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Abbreviation : CRX
Long Form : cone-rod homeobox
No. Year Title Co-occurring Abbreviation
2018 A massively parallel reporter assay reveals context-dependent activity of homeodomain binding sites in vivo. CREs, TF
2018 A novel dominant CRX mutation causes adult-onset macular dystrophy. BCAMD, VA
2018 Characterization and Transplantation of CD73-Positive Photoreceptors Isolated from Human iPSC-Derived Retinal Organoids. hiPSCs, MACS
2018 Cone-rod homeobox CRX controls presynaptic active zone formation in photoreceptors of mammalian retina. CAZ, NRL
2018 Impairment of photoreceptor ribbon synapses in a novel Pomt1 conditional knockout mouse model of dystroglycanopathy. alpha-DG, cKO, OPL, POMT1
2018 In silico modeling of epigenetic-induced changes in photoreceptor cis-regulatory elements. ---
2017 Crx-L253X Mutation Produces Dominant Photoreceptor Defects in TVRM65 Mice. PTC
2017 Knock-in strategy at 3'-end of Crx gene by CRISPR/Cas9 system shows the gene expression profiles during human photoreceptor differentiation. iPSC
2017 Retinal expression and localization of Mef2c support its important role in photoreceptor gene expression. Arr3, Mapk15, MEF2C, NRL, Pde6h
10  2016 CrxRdy Cat: A Large Animal Model for CRX-Associated Leber Congenital Amaurosis. ERG
11  2016 Minimal Disseminated Disease in Nonmetastatic Retinoblastoma With High-Risk Pathologic Features and Association With Disease-Free Survival. BM, CSF, DFS, HRPFs, MD
12  2016 Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation. GFP, hESC, PCR, ZFNs
13  2015 Association of Cone-Rod Homeobox Transcription Factor Messenger RNA With Pediatric Metastatic Retinoblastoma. CSF, MD, mRNA
14  2015 De novo mutations in the cone-rod homeobox gene associated with leber congenital amaurosis in Chinese patients. EOSRD, LCA, OCT
15  2015 Transcriptome Dynamics of Developing Photoreceptors in Three-Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks. GFP, NRL
16  2014 Behavioral analyses of visually impaired Crx knockout mice revealed sensory compensation in exploratory activities on elevated platforms. ---
17  2014 Circadian dynamics of the cone-rod homeobox (CRX) transcription factor in the rat pineal gland and its role in regulation of arylalkylamine N-acetyltransferase (AANAT). AANAT
18  2014 Homeobox genes and melatonin synthesis: regulatory roles of the cone-rod homeobox transcription factor in the rodent pineal gland. AANAT
19  2014 Is CRX protein a useful marker in differential diagnosis of tumors of the pineal region? Otx
20  2014 Mechanistically distinct mouse models for CRX-associated retinopathy. CoRD, K-IN, KO, LCA, RP, WT
21  2014 RETINA-specific expression of Kcnv2 is controlled by cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl). CBS, CDSRR, ChIP, ERG, NBS, NRL
22  2014 The phenotypic variability of retinal dystrophies associated with mutations in CRX, with report of a novel macular dystrophy phenotype. COD, CORD, LCA, RCD
23  2013 Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish. ---
24  2013 Massively parallel in vivo enhancer assay reveals that highly local features determine the cis-regulatory function of ChIP-seq peaks. TFs
25  2013 Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina. SAM
26  2013 Upregulation of SOX9 in Glial (Muller) cells in retinal light damage of rats. GS, LD, SD, SRY
27  2012 Establishment of retinal progenitor cell clones by transfection with Pax6 gene of mouse induced pluripotent stem (iPS) cells. iPS
28  2012 Novel p.M96T variant of NRL and shRNA-based suppression and replacement of NRL mutants associated with autosomal dominant retinitis pigmentosa. NRL, RHO, RP
29  2011 Crx broadly modulates the pineal transcriptome. ---
