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Abbreviation : DNL
Long Form : de novo lipogenesis
No. Year Title Co-occurring Abbreviation
2019 3,5-diiodo-L-thyronine increases de novo lipogenesis in liver from hypothyroid rats by SREBP-1 and ChREBP-mediated transcriptional mechanisms. ---
2019 Abnormality of hepatic triglyceride metabolism in ApcMin/+ mice with colon cancer cachexia. GPIHBP1, LPL, NF-kappaB, Oct-1, TNF-alpha, VLDL-TG
2019 Adipokinome Signatures in Obese Mouse Models Reflect Adipose Tissue Health and Are Associated with Serum Lipid Composition. ---
2019 Association between carbohydrate intake and fatty acids in the de novo lipogenic pathway in serum phospholipids and adipose tissue in a population of Swedish men. AT, MUFA, PL, SCD, SFA
2019 Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation. CES, HSD, NAFLD
2019 Chronic psychosocial defeat differently affects lipid metabolism in liver and white adipose tissue and induces hepatic oxidative stress in mice fed a high-fat diet. CPD, FAO, HFD, Un
2019 Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold. BAT, mTORC1
2019 Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue. FA, GLY, MAT, NMR, SCAT, SFA, TG
2019 Evidence for the existence of de novo lipogenesis in goose granulosa cells. ---
10  2019 Fasting hepatic de novo lipogenesis is not reliably assessed using circulating fatty acid markers. FA, VLDL-TG
11  2019 GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH). ACC, NASH
12  2019 HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP. ChREBP, HCF-1
13  2019 Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients. BMI, SREBP1
14  2019 Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition. ---
15  2019 Impact of dietary starch on extrahepatic tissue lipid metabolism in farmed European (Dicentrarchus labrax) and Asian seabass (Lates calcarifer). TAG, VAT
16  2019 Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma. ACC1 Ser79Ala, ACC2, AMPK, HCC
17  2019 Isocaloric Fructose Restriction Reduces Serum d-Lactate Concentration in Children With Obesity and Metabolic Syndrome. AUC, TG
18  2019 Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes. FAO, HFCF, LCN2, NAFLD
19  2019 Measuring Human Lipid Metabolism Using Deuterium Labeling: In Vivo and In Vitro Protocols. NAFLD
20  2019 Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain. REL, WLM
21  2019 Risk of diabetes associated with fatty acids in the de novo lipogenesis pathway is independent of insulin sensitivity and response: the Insulin Resistance Atherosclerosis Study (IRAS). AIR, IRAS
22  2019 SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1. AT, ChREBP, INSIG1, SREBPs
23  2019 The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver. NAFLD, sFRP
24  2019 The Antagonist of CXCR1 and CXCR2 Protects db/db mice from Metabolic Diseases through Modulating Inflammation. ---
25  2019 Time-Restricted Feeding a High-fat Diet in Mice Elevates Hepatic Long-Chain Polyunsaturated Fatty Acid Content and Modifies the Triacylglyceryl Lipidome (P21-013-19). FAME, HF, LCPUFAs, TAG, TRF
26  2019 Transfer of Glucose Hydrogens via Acetyl-CoA, Malonyl-CoA and NADPH to Fatty Acids during de novo Lipogenesis. ---
27  2019 Understanding how birds rebuild fat stores during migration: insights from an experimental study. ---
28  2018 "Trans-nonachlor increases extracellular free fatty acid accumulation and de novo lipogenesis to produce hepatic steatosis in McArdle-RH7777 cells". NAFLD, OC
29  2018 Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis. MRE, NASH
30  2018 Adult-Onset Hepatocyte GH Resistance Promotes NASH in Male Mice, Without Severe Systemic Metabolic Dysfunction. aHepGHRkd, NAFLD, NASH
31  2018 Association between erythrocyte fatty acids in de novo lipogenesis pathway and DXA-derived body fat and trunk fat distribution in Chinese adults: a prospective study. FAs, FM, TB
32  2018 Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. BAT
