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Abbreviation : CDK4
Long Form : cyclin-dependent kinase 4
No. Year Title Co-occurring Abbreviation
2020 A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G0/G1 phase and induces mitochondrial apoptosis in non-small cell lung cancer cells. CDK6, MMP, NSCLC, PI
2020 A Phase II Study of Abemaciclib in Patients with Brain Metastases Secondary to Hormone Receptor-Positive Breast Cancer. CI, iCBR, iORR, LM, MBC, OS
2020 A refractory case of CDK4-amplified spinal astrocytoma achieving complete response upon treatment with a Palbociclib-based regimen:a case report. NGS
2020 Abnormal spindle-like microcephaly-associated protein (ASPM) contributes to the progression of Lung Squamous Cell Carcinoma (LSCC) by regulating CDK4. ASPM, ASPM, CCND1, LSCC
2020 Activation-Induced Cytidine Deaminase Expression Facilitates the Malignant Phenotype and Epithelial-to-Mesenchymal Transition in Clear Cell Renal Cell Carcinoma. AID, ccRCC
2020 All-trans-retinoid acid induces the differentiation of P19 cells into neurons involved in the PI3K/Akt/GSK3beta signaling pathway. DEMs, GSK3beta, mRNAs, NEFM, RA
2020 Antihypertensive drug telmisartan suppresses the proliferation of gastric cancer cells invitro and invivo. ARB, EGFR, pRb
2020 Antrodia cinnamomea is a potentially effective complementary medicine for adjuvant therapy against breast cancer with bone metastasis: A case report. AC, BC, CTCs, FUL, HER2, HR, MBC, PAL
2020 Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas. CR, FLT1, GLI1, NGS, PDGFRA, PDGFRB, phospho-RTK, RTK, VEGFR
10  2020 Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-beta). CCK-8, CQ, HK-2, p-Rb, PI, TECs, TGF, TGF-beta
11  2020 Bear Bile Powder Inhibits Growth of Hepatocellular Carcinoma via Suppressing STAT3 Signaling Pathway in Mice. BBP, CD31, HCC, IHC, PCNA, RT-PCR, STAT3, VEGF-A
12  2020 Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells. AO/EB, PI
13  2020 Casein Kinase 2alpha Enhances 5-Fluorouracil Resistance in Colorectal Cancer Cells by Inhibiting Endoplasmic Reticulum Stress. 5-FU, CK2alpha, CRC, ER
14  2020 CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis. ATF4, Bax, Bcl-2, C/EBP, eIF2alpha, mTOR, PERK, TNBC
15  2020 CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP. Drp1, PD
16  2020 CDK4/6 inhibition suppresses tumour growth and enhances the effect of temozolomide in glioma cells. ---
17  2020 CDK4/RB/E2Fs axis as potential therapeutic target of endometrial cancer. EC, mRNA
18  2020 Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. circRNAs, miRNA, MMP9, VEGF
19  2020 Effect of Angelica gigas Nakai Ethanol Extract and Decursin on Human Pancreatic Cancer Cells. AGE, MMP, PC
20  2020 Eprinomectin, a novel semi-synthetic macrocylic lactone is cytotoxic to PC3 metastatic prostate cancer cells via inducing apoptosis. EP, PCa
21  2020 Heterogeneous EGFR, CDK4, MDM4, and PDGFRA Gene Expression Profiles in Primary GBM: No Association with Patient Survival. EGFR, GBM, iFISH, MDM4, PDGFRA
22  2020 Human Derived Immortalized Dermal Papilla Cells With a Constant Expression of Testosterone Receptor. AGA, DPCs, TERT
23  2020 Immunomodulation by anticancer cell cycle inhibitors. ---
24  2020 Inhibition of fatty acid synthase (FASN) affects the proliferation and apoptosis of HepG2 hepatoma carcinoma cells via the beta-catenin/C-myc signaling pathway. CCK-8, FASN, HCC
