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Abbreviation : CDK9
Long Form : cyclin-dependent kinase 9
No. Year Title Co-occurring Abbreviation
2020 AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells. PD
2020 CDK9 inhibitors reactivate p53 by downregulating iASPP. OS
2020 CDK9 is dispensable for YAP-driven hepatoblastoma development. HB
2019 Analog-sensitive cell line identifies cellular substrates of CDK9. ---
2019 CDK9 as an Appealing Target for Therapeutic Interventions. RNAP
2019 CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation. AMPK, FAO
2019 CDK9: a signaling hub for transcriptional control. Pol II
2019 CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia. AML, MLL
2019 CSB-Dependent Cyclin-Dependent Kinase 9 Degradation and RNA Polymerase II Phosphorylation during Transcription-Coupled Repair. CSB
10  2019 Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma. ---
11  2019 Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in ovarian cancer. CDK
12  2019 Cyclin-dependent kinase 9 expression and its association with CD8+ T cell infiltration in microsatellite-stable colorectal cancer. mCRC, MSS, PD-1
13  2019 Cyclin-dependent kinase 9 promotes cervical cancer development via AKT2/p53 pathway. ---
14  2019 Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent invitro and invivo antitumor activity. AML
15  2019 Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models. AML
16  2019 Identification and targeting of novel CDK9 complexes in acute myeloid leukemia. AML, mRNA, mTOR
17  2019 LDC000067 suppresses RANKL-induced osteoclastogenesis in vitro and prevents LPS-induced osteolysis in vivo. CTR, CTSK, DC-STAMP, NF-kappaB, NFATc1, RANKL, TRAP
18  2019 Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer. CSCs, NSCLC
19  2019 Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts. HPV
20  2019 Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses. IFNs, ISGs, JAK, SIRT2, STAT
21  2019 Targeting CDK9 for treatment of colorectal cancer. CRC
22  2019 Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma. PDX, RPPA
23  2019 Targeting cyclin-dependent kinase 9 sensitizes medulloblastoma cells to chemotherapy. BRD4, ChIP, CTD, MB, pRNA Pol II ser2, RNA Pol II, Ser2
24  2019 The efficacy of a cyclin dependent kinase 9 (CDK9) inhibitor, FIT039, on verruca vulgaris: study protocol for a randomized controlled trial. HPVs, HSV-1
25  2019 The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. NELF, Pol II
26  2019 Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression. c-FLIP, RIPK3
27  2019 Transcription Repressor Hes1 Contributes to Neuropathic Pain Development by Modifying CDK9/RNAPII-Dependent Spinal mGluR5 Transcription. Hes1, mGluR5, RNAPII, siRNA
28  2018 A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II. CycT1, P-TEFb, Pol II, PP1
29  2018 An in silico-designed flavone derivative, 6-fluoro-4'-hydroxy-3',5'-dimetoxyflavone, has a greater anti-human cytomegalovirus effect than ganciclovir in infected cells. GCV, HCMV, HEL
30  2018 Antineoplastic effects of selective CDK9 inhibition with atuveciclib on cancer stem-like cells in triple-negative breast cancer. BCSLCs, CSLCs, TNBC
31  2018 Argonaute2 attenuates active transcription by limiting RNA Polymerase II elongation in Drosophila melanogaster. Ago2, NELF, Pol II
32  2018 CDK9 Expression Shows Role as a Potential Prognostic Biomarker in Breast Cancer Patients Who Fail to Achieve Pathologic Complete Response after Neoadjuvant Chemotherapy. DFFS, EFS, LRRFS, NACT, OS, RFS, TMA
33  2018 CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. CIN, HPV
34  2018 CDK9 inhibitors in acute myeloid leukemia. AML
35  2018 CDK9: A key player in cancer and other diseases. P-TEFb
36  2018 Current and emerging therapies for patients with acute myeloid leukemia: a focus on MCL-1 and the CDK9 pathway. AML, Mcl-1, R/R
37  2018 Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation. BRD4, CDK7, CycT1, T-loop
38  2018 Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation. BMMs
39  2018 In Vitro and In Vivo Antitumor and Anti-Inflammatory Capabilities of the Novel GSK3 and CDK9 Inhibitor ABC1183. ---
40  2018 MALAT1 induces osteosarcoma progression by targeting miR-206/CDK9 axis. LncRNAs, MALAT1
41  2018 MicroRNA-874 inhibits cell proliferation and invasion by targeting cyclin-dependent kinase 9 in osteosarcoma. miRNAs
42  2018 Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. CRBN
43  2018 Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer. ---
44  2018 The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 9. HCMV, HEL
45  2018 Transcription Elongation Factor P-TEFb Is Involved in IL-17F Signaling in Airway Smooth Muscle Cells. Brd4, P-TEFb, siRNAs
46  2017 Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma. EAC
47  2017 BRD4 Couples NF-kappaB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection. BRD4, CTD, GRN, IFN, IRF1, ISGs, pol, RSV, TLR3
48  2017 Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC). CDK, CRBN, PROTAC
49  2017 Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFbeta-induced Nox4 expression and myofibroblast transdifferentiation. alpha-SMA, BET, ECM, HDFs, IP-SRM, ROS
50  2017 Cyclin-dependent kinase 9 is a novel specific molecular target in adult T-cell leukemia/lymphoma. ATL, CTD, HTLV-1, P-TEFb, RNAPII