33  2018 Carvacrol reduces adipogenic differentiation by modulating autophagy and ChREBP expression. CQ
34  2018 Combination of Mitochondrial and Plasma Membrane Citrate Transporter Inhibitors Inhibits De Novo Lipogenesis Pathway and Triggers Apoptosis in Hepatocellular Carcinoma Cells. CPT-1, CTP, CTPi, PMCT, PMCTi
35  2018 De novo lipogenesis and desaturation of fatty acids during adipogenesis in bovine adipose-derived mesenchymal stem cells. ADSCs, bADSCs, FA, MUFA, PUFA, SFA
36  2018 Dietary carbohydrates and fatty liver disease: de novo lipogenesis. NAFLD
37  2018 Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice. AMPKalpha, DIO, FGF21, IBAT, LCPUFA, PPARalpha, TAG
38  2018 Dose-dependent quantitative effects of acute fructose administration on hepatic de novo lipogenesis in healthy humans. ---
39  2018 Effects of environmental stressors on lipid metabolism in aquatic invertebrates. FFA
40  2018 Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells. CPT-1, EC, EGCG, FASN, MMP, ROS
41  2018 Gamma-Tocotrienol Attenuates the Hepatic Inflammation and Fibrosis by Suppressing Endoplasmic Reticulum Stress in Mice. MCD, NAFLD
42  2018 Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition. CA, NASH, T2D
43  2018 Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption. PPP1R3B, TAGs
44  2018 High fructose diet-induced metabolic syndrome: Pathophysiological mechanism and treatment by traditional Chinese medicine. MetS, TCM, UA
45  2018 Hospital Diet Enriched With Rapeseed or Sunflower Oils Is Associated With a Decrease in Plasma 16:1n-7 and Some Metabolic Disorders in the Elderly. MetS, PUFA, RO, SO
46  2018 In silico screening for identification of fatty acid synthase inhibitors and evaluation of their antiproliferative activity using human cancer cell lines. FASN, KS, MD
47  2018 Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice. ER, MetS, NAFLD
48  2018 Loss of progesterone receptor membrane component 1 promotes hepatic steatosis via the induced de novo lipogenesis. KO, NAFLD, NASH, PGRMC1, SREBP-1
49  2018 Muscle Loss in Chronic Liver Diseases: The Example of Nonalcoholic Liver Disease. NAFLD
50  2018 Neonatal overfeeding induced glucocorticoid overexposure accelerates hepatic lipogenesis in male rats. FASN, GC, GR, HF, Mi, NAFLD, OA, SCD1, SREBP-1c, TG
51  2018 Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis. BAT, FASN, WAT
52  2018 Omega-3 fatty acids and adipose tissue biology. omega-3 PUFA, TAG/FA
53  2018 Racial differences in in vivo adipose lipid kinetics in humans. AT, fTG, scABD, scFEM, TGs
54  2018 Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues. ---
55  2018 Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice. ER, HF, HFru, Mtr, STZ
56  2018 Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars. IHTG, SAT, UNSAT
57  2018 Sex Differences in Hepatic De Novo Lipogenesis with Acute Fructose Feeding. ---
58  2018 Suppressed de novo lipogenesis by plasma membrane citrate transporter inhibitor promotes apoptosis in HepG2 cells. CPT-1, DeltaPsim, PMCT, PMCTi
59  2018 Tumor suppressor RARRES1- A novel regulator of fatty acid metabolism in epithelial cells. FASN, PPAR, RARRES1
60  2018 Using [2H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies. ---
61  2017 Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. AdChREBP KO, AT, PAHSAs
62  2017 Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double-blind, crossover study. ACC
63  2017 Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity. OFTT
64  2017 Association between Nicotinamide Phosphoribosyltransferase and de novo Lipogenesis in Nonalcoholic Fatty Liver Disease. CAP, NAFLD, NAMPT
65  2017 Characterization of fat metabolism in the fatty liver caused by a high-fat, low-carbohydrate diet: A study under equal energy conditions. CON, HFLC
66  2017 Conversion of Sugar to Fat: Is Hepatic de Novo Lipogenesis Leading to Metabolic Syndrome and Associated Chronic Diseases? ---
67  2017 Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study. DHA, FAs, NAFLD
