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Abbreviation : DNA-PK
Long Form : DNA-dependent protein kinase
No. Year Title Co-occurring Abbreviation
2020 Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation. DSBs, NHEJ
2020 Adefovir dipivoxil induces DNA replication stress and augments ATR inhibitor-related cytotoxicity. ATM, DDR, ssDNA
2020 Baculovirus Transduction in Mammalian Cells Is Affected by the Production of Type I and III Interferons, Which Is Mediated Mainly by the cGAS-STING Pathway. cGAS-STING
2020 Beta Human Papillomavirus 8E6 Attenuates Non-Homologous End Joining by Hindering DNA-PKcs Activity. beta-HPVs, NHEJ
2020 CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway. CAS9, CRISPR, DSB, gRNA, NHEJ
2020 CHAF1B induces radioresistance by promoting DNA damage repair in nasopharyngeal carcinoma. CHAF1B, IHC, MTT, NPC
2020 Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response. PP6
2020 Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage. FTD, FTLD, FUS, p-FUS
2020 DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR. CTD, HAART, PBMCs, RNAPII, Ser2, Ser5, TRIM28
10  2020 DNA-dependent protein kinase in telomere maintenance and protection. DSB, NHEJ
11  2020 DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP. ---
12  2020 DNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia. ADC, AML, DSB
13  2020 DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer. AR, mTOR, PCa
14  2020 DNA-PK: gatekeeper for IKKgamma/NEMO nucleocytoplasmic shuttling in genotoxic stress-induced NF-kappaB activation. DSB, IR, NF-kappaB
15  2020 DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. cNHEJ, rRNA
16  2020 DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination. cNHEJ, CSR
17  2020 DNA-PKcs Ser2056 auto-phosphorylation is affected by an O-GlcNAcylation/phosphorylation interplay. DDR, DSB, NHEJ, PTM
18  2020 Effects of the scid mutation on X-ray-induced deletions in the brain and spleen of gpt delta mice. MFs, NHEJ, SCID, WT
19  2020 En Guard! The Interactions between Adenoviruses and the DNA Damage Response. Ad, ATM, ATR, DDR, MRN
20  2020 Human DNA-PK activates a STING-independent DNA sensing pathway. SIDSP
21  2020 Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells. DSBs, NHEJ, Top2
22  2020 Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells. DNA-PKcs, DSB, NHEJ, NSLC, PKA
23  2020 Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence. lncRNAs, NR, SNHG12
24  2020 M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells. ABC, MDR
25  2020 Network analysis, sequence and structure dynamics of key proteins of coronavirus and human host, and molecular docking of selected phytochemicals of nine medicinal plants. 3CLpro, nCoV-19, PLpro
26  2020 Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models. DSB, IR, NHEJ
27  2020 Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication. DSB, NHEJ
28  2020 PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin. PRMT1
29  2020 Ribosomal protein S3 is a novel negative regulator of non-homologous end joining repair of DNA double-strand breaks. DSBs, NHEJ, RPS3
30  2020 Targeting DNA-PK in cancer. ---
31  2020 The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor. DNA-PKcs
32  2020 The effect of inhibitors of phosphatidylinositol 3-kinase-related kinases on dibenzo[def,p]chrysene genotoxicity measured by gammaH2AX levels and neutral comet assay in HepG2 human hepatocellular cancer cells. ATM, DBC, PIKK
33  2020 The recent advances in non-homologous end-joining through the lens of lymphocyte development. Alt-EJ, cNHEJ, CSR, DDR, DSB
34  2020 Transcriptional Regulation at DSBs: Mechanisms and Consequences. ATM, DSB, HDACs, NELF, PARP1, Pol II
35  2020 Viral interactions with non-homologous end-joining: a game of hide-and-seek. DDR, NHEJ
36  2020 Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, induces accumulation of DNA double-strand breaks. ATM, DSBs, PI3K
37  2019 Abrogation of FBW7alpha-dependent p53 degradation enhances p53's function as a tumor suppressor. Fbw7alpha, GSK3beta
38  2019 Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models. PLD
39  2019 AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. DDR, DSBs, NHEJ, PDX
40  2019 Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism. ATM, ATR, CTD, DDR, DSBs, HR, MAPK, nc, NER, NHEJ, RNAi, RNAPII, UVR
41  2019 Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK. Ad, DDR, RCs
42  2019 CC-115, a Dual Mammalian Target of Rapamycin/DNA-Dependent Protein Kinase Inhibitor in Clinical Trial, Is a Substrate of ATP-Binding Cassette G2, a Risk Factor for CC-115 Resistance. ABCG2, FASN, mTOR
43  2019 DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway. ---
44  2019 DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer. DSB
45  2019 DNA-PK as an Emerging Therapeutic Target in Cancer. PIKK
46  2019 Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines. DNA-PKcs
47  2019 Genotoxic stress causes the accumulation of DNA-dependent protein kinase catalytic subunit phosphorylated at serine 2056 at nuclear speckles and alters pre-mRNA alternative splicing. DDR, DNA-PKcs, DSB
48  2019 High Fidelity Deep Sequencing Reveals No Effect of ATM, ATR, and DNA-PK Cellular DNA Damage Response Pathways on Adenovirus Mutation Rate. ATR, DDR