25  2020 Knockout of the Transducin-Like Enhancer of Split 6 Gene Affects the Proliferation and Cell Cycle Process of Mouse Spermatogonia. CRISPR, G-CSF, KO, PCNA, Skp2
26  2020 LINC00511 influences cellular proliferation through cyclin-dependent kinases in papillary thyroid carcinoma. CDK2, EZH2, LINC00511, lncRNAs, PTC, qRT-PCR
27  2020 Linc00703 suppresses non-small cell lung cancer progression by modulating CyclinD1/CDK4 expression. CCK-8, NSCLC, qRT-PCR
28  2020 Medulloblastoma malignant biological behaviors are associated with HOTAIR/miR-483-3p/CDK4 axis. BrdU, HOTAIR, IHC
29  2020 miR-122-5p Mediates Fluoride-Induced Osteoblast Activation by Targeting CDK4. ---
30  2020 MiR-214-3p promotes proliferation and inhibits estradiol synthesis in porcine granulosa cells. Cyclin B, Cyclin D, CyclinE, CYP11A1, CYP19A1, GCs, StAR
31  2020 miR-4270 regulates cell proliferation and apoptosis in patients with Sertoli cell-only syndrome by targeting GADD45A and inactivating the NOTCH signaling pathway. CASP3, CASP6, CASP7, CCND1, cyclin E1, NOTCH1, SC, SCOS
32  2020 Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins. CDK2
33  2020 Molecular Profiling of Benign Metastasizing Leiomyoma of the Uterus Revealing Unique Novel Therapeutic Targets. AR1D1A, BML, HNF1A, IVC, IVL, RB1, TTE
34  2020 Nuclear expression of MDM2 in hibernoma: a potential diagnostic pitfall. ALT/WDLS, FISH, MDM2, UCP1, USP7
35  2020 Over expression of CDK4 and MDM2 in a patient with recurrent ALK-negative mediastinal inflammatory myofibroblastic tumor: A case report. ALK, DDR2, IMT, MDM2, SDHC, TSHR
36  2020 Paeonol Inhibits Cell Proliferation, Migration and Invasion and Induces Apoptosis in Hepatocellular Carcinoma by Regulating miR-21-5p/KLF6 Axis. Bax, Bcl-2, CCK-8, HCC, KLF6, miRNAs, MMP2, MMP9, qRT-PCR
37  2020 Prevention of Prostate Cancer in Transgenic Adenocarcinoma of the Mouse Prostate Mice by Yellow Passion Fruit Extract and Antiproliferative Effects of Its Bioactive Compound Piceatannol. PFE, PIC
38  2020 Promising Anticancer Effect of Aurisin A Against the Human Lung Cancer A549 Cell Line. Bcl-2, EGFR, p-p38, SRB
39  2020 Short-chain fatty acids inhibit bovine rumen epithelial cells proliferation via upregulation of cyclin-dependent kinase inhibitors 1A, but not mediated by G protein-coupled receptor 41. BRECs, CDKN1A, GPR41, GPR41KD, SCFAs
40  2020 Simulated microgravity reduces proliferation and reorganizes the cytoskeleton of human umbilical cord mesenchymal stem cells. hUCMSCs, SMG
41  2020 SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1. CDK6, PCa, PD, PI, siSOX7, SOX7
42  2020 Successful pregnancy after complete resection of leiomyomatosis peritonealis disseminate without recurrence:a case report with next-generation sequencing analysis and literature review. MYC
43  2020 Targeted Gene Expression Profile Reveals CDK4 as Therapeutic Target for Selected Patients With Adrenocortical Carcinoma. ACC
44  2020 Targeting CDK4 (cyclin-dependent kinase) amplification in liposarcoma: A comprehensive review. WD/DD
45  2020 The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. ---
46  2020 The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice. AKI, ATN, KRAS, LC3-II, NSCLC, PD-L1
47  2020 The role of CDK6 in cancer. CDK6
48  2020 Triptolide inhibits PDGF-induced proliferation of ASMCs through G0/G1 cell cycle arrest and suppression of the AKT/NF-kappaB/cyclinD1 signaling pathway. ASMCs, CCK-8, NF-kappaB, PCNA, PDGF, PDTC, PI3K
