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Abbreviation : CTSK
Long Form : cathepsin K
No. Year Title Co-occurring Abbreviation
2019 18F-FDG PET/MR-imaging in a Gottingen Minipig model of atherosclerosis: Correlations with histology and quantitative gene expression. 18F-FDG, CD68, FFC, MMP9, PET/MRI, SPP1, VCAM-1
2019 AP-1 and Mitf interact with NFATc1 to stimulate cathepsin K promoter activity in osteoclast precursors. AP-1, MITF, NFATc1, RANKL
2019 AZD8835 inhibits osteoclastogenesis and periodontitis-induced alveolar bone loss in rats. ABL, CP, CTR, PI3K, RANKL, TRAP
2019 Cannabinoid Receptor 2 Agonist Prevents Local and Systemic Inflammatory Bone Destruction in Rheumatoid Arthritis. CB2, CIA, IL, MMP-9, NF-kappaB, NFAT-1, TNF-alpha, TRAP
2019 CDDO-Me, Sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response. DC-STAMP, MMP-9, NFATC1, Nrf2, OC, RANKL, ROS, SFN, tBHQ, TNF-alpha, TRAP
2019 ClC-7 Regulates the Pattern and Early Development of Craniofacial Bone and Tooth. ClC-7
2019 Daidzin inhibits RANKL-induced osteoclastogenesis in vitro and prevents LPS-induced bone loss in vivo. c-Fos, NFATc1, RANKL, TRAP
2019 Effect of tumor necrosis factor alpha on ability of SHED to promote osteoclastogenesis during physiological root resorption. DPSCs, ELISA, NF-kappaB, OPG, p-IkappaBalpha, PBMCs, RANKL, RT-PCR, SHED, TNF-alpha, TRAP
2019 Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer. CRC, TAMs, TLR4
10  2019 Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. eQTL, FGF18, TGFB1
11  2019 Inhibitory Effect of KP-A038 on Osteoclastogenesis and Inflammatory Bone Loss Is Associated With Downregulation of Blimp1. BCL6, IRF8, LPS, Mmp9, NFATc1, RANKL
12  2019 Interleukin 29 inhibits RANKL-induced osteoclastogenesis via activation of JNK and STAT, and inhibition of NF-kappaB and NFATc1. BMMs, IL, IL-28Ralpha, MMP-9, NF-kappaB, NFATc1, PBMCs, RANKL, TRAP
13  2019 Irp2 Knockout Causes Osteoporosis by Inhibition of Bone Remodeling. BALP, BGP, BMD, Col I alpha1, FPN1, TfR1, TRAP
14  2019 Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation. ---
15  2019 LncRNA-Jak3:Jak3 coexpressed pattern regulates monosodium urate crystal-induced osteoclast differentiation through Nfatc1/Ctsk expression. MSU, NFATc1
16  2019 MiR-377 inhibits wear particle-induced osteolysis via targeting RANKL. BMMs, IL-6, PIO, RANKL, Ti, TNF-alpha, TRAP
17  2019 Multisuture Craniosynostosis and Papilledema in Pycnodysostosis: A Paradox? PYCD
18  2019 Osteocytes respond to particles of clinically-relevant conventional and cross-linked polyethylene and metal alloys by up-regulation of resorptive and inflammatory pathways. CA2, UHMWPE
19  2019 Pectolinarigenin prevents bone loss in ovariectomized mice and inhibits RANKL-induced osteoclastogenesis via blocking activation of MAPK and NFATc1 signaling. MMP9, OP, PEC, RANKL, TRACP
20  2019 Protective effects of Wang-Bi tablet on bone destruction in collagen-induced arthritis by regulating osteoclast-osteoblast functions. CIA, RA, RANKL, TRAP, WB
21  2019 Tiliroside is a new potential therapeutic drug for osteoporosis in mice. RANKL, Tle
22  2018 Bu-Shen-Tong-Luo decoction prevents bone loss via inhibition of bone resorption and enhancement of angiogenesis in ovariectomy-induced osteoporosis of rats. BSTLD, CALCR, HIF-1alpha, muCT, OPG, PMO, RANKL, VEGF
23  2018 C/ebpalpha controls osteoclast terminal differentiation, activation, function, and postnatal bone homeostasis through direct regulation of Nfatc1. CCRE, cKO, Fos, NFATc1
