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[Related PubMed/MEDLINE]
Total Number of Papers: 814
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| Abbreviation |
: DNA-PK |
| Long Form |
: DNA-dependent protein kinase |
|
| No. |
Year |
Title |
Co-occurring Abbreviation |
| 1 |
2020 |
Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation. |
DSBs, NHEJ |
| 2 |
2020 |
Adefovir dipivoxil induces DNA replication stress and augments ATR inhibitor-related cytotoxicity. |
ATM, DDR, ssDNA |
| 3 |
2020 |
Baculovirus Transduction in Mammalian Cells Is Affected by the Production of Type I and III Interferons, Which Is Mediated Mainly by the cGAS-STING Pathway. |
cGAS-STING |
| 4 |
2020 |
Beta Human Papillomavirus 8E6 Attenuates Non-Homologous End Joining by Hindering DNA-PKcs Activity. |
beta-HPVs, NHEJ |
| 5 |
2020 |
CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway. |
CAS9, CRISPR, DSB, gRNA, NHEJ |
| 6 |
2020 |
CHAF1B induces radioresistance by promoting DNA damage repair in nasopharyngeal carcinoma. |
CHAF1B, IHC, MTT, NPC |
| 7 |
2020 |
Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response. |
PP6 |
| 8 |
2020 |
Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage. |
FTD, FTLD, FUS, p-FUS |
| 9 |
2020 |
DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR. |
CTD, HAART, PBMCs, RNAPII, Ser2, Ser5, TRIM28 |
| 10 |
2020 |
DNA-dependent protein kinase in telomere maintenance and protection. |
DSB, NHEJ |
| 11 |
2020 |
DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP. |
--- |
| 12 |
2020 |
DNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia. |
ADC, AML, DSB |
| 13 |
2020 |
DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer. |
AR, mTOR, PCa |
| 14 |
2020 |
DNA-PK: gatekeeper for IKKgamma/NEMO nucleocytoplasmic shuttling in genotoxic stress-induced NF-kappaB activation. |
DSB, IR, NF-kappaB |
| 15 |
2020 |
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis. |
cNHEJ, rRNA |
| 16 |
2020 |
DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination. |
cNHEJ, CSR |
| 17 |
2020 |
DNA-PKcs Ser2056 auto-phosphorylation is affected by an O-GlcNAcylation/phosphorylation interplay. |
DDR, DSB, NHEJ, PTM |
| 18 |
2020 |
Effects of the scid mutation on X-ray-induced deletions in the brain and spleen of gpt delta mice. |
MFs, NHEJ, SCID, WT |
| 19 |
2020 |
En Guard! The Interactions between Adenoviruses and the DNA Damage Response. |
Ad, ATM, ATR, DDR, MRN |
| 20 |
2020 |
Human DNA-PK activates a STING-independent DNA sensing pathway. |
SIDSP |
| 21 |
2020 |
Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells. |
DSBs, NHEJ, Top2 |
| 22 |
2020 |
Inhibition of non-homologous end joining of gamma ray-induced DNA double-strand breaks by cAMP signaling in lung cancer cells. |
DNA-PKcs, DSB, NHEJ, NSLC, PKA |
| 23 |
2020 |
Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence. |
lncRNAs, NR, SNHG12 |
| 24 |
2020 |
M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells. |
ABC, MDR |
| 25 |
2020 |
Network analysis, sequence and structure dynamics of key proteins of coronavirus and human host, and molecular docking of selected phytochemicals of nine medicinal plants. |
3CLpro, nCoV-19, PLpro |
| 26 |
2020 |
Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models. |
DSB, IR, NHEJ |
| 27 |
2020 |
Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication. |
DSB, NHEJ |
| 28 |
2020 |
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin. |
PRMT1 |
| 29 |
2020 |
Ribosomal protein S3 is a novel negative regulator of non-homologous end joining repair of DNA double-strand breaks. |
DSBs, NHEJ, RPS3 |
| 30 |
2020 |
Targeting DNA-PK in cancer. |
--- |
| 31 |
2020 |
The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor. |
DNA-PKcs |
| 32 |
2020 |
The effect of inhibitors of phosphatidylinositol 3-kinase-related kinases on dibenzo[def,p]chrysene genotoxicity measured by gammaH2AX levels and neutral comet assay in HepG2 human hepatocellular cancer cells. |
