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[Related PubMed/MEDLINE]
Total Number of Papers: 1054
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| Abbreviation |
: CUMS |
| Long Form |
: chronic unpredictable mild stress |
|
| No. |
Year |
Title |
Co-occurring Abbreviation |
| 1 |
2022 |
A Network Pharmacology-Based Study on Antidepressant Effect of Salicornia europaea L. Extract with Experimental Support in Chronic Unpredictable Mild Stress Model Mice. |
CM, CNS, CORT, DA, ELISA, FST, GO, HO-1, Keap1, KEGG, Nrf2, OFT, PPI, TST |
| 2 |
2022 |
A preliminary study on the diversity of butyrate-producing bacteria in response to the treatment of depression with Xiaoyaosan. |
TCM, XYS |
| 3 |
2022 |
Acupuncture Relieves Stress-Induced Depressive Behavior by Reducing Oxidative Stress and Neuroapoptosis in Rats. |
--- |
| 4 |
2022 |
Aggravating Effects of Psychological Stress on Ligature-Induced Periodontitis via the Involvement of Local Oxidative Damage and NF-κB Activation. |
HIF-1alpha, MDA, NF-kappaB, ROS |
| 5 |
2022 |
Alleviative effects of foraging exercise on depressive-like behaviors in chronic mild stress-induced ischemic rat model. |
FE, PSD |
| 6 |
2022 |
Anti-depressant effects of acupuncture: The insights from NLRP3 mediated pyroptosis and inflammation. |
--- |
| 7 |
2022 |
Antidepressant Effect of Water Extract of Royal Sun Medicinal Mushroom, Agaricus brasiliensis (Agaricomycetes), in Mice Exposed to Chronic Unpredictable Mild Stress. |
AWE, DA, NE, TST |
| 8 |
2022 |
Antidepressant Shugan Jieyu Capsule Alters Gut Microbiota and Intestinal Microbiome Function in Rats With Chronic Unpredictable Mild Stress -Induced Depression. |
CNS, SG |
| 9 |
2022 |
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression. |
2-ME, GRd, HIF-1alpha, PSD-95, SYN1 |
| 10 |
2022 |
Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134-mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression. |
BDNF, miR-134, miRNAs |
| 11 |
2022 |
Antidepressant-like effect of sodium orthovanadate in a mouse model of chronic unpredictable mild stress. |
BDNF, ELISA, LPO, NO, OFT, SOD, SOV, SPT, TrkB receptor, TST |
| 12 |
2022 |
Antidepressant-like effects of aqueous extracts of miswak (Salvadora persica) and date palm (Phoenix dactylifera) on depression-like behaviors using CUMS model in male rats. |
AChE, MDA |
| 13 |
2022 |
Associations Between Disordered Microbial Metabolites and Changes of Neurotransmitters in Depressed Mice. |
--- |
| 14 |
2022 |
Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression. |
AST, ATP, DG, IL-4R, iNOS, JAK, LPS, STAT |
| 15 |
2022 |
Baicalin Attenuates Continuous Activation of β-Catenin Induced by Lipopolysaccharide (LPS) and Depression Complicated by Infertility in Male Rats. |
BA, DCMI, FST, LPS, NPY, OFT, SPT, TST |
| 16 |
2022 |
Bupleurum chinense DC improves CUMS-induced depressive symptoms in rats through upregulation of the cAMP/PKA/CREB signalling pathway. |
CREB, ELISA, RT-PCR, WB |
| 17 |
2022 |
Cang-Ai Volatile Oil Ameliorates Depressive Behavior Induced by Chronic Stress Through IDO-Mediated Tryptophan Degradation Pathway. |
5-HIAA, CAVO, FST, IDO, IFN-gamma, IL-10, IL-1beta, IL-4, IL-6, KYN, KYNA, OFT, QUIN, SPT, TNF-alpha, Trp |
| 18 |
2022 |
Central and cardiac stress resilience consistently linked to integrated immuno-neuroendocrine responses across stress models in male mice. |