68  2017 Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity. IQR, VAT
69  2017 eIF2alpha phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet. eIF2alpha, ER, HFrD, NAFLD, UPR
70  2017 Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease. NAFLD
71  2017 Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones. NAFLD, PPAR
72  2017 Hepatocyte-specific, PPARgamma-regulated mechanisms to promote steatosis in adult mice. FA, HF, MAG, PPARgamma, TAG, TZDs
73  2017 HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRalpha and PPARalpha dysregulation: implications for HIV-specific pathogenesis of NAFLD. LXRalpha, Vpr
74  2017 Increased FNDC5/Irisin expression in human hepatocellular carcinoma. FNDC5, HCC, NOTCH1
75  2017 Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype. CE, eWAT, FA, TAG, WAT
76  2017 Mammalian target of rapamycin complex 1 and FoxO1 in the transcriptional control of lipolysis and de novo lipogenesis. mTORC1
77  2017 Nicotinic acid timed to feeding reverses tissue lipid accumulation and improves glucose control in obese Zucker rats[S]. FFA, NiAc
78  2017 Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications. PA, PEA, PL
79  2017 Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. FAs, NAFLD, TH, TSH
80  2017 Polymorphism rs1761667 in the CD36 Gene Is Associated to Changes in Fatty Acid Metabolism and Circulating Endocannabinoid Levels Distinctively in Normal Weight and Obese Subjects. FA, NW, OB, RBC
81  2017 Pu'erh tea extract-mediated protection against hepatosteatosis and insulin resistance in mice with diet-induced obesity is associated with the induction of de novo lipogenesis in visceral adipose tissue. GPR-120, HFD, PTE, SAT, VAT, WAT
82  2017 Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20. ---
83  2017 The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation. TAG
84  2017 The role of glucose, insulin and NEFA in regulating tissue triglyceride accumulation: Substrate cooperation in adipose tissue versus substrate competition in skeletal muscle. SCAT
85  2017 Young, healthy South Asians have enhanced lipogenic sensitivity to dietary sugar. TG, VLDL
86  2016 A brominated flame retardant 2,2',4,4' tetrabrominated diphenyl ether (BDE-47) leads to lipogenesis in the copepod Tigriopus japonicus. ACC, ACLY, SREBP
87  2016 Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. mTORC2, WAT
88  2016 Associations of erythrocyte fatty acid patterns with insulin resistance. FAs, HOMA-IR
89  2016 ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. ACLY, CoA
90  2016 BDE-47 induces oxidative stress, activates MAPK signaling pathway, and elevates de novo lipogenesis in the copepod Paracyclopina nana. ERK, JNK, MAPK, PUFAs, SFAs, TFs
91  2016 Calorie Restricted High Protein Diets Downregulate Lipogenesis and Lower Intrahepatic Triglyceride Concentrations in Male Rats. AL, CR, FASN, HOMA-beta, HOMA-IR, PDK4, PRO, SCD1
92  2016 Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease. NAFLD
93  2016 De novo lipogenesis in Atlantic salmon adipocytes. ---
94  2016 De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose. ---
95  2016 Denovo lipogenesis is suppressed during fasting but upregulated at population decline in cyclic voles. ACC1, FAS
96  2016 Dietary carbohydrate and control of hepatic gene expression: mechanistic links from ATP and phosphate ester homeostasis to the carbohydrate-response element-binding protein. NAFLD
97  2016 Dietary long-chain unsaturated fatty acids acutely and differently reduce the activities of lipogenic enzymes and of citrate carrier in rat liver. ACC, CIC, FAS, PUFAs, SFAs, TAG, UFAs
98  2016 E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis. E4BP4, SREBP
99  2016 Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.). CHO, CTRL, DS, G6PDH, RS
100  2016 Hepatic fatty acid biosynthesis is more responsive to protein than carbohydrate in rainbow trout during acute stimulations. AAs, ACC, ACLY, D6D, Elovl5, FAS, G6PDH, ME, SCD1