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[Related PubMed/MEDLINE]
Total Number of Papers: 669
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| Abbreviation |
: CDK4 |
| Long Form |
: cyclin-dependent kinase 4 |
|
| No. |
Year |
Title |
Co-occurring Abbreviation |
| 1 |
2020 |
A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G0/G1 phase and induces mitochondrial apoptosis in non-small cell lung cancer cells. |
CDK6, MMP, NSCLC, PI |
| 2 |
2020 |
A Phase II Study of Abemaciclib in Patients with Brain Metastases Secondary to Hormone Receptor-Positive Breast Cancer. |
CI, iCBR, iORR, LM, MBC, OS |
| 3 |
2020 |
A refractory case of CDK4-amplified spinal astrocytoma achieving complete response upon treatment with a Palbociclib-based regimen:a case report. |
NGS |
| 4 |
2020 |
Abnormal spindle-like microcephaly-associated protein (ASPM) contributes to the progression of Lung Squamous Cell Carcinoma (LSCC) by regulating CDK4. |
ASPM, ASPM, CCND1, LSCC |
| 5 |
2020 |
Activation-Induced Cytidine Deaminase Expression Facilitates the Malignant Phenotype and Epithelial-to-Mesenchymal Transition in Clear Cell Renal Cell Carcinoma. |
AID, ccRCC |
| 6 |
2020 |
All-trans-retinoid acid induces the differentiation of P19 cells into neurons involved in the PI3K/Akt/GSK3beta signaling pathway. |
DEMs, GSK3beta, mRNAs, NEFM, RA |
| 7 |
2020 |
Antihypertensive drug telmisartan suppresses the proliferation of gastric cancer cells invitro and invivo. |
ARB, EGFR, pRb |
| 8 |
2020 |
Antrodia cinnamomea is a potentially effective complementary medicine for adjuvant therapy against breast cancer with bone metastasis: A case report. |
AC, BC, CTCs, FUL, HER2, HR, MBC, PAL |
| 9 |
2020 |
Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas: Analysis of a Tumor Sample from a Responder and Patients with Other Soft-tissue Sarcomas. |
CR, FLT1, GLI1, NGS, PDGFRA, PDGFRB, phospho-RTK, RTK, VEGFR |
| 10 |
2020 |
Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-beta). |
CCK-8, CQ, HK-2, p-Rb, PI, TECs, TGF, TGF-beta |
| 11 |
2020 |
Bear Bile Powder Inhibits Growth of Hepatocellular Carcinoma via Suppressing STAT3 Signaling Pathway in Mice. |
BBP, CD31, HCC, IHC, PCNA, RT-PCR, STAT3, VEGF-A |
| 12 |
2020 |
Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells. |
AO/EB, PI |
| 13 |
2020 |
Casein Kinase 2alpha Enhances 5-Fluorouracil Resistance in Colorectal Cancer Cells by Inhibiting Endoplasmic Reticulum Stress. |
5-FU, CK2alpha, CRC, ER |
| 14 |
2020 |
CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis. |
ATF4, Bax, Bcl-2, C/EBP, eIF2alpha, mTOR, PERK, TNBC |
| 15 |
2020 |
CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP. |
Drp1, PD |
| 16 |
2020 |
CDK4/6 inhibition suppresses tumour growth and enhances the effect of temozolomide in glioma cells. |
--- |
| 17 |
2020 |
CDK4/RB/E2Fs axis as potential therapeutic target of endometrial cancer. |
EC, mRNA |
| 18 |
2020 |
Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. |
circRNAs, miRNA, MMP9, VEGF |
| 19 |
2020 |
Effect of Angelica gigas Nakai Ethanol Extract and Decursin on Human Pancreatic Cancer Cells. |
AGE, MMP, PC |
| 20 |
2020 |
Eprinomectin, a novel semi-synthetic macrocylic lactone is cytotoxic to PC3 metastatic prostate cancer cells via inducing apoptosis. |
EP, PCa |
| 21 |
2020 |
Heterogeneous EGFR, CDK4, MDM4, and PDGFRA Gene Expression Profiles in Primary GBM: No Association with Patient Survival. |
EGFR, GBM, iFISH, MDM4, PDGFRA |
| 22 |
2020 |
Human Derived Immortalized Dermal Papilla Cells With a Constant Expression of Testosterone Receptor. |
AGA, DPCs, TERT |
| 23 |
2020 |
Immunomodulation by anticancer cell cycle inhibitors. |
--- |
| 24 |
2020 |
