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Abbreviation : CaR
Long Form : calcium-sensing receptor
No. Year Title Co-occurring Abbreviation
2019 Treatment of Autosomal Dominant Hypocalcemia Type 1 With the Calcilytic NPSP795 (SHP635). ADH1, FECa, PTH, WT
2018 The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology. GPCR
2017 Activity of the calcium-sensing receptor influences blood glucose and insulin levels in rats. ---
2017 The Role of Calcium-Sensing Receptors in Endothelin-1-Dependent Effects on Adult Rat Ventricular Cardiomyocytes: Possible Contribution to Adaptive Myocardial Hypertrophy. ET-1, L-NAME, NO, RAMP
2016 Recent advances in understanding the extracellular calcium-sensing receptor. GPCR
2015 Mechanisms by which calcium receptor stimulation modifies electromechanical coupling in isolated ventricular cardiomyocytes. ---
2015 NKCC2 activity is inhibited by the Bartter's syndrome type 5 gain-of-function CaR-A843E mutant in renal cells. AA, HEK293, PLA2, TAL
2015 Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism. CaR-HEK, PTH
2014 Calcium sensing receptor promotes cardiac fibroblast proliferation and extracellular matrix secretion. ECM, ISO, MMP-3 and -9, PLC-IP3
10  2014 In vitro characterization of acid secretion in the gilthead sea bream (Sparus aurata) stomach. FK, IBMX
11  2014 Obligatory roles of filamin A in E-cadherin-mediated cell-cell adhesion in epidermal keratinocytes. ---
12  2013 Altered monocyte calcium-sensing receptor expression in patients with type 2 diabetes mellitus and atherosclerosis. PAD
13  2013 Calcimimetics and outcomes in CKD. CKD
14  2013 Molecular and clinical analysis of a neonatal severe hyperparathyroidism case caused by a stop mutation in the calcium-sensing receptor extracellular domain representing in effect a human 'knockout'. NSHPT, PTH
15  2013 Role of the calcium-sensing receptor in cardiomyocyte apoptosis via the sarcoplasmic reticulum and mitochondrial death pathway in cardiac hypertrophy and heart failure. ER/SR, ISO, TAC
16  2012 Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. LBs
17  2012 Allosteric agonists of the calcium receptor (CaR): fluorine and SF5 analogues of cinacalcet. ---
18  2012 Calcium-sensing receptor activation increases cell-cell adhesion and beta-cell function. BrdU
19  2012 Calcium-sensing receptor and aquaporin 2 interplay in hypercalciuria-associated renal concentrating defect in humans. An in vivo and in vitro study. AQP2, FK
20  2012 Calcium-sensing receptor, calcimimetics, and cardiovascular calcifications in chronic kidney disease. CKD, PTH, PTHrP, SHPT
21  2012 Eicosanoids and tumor necrosis factor-alpha in the kidney. AA, COX, cTAL, CYP450, NKCC2, TAL
22  2012 New concepts in calcium-sensing receptor pharmacology and signalling. NAMs, PAM, PTH
23  2012 Post-conditioning protecting rat cardiomyocytes from apoptosis via attenuating calcium-sensing receptor-induced endo(sarco)plasmic reticulum stress. ATF6, ER, I/R, PC, PLC
24  2012 Recent advances in gut nutrient chemosensing. GPCRs, GPRC6A, mGluR, OEA, SGLT-1
25  2011 Activation of calcium-sensing receptor increases TRPC3 expression in rat cardiomyocytes. ER/SR, RT-PCR, TRP
26  2011 Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids. ---
27  2011 Cinacalcet as alternative treatment for primary hyperparathyroidism: achievements and prospects. PHPT
28  2011 Glucose-mediated spatial interactions of voltage dependent calcium channels and calcium sensing receptor in insulin producing beta-cells. ELISA, NF-kappaB, VDCC
29  2011 L-histidine sensing by calcium sensing receptor inhibits voltage-dependent calcium channel activity and insulin secretion in beta-cells. ELISA, VDCC
30  2011 Pharmacodynamic model of parathyroid hormone modulation by a negative allosteric modulator of the calcium-sensing receptor. PTH
