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Abbreviation : CYP1A2
Long Form : cytochrome P450 1A2
No. Year Title Co-occurring Abbreviation
2022 Bioprinting of a Hepatic Tissue Model Using Human-Induced Pluripotent Stem Cell-derived Hepatocytes for Drug-Induced Hepatotoxicity Evaluation. 3DP, hiPSC-Heps, hiPSCs
2022 Danlu tongdu tablets: Preclinical safety evaluation and mechanism of hepatotoxicity. ALT, AST, CYP1, CYP1A1, DLTD, MFD
2022 Development of an in vitro insulin resistance dissociated model of hepatic steatosis by co-culture system. CYP2E1, CYP3A, ELOVL6, G6Pase, PCK1, PDK4, rHPCs, SREBP-1c
2022 Evaluation of CYP1A2 activity: Relationship between the endogenous urinary 6-hydroxymelatonin to melatonin ratio and paraxanthine to caffeine ratio in dried blood spots. ---
2022 Functional single-nucleotide polymorphism (rs762551) in CYP1A2 gene affects white coffee intake in healthy 20- to 40-year-old adults. ADORA2A, TG
2022 Glutathione-S-transferase activity in various organs of Crocodylus siamensis and its attenuation role in aflatoxin B1-induced cell apoptosis in human hepatocarcinoma cells. AFB1, GST, GSTP
2022 Intermittent Hypoxia Inhibits Hepatic CYP1a2 Expression and Delays Aminophylline Metabolism. IH
2022 Pharmacokinetics of Caffeine: A Systematic Analysis of Reported Data for Application in Metabolic Phenotyping and Liver Function Testing. ---
2022 Reflections on the Complex History of the Concept of Clozapine-Induced Inflammation during Titration. CRP, PM
10  2022 [Prediction of immune-related genes associated with prognosis in patients with hepatocellular carcinoma by bioinformatics methods]. C-index, FCN3, HCC, HDGFL1, LASSO, LCN2, MTCO2P12, PADI3, RGS16, ROC curve
11  2021 Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-kappaB-mediated signaling pathway in vitro and in vivo. AOPPs, BSA, CKD
12  2021 Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese. CI, CVDs, OR, SNP
13  2021 Body weight gain in clozapine-treated patients: Is norclozapine the culprit? BMI, HbA1c
14  2021 Borneol influences the pharmacokinetics of florfenicol through regulation of cytochrome P450 1A2 (CYP1A2), CYP2C11, CYP3A1, and multidrug resistance 1 (MDR1) mRNA expression levels in rats. BW, CYP3A1, MDR1
15  2021 CYP1A2 suppresses hepatocellular carcinoma through antagonizing HGF/MET signaling. HCC, MMPs
16  2021 Detoxification gene expression, genotoxicity, and hepatorenal damage induced by subacute exposure to the new pyrethroid, imiprothrin, in rats. AST, b.wt, BMD, CA, i.p, SOD
17  2021 Functional Characterization of 21 Rare Allelic CYP1A2 Variants Identified in a Population of 4773 Japanese Individuals by Assessing Phenacetin O-Deethylation. ---
18  2021 Identification of the contact region responsible for the formation of the homomeric CYP1A2•CYP1A2 complex. BRET, WT-CYP1A2
19  2021 In silico screening and analysis of nonsynonymous SNPs in human CYP1A2 to assess possible associations with pathogenicity and cancer susceptibility. nsSNPs
20  2021 Shengmai Yin formula exerts cardioprotective effects on rats with chronic heart failure via regulating Linoleic Acid metabolism. ALOX15, CHF, ELISA, SMY, WB
21  2021 The dietary carcinogen PhIP activates p53-dependent DNA damage response in the colon of CYP1A-humanized mice. hCYP1A, PhIP
22  2020 ATSC transplantation contributes to liver regeneration following paracetamol-induced acute liver injury through differentiation into hepatic-like cells. AFP, ALI, ATSCs, DILI, FISH, HGF, HNF4alpha, LG, qRT-PCR
23  2020 CYP1A2 and tobacco interaction: a major pharmacokinetic challenge during smoking cessation. ---
24  2020 Cytochrome P450 1A2 overcomes nuclear factor kappa B-mediated sorafenib resistance in hepatocellular carcinoma. HCC, NF-kappaB, SR
25  2020 Erratum to decreased expression of hepatic cytochrome P450 1A2 (CYP1A2) in a chronic intermittent hypoxia mouse model. ---
26  2020 Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity. RRPs, THS
27  2020 Investigation on Intestinal Proteins and Drug Metabolizing Enzymes in Simulated Microgravity Rats by a Proteomics Method. ADH1, ALDH, DEPs, GSTM5, IDMEs, SMG
28  2020 Licorice Ameliorates Cisplatin-Induced Hepatotoxicity Through Antiapoptosis, Antioxidative Stress, Anti-Inflammation, and Acceleration of Metabolism. Bcl-2, CP, CYP1A1, CYP4A2, HMGB1, IL-1beta, SOD, TNF-alpha, TOP2A