49  2019 Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361. DNA-PKi, DSB
50  2019 Identification of Novel Interaction Partners of Ets-1: Focus on DNA Repair. ---
51  2019 Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma. mRNA, NHEJ, SCE, siRNA, UM
52  2019 Multicomponent assemblies in DNA-double-strand break repair by NHEJ. NHEJ
53  2019 Nuclear localized Raf1 isoform alters DNA-dependent protein kinase activity and the DNA damage response. ---
54  2019 Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination. cNHEJ, DNA-PKcs, Ku
55  2019 Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia. HNSCC, PARP1, SER
56  2019 Reactivation of heat-inactivated Ku proteins by heat shock cognate protein HSC73. HSC, HSP, SDS, sh
57  2019 Real-time surface plasmon resonance monitoring of site-specific phosphorylation of p53 protein and its interaction with MDM2 protein. JNK2alpha2, PKC, SPR, TAD1
58  2019 Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells. ATM, ATR, EdU
59  2019 Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy. ChB, DSB, RPA
60  2019 The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network. MYT1L
61  2019 Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814. ATM, Chk2, DSB
62  2019 WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks. DSBs, NHEJ, RNAPII
63  2018 DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage. DNA-PKI, IFNs, OVs
64  2018 DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing. PRRs, VACV
65  2018 Ets-1 interacts through a similar binding interface with Ku70 and Poly (ADP-Ribose) Polymerase-1. ---
66  2018 Fumarase: From the TCA Cycle to DNA Damage Response and Tumor Suppression. DDR, DSBs, HR, NHEJ, TCA
67  2018 Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic ERCC6L2 variants. BMF, ERCC6L2, LCLs, RNA Pol II, TC-NER
68  2018 In cellulo phosphorylation of DNA double-strand break repair protein XRCC4 on Ser260 by DNA-PK. DSB, NHEJ
69  2018 Inactivation of DNA-PK by knockdown DNA-PKcs or NU7441 impairs non-homologous end-joining of radiation-induced double strand break repair. MEF, NHEJ, NPC
70  2018 Inhibiting polo-like kinase 1 enhances radiosensitization via modulating DNA repair proteins in non-small-cell lung cancer. DSB, NSCLC, Plk1
71  2018 Oxidative damage and DNA damage in lungs of an ovalbumin-induced asthmatic murine model. 3-NT, AHR, BALF, HE, OVA
72  2018 PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway. DSB, PIDD
73  2018 Polyploidy and Mitotic Cell Death Are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells. PIKK, RTECs
74  2018 Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice. HSCs, OCs
75  2018 Safety, clinical activity and pharmacological biomarker evaluation of the DNA-dependent protein kinase (DNA-PK) inhibitor M3814: Results from two phase I trials. ---
76  2018 Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. CSCs
77  2018 The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication. ATR, DDR, hpi, HSV-1
78  2018 The Future of Radiobiology. ATM, ATR, DDR
79  2018 The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization. FUS
80  2018 The role of DNA-PK in aging and energy metabolism. DNA-PKcs, dsDNA, NHEJ
81  2018 Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth. ALDOA, DR
82  2017 Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging. DSB
83  2017 CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro. ATM, HR, mTOR, NHEJ, PD, XRCC4
84  2017 Cryo-EM structure of human DNA-PK holoenzyme. NHEJ
85  2017 Cryo-EM structure of the DNA-PK holoenzyme. cryo-EM, DNA-PKcs, NHEJ
86  2017 DNA-dependent protein kinase plays a central role in transformation of breast epithelial cells following alkylation damage. EMT
87  2017 DNA-PK and P38 MAPK: A Kinase Collusion in Alzheimer's Disease? AD, DSB, NHEJ
88  2017 DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair. DSBs, NHEJ, NSCLC, pDNA-PKcs
89  2017 DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. AMPK
90  2017 Engagement of Components of DNA-Break Repair Complex and NFkappaB in Hsp70A1A Transcription Upregulation by Heat Shock. DBR, PARP-1
91  2017 Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle. ATM, DDR, EBV
92  2017 Galphai3 nuclear translocation causes irradiation resistance in human glioma cells. ---
93  2017 Ganoderma lucidum polysaccharide enhances radiosensitivity of hepatocellular carcinoma cell line HepG2 through Akt signaling pathway. ATM, GLP, HCC
94  2017 Hsp90alpha regulates ATM and NBN functions in sensing and repair of DNA double-strand breaks. ATM, DDR, DSBs, IR, NBN
95  2017 Inhibition of DNA-PK enhances chemosensitivity of B-cell precursor acute lymphoblastic leukemia cells to doxorubicin. BCP-ALL, DSBs
96  2017 Ku70 inhibits gemcitabine-induced DNA damage and pancreatic cancer cell apoptosis. SCID
97  2017 Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy. PBLs
98  2017 P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting. 5-FU, ATM, ChIP, DPYD, p53BS, TS
99  2017 Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. HGPS
100  2017 Small molecule inhibitors of DNA-PK for tumor sensitization to anticancer therapy. ---