ATM, DBC, PIKK |
| 33 |
2020 |
The recent advances in non-homologous end-joining through the lens of lymphocyte development. |
Alt-EJ, cNHEJ, CSR, DDR, DSB |
| 34 |
2020 |
Transcriptional Regulation at DSBs: Mechanisms and Consequences. |
ATM, DSB, HDACs, NELF, PARP1, Pol II |
| 35 |
2020 |
Viral interactions with non-homologous end-joining: a game of hide-and-seek. |
DDR, NHEJ |
| 36 |
2020 |
Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, induces accumulation of DNA double-strand breaks. |
ATM, DSBs, PI3K |
| 37 |
2019 |
Abrogation of FBW7alpha-dependent p53 degradation enhances p53's function as a tumor suppressor. |
Fbw7alpha, GSK3beta |
| 38 |
2019 |
Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models. |
PLD |
| 39 |
2019 |
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. |
DDR, DSBs, NHEJ, PDX |
| 40 |
2019 |
Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism. |
ATM, ATR, CTD, DDR, DSBs, HR, MAPK, nc, NER, NHEJ, RNAi, RNAPII, UVR |
| 41 |
2019 |
Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK. |
Ad, DDR, RCs |
| 42 |
2019 |
CC-115, a Dual Mammalian Target of Rapamycin/DNA-Dependent Protein Kinase Inhibitor in Clinical Trial, Is a Substrate of ATP-Binding Cassette G2, a Risk Factor for CC-115 Resistance. |
ABCG2, FASN, mTOR |
| 43 |
2019 |
DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway. |
--- |
| 44 |
2019 |
DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer. |
DSB |
| 45 |
2019 |
DNA-PK as an Emerging Therapeutic Target in Cancer. |
PIKK |
| 46 |
2019 |
Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines. |
DNA-PKcs |
| 47 |
2019 |
Genotoxic stress causes the accumulation of DNA-dependent protein kinase catalytic subunit phosphorylated at serine 2056 at nuclear speckles and alters pre-mRNA alternative splicing. |
DDR, DNA-PKcs, DSB |
| 48 |
2019 |
High Fidelity Deep Sequencing Reveals No Effect of ATM, ATR, and DNA-PK Cellular DNA Damage Response Pathways on Adenovirus Mutation Rate. |
ATR, DDR |
| 49 |
2019 |
Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361. |
DNA-PKi, DSB |
| 50 |
2019 |
Identification of Novel Interaction Partners of Ets-1: Focus on DNA Repair. |
--- |
| 51 |
2019 |
Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma. |
mRNA, NHEJ, SCE, siRNA, UM |
| 52 |
2019 |
Multicomponent assemblies in DNA-double-strand break repair by NHEJ. |
NHEJ |
| 53 |
2019 |
Nuclear localized Raf1 isoform alters DNA-dependent protein kinase activity and the DNA damage response. |
--- |
| 54 |
2019 |
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination. |
cNHEJ, DNA-PKcs, Ku |
| 55 |
2019 |
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia. |
HNSCC, PARP1, SER |
| 56 |
2019 |
Reactivation of heat-inactivated Ku proteins by heat shock cognate protein HSC73. |
HSC, HSP, SDS, sh |
| 57 |
2019 |
Real-time surface plasmon resonance monitoring of site-specific phosphorylation of p53 protein and its interaction with MDM2 protein. |
JNK2alpha2, PKC, SPR, TAD1 |
| 58 |
2019 |
Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells. |
ATM, ATR, EdU |
| 59 |
2019 |
Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy. |
ChB, DSB, RPA |
| 60 |
2019 |
The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network. |
MYT1L |
| 61 |
2019 |
Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814. |
ATM, Chk2, DSB |
| 62 |
2019 |
WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks. |
DSBs, NHEJ, RNAPII |
| 63 |
2018 |
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage. |
DNA-PKI, IFNs, OVs |
| 64 |
2018 |
DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing. |
PRRs, VACV |
| 65 |
2018 |
Ets-1 interacts through a similar binding interface with Ku70 and Poly (ADP-Ribose) Polymerase-1. |
--- |
| 66 |
2018 |