29  2019 Biomarker Discovery for Cytochrome P450 1A2 Activity Assessment in Rats, Based on Metabolomics. ---
30  2019 CYP1A2 contributes to alcohol-induced abnormal lipid metabolism through the PTEN/AKT/SREBP-1c pathway. PTEN, SREBP-1c
31  2019 Dynamic determination of functional liver capacity with the LiMAx test in post-cardiac arrest patients undergoing targeted temperature management-A prospective trial. HH, ICU, TTM
32  2019 Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine's Effect on Postprandial Glycaemia. ADORA2A, AUC, CHO, GLU, SNPs
33  2019 HepG2-1A2 C2 and C7: Lentivirus vector-mediated stable and functional overexpression of cytochrome P450 1A2 in human hepatoblastoma cells. ---
34  2019 Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: a prospective analysis of up to 347,077 individuals and 8368 cases. CVD
35  2019 Multiple CH/pi Interactions Maintain the Binding of Aflatoxin B₁ in the Active Cavity of Human Cytochrome P450 1A2. ---
36  2019 Pharmacogenomics analysis in Chinese pediatric liver transplantation patients with renal toxicity induced by tacrolimus. PON1, TDM
37  2019 Phe-125 and Phe-226 of pig cytochrome P450 1A2 stabilize the binding of aflatoxin B1 and 7-ethoxyresorufin through the key CH/pi interactions. 7-ER, AFB1
38  2019 SNP's in xenobiotic metabolism and male infertility. CYP2D6, GST, GSTM1, GSTP1, GSTT1, PCR
39  2018 Ahr and Cyp1a2 genotypes both affect susceptibility to motor deficits following gestational and lactational exposure to polychlorinated biphenyls. PCBs
40  2018 Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study. OR, SBP
41  2018 Decreased expression of hepatic cytochrome P450 1A2 (CYP1A2) in a chronic intermittent hypoxia mouse model. CIH
42  2018 Highly sensitive fluorescent bioassay of 2,3,7,8-tetrachloro-dibenzo-p-dioxin based on abnormal expression of cytochrome P450 1A2 in human cells. 7-ER, CYP1A1, HBMN
43  2018 Increased Phenacetin Oxidation upon the L382V Substitution in Cytochrome P450 1A2 is Associated with Altered Substrate Binding Orientation. NMR, WT
44  2018 Interaction between caffeine and polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2) on Parkinson's disease risk. GRIN2A, PD
45  2017 CYP1A2 is a predictor of HCC recurrence in HCV-related chronic liver disease: A retrospective multicentric validation study. HCC
46  2017 Effect of health foods on cytochrome P450-mediated drug metabolism. ---
47  2017 Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. PCBs
48  2017 Genetic polymorphisms of cytochrome P450-1A2 (CYP1A2) among Emiratis. HPLC
49  2017 Investigation of substrate recognition for cytochrome P450 1A2 mediated by water molecules using docking and molecular dynamics simulations. 7-ER, ANF, MD
50  2017 The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p. 3'-UTR, LDH, miRNAs
51  2017 The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis. ---
52  2016 Assessment of CYP1A2 enzyme activity in relation to type-2 diabetes and habitual caffeine intake. ---
53  2016 Co-expression of active human cytochrome P450 1A2 and cytochrome P450 reductase on the cell surface of Escherichia coli. ---
54  2016 Cytochrome P450 1A2 Metabolizes 17beta-Estradiol to Suppress Hepatocellular Carcinoma. 2-ME, HCC
55  2016 Functional allele and genotype frequencies of CYP1A2, CYP2B6 and iNOS among mainland Chinese Tibetan, Mongolian, Uygur and Han populations. iNOS, PCR-RFLP
56  2016 Heritability of Caffeine Metabolism: Environmental Effects Masking Genetic Effects on CYP1A2 Activity but Not on NAT2. AUC, DZ, MZ, NAT2
57  2016 Impact of dioxins on antipyrine metabolism in firefighters. 3HMAP, AP
58  2016 Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk. ORs
59  2016 Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants. ---
60  2016 Prediction of three-dimensional structures and structural flexibilities of wild-type and mutant cytochrome P450 1A2 using molecular dynamics simulations. MD
61  2015 Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping. CAF, PX
62  2015 Functional characterization of 20 allelic variants of CYP1A2. ---
63  2015 Genetic and Clinical Factors Affecting Plasma Clozapine Concentration. MDR1, UGT1A4