CTRL, FC, RS, SS |
| 19 |
2022 |
CircDYM ameliorates CUMS mice depressive-like behavior and inhibits hippocampal neurons injury via miR-497a-5p/NR3C1 axis. |
circRNA, miR |
| 20 |
2022 |
Combined Administration of (R)-Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Induces Rapid and Sustained Effects in the CUMS Model of Depression via a TrkB/BDNF-Dependent Mechanism. |
RAAD, TST |
| 21 |
2022 |
Comparative Pharmacokinetic Study of Three Major Bioactive Components in the Normal and Different Courses of Liver-Stagnation and Spleen-Deficiency Syndrome Depressive Rats after Intragastric Administration of Zhi-Zi-Hou-Po Decoction. |
ZZHPD |
| 22 |
2022 |
Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring. |
OFT, PMS, SPT, STT |
| 23 |
2022 |
Correlation between intestinal microbiotal imbalance and 5-HT metabolism, immune inflammation in chronic unpredictable mild stress male rats. |
ELISA, FST, qPCR, SPT |
| 24 |
2022 |
CUMS and dexamethasone induce depression-like phenotypes in mice by differentially altering gut microbiota and triggering macroglia activation. |
CON, CORT, DEX, ELISA, GFAP, IL-1beta |
| 25 |
2022 |
Decreased Phase-Amplitude Coupling Between the mPFC and BLA During Exploratory Behaviour in Chronic Unpredictable Mild Stress-Induced Depression Model of Rats. |
BLA, LFPs, mPFC, PAC |
| 26 |
2022 |
DFO treatment protects against depression-like behaviors and cognitive impairment in CUMS mice. |
DFO, EPT, FST, HIF-1alpha, MWM, OFT, SPT, TST |
| 27 |
2022 |
Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo. |
5-HT1AR, GPCR, OX1R, TMs |
| 28 |
2022 |
Downregulation of CRTC1 Is Involved in CUMS-Induced Depression-Like Behavior in the Hippocampus and Its RNA Sequencing Analysis. |
AAV, CREB, CRTC1, shRNA |
| 29 |
2022 |
Dynamic effects of chronic unpredictable mild stress on the hippocampal transcriptome in rats. |
DEGs, GO |
| 30 |
2022 |
Effects of Huolisu Oral Solution on Depression-Like Behavior in Rats: Neurotransmitter and HPA Axis. |
5-HT, ACTH, beta-EP, CORT, DA, ELISA, FST, HLS, HPA, HPLC, NE, TST |
| 31 |
2022 |
Effects of repeated drug administration on behaviors in normal mice and fluoxetine efficacy in chronic unpredictable mild stress mice. |
i.g, i.p, TVI |
| 32 |
2022 |
Electroacupuncture Alleviates Visceral Hypersensitivity in IBS-D Rats by Inhibiting EGCs Activity through Regulating BDNF/TrkB Signaling Pathway. |
AWR, EA, IBS-D, RT-PCR, WB |
| 33 |
2022 |
Elevated BICD2 DNA methylation in blood of major depressive disorder patients and reduction of depressive-like behaviors in hippocampal Bicd2-knockdown mice. |
MDD, MSE-qPCR |
| 34 |
2022 |
Endogenous hippocampal estrogen is involved in stress-induced depression-like behaviors and spine plasticity in male rats. |
--- |
| 35 |
2022 |
Exosomes deliver lncRNA DARS-AS1 siRNA to inhibit chronic unpredictable mild stress-induced TNBC metastasis. |
Exos, TNBC |
| 36 |
2022 |
Exploration of a Brain-Liver-Communication-Related Mechanism Involved in the Experimental Perimenopausal Depression Rat Model using Chaihu-Shugan-San. |
CSS, PMS |
| 37 |
2022 |
Exploring the potential antidepressant mechanisms of puerarin: Anti-inflammatory response via the gut-brain axis. |
BDNF, FST, NF-kappaB, OFT, SPT |
| 38 |
2022 |
Extracellular Nucleosomes Accelerate Microglial Inflammation via C-Type Lectin Receptor 2D and Toll-Like Receptor 9 in mPFC of Mice With Chronic Stress. |
