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Abbreviation : CB2
Long Form : cannabinoid receptor 2
No. Year Title Co-occurring Abbreviation
2020 Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production. DCs, IBD, THC
2020 Adolescent binge-ethanol accelerates cognitive impairment and beta-amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice. AD, DAGLalpha, ECS, EtOH, MAGL
2020 beta-Caryophyllene Inhibits Cell Proliferation through a Direct Modulation of CB2 Receptors in Glioblastoma Cells. BCP, GSCs, JNK, PPARG
2020 beta-Caryophyllene Reduces the Inflammatory Phenotype of Periodontal Cells by Targeting CB2 Receptors. BCP, EC, GF
2020 Cannabinoid CB2 Receptor Modulation by the Transcription Factor NRF2 is Specific in Microglial Cells. Nrf2
2020 Cannabinoid receptor 2 activation alleviates septic lung injury by promoting autophagy via inhibition of inflammatory mediator release. CLP
2020 Cannabinoid receptor 2 agonist promotes parameters implicated in mucosal healing in patients with inflammatory bowel disease. hr, IBD, IL-8, MH, MMP9
2020 Cannabinoids and Cannabinoid Receptors: The Story so Far. CB1, GPCRs
2020 Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis. LPS, SLCA
10  2020 Effect of flaxseed oil supplementation on the erythrocyte membrane fatty acid composition and endocannabinoid system modulation in patients with coronary artery disease: a double-blind randomized controlled trial. AEA, CAD, CB1, ECS, FAAH, LA
11  2020 Effect of monoacylglycerol lipase inhibition on intestinal permeability in chronic stress model. 2-AG, CB1, i.p, MAGL, WAS
12  2020 Fast-Acting and Receptor-Mediated Regulation of Neuronal Signaling Pathways by Copaiba Essential Oil. ---
13  2020 Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors. PET
14  2020 Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics. NMDA, SE
15  2020 Negative allosteric modulators of cannabinoid receptor 2: protein modeling, binding site identification and molecular dynamics simulations in the presence of an orthosteric agonist. AMs, DHGA, MD, TBC
16  2020 Nrf2 is required for suppressing osteoclast RANKL-induced differentiation in RAW 264.7cells via inactivating cannabinoid receptor type 2 with AM630. Nrf2, TRAP
17  2020 Plant Natural Sources of the Endocannabinoid (E)-beta-Caryophyllene: A Systematic Quantitative Analysis of Published Literature. BCP
18  2020 Safety and efficacy of lenabasum in a phase 2 randomized, placebo-controlled trial in adults with cystic fibrosis. AE, CF, PEx
19  2020 Serendipitous base catalysed condensation-heteroannulation of iminoesters: a regioselective route to the synthesis of 4,6-disubstituted 5-azaindoles. ---
20  2020 The Critical Role of Cannabinoid Receptor 2 in URB602-Induced Protective Effects Against Renal Ischemia-Reperfusion Injury in the Rat. 2-AG, AKI, CB1, IRI
21  2020 The expression level of cannabinoid receptors type 1 and 2 in the different types of astrocytomas. CB1
22  2020 The Role of Cannabinoid Receptor Type 2 in the Bone Loss Associated with pediatric Celiac Disease. CD, GFD, OCs
23  2020 The Role of Cannabinoid Receptor Type 2 in the Bone Loss Associated With Pediatric Celiac Disease. CD, GFD, OCs
24  2020 Virtual Screening of C. Sativa Constituents for the Identification of Selective Ligands for Cannabinoid Receptor 2. PDB, QSAR
25  2019 -opioid receptor, beta-endorphin, and cannabinoid receptor-2 are increased in the colonic mucosa of irritable bowel syndrome patients. AC, beta-END, IBS, IR
26  2019 A New Use for an Old Drug: Carmofur Attenuates Lipopolysaccharide (LPS)-Induced Acute Lung Injury via Inhibition of FAAH and NAAA Activities. ALI, FAAH, LPS, NAAA, NF-kappaB, PPARalpha
27  2019 A pharmacoinformatic approach on Cannabinoid receptor 2 (CB2) and different small molecules: Homology modelling, molecular docking, MD simulations, drug designing and ADME analysis. ADME, GPCRs
28  2019 A selective CB2 agonist protects against the inflammatory response and joint destruction in collagen-induced arthritis mice. CIA, OPG, RA
29  2019 A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes. ---
30  2019 Absence of Entourage: Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Functional Activity of Delta9-THC at Human CB1 and CB2 Receptors. CB1, Delta9-THC
31  2019 Activation of the cannabinoid receptor 2 increases renal perfusion. AKI