31  2011 Pharmacologic modulation of the calcium-sensing receptor enhances hematopoietic stem cell lodgment in the adult bone marrow. BM, HSCs
32  2011 Role of calcium-sensing receptor in bone biology. ---
33  2011 Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting L-type Ca(+) channels. ---
34  2011 Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling. ---
35  2011 The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium, phosphorus, and PTH. NSHPT
36  2011 The calcium-sensing receptor and calcimimetics in blood pressure modulation. PTH
37  2011 The calcium-sensing receptor is necessary for the rapid development of hypercalcemia in human lung squamous cell carcinoma. HHM, PTHrP, SCC
38  2011 The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates. PTH, WT
39  2011 The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. siRNA
40  2011 The calcium-sensing receptor: a molecular perspective. ---
41  2011 The vascular extracellular calcium-sensing receptor: an update. ---
42  2011 Vascular actions of calcimimetics: role of Ca(+) -sensing receptors versus Ca(+) influx through L-type Ca(+) channels. ---
43  2010 Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice. PTH, PTHrP
44  2010 Calcium-sensing receptor activation contributed to apoptosis stimulates TRPC6 channel in rat neonatal ventricular myocytes. CCE, ER/SR, TG, TRP
45  2010 Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. ---
46  2010 Calcium-sensing receptors induce apoptosis in rat cardiomyocytes via the endo(sarco)plasmic reticulum pathway during hypoxia/reoxygenation. ATF6, ER, GRP78, PKR
47  2010 Differential modulation of intracellular Ca2+ responses associated with calcium-sensing receptor activation in renal collecting duct cells. ROK
48  2010 Effect of paricalcitol and cinacalcet on serum phosphate, FGF-23, and bone in rats with chronic kidney disease. PTH
49  2010 Expression of calcium-sensing receptor in quail granulosa explants: a key to survival during folliculogenesis. GCs
50  2010 Implication of the calcium sensing receptor and the Phosphoinositide 3-kinase/Akt pathway in the extracellular calcium-mediated migration of RAW 264.7 osteoclast precursor cells. PI3K
51  2010 Increased receptor stimulation elicits differential calcium-sensing receptor(T888) dephosphorylation. ---
52  2010 Involvement of alpha-klotho and fibroblast growth factor receptor in the development of secondary hyperparathyroidism. FGF23, FGFR, PTH, SHPT
53  2010 Novel Ca receptor signaling pathways for control of renal ion transport. DCT
54  2010 Post-conditioning protects cardiomyocytes from apoptosis via PKC(epsilon)-interacting with calcium-sensing receptors to inhibit endo(sarco)plasmic reticulum-mitochondria crosstalk. ER, I/R, IRI, MAM, PC, PKC
55  2010 Residue 826 in the calcium-sensing receptor is implicated in the response to calcium and to R-568 calcimimetic compound. ---
56  2010 Roles of calcium-sensing receptor and vitamin d receptor in the pathophysiology of secondary hyperparathyroidism. HPT, PTH, VDR
57  2010 Soybean beta 51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells. CCK
58  2010 Strontium ranelate decreases receptor activator of nuclear factor-KappaB ligand-induced osteoclastic differentiation in vitro: involvement of the calcium-sensing receptor. PBMCs, RANKL
59  2010 The Calcium-sensing Receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization. ERK
60  2010 The emerging role of promiscuous 7TM receptors as chemosensors for food intake. FFAs, GI, GPRC6A
61  2009 Activation of the calcium sensing receptor stimulates gastrin and gastric acid secretion in healthy participants. ---
62  2009 Activation of the calcium-sensing receptor by high calcium induced breast cancer cell proliferation and TRPC1 cation channel over-expression potentially through EGFR pathways. EGFR, MMPs, TRPC1
63  2009 Adenomatous human parathyroid cells exhibit impaired sensitivity to L-amino acids. L-Phe