49  2020 What Are the Results of Resection of Localized Dedifferentiated Liposarcomas in the Extremities? ALT, DDLPS, FDG-PET, PET/CT
50  2019 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice. AhR, TCDD, VSMCs
51  2019 A clinical comparison between dedifferentiated low-grade osteosarcoma and conventional osteosarcoma. COS, DLOS, IQR, MDM2, OAS, PFS
52  2019 Ara-c induces cell cycle G1/S arrest by inducing upregulation of the INK4 family gene or directly inhibiting the formation of the cell cycle-dependent complex CDK4/cyclin D1. CCND1, INK4
53  2019 beta-Thujaplicin inhibits basal-like mammary tumor growth by regulating glycogen synthase kinase-3beta/beta-catenin signaling. AKT, ER
54  2019 Bisphenol S promotes the cell cycle progression and cell proliferation through ERalpha-cyclin D-CDK4/6-pRb pathway in MCF-7 breast cancer cells. BPS, p-Rb
55  2019 Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling. ROS
56  2019 CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival. FLCN
57  2019 Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. ---
58  2019 Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy. ---
59  2019 Cross-disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma. EPAS1, LA, LSCC, MLR, SLC2A1
60  2019 Curcumin Promoted miR-34a Expression and Suppressed Proliferation of Gastric Cancer Cells. Bcl-2, mRNA
61  2019 Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB. Rb
62  2019 Differential Apoptotic and Mitogenic Effects of Lectins in Zebrafish. Akt, BAD, Bcl-2, G6PD, GLUD, PNA, Rb, SBA, TOR
63  2019 Exportin-T promotes tumor proliferation and invasion in hepatocellular carcinoma. ANLT, CCK-8, CCNA1, CCNB1, CCNB2, CCNE2, CDK1, CDK2, GSEA, HCC, si
64  2019 Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion. MDM2, NF
65  2019 Extended proliferation of chicken- and Okinawa rail-derived fibroblasts by expression of cell cycle regulators. HPV, SV40T
66  2019 High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone. Bax, ERK, HBlEpCs, p38 MAPK
67  2019 Huganpian, a traditional chinese medicine, inhibits liver cancer growth in vitro and in vivo by inducing autophagy and cell cycle arrest. CDK2, HGP
68  2019 Human-Derived Corneal Epithelial Cells Expressing Cell Cycle Regulators as a New Resource for in vitro Ocular Toxicity Testing. TERT
69  2019 Ifenprodil and Flavopiridol Identified by Genomewide RNA Interference Screening as Effective Drugs To Ameliorate Murine Acute Lung Injury after Influenza A H5N1 Virus Infection. ALI, NMDA, RNAi
70  2019 In vitro study to assess the efficacy of CDK4/6 inhibitor Palbociclib (PD-0332991) for treating canine mammary tumours. CMTs, pRb
71  2019 Interferon-gamma regulates cell malignant growth via the c-Abl/HDAC2 signaling pathway in mammary epithelial cells. BMECs, c-Abl, HDAC2, IFN-gamma, VPA
72  2019 Interleukin-6 and tumour necrosis factor-alpha cooperatively promote cell cycle regulators and proliferate rheumatoid arthritis fibroblast-like synovial cells. IL-6, phospho-pRB, pRb, RA-FLSs, sIL-6R, TNF-alpha
73  2019 LncRNA KB-1471A8.2 Overexpression Suppresses Cell Proliferation and Migration and Antagonizes the Paclitaxel Resistance of Ovarian Cancer Cells. ---
74  2019 MicroRNA-338-3p inhibits tumor growth and metastasis in osteosarcoma cells by targeting RUNX2/CDK4 and inhibition of MAPK pathway. MAPK, miRNAs, MTT, OS