32  2019 Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2. CO, PTZ, VPA
33  2019 AM-1241 CB2 Receptor Agonist Attenuates Inflammation, Apoptosis and Stimulate Progenitor Cells in Bile Duct Ligated Rats. BDL
34  2019 Amelioration of visual deficits and visual system pathology after mild TBI via the cannabinoid Type-2 receptor inverse agonism of raloxifene. ERG, TBI
35  2019 Beta-caryophyllene enhances wound healing through multiple routes. ---
36  2019 beta-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-gamma Receptors. BCP, CAIA, LPS, PPARgamma
37  2019 beta-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced chronic cardiotoxicity via activation of myocardial cannabinoid type-2 (CB2) receptors in rats. BCP, DOX, NF-kappaB
38  2019 Bipolar disorder and the endocannabinoid system. BD, CBs, ECS
39  2019 Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal. CFA, HEK, PSNL
40  2019 Cannabinoid Receptor 2 (CB2) Signals via G-alpha-s and Induces IL-6 and IL-10 Cytokine Secretion in Human Primary Leukocytes. IL-6
41  2019 Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1beta-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor. AIA, COX-2, GR, IL-1beta, RA, RASFs
42  2019 Cannabinoid Receptor 2 Agonist Prevents Local and Systemic Inflammatory Bone Destruction in Rheumatoid Arthritis. CIA, CTSK, IL, MMP-9, NF-kappaB, NFAT-1, TNF-alpha, TRAP
43  2019 Cannabinoid receptor 2‑selective agonist JWH015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord. BCP, IL, LC3B, LPS
44  2019 Cannabinoid type 2 receptor agonist JWH-133, attenuates Okadaic acid induced spatial memory impairment and neurodegeneration in rats. AD, i.c.v, IL-1beta, OKA, TNF-alpha
45  2019 Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation. BMT, CBD, GVHD, THC
46  2019 CoCl2 induced hypoxia enhances osteogenesis of rat bone marrow mesenchymal stem cells through cannabinoid receptor 2. ARS, BMSCs
47  2019 Computational Systems Pharmacology-Target Mapping for Fentanyl-Laced Cocaine Overdose. ADME, P-gp, PBPK
48  2019 Cutting Edge: Dysregulated Endocannabinoid-Rheostat for Plasmacytoid Dendritic Cell Activation in a Systemic Lupus Endophenotype. 2-AG, ABHD6, pDCs, SLE
49  2019 Delta9-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. IL, MCP, THC, TLR7
50  2019 Effects of endurance training on hippocampus DJ-1, cannabinoid receptor type2 and blood glucose concentration in diabetic rats. DE
51  2019 Inflammation and oxidative stress are key mediators in AKB48-induced neurotoxicity in vitro. CB1, IL-6, MAPK8, NF-B, TNF-alpha
52  2019 Joints for joints: cannabinoids in the treatment of rheumatoid arthritis. CB1, CBD, RA
53  2019 Liver X Receptor alpha-Induced Cannabinoid Receptor 2 Inhibits Ubiquitin-Specific Peptidase 4 Through miR-27b, Protecting Hepatocytes From TGF-beta. LXRalpha, miR-27b, TGF-beta, USP4
54  2019 Long-term administration of fatty acid amide hydrolase inhibitor (URB597) to rats with spontaneous hypertension disturbs liver redox balance and phospholipid metabolism. FAAH, ROS, SHRs
55  2019 Modulatory effects of cannabinoids on brain neurotransmission. CB1
56  2019 Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. CB1, CBD, ELISA, FD10, FD4, GPR119, GPR55, IFN-gamma, PEA, PKA, PKC, PPAR, TNF-alpha, TRPV1
57  2019 Paternal activation of CB2 cannabinoid receptor impairs placental and embryonic growth via an epigenetic mechanism. ---
58  2019 Review: brain neurobiology of gambling disorder based on rodent models. ACC, BLA, CB1, GABAA, GABAB, GD, mPFC, NAc, NMDA, OFC, PFC, STN
59  2019 Role of cannabinoid receptor 2 in mediating interleukin-1beta-induced inflammation in rheumatoid arthritis synovial fibroblasts. AP-1, COX-2, NF-kappaBp65, RASFs, siRNA, TAK1
60  2019 Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice. CR, SGZ
61  2019 Suppression of CpG-ODN-mediated IFNalpha and TNFalpha response in human plasmacytoid dendritic cells (pDC) by cannabinoid receptor 2 (CB2)-specific agonists. CB1, pDC, THC
62  2019 Synthesis and in vitro evaluation of fluorine-18 benzimidazole sulfones as CB2 PET-radioligands. ---
63  2019 The cannabinoid receptor 2 agonist, beta-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice. BCP
64  2019 The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts. ECS, FAAH, LA, NAPE-PLD
65  2019 The Endocannabinoid/Endovanilloid System in Bone: From Osteoporosis to Osteosarcoma. CB1, EC/EV, GC, OB, OC, TRPV1
