs
98  2018 Mechanosensitive microRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3. ECM, HAVECs
99  2018 Metformin ameliorates TGF-beta1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting beta-catenin signaling. AVICs
100  2018 Molecular imaging of calcific aortic valve disease. FDG