APC, Clec2d, DAMPs, mPFC, NF-kappaB, NLRP3, ROS, TLR9 |
| 39 |
2022 |
G721-0282 Exerts Anxiolytic-Like Effects on Chronic Unpredictable Mild Stress in Mice Through Inhibition of Chitinase-3-Like 1-Mediated Neuroinflammation. |
CHI3L1 |
| 40 |
2022 |
Gene expression profiling reveals candidate biomarkers and probable molecular mechanisms in chronic stress. |
DEGs |
| 41 |
2022 |
Ginsenoside Rh2 administration produces crucial antidepressant-like effects in a CUMS-induced mice model of depression. |
FST, TST |
| 42 |
2022 |
Gut Microbiota-Mediated Elevated Production of Secondary Bile Acids in Chronic Unpredictable Mild Stress. |
DCA |
| 43 |
2022 |
Gypenoside XVII, an Active Ingredient from Gynostemma Pentaphyllum, Inhibits C3aR-Associated Synaptic Pruning in Stressed Mice. |
--- |
| 44 |
2022 |
Herba Rhodiolae alleviates depression via the BDNF/TrkB-GSK-3β signaling pathway. |
GSK-3beta, HPLC |
| 45 |
2022 |
High-frequency repetitive transcranial magnetic stimulation mitigates depression-like behaviors in CUMS-induced rats via FGF2/FGFR1/p-ERK signaling pathway. |
rTMS |
| 46 |
2022 |
Histone methyltransferase enhancer of zeste 2 polycomb repressive complex 2 subunit exacerbates inflammation in depression rats by modulating microglia polarization. |
EZH2, LPS, miR, MMP-2 |
| 47 |
2022 |
Homocysteine-Induced Disturbances in DNA Methylation Contribute to Development of Stress-Associated Cognitive Decline in Rats. |
BDNF, Hcy, HHcy |
| 48 |
2022 |
Hydroxysafflor yellow A can improve depressive behavior by inhibiting hippocampal inflammation and oxidative stress through regulating HPA axis. |
HSYA |
| 49 |
2022 |
Hypothalamic NR3C1 DNA methylation in rats exposed to prenatal stress. |
PS |
| 50 |
2022 |
Icariin improves glucocorticoid resistance in a murine model of asthma with depression associated with enhancement of GR expression and function. |
BALF, OVA |
| 51 |
2022 |
Identification of Potential Diagnoses Based on Immune Infiltration and Autophagy Characteristics in Major Depressive Disorder. |
ARMGs, IIC, MDD, PPI |
| 52 |
2022 |
Inhibition of Connexin 36 attenuates HMGB1-mediated depressive-like behaviors induced by chronic unpredictable mild stress. |
CNS, Cx, ELISA, FST, GZA, HMGB1, IL-1beta, KP, LPS, OFT, SPT, TNF-alpha, TST |
| 53 |
2022 |
Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice. |
NLRP3 |
| 54 |
2022 |
Inhibition of TRPC1, TRPM4 and CHRNA6 ion channels ameliorates depression-like behavior in rats. |
MDD |
| 55 |
2022 |
Integrating Metabolomics and Network Analysis for Exploring the Mechanism Underlying the Antidepressant Activity of Paeoniflorin in Rats With CUMS-Induced Depression. |
PF |
| 56 |
2022 |
Integration of Non-Targeted Metabolomics and Targeted Quantitative Analysis to Elucidate the Synergistic Antidepressant Effect of Bupleurum Chinense DC-Paeonia Lactiflora Pall Herb Pair by Regulating Purine Metabolism. |
CBHP, IL, MDA, NLRP3, TNF, XDH, XOD |
| 57 |
2022 |
Jasmine Tea Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior in Rats via the Gut-Brain Axis. |
BGM |
| 58 |
2022 |
Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4/MyD88/NF-κB pathway in CUMS mice. |
FSTL1 |
| 59 |
2022 |
Knockdown of miRNA-134-5p rescues dendritic deficits by promoting AMPK-mediated mitophagy in a mouse model of depression. |
AMPK |
| 60 |
2022 |