66  2019 The Impact of Cannabinoid Receptor 2 Deficiency on Neutrophil Recruitment and Inflammation. ---
67  2019 The sesquiterpene beta-caryophyllene oxide attenuates ethanol drinking and place conditioning in mice. BCP, CPP, LORR
68  2019 Therapeutic potential of cannabinoid receptor 2 in the treatment of diabetes mellitus and its complications. CB1, IL-6, NF-kappabeta, TNF-alpha
69  2019 TLR4 Receptor Induces 2-AG-Dependent Tolerance to Lipopolysaccharide and Trafficking of CB2 Receptor in Mast Cells. 2-AG, ET, MCs
70  2019 [Cannabinoid receptor 2 deletion promotes proliferation and activation of hepatic macrophages in mice with acute liver injury induced by concanavalin A]. Con A
71  2018 Activating Cannabinoid Receptor 2 Protects Against Diabetic Cardiomyopathy Through Autophagy Induction. CCK-8, DCM, HG, LDH, STZ
72  2018 Antinociceptive effects of JWH015 in female and male rats. ---
73  2018 Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit. CB1, FAAH
74  2018 Cannabinoid receptor 2 as a novel target for promotion of renal cell carcinoma prognosis and progression. RCC
75  2018 Cannabinoid Receptor 2 Signalling Bias Elicited by 2,4,6-Trisubstituted 1,3,5-Triazines. cAMP, PTX
76  2018 Cannabinoid Receptor 2-Deficiency Ameliorates Disease Symptoms in a Mouse Model with Alzheimer's Disease-Like Pathology. AD, APP, ECS
77  2018 Cannabinoids in health and disease: pharmacological potential in metabolic syndrome and neuroinflammation. CB1
78  2018 Effects of cannabinoid receptor type 2 in respiratory syncytial virus infection in human subjects and mice. ARTI, RSV
79  2018 Evaluation of 4-oxo-quinoline-based CB2 PET radioligands in R6/2 chorea huntington mouse model and human ALS spinal cord tissue. CB1
80  2018 In vivo evidence that the cannabinoid receptor 2-63 RR variant is associated with the acquisition and/or expansion of HIV infection. AST, BMI, GGT, HAI, HCV
81  2018 Optimization of the metabolic stability of a fluorinated cannabinoid receptor subtype 2 (CB2) ligand designed for PET studies. ---
82  2018 Peripheral modulation of the endocannabinoid system in metabolic disease. CB1, ECS
83  2018 Recent advances in LC-MS/MS methods to determine endocannabinoids in biological samples: Application in neurodegenerative diseases. 2-AG, AEA, CB1, ECs
84  2018 Selective Cannabinoid 2 Receptor Stimulation Reduces Tubular Epithelial Cell Damage after Renal Ischemia-Reperfusion Injury. AKI, IRI, TUNEL
85  2018 Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renalfibrosis. ---
86  2018 The endocannabinoid system in canine Steroid-Responsive Meningitis-Arteritis and Intraspinal Spirocercosis. 2-AG, AEA, CNS, ECs, IHC, IS, SRMA, SRMA A, SRMA Tr
87  2018 The presence and distribution of cannabinoid type 1 and 2 receptors in the mandibular gland: The influence of different physical forms of diets on their expression in piglets. CB1, CE, CM, CP, FP
88  2018 The Role of Cannabinoid Receptor 1 in the Immunopathology of Respiratory Syncytial Virus. CB1, RSV
89  2018 The Role of Cannabinoids in the Setting of Cirrhosis. 2-AG, AEA, CB1
90  2018 Ximenia americana heteropolysaccharides ameliorate inflammation and visceral hypernociception in murine caerulein-induced acute pancreatitis: Involvement of CB2 receptors. AP, MPO, TPL-Xa
91  2017 (-)-beta-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis. BCP, CNS, EAE, MS
92  2017 4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice. AEA, ALD, ECs, HSC, LC-MS, MHK, MMP, NAEs
93  2017 A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2. GRK2
94  2017 Activation of CB2 receptor system restores cognitive capacity and hippocampal Sox2 expression in a transgenic mouse model of Alzheimer's disease. AD, DG
95  2017 An Update on Non-CB1, Non-CB2 Cannabinoid Related G-Protein-Coupled Receptors. CB1, ECS, GPCRs
96  2017 beta-Caryophyllene/Hydroxypropyl-beta-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway. CBF, VD
97  2017 Bufalin attenuates cancer-induced pain and bone destruction in a model of bone cancer. OPG, RANKL
98  2017 Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice. CB1, KO, WT
99  2017 Cannabinoid receptor 1/2 double-knockout mice develop epilepsy. CB1
100  2017 Cannabinoid receptor 2 activation restricts fibrosis and alleviates hydrocephalus after intraventricular hemorrhage. IVH, TGF-beta1