64  2015 Lack of a significant change in caffeine metabolism in underweight children as determined by the caffeine breath test. ---
65  2015 Measurement of human CYP1A2 induction by inhalation exposure to benzo(a)pyrene based on in vivo isotope breath method. BaP, PAHs
66  2015 Treatment Resistance Enigma Resolved by Pharmacogenomics - A Case Study of Clozapine Therapy in Schizophrenia. CYP450
67  2014 Activity of cytochrome P450 1A2 in relation to hepatic iron accumulation in transfusion-dependent beta-thalassaemia major patients. OR, PDR
68  2014 Effects of Guanxinning injection on rat cytochrome P450 isoforms activities in vivo and in vitro. GXNI, HPLC
69  2014 Four polymorphisms in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer risk: a meta-analysis. ---
70  2014 Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay. ASD, ASMT
71  2014 In vitro effect of important herbal active constituents on human cytochrome P450 1A2 (CYP1A2) activity. CEC
72  2014 Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury. i.p, mAb, PCNA, VEGF
73  2014 Proper heat shock pretreatment reduces acute liver injury induced by carbon tetrachloride and accelerates liver repair in mice. AST, HSP70, i.p, min, PCNA
74  2014 Role of the CYP1A2 Gene Polymorphism on Early Ageing from Occupational Exposure. MN, RFLP-PCR, RT-PCR
75  2013 Association between CYP1A2 gene single nucleotide polymorphisms and clinical responses to clozapine in patients with treatment-resistant schizophrenia. SNP, TRS
76  2013 Decreased metabolism of 13C-caffeine via hepatic CYP1A2 in marasmus and kwashiorkor based on breath test. ANOVA, CBT, cPDR
77  2013 Dietary aflatoxin B1 intake, genetic polymorphisms of CYP1A2, CYP2E1, EPHX1, GSTM1, and GSTT1, and gastric cancer risk in Korean. AFB1
78  2013 Diurnal variation in CYP1A2 enzyme activity in South Asians and Europeans. ---
79  2013 Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and urothelial cancer. AA, AAI, AAIa, AAN, BEN
80  2013 Evaluations of in vitro metabolism, drug-drug interactions mediated by reversible and time-dependent inhibition of CYPs, and plasma protein binding of MMB4 DMS. 4-PA, DMS, INA, MMB4, TDI
81  2013 High coffee intake, but not caffeine, is associated with reduced estrogen receptor negative and postmenopausal breast cancer risk with no effect modification by CYP1A2 genotype. CI, ER, MVOR
82  2013 Pharmacogenetics of CYP1A2 activity and inducibility in smokers and exsmokers. ---
83  2013 quantitative assessment of the influence of cytochrome P450 1A2 gene polymorphism and colorectal cancer risk. CRC
84  2013 Using molecular features of xenobiotics to predict hepatic gene expression response. AUROC
85  2012 Ahrd Cyp1a2(-/-) mice show increased susceptibility to PCB-induced developmental neurotoxicity. AhR, GD10, PCBs, PND5, PPI
86  2012 CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies. CI, OR
87  2012 Genetic susceptibility to dioxin-like chemicals' induction of cytochrome P4501A2 in the human adult linked to specific AhRR polymorphism. AhR, ARNT, DREs
88  2012 Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species. gpt, ROS
89  2012 Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population. NAT2
90  2012 Influence of cytochrome P450 oxidoreductase genetic polymorphisms on CYP1A2 activity and inducibility by smoking. ---
91  2012 Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury. ---
92  2012 Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis. ABCG2, CYP2C19, DHODH, RA, SNPs
93  2012 Role of CYP1A2 polymorphisms in breast cancer risk in women. AAc, BC, EETs, HAs, PAHs
94  2012 Role of CYP1A2 polymorphisms on lung cancer risk in a prospective study. ---
95  2012 The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl(4)-model rats. SULT1A1, UGT1A6
96  2012 [Influence of jinlingzi powder with different compatibility on activity of cytochrome P1 A2 from rat liver microsomes]. ---
97  2011 Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease. ADORA2A, CI, OR, PD, PEGASUS
98  2011 Cytochrome P4501A2 phenotype and bladder cancer risk: The Shanghai bladder cancer study. NAT2
99  2011 Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism. EGFP, IRES
100  2011 Effects of furanocoumarins from apiaceous vegetables on the catalytic activity of recombinant human cytochrome P-450 1A2. hCYP1A2, MBI, MROD