Kolaviron ameliorates chronic unpredictable mild stress-induced anxiety and depression: involvement of the HPA axis, antioxidant defense system, cholinergic, and BDNF signaling. |
EPM, FST, KV, TST |
| 61 |
2022 |
L. Cucurbita pepo modulates contact dermatitis in depressed rats through downregulation of proinflammatory cytokines and upregulation of antioxidant status. |
CAT, CD, COX-2, DNFB, GPx, IL-6, iNOS, MDA, SOD, TNF-alpha |
| 62 |
2022 |
Lactobacillus rhamnosus zz-1 exerts preventive effects on chronic unpredictable mild stress-induced depression in mice via regulating the intestinal microenvironment. |
BDNF, HPA, L. rhamnosus, TrkB |
| 63 |
2022 |
Liquiritin Alleviates Depression-Like Behavior in CUMS Mice by Inhibiting Oxidative Stress and NLRP3 Inflammasome in Hippocampus. |
CETSA, EPM, FST, IL-18, IL-1beta, MDA, SOD, TST |
| 64 |
2022 |
Loureirin C and Xanthoceraside Attenuate Depression-Like Behaviors and Expression of Interleukin-17 in the Prefrontal Cortex Induced by Chronic Unpredictable Mild Stress in Mice. |
IL-17, MDD, PFC |
| 65 |
2022 |
Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats. |
PPD |
| 66 |
2022 |
Luteolin Enhances Choroid Plexus 5-MTHF Brain Transport to Promote Hippocampal Neurogenesis in LOD Rats. |
5-MTHF, CP, CPECs, CSF, FR-alpha, LOD, NSCs, PCFT, RFC, ZO-1 |
| 67 |
2022 |
Lysosomal dysfunction is associated with NLRP3 inflammasome activation in chronic unpredictable mild stress-induced depressive mice. |
--- |
| 68 |
2022 |
Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits. |
DD, DGCR8, Gab1, m6A, METTL3, miR |
| 69 |
2022 |
Mechanistic Studies of Gypenosides in Microglial State Transition and its Implications in Depression-Like Behaviors: Role of TLR4/MyD88/NF-κB Signaling. |
FST, LPS, OFT, SPT, Thunb |
| 70 |
2022 |
Metabolomics Analysis of the Prefrontal Cortex in a Rat Chronic Unpredictable Mild Stress Model of Depression. |
BW, FST, PFC, SPT |
| 71 |
2022 |
Metabolomics Based on Peripheral Blood Mononuclear Cells to Dissect the Mechanisms of Chaigui Granules for Treating Depression. |
PBMC, TCM |
| 72 |
2022 |
Mongolian Medicine Areca Thirteen Pill (GY-13) Improved Depressive Syndrome via upregulating cAMP/PKA/CREB/BDNF signaling pathway. |
BDNF, CREB, GY-13 |
| 73 |
2022 |
MST1-knockdown protects against impairment of working memory via regulating neural activity in depression-like mice. |
--- |
| 74 |
2022 |
Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety- and Depression-like Phenotypes by Modulating Gut Microbiome-Brain Activity in Rats. |
EPM, FST, MS, OFT, SPT |
| 75 |
2022 |
N-3 PUFA Ameliorates the Gut Microbiota, Bile Acid Profiles, and Neuropsychiatric Behaviours in a Rat Model of Geriatric Depression. |
BGM, PUFAs |
| 76 |
2022 |
Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression. |
AAV, HC, IL-1beta, IL-6, JAK, miRNAs, SOCS2, STAT3, TNF-alpha |
| 77 |
2022 |
Neuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway. |
DMF |
| 78 |
2022 |
Neuroprotective Efficiency of Prodigiosins Conjugated with Selenium Nanoparticles in Rats Exposed to Chronic Unpredictable Mild Stress is Mediated Through Antioxidative, Anti-Inflammatory, Anti-Apoptotic, and Neuromodulatory Activities. |
PDGs |
| 79 |
2022 |
Oral administration of Lactococcus lactis WHH2078 alleviates depressive and anxiety symptoms in mice with induced chronic stress. |
5-HT, 5-HTP, TPH1 |
| 80 |
2022 |