24  2018 Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma. HPV, LNM, OSCC
25  2018 De novo transcriptome assembly and analysis of differential gene expression following lipopolysaccharide challenge in Pelteobagrus fulvidraco. CXCL2, DEGs, GO, KEGG, LPS, PBS
26  2018 Hormonal Regulation of Osteocyte Perilacunar and Canalicular Remodeling in the Hyp Mouse Model of X-Linked Hypophosphatemia. FGF23, FGF23Ab, MMP13, XLH
27  2018 Inhibitory Effect of Purpurogallin on Osteoclast Differentiation in Vitro through the Downregulation of c-Fos and NFATc1. BCL6, Blimp-1, BMMs, IRF8, RANKL, TRAP
28  2018 Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL-induced NFAT activation and calcium signaling. RANKL
29  2018 MLN64 deletion suppresses RANKL-induced osteoclastic differentiation and attenuates diabetic osteoporosis in streptozotocin (STZ)-induced mice. ALP, IL-1beta, NF, OPN, RANKL, StAR, STZ, STZ, TNF-alpha, TRAP
30  2018 Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption. Mmp9, Nfatc1, RANKL
31  2018 Neogambogic Acid Suppresses Receptor Activator of Nuclear Factor kappaB Ligand (RANKL)-Induced Osteoclastogenesis by Inhibiting the JNK and NF-kappaB Pathways in Mouse Bone Marrow-Derived Monocyte/Macrophages. BMMs, CTR, NFATc1, NGA, RANKL, TRAP
32  2018 Not all pycnodysostosis-related mutants of human cathepsin K are inactive - crystal structure and biochemical studies of an active mutant I249T. ---
33  2018 Oleanolic acid exerts bone protective effects in ovariectomized mice by inhibiting osteoclastogenesis. BMMs, LPS, MMP9, NFATc1, OA, POP, RANKL, TRAP
34  2018 Osteon Myospalacem Baileyi attenuates osteoclast differentiation through RANKL induced NFAT pathways. CTR, DC-STAMP, NFATc1, OSCAR
35  2018 Ostm1 Bifunctional Roles in Osteoclast Maturation: Insights From a Mouse Model Mimicking a Human OSTM1 Mutation. TRAP
36  2018 Preservation of type H vessels and osteoblasts by enhanced preosteoclast platelet-derived growth factor type BB attenuates glucocorticoid-induced osteoporosis in growing mice. GIO, PDGF-BB, WT
37  2018 Pycnodysostosis: Novel Variants in CTSK and Occurrence of Giant Cell Tumor. ---
38  2018 Reduced miR-144-3p expression in serum and bone mediates osteoporosis pathogenesis by targeting RANK. miRNAs
39  2018 Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-kappaB pathway. BMMs, c-Fos, MMP-9, NFATc1, RBM
40  2018 The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover. ARSB, ERT, MPS-VI, SOST
41  2018 The naturally derived small compound Osthole inhibits osteoclastogenesis to prevent ovariectomy-induced bone loss in mice. BMMs, MMP9, NFATc1, OT, RANKL, TRAP
42  2018 The systemic bone protective effects of Gushukang granules in ovariectomized mice by inhibiting osteoclastogenesis and stimulating osteoblastogenesis. ALP, BMMs, GSK, MMP9, MSCs, NFATc1, POP, RANKL, TCM
43  2018 Zoledronate and high glucose levels influence osteoclast differentiation and bone absorption via the AMPK pathway. NFATc1, Syk, TRAP, ZOL
44  2018 [Experimental study on the effect of hepcidin overexpression on osteoclasts and bone mass in iron accumulation mice]. CTK, CTR group, CTX, ELISA, micro-CT, PTK2beta, TRAP
45  2017 Autocrine and paracrine STIP1 signaling promote osteolytic bone metastasis in renal cell carcinoma. RCC, STIP1
46  2017 Bajijiasu Abrogates Osteoclast Differentiation via the Suppression of RANKL Signaling Pathways through NF-kappaB and NFAT. ERK, IkappaB-alpha, MMP2, NFATc1, RANKL, TRACP, V-ATPase d2