Inhibition of fatty acid synthase (FASN) affects the proliferation and apoptosis of HepG2 hepatoma carcinoma cells via the beta-catenin/C-myc signaling pathway. |
CCK-8, FASN, HCC |
| 25 |
2020 |
Knockout of the Transducin-Like Enhancer of Split 6 Gene Affects the Proliferation and Cell Cycle Process of Mouse Spermatogonia. |
CRISPR, G-CSF, KO, PCNA, Skp2 |
| 26 |
2020 |
LINC00511 influences cellular proliferation through cyclin-dependent kinases in papillary thyroid carcinoma. |
CDK2, EZH2, LINC00511, lncRNAs, PTC, qRT-PCR |
| 27 |
2020 |
Linc00703 suppresses non-small cell lung cancer progression by modulating CyclinD1/CDK4 expression. |
CCK-8, NSCLC, qRT-PCR |
| 28 |
2020 |
Medulloblastoma malignant biological behaviors are associated with HOTAIR/miR-483-3p/CDK4 axis. |
BrdU, HOTAIR, IHC |
| 29 |
2020 |
miR-122-5p Mediates Fluoride-Induced Osteoblast Activation by Targeting CDK4. |
--- |
| 30 |
2020 |
MiR-214-3p promotes proliferation and inhibits estradiol synthesis in porcine granulosa cells. |
Cyclin B, Cyclin D, CyclinE, CYP11A1, CYP19A1, GCs, StAR |
| 31 |
2020 |
miR-4270 regulates cell proliferation and apoptosis in patients with Sertoli cell-only syndrome by targeting GADD45A and inactivating the NOTCH signaling pathway. |
CASP3, CASP6, CASP7, CCND1, cyclin E1, NOTCH1, SC, SCOS |
| 32 |
2020 |
Molecular docking analysis of piperine with CDK2,CDK4,Cyclin D and Cyclin T proteins. |
CDK2 |
| 33 |
2020 |
Molecular Profiling of Benign Metastasizing Leiomyoma of the Uterus Revealing Unique Novel Therapeutic Targets. |
AR1D1A, BML, HNF1A, IVC, IVL, RB1, TTE |
| 34 |
2020 |
Nuclear expression of MDM2 in hibernoma: a potential diagnostic pitfall. |
ALT/WDLS, FISH, MDM2, UCP1, USP7 |
| 35 |
2020 |
Over expression of CDK4 and MDM2 in a patient with recurrent ALK-negative mediastinal inflammatory myofibroblastic tumor: A case report. |
ALK, DDR2, IMT, MDM2, SDHC, TSHR |
| 36 |
2020 |
Paeonol Inhibits Cell Proliferation, Migration and Invasion and Induces Apoptosis in Hepatocellular Carcinoma by Regulating miR-21-5p/KLF6 Axis. |
Bax, Bcl-2, CCK-8, HCC, KLF6, miRNAs, MMP2, MMP9, qRT-PCR |
| 37 |
2020 |
Prevention of Prostate Cancer in Transgenic Adenocarcinoma of the Mouse Prostate Mice by Yellow Passion Fruit Extract and Antiproliferative Effects of Its Bioactive Compound Piceatannol. |
PFE, PIC |
| 38 |
2020 |
Promising Anticancer Effect of Aurisin A Against the Human Lung Cancer A549 Cell Line. |
Bcl-2, EGFR, p-p38, SRB |
| 39 |
2020 |
Short-chain fatty acids inhibit bovine rumen epithelial cells proliferation via upregulation of cyclin-dependent kinase inhibitors 1A, but not mediated by G protein-coupled receptor 41. |
BRECs, CDKN1A, GPR41, GPR41KD, SCFAs |
| 40 |
2020 |
Simulated microgravity reduces proliferation and reorganizes the cytoskeleton of human umbilical cord mesenchymal stem cells. |
hUCMSCs, SMG |
| 41 |
2020 |
SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1. |
CDK6, PCa, PD, PI, siSOX7, SOX7 |
| 42 |
2020 |
Successful pregnancy after complete resection of leiomyomatosis peritonealis disseminate without recurrence:a case report with next-generation sequencing analysis and literature review. |
MYC |
| 43 |
2020 |
Targeted Gene Expression Profile Reveals CDK4 as Therapeutic Target for Selected Patients With Adrenocortical Carcinoma. |
ACC |
| 44 |
2020 |
Targeting CDK4 (cyclin-dependent kinase) amplification in liposarcoma: A comprehensive review. |
WD/DD |
| 45 |
2020 |
The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. |
--- |
| 46 |
2020 |
The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice. |
AKI, ATN, KRAS, LC3-II, NSCLC, PD-L1 |
| 47 |
2020 |
The role of CDK6 in cancer. |
CDK6 |
| 48 |
2020 |
Triptolide inhibits PDGF-induced proliferation of ASMCs through G0/G1 cell cycle arrest and suppression of the AKT/NF-kappaB/cyclinD1 signaling pathway. |