Fumarase: From the TCA Cycle to DNA Damage Response and Tumor Suppression. |
DDR, DSBs, HR, NHEJ, TCA |
| 67 |
2018 |
Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic ERCC6L2 variants. |
BMF, ERCC6L2, LCLs, RNA Pol II, TC-NER |
| 68 |
2018 |
In cellulo phosphorylation of DNA double-strand break repair protein XRCC4 on Ser260 by DNA-PK. |
DSB, NHEJ |
| 69 |
2018 |
Inactivation of DNA-PK by knockdown DNA-PKcs or NU7441 impairs non-homologous end-joining of radiation-induced double strand break repair. |
MEF, NHEJ, NPC |
| 70 |
2018 |
Inhibiting polo-like kinase 1 enhances radiosensitization via modulating DNA repair proteins in non-small-cell lung cancer. |
DSB, NSCLC, Plk1 |
| 71 |
2018 |
Oxidative damage and DNA damage in lungs of an ovalbumin-induced asthmatic murine model. |
3-NT, AHR, BALF, HE, OVA |
| 72 |
2018 |
PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway. |
DSB, PIDD |
| 73 |
2018 |
Polyploidy and Mitotic Cell Death Are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells. |
PIKK, RTECs |
| 74 |
2018 |
Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice. |
HSCs, OCs |
| 75 |
2018 |
Safety, clinical activity and pharmacological biomarker evaluation of the DNA-dependent protein kinase (DNA-PK) inhibitor M3814: Results from two phase I trials. |
--- |
| 76 |
2018 |
Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. |
CSCs |
| 77 |
2018 |
The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication. |
ATR, DDR, hpi, HSV-1 |
| 78 |
2018 |
The Future of Radiobiology. |
ATM, ATR, DDR |
| 79 |
2018 |
The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization. |
FUS |
| 80 |
2018 |
The role of DNA-PK in aging and energy metabolism. |
DNA-PKcs, dsDNA, NHEJ |
| 81 |
2018 |
Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth. |
ALDOA, DR |
| 82 |
2017 |
Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging. |
DSB |
| 83 |
2017 |
CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro. |
ATM, HR, mTOR, NHEJ, PD, XRCC4 |
| 84 |
2017 |
Cryo-EM structure of human DNA-PK holoenzyme. |
NHEJ |
| 85 |
2017 |
Cryo-EM structure of the DNA-PK holoenzyme. |
cryo-EM, DNA-PKcs, NHEJ |
| 86 |
2017 |
DNA-dependent protein kinase plays a central role in transformation of breast epithelial cells following alkylation damage. |
EMT |
| 87 |
2017 |
DNA-PK and P38 MAPK: A Kinase Collusion in Alzheimer's Disease? |
AD, DSB, NHEJ |
| 88 |
2017 |
DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair. |
DSBs, NHEJ, NSCLC, pDNA-PKcs |
| 89 |
2017 |
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging. |
AMPK |
| 90 |
2017 |
Engagement of Components of DNA-Break Repair Complex and NFkappaB in Hsp70A1A Transcription Upregulation by Heat Shock. |
DBR, PARP-1 |
| 91 |
2017 |
Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle. |
ATM, DDR, EBV |
| 92 |
2017 |
Galphai3 nuclear translocation causes irradiation resistance in human glioma cells. |
--- |
| 93 |
2017 |
Ganoderma lucidum polysaccharide enhances radiosensitivity of hepatocellular carcinoma cell line HepG2 through Akt signaling pathway. |
ATM, GLP, HCC |
| 94 |
2017 |
Hsp90alpha regulates ATM and NBN functions in sensing and repair of DNA double-strand breaks. |
ATM, DDR, DSBs, IR, NBN |
| 95 |
2017 |
Inhibition of DNA-PK enhances chemosensitivity of B-cell precursor acute lymphoblastic leukemia cells to doxorubicin. |
BCP-ALL, DSBs |
| 96 |
2017 |
Ku70 inhibits gemcitabine-induced DNA damage and pancreatic cancer cell apoptosis. |
SCID |
| 97 |
2017 |
Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy. |
PBLs |
| 98 |
2017 |
P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting. |
5-FU, ATM, ChIP, DPYD, p53BS, TS |
| 99 |
2017 |
Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. |
HGPS |
| 100 |
2017 |
Small molecule inhibitors of DNA-PK for tumor sensitization to anticancer therapy. |
--- |
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