47  2017 beta-Carotene suppresses osteoclastogenesis and bone resorption by suppressing NF-kappaB signaling pathway. BMM, LDH, MAPK, NF-B, NFATc1, RANKL
48  2017 Diphlorethohydroxycarmalol from Ishige okamurae Suppresses Osteoclast Differentiation by Downregulating the NF-kappaB Signaling Pathway. DPHC, M-CSF, Nfatc1, RANKL, TRAP
49  2017 Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse. ---
50  2017 Drug Treatment and In Vivo Imaging of Osteoblast-Osteoclast Interactions in a Medaka Fish Osteoporosis Model. Osx, RANKL
51  2017 Effects of cathepsin K on Emdogain-induced hard tissue formation by human periodontal ligament stem cells. hPDLSCs
52  2017 Genetic Analysis of Giant Cell Lesions of the Maxillofacial and Axial/Appendicular Skeletons. AA, GCLs, GCs, MF, MMP-9, TCIRG1, TMA
53  2017 Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis. BMDMs, DCSTAMP, DMARDs, M-CSF, MMP, RA, STIA, TRAP, Wnt5a cKO
54  2017 I‑BET151 inhibits osteoclastogenesis via the RANKL signaling pathway in RAW264.7 macrophages. JNK, MMP9, RANKL, TRACP
55  2017 Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption. LPS, ND, NFATc1, OC, RANKL
56  2017 Osteoclastic differentiation and resorption is modulated by bioactive metal ions Co2+, Cu2+ and Cr3+ incorporated into calcium phosphate bone cements. CAII, CPC, PBMC, TRAP
57  2017 Osteoclastogenic capacity of peripheral blood mononuclear cells is not different between women with and without osteoporosis. DPD, PBMCs
58  2017 Palmitoleic Acid Inhibits RANKL-Induced Osteoclastogenesis and Bone Resorption by Suppressing NF-kappaB and MAPK Signalling Pathways. ERK, FAs, JNK, MAPK, MMP9, NF-kappaB, PLA, TRAP
59  2017 Prolactin blocks the expression of receptor activator of nuclear factor kappaB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis. AIA, IFN, MAIA, MMP9, PRL, STAT3, Th, TRAP
60  2017 Regulation of osteoclast differentiation by static magnetic fields. MMP9, SMF
61  2017 Relevance of osteoclast-specific enzyme activities in cell-based in vitro resorption assays. CAII, CPC, ECM, TRAP
62  2017 Sciadopitysin suppresses RANKL-mediated osteoclastogenesis and prevents bone loss in LPS-treated mice. ROS, Sc, TRAP
63  2017 The inhibitory effect of beta-lapachone on RANKL-induced osteoclastogenesis. AMPK, beta-L, DC-STAMP, NFATc1, PGC-1beta, PPARgamma, RANKL
64  2017 [Overexpression of Klotho inhibits differentiation of RAW264.7 cells into osteoclasts]. KL, qRT-PCR, sRANKL, TRAP
65  2016 Ablation of Y1 receptor impairs osteoclast bone-resorbing activity. MCP-1, MMP-9, TRACP-5b, Y1R
66  2016 Advanced glycation end products biphasically modulate bone resorption in osteoclast-like cells. AGEs, OCLs, RANK, TRAP
67  2016 Aminothiazoles inhibit RANKL- and LPS-mediated osteoclastogenesis and PGE2 production in RAW 264.7 cells. LPS, OPG, PGE2, RANK, RANKL, TRAP
68  2016 Anti-Inflammatory, Anti-Osteoclastogenic and Antioxidant Effects of Malva sylvestris Extract and Fractions: In Vitro and In Vivo Studies. AF, CAII, MMP-9, TRAP
69  2016 Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis. CMA1, DPD, MMP-1
70  2016 Discovery of a New Class of Cathepsin K Inhibitors in Rhizoma Drynariae as Potential Candidates for the Treatment of Osteoporosis. NF-kappaB, RD
71  2016 Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model. FBGCs, HA, MNGCs, TRAP
72  2016 Effects of 10-hydroxycamptothecin on differentiation of RAW264.7 cells into osteoclasts. 10-HCPT, CCK-8, M-CSF, MMP-9, PCR, RANKL, TRAP
73  2016 Effects of combined ovariectomy with dexamethasone on rat lumbar vertebrae. BL, DEXA, LRP-5, OPG, PINP, sham