Oridonin relieves depressive-like behaviors by inhibiting neuroinflammation and autophagy impairment in rats subjected to chronic unpredictable mild stress. |
FLX, MDD |
| 81 |
2022 |
Peripheral and central pathophysiological changes in a new rat model of acid reflux combined with mental stress. |
CRF, DIS, Dsg1, GABA, GERD, PKA |
| 82 |
2022 |
Pinocembrin ameliorates depressive-like behaviors by regulating P2X7/TRL4 receptors expression in mouse hippocampus. |
MDD, NLRP3, P2X7R, SPTs, TLR4, TSTs |
| 83 |
2022 |
Pinocembrin Decreases Atrial Fibrillation Susceptibility in a Rodent Model of Depression. |
AF, APD, ERP, HRV, ICa,L |
| 84 |
2022 |
Platycladus orientalis seed extract as a potential triple reuptake MAO inhibitor rescue depression phenotype through restoring monoamine neurotransmitters. |
5-HT, TCM |
| 85 |
2022 |
Prenatal chronic stress impairs the learning and memory ability via inhibition of the NO/cGMP/PKG pathway in the Hippocampus of offspring. |
cGMP-PKG, DEPs, iTRAQ |
| 86 |
2022 |
Protective effects of Thai Mucuna pruriens (L.) DC. var. pruriens seeds on sexual behaviors and essential reproductive markers in chronic unpredictable mild stress mice. |
--- |
| 87 |
2022 |
Proteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress. |
DEPs, FST, GABA, GO, PPI, SPT, TCM, TMT |
| 88 |
2022 |
Puerarin Alleviates Depression-Like Behavior Induced by High-Fat Diet Combined With Chronic Unpredictable Mild Stress via Repairing TLR4-Induced Inflammatory Damages and Phospholipid Metabolism Disorders. |
COX-2, cPLA2, HFD, IL-6, PGE2, TLR4, TNF-alpha |
| 89 |
2022 |
Rapid and sustained restoration of astrocytic functions by ketamine in depression model mice. |
ACTH, BDNF, GFAP, GLT-1 |
| 90 |
2022 |
Rapid Eye Movement Sleep Deprivation Enhances Adenosine Receptor Activation and the CREB1/YAP1/c-Myc Axis to Alleviate Depressive-like Behaviors in Rats. |
REMSD |
| 91 |
2022 |
Regulation of the kynurenine/serotonin pathway by berberine and the underlying effect in the hippocampus of the chronic unpredictable mild stress mice. |
5-HIAA, BBR, DDC, HPLC, IDO1, KYN, MAOA, qRT-PCR, Trp, WB |
| 92 |
2022 |
Repeated testing modulates chronic unpredictable mild stress effects in male rats. |
--- |
| 93 |
2022 |
Repetitive transcranial magnetic stimulation exerts anti-inflammatory effects via modulating glial activation in mice with chronic unpredictable mild stress-induced depression. |
IL, rTMS, TNF-alpha |
| 94 |
2022 |
S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats. |
LTP, MDD |
| 95 |
2022 |
Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress. |
FLU, mTOR, NC, PSD-95, SSD, SYP |
| 96 |
2022 |
Selection of the Male or Female Sex in Chronic Unpredictable Mild Stress-Induced Animal Models of Depression. |
--- |
| 97 |
2022 |
Selective activation of ABCA1/ApoA1 signaling in the V1 by magnetoelectric stimulation ameliorates depression via regulation of synaptic plasticity. |
ABCA1, ApoA1, c-MSST, LPS, MDD |
| 98 |
2022 |
Serum metabolomic responses to aerobic exercise in rats under chronic unpredictable mild stress. |
--- |
| 99 |
2022 |
Shanzhiside methylester protects against depression by inhibiting inflammation via the miRNA-155-5p/SOCS1 axis. |
FST, SM, SPT, TST |
| 100 |
2022 |
Shuxie-1 Decoction Alleviated CUMS -Induced Liver Injury via IL-6/JAK2/STAT3 Signaling. |
CCK-8, FLU, HE, IL-6, JAK2, STAT3, SX-1 |
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