51  2017 Effects of caloric restriction on peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in obese rats. CR, FPG, HOMA-IR, IF, P-TEFb, PPARs
52  2017 Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages. GC, GRE, GRIP1
53  2017 miR-206 inhibits the growth of hepatocellular carcinoma cells via targeting CDK9. HCC
54  2017 Phosphorylation of SPT5 by CDKD;2 Is Required for VIP5 Recruitment and Normal Flowering in Arabidopsis thaliana. CAK4, FLC, Paf1, Spt5, VIP5
55  2017 Regulation of the human papillomavirus type 16 late promoter by transcriptional elongation. Brd4, HPV-16
56  2017 Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases. MAP
57  2017 Targeting of CDK9 with indirubin 3'-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice. IM
58  2016 Down-regulating cyclin-dependent kinase 9 of alloreactive CD4+ T cells prolongs allograft survival. ---
59  2016 Heat Shock Protein 90 Facilitates Latent HIV Reactivation through Maintaining the Function of Positive Transcriptional Elongation Factor b (p-TEFb) under Proteasome Inhibition. HSF1, HSP, LRAs, P-TEFb, PIs
60  2016 Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. PTOA
61  2016 P-TEFb goes viral. CTD, P-TEFb, Pol II
62  2016 P-TEFb goes viral. CTD, P-TEFb, Pol II
63  2016 Positive cyclin T expression as a favorable prognostic factor in treating gastric gastrointestinal stromal tumors. DFS, GISTs, P-TEFb
64  2016 Protein Phosphatase-1 Regulates Expression of Neuregulin-1. CTD, mNIPP1, NIPP1, NRG-1, PP1, RNAPII
65  2016 Quantification of the HIV transcriptional activator complex in live cells by image-based protein-protein interaction analysis. CycT1
66  2016 Short Communication: The Broad-Spectrum Histone Deacetylase Inhibitors Vorinostat and Panobinostat Activate Latent HIV in CD4(+) T Cells In Part Through Phosphorylation of the T-Loop of the CDK9 Subunit of P-TEFb. HAART, HDACIs, P-TEFb
67  2016 Targeting CDK9: a promising therapeutic opportunity in prostate cancer. AR, PCa
68  2016 The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation. aa, ARS, ATF4, CARE, CHOP, Pol II, TSS
69  2016 The impact of CDK9 on radiosensitivity, DNA damage repair and cell cycling of HNSCC cancer cells. DSBs, HNSCC
70  2015 Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing. CDK12, CTD, SEC
71  2015 Discovery of novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9. FVP, SRB
72  2015 Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. 5-FU, Cdc7, Chk1, HCC
73  2015 Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma. DFS
74  2015 RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II. CTD, P-TEFb, PAF1, PAF1C, Pol II
75  2015 Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases. CDK, ChIP, DDX, IIR, IP
76  2014 AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation. 7SK snRNP, AFF1, Brd4, P-TEFb, SECs, Tat
77  2014 ATM regulates NF-kappaB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment. ATM
78  2014 CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses. HSV-1
79  2014 CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. HCC
80  2014 Cyclin-dependent kinase 9 may as a novel target in downregulating the atherosclerosis inflammation (Review). ECs, P-TEFb
81  2014 Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells. 7SK, CycT1, HEXIM, LARP7, P-TEFb, snRNP
82  2014 Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1. c-FLIP, PI3K, TRAIL
83  2014 Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway. BaP, CYP1B1, MSK1, P-TEFb, RNAPII, TNF-alpha
84  2013 Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation. ---
85  2013 CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells. BRD4, CTD, dsRNA, IFN, ISGs, ISRE, Pol II, Q-RT-PCR, RSV, siRNA
86  2013 Computational study and peptide inhibitors design for the CDK9 - cyclin T1 complex. MM-PBSA, SMD
87  2013 Computer-aided design, synthesis and validation of 2-phenylquinazolinone fragments as CDK9 inhibitors with anti-HIV-1 Tat-mediated transcription activity. ---
88  2013 Cyclin-dependent kinase 9 links RNA polymerase II transcription to processing of ribosomal RNA. P-TEFb, RNAPII, rRNA
89  2013 Direct protein interactions are responsible for Ikaros-GATA and Ikaros-Cdk9 cooperativeness in hematopoietic cells. Ik, P-TEFb
90  2013 HEXIM1 induces differentiation of human pluripotent stem cells. HEXIM1, hPSCs, P-TEFb
91  2013 Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant. CycT1, LTR, P-TEFb, Pol II
92  2013 Ribavirin-induced intracellular GTP depletion activates transcription elongation in coagulation factor VII gene expression. ELL, FVII
93  2013 SIRT2 directs the replication stress response through CDK9 deacetylation. SIRT2
94  2013 The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast. PAF, RNAPII
95  2012 Complex effects of flavopiridol on the expression of primary response genes. FVP, LPS, P-TEFb, PRGs, RNAPII
96  2012 Estrogen receptor-alpha recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene. ---
97  2012 Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target. CDKs
98  2012 Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function. CTD, H2Bub1, PCNA, RNAPII
99  2012 Preventing the formation of positive transcription elongation factor b by human cyclin T1-binding RNA aptamer for anti-HIV transcription. CycT1, SELEX
100  2012 Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9. MM, SLM