74  2016 Eriodictyol Inhibits RANKL-Induced Osteoclast Formation and Function Via Inhibition of NFATc1 Activity. RANKL
75  2016 Evidence that osteocyte perilacunar remodelling contributes to polyethylene wear particle induced osteolysis. CA2, Lac.Ar, PE, PO, THR, TRAP, UHMWPE
76  2016 Genetics of osteoporosis: searching for candidate genes for bone fragility. GWAS, SOST
77  2016 Isolation of osteocytes from human trabecular bone. Car2, DMP1, EDTA, FGF23, MEPE, MMP13, PHEX, PTH
78  2016 Niclosamide suppresses RANKL-induced osteoclastogenesis and prevents LPS-induced bone loss. IkappaB, RANKL, STAT3
79  2016 Osteoclasts are not activated in middle ear cholesteatoma. CALCR, MMP9, mRNA, OPG, OSCAR, RANK, RANKL, TRAP
80  2016 Qishen Yiqi Drop Pill improves cardiac function after myocardial ischemia. iNOS, LVEDD, LVEDs, MI, QYDP, SD
81  2016 Regulation and Biological Significance of Formation of Osteoclasts and Foreign Body Giant Cells in an Extraskeletal Implantation Model. beta-TCP, BMMCs, FBGCs, MNGCs, TRAP
82  2016 Sinusoidal electromagnetic fields promote bone formation and inhibit bone resorption in rat femoral tissues in vitro. ALP, M-CSF, Osx, SEMFs, TRACP
83  2016 Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis. A. actinomycetemcomitans, ACP5, BMMs, NFATc1, S1PR2
84  2016 The role of cathepsin K in oral and maxillofacial disorders. ---
85  2016 The silencing of cathepsin K used in gene therapy for periodontal disease reveals the role of cathepsin K in chronic infection and inflammation. AAV, sh
86  2016 WHI-131 Promotes Osteoblast Differentiation and Prevents Osteoclast Formation and Resorption in Mice. Btk, C-SRC, IkappaB, IL, JAK-STAT, NFATc1, OSCAR, PLCgamma2, RANKL, TRAP
87  2016 Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways. AKAPs, BMM, cAMP, LRP, PKA
88  2015 17-Hydroxy-jolkinolide A inhibits osteoclast differentiation through suppressing the activation of NF-kappaB and MAPKs. BMMs, HJA, MNCs, OC, TRAP
89  2015 A Mutation in CTSK Gene in an Autosomal Recessive Pycnodysostosis Family of Chinese Origin. ---
90  2015 A pterostilbene derivative suppresses osteoclastogenesis by regulating RANKL-mediated NFkappaB and MAPK signaling in RAW264.7 cells. MMP9, NFATc1, ROS, TRAP
91  2015 A small molecule, odanacatib, inhibits inflammation and bone loss caused by endodontic disease. ELISA, micro-CT, ODN, qRT-PCR
92  2015 Andrographolide Inhibits Ovariectomy-Induced Bone Loss via the Suppression of RANKL Signaling Pathways. AP, micro-CT, Tb.N, Tb.Th
93  2015 Berberine Sulfate Attenuates Osteoclast Differentiation through RANKL Induced NF-kappaB and NFAT Pathways. BMMs, NFATc1, V-ATPase d2
94  2015 Bone status of adult female butyrylcholinesterase gene-deficient mice. AChE, BChE, TRAP, WT
95  2015 Calycosin Suppresses RANKL-Mediated Osteoclastogenesis through Inhibition of MAPKs and NF-kappaB. BMMs, TRAP
96  2015 CTSK inhibitor exert its anti-obesity effects through regulating adipocyte differentiation in high-fat diet induced obese mice. CKSI, HFD, HOMA, PPARgamma
97  2015 Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role. RA, TLRs
98  2015 Dental Abnormalities Caused by Novel Compound Heterozygous CTSK Mutations. ---
99  2015 FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans. A. actinomycetemcomitans, ACP5, BMMs, ELISA, IL, M-CSF, Nfatc1, p-ERK, p-PI3K, PCR, RANKL, S1P, TNF, TRAP
100  2015 Inhibitory effects of eugenol on RANKL-induced osteoclast formation via attenuation of NF-kappaB and MAPK pathways. MAPK, MMP-9, RANKL