30  2011 No interaction of barrier-to-autointegration factor (BAF) with HIV-1 MA, cone-rod homeobox (Crx) or MAN1-C in absence of DNA. BAF
31  2011 Retinal expression of the X-linked juvenile retinoschisis (RS1) gene is controlled by an upstream CpG island and two opposing CRX-bound regions. TSS, XLRS
32  2011 The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide. NRL, PAX6, RHO, RPE, SOX2
33  2010 A hypoplastic retinal lamination in the purpurin knock down embryo in zebrafish. ---
34  2010 Anatomical changes in the primary visual cortex of the congenitally blind Crx-/- mouse. LCA
35  2010 CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors. ChIP-seq
36  2009 Mutations that are a common cause of Leber congenital amaurosis in northern America are rare in southern India. AIPL1, CRB1, GUCY2D, LCA, NPHP6, RDH12, RPE65, RPGRIP1
37  2008 CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene. GFP
38  2008 FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. ChIP, NRL, Rho
39  2005 Evolutionarily conserved and divergent regulatory sequences in the fish rod opsin promoter. EMSA, RPPR
40  2005 Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. SCA7
41  2005 Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements. NRL
42  2004 Deciphering the contribution of known cis-elements in the mouse cone arrestin gene to its cone-specific expression. CAR, EGFP, mCAR
43  2004 Inner retinal abnormalities in a mouse model of Leber's congenital amaurosis. LCA
44  2004 Novel 615delC mutation in the CRX gene in a Japanese family with cone-rod dystrophy. ERGs
45  2004 Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors. NRL
46  2004 Zebrafish cone-rod (crx) homeobox gene promotes retinogenesis. ---
47  2002 Cloning and characterization of the canine photoreceptor specific cone-rod homeobox (CRX) gene and evaluation as a candidate for early onset photoreceptor diseases in the dog. cd, ORF, RDA, RH
48  2002 Functional analysis of cone-rod homeobox (CRX) mutations associated with retinal dystrophy. HD
49  2002 Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7. BAC, Chr, hyh, MGD, YAC
50  2002 Novel de novo mutation in CRX gene in a Japanese patient with leber congenital amaurosis. LCA
51  2002 Otx5 regulates genes that show circadian expression in the zebrafish pineal complex. Otx
52  2002 Pineal expression-promoting element (PIPE), a cis-acting element, directs pineal-specific gene expression in zebrafish. PIPE, Rh
53  2002 Spinocerebellar ataxia type 7 (SCA7) shows a cone-rod dystrophy phenotype. SCA7
54  2002 The effect of retinoids and butyrate on the expression of CRX and IRBP in retinoblastoma cells. IRBP
55  2001 Developmentally regulated expression of GABA receptor rho1 and rho2 subunits, L7 and cone-rod homeobox (CRX) genes in mouse retina. RT-PCR
56  2001 Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. INL, p.c
57  2000 A CRX null mutation is associated with both Leber congenital amaurosis and a normal ocular phenotype. ---
58  2000 Functional domains of the cone-rod homeobox (CRX) transcription factor. ---
59  2000 Modulation of CRX transactivation activity by phosducin isoforms. G protein, GST, IRBP, Phd, PhLOPs, PhLPs
60  2000 Mutational analysis and clinical correlation in Leber congenital amaurosis. ERG
61  2000 Nuclear trafficking of photoreceptor protein crx: the targeting sequence and pathologic implications. GFP, HEK, LCA, NLS, PCR
62  2000 p300/CBP acts as a coactivator of the cone-rod homeobox transcription factor. ---
63  2000 The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation. CRX-HD, NRL
64  1999 Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function. CORD, LCA
65  1998 A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX. HIOMT, NAT, PINA, PIRE
66  1998 Retinal degenerations with truncation mutations in the cone-rod homeobox (CRX) gene. ERG, OCT