75  2019 miR-216a-5p promotes mesangial cell proliferation by targeting FoxO1 in diabetic nephropathy. CCK-8, DN, FOXO1, HMC, miRNAs, PI, qRT-PCR, WB
76  2019 MiR-34b-3p represses cell proliferation, cell cycle progression and cell apoptosis in non-small-cell lung cancer (NSCLC) by targeting CDK4. 3'-UTR, miRNAs, NSCLC
77  2019 Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis. EGFR, IHC, MMP2, MMP9, qRT-PCR
78  2019 Overexpression of CMTM7 inhibits cell growth and migration in liver cancer. CKLF, CMTM7, CMTMs, MARVEL
79  2019 Regulation of p53 in the red-eared slider (Trachemys scripta elegans) in response to salinity stress. CDK6
80  2019 Repressing of NHERF1 inhibits liver cancer progression by promoting the production of ROS. HCC, JNK, PTEN, ROS
81  2019 Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. SARD
82  2019 Schizandrin A inhibits proliferation, migration and invasion of thyroid cancer cell line TPC-1 by down regulation of microRNA-429. ERK, MEK, MMP, NC, Sch A, TC
83  2019 Stephanthraniline A suppresses proliferation of HCT116 human colon cancer cells through induction of caspase-dependent apoptosis, dysregulation of mitochondrial function, cell cycle arrest and regulation of Akt/p38 signaling pathways. STA
84  2019 SWOG S1400C (NCT02154490)-A Phase II Study of Palbociclib for Previously Treated Cell Cycle Gene Alteration-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy). CCND1, CCND2, CCND3, CI
85  2019 Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor/phosphatidylinositol-3-kinase signaling pathway. EdU, GSK3beta, IGF-1, IRS, mTOR, MTS, PI3K, rpS6, VSMC
86  2019 Tetrandrine inhibits colon carcinoma HT-29 cells growth via the Bcl-2/Caspase 3/PARP pathway and G1/S phase. CCND1, pRb, Tet
87  2019 The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1. ss
88  2019 The functions of microRNA-124 on bladder cancer. BC, qPCR, VEGF
89  2019 The role of cyclin-dependent kinases in oral potentially malignant disorders and oral squamous cell carcinoma. OPMDs, OSCC
90  2019 Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells. CDK2, GLTP, GSL, pMLKL, RIPK-3
91  2019 WD repeat and SOCS box containing protein 2 in the proliferation, cycle progression, and migration of melanoma cells. EdU, pRb, WSB
92  2019 Wound Healing Potential of Spirulina Protein on CCD-986sk Cells. BrdU, CDK2, CDK6, PI3K, SPCP
93  2019 Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy. PCNA, TEAD, WT1, YAP
94  2019 [A Case of Dedifferentiated Liposarcoma of the Spermatic Cord]. MDM2
95  2019 [Construction of miR-331-3p overexpression vector and its effect on cell proliferation]. CDK2, CDK3, CDKN1A, miR-331-3p NC, PI
96  2019 [Effects of Salvia przewalskii Maxim. on high-altitude pulmonary hypertension in rats and its mechanism]. HAPH, mPAP, PCNA, SPM
97  2019 [Role of p53/p21 signal transduction pathway in the malignant transformation of human embryonic lung fibroblasts induced by quartz]. PFT-alpha, T-HELF
98  2018 A case report of primary cardiac sarcoma: a diagnostic and therapeutic challenge. ---
99  2018 A combination of the PI3K pathway inhibitor plus cell cycle pathway inhibitor to combat endocrine resistance in hormone receptor-positive breast cancer: a genomic algorithm-based treatment approach. Rb
100  2018 A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway. MAPK, ROS