64  2009 Agonists and allosteric modulators of the calcium-sensing receptor and their therapeutic applications. ---
65  2009 Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. CKD, VC, VSMC
66  2009 Calcium sensing receptor and heart diseases. IP
67  2009 Calcium, vitamin D and cancer. VDR
68  2009 Calcium-sensing receptor expression is regulated by glial cells missing-2 in human parathyroid cells. Gcm2, PCNA, VDR
69  2009 Calcium-sensing receptor in cancer: good cop or bad cop? PTHrP
70  2009 Cinacalcet in hyperfunctioning parathyroid diseases. PTH, SHPT
71  2009 Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease. ---
72  2009 Effects of calcimimetic on vascular calcification and atherosclerosis in uremic mice. CKD
73  2009 Expression and function of NFAT5 in medullary thick ascending limb (mTAL) cells. MTAL, NFAT5, TNF
74  2009 Extracellular signal-regulated kinases 1 and 2 and TRPC1 channels are required for calcium-sensing receptor-stimulated MCF-7 breast cancer cell proliferation. 2-APB, SOCs, TRPC1
75  2009 Hypercalcemia of primary hyperparathyroidism was treated by cinacalcet in a patient with liver cirrhosis. FDA, PTH
76  2009 PTH(1-34) replacement therapy in a child with hypoparathyroidism caused by a sporadic calcium receptor mutation. ADH, BMDD, qBEI
77  2009 Regulation of cellular signal transduction pathways by the extracellular calcium-sensing receptor. ---
78  2009 The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice. Ca, CRF
79  2009 The calcium-sensing receptor and parathyroid hormone-related protein are expressed in differentiated, favorable neuroblastic tumors. BrdU, mRNA, PTHrP
80  2009 The role of the calcium-sensing receptor in bone biology and pathophysiology. PTH, PTHrP
81  2009 The role of the calcium-sensing receptor in the development and progression of cancer. ---
82  2009 Treatment of secondary hyperparathyroidism in CKD patients with cinacalcet and/or vitamin D derivatives. ---
83  2009 Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. VDR
84  2009 [The role of calcium, calcitriol and their receptors in parathyroid regulation]. CKD-MBD, PTH, VDR
85  2008 A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of langerhans. ---
86  2008 Calcimimetics in CKD-results from recent clinical studies. CKD, PTH, SHPT
87  2008 Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null mice. OPCs
88  2008 Calcium-sensing receptor antagonism or lithium treatment ameliorates aminoglycoside-induced cell death in renal epithelial cells. OK
89  2008 Calcium-sensing receptor mediates phenylalanine-induced cholecystokinin secretion in enteroendocrine STC-1 cells. CCK, Phe
90  2008 Calcium-sensing receptor signaling pathways in medullary thick ascending limb cells mediate COX-2-derived PGE2 production: functional significance. CaN, COX, MTAL, PGE2, PKC, TNF
91  2008 CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism. CaN, MTAL, NFAT, PTX
92  2008 Cardiovascular distribution of the calcium sensing receptor before and after burns. ---
93  2008 Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia. CIN, OFA, PTH
94  2008 Extracellular calcium regulates parathyroid hormone-related peptide expression in osteoblasts and osteoblast progenitor cells. hMSC, PTHrP
95  2008 Extracellular calcium- and magnesium-mediated regulation of passive calcium transport across Caco-2 monolayers. TER
96  2008 Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. AJs, PI3K
97  2008 Intracellular signal transduction by the extracellular calcium-sensing receptor of Xenopus melanotrope cells. L-Phe
98  2008 Rebalancing bone turnover in favour of formation with strontium ranelate: implications for bone strength. OPG, RANKL
99  2008 Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. ---
100  2008 Secondary hyperparathyroidism disease stabilization following calcimimetic therapy. Ca P, PTH, SHPT