ASMCs, CCK-8, NF-kappaB, PCNA, PDGF, PDTC, PI3K |
| 49 |
2020 |
What Are the Results of Resection of Localized Dedifferentiated Liposarcomas in the Extremities? |
ALT, DDLPS, FDG-PET, PET/CT |
| 50 |
2019 |
2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes injury-induced vascular neointima formation in mice. |
AhR, TCDD, VSMCs |
| 51 |
2019 |
A clinical comparison between dedifferentiated low-grade osteosarcoma and conventional osteosarcoma. |
COS, DLOS, IQR, MDM2, OAS, PFS |
| 52 |
2019 |
Ara-c induces cell cycle G1/S arrest by inducing upregulation of the INK4 family gene or directly inhibiting the formation of the cell cycle-dependent complex CDK4/cyclin D1. |
CCND1, INK4 |
| 53 |
2019 |
beta-Thujaplicin inhibits basal-like mammary tumor growth by regulating glycogen synthase kinase-3beta/beta-catenin signaling. |
AKT, ER |
| 54 |
2019 |
Bisphenol S promotes the cell cycle progression and cell proliferation through ERalpha-cyclin D-CDK4/6-pRb pathway in MCF-7 breast cancer cells. |
BPS, p-Rb |
| 55 |
2019 |
Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling. |
ROS |
| 56 |
2019 |
CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival. |
FLCN |
| 57 |
2019 |
Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. |
--- |
| 58 |
2019 |
Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy. |
--- |
| 59 |
2019 |
Cross-disease analysis identified novel common genes for both lung adenocarcinoma and lung squamous cell carcinoma. |
EPAS1, LA, LSCC, MLR, SLC2A1 |
| 60 |
2019 |
Curcumin Promoted miR-34a Expression and Suppressed Proliferation of Gastric Cancer Cells. |
Bcl-2, mRNA |
| 61 |
2019 |
Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB. |
Rb |
| 62 |
2019 |
Differential Apoptotic and Mitogenic Effects of Lectins in Zebrafish. |
Akt, BAD, Bcl-2, G6PD, GLUD, PNA, Rb, SBA, TOR |
| 63 |
2019 |
Exportin-T promotes tumor proliferation and invasion in hepatocellular carcinoma. |
ANLT, CCK-8, CCNA1, CCNB1, CCNB2, CCNE2, CDK1, CDK2, GSEA, HCC, si |
| 64 |
2019 |
Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion. |
MDM2, NF |
| 65 |
2019 |
Extended proliferation of chicken- and Okinawa rail-derived fibroblasts by expression of cell cycle regulators. |
HPV, SV40T |
| 66 |
2019 |
High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone. |
Bax, ERK, HBlEpCs, p38 MAPK |
| 67 |
2019 |
Huganpian, a traditional chinese medicine, inhibits liver cancer growth in vitro and in vivo by inducing autophagy and cell cycle arrest. |
CDK2, HGP |
| 68 |
2019 |
Human-Derived Corneal Epithelial Cells Expressing Cell Cycle Regulators as a New Resource for in vitro Ocular Toxicity Testing. |
TERT |
| 69 |
2019 |
Ifenprodil and Flavopiridol Identified by Genomewide RNA Interference Screening as Effective Drugs To Ameliorate Murine Acute Lung Injury after Influenza A H5N1 Virus Infection. |
ALI, NMDA, RNAi |
| 70 |
2019 |
In vitro study to assess the efficacy of CDK4/6 inhibitor Palbociclib (PD-0332991) for treating canine mammary tumours. |
CMTs, pRb |
| 71 |
2019 |
Interferon-gamma regulates cell malignant growth via the c-Abl/HDAC2 signaling pathway in mammary epithelial cells. |
BMECs, c-Abl, HDAC2, IFN-gamma, VPA |
| 72 |
2019 |
Interleukin-6 and tumour necrosis factor-alpha cooperatively promote cell cycle regulators and proliferate rheumatoid arthritis fibroblast-like synovial cells. |
IL-6, phospho-pRB, pRb, RA-FLSs, sIL-6R, TNF-alpha |
| 73 |
2019 |
LncRNA KB-1471A8.2 Overexpression Suppresses Cell Proliferation and Migration and Antagonizes the Paclitaxel Resistance of Ovarian Cancer Cells. |
--- |
| 74 |
2019 |
MicroRNA-338-3p inhibits tumor growth and metastasis in osteosarcoma cells by targeting RUNX2/CDK4 and inhibition of MAPK pathway. |
MAPK, miRNAs, MTT, OS |
| 75 |
2019 |
miR-216a-5p promotes mesangial cell proliferation by targeting FoxO1 in diabetic nephropathy. |
CCK-8, DN, FOXO1, HMC, miRNAs, PI, qRT-PCR, WB |
| 76 |
2019 |
MiR-34b-3p represses cell proliferation, cell cycle progression and cell apoptosis in non-small-cell lung cancer (NSCLC) by targeting CDK4. |
3'-UTR, miRNAs, NSCLC |
| 77 |
2019 |
Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis. |
EGFR, IHC, MMP2, MMP9, qRT-PCR |
| 78 |
2019 |
Overexpression of CMTM7 inhibits cell growth and migration in liver cancer. |
CKLF, CMTM7, CMTMs, MARVEL |
| 79 |
2019 |
Regulation of p53 in the red-eared slider (Trachemys scripta elegans) in response to salinity stress. |
CDK6 |
| 80 |
2019 |
Repressing of NHERF1 inhibits liver cancer progression by promoting the production of ROS. |
HCC, JNK, PTEN, ROS |
| 81 |
2019 |
Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex. |
SARD |
| 82 |
2019 |
Schizandrin A inhibits proliferation, migration and invasion of thyroid cancer cell line TPC-1 by down regulation of microRNA-429. |
ERK, MEK, MMP, NC, Sch A, TC |
| 83 |
2019 |
Stephanthraniline A suppresses proliferation of HCT116 human colon cancer cells through induction of caspase-dependent apoptosis, dysregulation of mitochondrial function, cell cycle arrest and regulation of Akt/p38 signaling pathways. |
STA |
| 84 |
2019 |
SWOG S1400C (NCT02154490)-A Phase II Study of Palbociclib for Previously Treated Cell Cycle Gene Alteration-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy). |
CCND1, CCND2, CCND3, CI |
| 85 |
2019 |
Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor/phosphatidylinositol-3-kinase signaling pathway. |
EdU, GSK3beta, IGF-1, IRS, mTOR, MTS, PI3K, rpS6, VSMC |
| 86 |
2019 |
Tetrandrine inhibits colon carcinoma HT-29 cells growth via the Bcl-2/Caspase 3/PARP pathway and G1/S phase. |
CCND1, pRb, Tet |
| 87 |
2019 |
The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1. |
ss |
| 88 |
2019 |
The functions of microRNA-124 on bladder cancer. |
BC, qPCR, VEGF |
| 89 |
2019 |
The role of cyclin-dependent kinases in oral potentially malignant disorders and oral squamous cell carcinoma. |
OPMDs, OSCC |
| 90 |
2019 |
Upregulation of human glycolipid transfer protein (GLTP) induces necroptosis in colon carcinoma cells. |
CDK2, GLTP, GSL, pMLKL, RIPK-3 |
| 91 |
2019 |
WD repeat and SOCS box containing protein 2 in the proliferation, cycle progression, and migration of melanoma cells. |
EdU, pRb, WSB |
| 92 |
2019 |
Wound Healing Potential of Spirulina Protein on CCD-986sk Cells. |
BrdU, CDK2, CDK6, PI3K, SPCP |
| 93 |
2019 |
Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy. |
PCNA, TEAD, WT1, YAP |
| 94 |
2019 |
[A Case of Dedifferentiated Liposarcoma of the Spermatic Cord]. |
MDM2 |
| 95 |
2019 |
[Construction of miR-331-3p overexpression vector and its effect on cell proliferation]. |
CDK2, CDK3, CDKN1A, miR-331-3p NC, PI |
| 96 |
2019 |
[Effects of Salvia przewalskii Maxim. on high-altitude pulmonary hypertension in rats and its mechanism]. |
HAPH, mPAP, PCNA, SPM |
| 97 |
2019 |
[Role of p53/p21 signal transduction pathway in the malignant transformation of human embryonic lung fibroblasts induced by quartz]. |
PFT-alpha, T-HELF |
| 98 |
2018 |
A case report of primary cardiac sarcoma: a diagnostic and therapeutic challenge. |
--- |
| 99 |
2018 |
A combination of the PI3K pathway inhibitor plus cell cycle pathway inhibitor to combat endocrine resistance in hormone receptor-positive breast cancer: a genomic algorithm-based treatment approach. |
Rb |
| 100 |
2018 |
A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway. |
MAPK, ROS |
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