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Abbreviation : DRs
Long Form : death receptors
No. Year Title Co-occurring Abbreviation
2022 Cancer and Apoptosis. ECM, IAPs
2022 Combating Cancer Stem-Like Cell-Derived Resistance to Anticancer Protein by Liposome-Mediated Acclimatization Strategy. CSCs, TRAIL
2022 Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks. c-FLIP, NF-kappaB
2021 Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL. TRAIL
2021 Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex. DED, DISC, FADD, IL, TRAIL
2021 Necroptosis: A Novel Pathway in Neuroinflammation. MLKL, Nec-1, RIPK, TLR, TNF
2021 RIPK1-Associated Inborn Errors of Innate Immunity. LOF, PRRs, PTMs
2021 Tanshinone IIA sensitizes TRAIL-induced apoptosis in glioblastoma through inducing the expression of death receptors (and suppressing STAT3 activation). GBM, TIIA, TRAIL
2021 Thymus hirtus sp. algeriensis Boiss. and Reut. volatile oil enhances TRAIL/Apo2L induced apoptosis and inhibits colon carcinogenesis through upregulation of death receptor pathway. DcRs, TS
10  2021 Volatile oil of Teucrium alopecurus sensitizes colon cancer cells to TRAIL-induced cell death. CHOP, DcRs, Sp1, TA
11  2020 Altered mitochondrial calcium handling and cell death by necroptosis: An emerging paradigm. mito-dysfunction
12  2020 CtBP determines ovarian cancer cell fate through repression of death receptors. CtBP2, HGSOC
13  2020 Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway. Cur-NLC
14  2020 Icariin sensitizes human colon cancer cells to TRAIL‑induced apoptosis via ERK‑mediated upregulation of death receptors. CHOP, ICA, ROS, TRAIL
15  2020 Interplay between inflammation and cancer. NK
16  2020 Regulation of pancreatic cancer TRAIL resistance by protein O-GlcNAcylation. OGT
17  2019 Induction of Apoptosis Scutellaria baicalensis Georgi Root Extract by Inactivation of the Phosphatidyl Inositol 3-kinase/Akt Signaling Pathway in Human Leukemia U937 Cells. EESB, MMP, PI3K
18  2019 Ligand nanovectorization using graphene to target cellular death receptors of cancer cell. TRAIL
19  2019 RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer. ROS, SOD3, TRAIL
20  2019 Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma. alpha-SMA, MFBs, TRAIL
21  2019 The Role of TRAIL/DRs in the Modulation of Immune Cells and Responses. ---
22  2019 TRAF2 Controls Death Receptor-Induced Caspase-8 Processing and Facilitates Proinflammatory Signaling. IL-8, KO, TNF
23  2019 Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics. c-FLIP, IAPs
24  2019 [Mechanisms of Procaspase-8 Activation in the Extrinsic Programmed Cell Death Pathway]. DED
25  2018 Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress. ER
26  2018 Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis. rhTRAIL, TRAIL
27  2018 Lipocalin 2 inversely regulates TRAIL sensitivity through p38 MAPK-mediated DR5 regulation in colorectal cancer. CRC, LCN2, TRAIL
28  2018 Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis. CASP8, DISC, FXR
29  2018 Sphingomyelin synthase 2 overexpression promotes cisplatin-induced apoptosis of HepG2 cells. HB, SM, SMS2
30  2018 The Anticancer Properties of Cordycepin and Their Underlying Mechanisms. EGFR, GSK-3beta, MAPKs
31  2018 Trichosanthin enhances sensitivity of non-small cell lung cancer (NSCLC) TRAIL-resistance cells. NSCLC, TCS, TRAIL
32  2017 Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species. ROS, TrxR
33  2017 Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes. iPS-CMs, TRAIL
34  2017 PEGylated TRAIL ameliorates experimental inflammatory arthritis by regulation of Th17 cells and regulatory T cells. CAIA, CIA, RA, TRAIL
35  2017 Plumbagin enhances TRAIL-induced apoptosis of human leukemic Kasumi‑1 cells through upregulation of TRAIL death receptor expression, activation of caspase-8 and inhibition of cFLIP. AML, ROS, rsTRAIL
36  2017 Secretory stressors induce intracellular death receptor accumulation to control apoptosis. ER
37  2016 Hwang-Heuk-San induces apoptosis in HCT116 human colorectal cancer cells through the ROS-mediated activation of caspases and the inactivation of the PI3K/Akt signaling pathway. CRC, HHS, PI3K, ROS
38  2016 Perturbation of the Warburg effect increases the sensitivity of cancer cells to TRAIL-induced cell death. PKM, siR-PTBP1, TNF
39  2016 Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. NCoR
40  2016 Targeting miRNAs associated with surface expression of death receptors to modulate TRAIL resistance in breast cancer. miRNAs, TRAIL
41  2015 Ethanol extract of Kalopanax septemlobus leaf induces caspase-dependent apoptosis associated with activation of AMPK in human hepatocellular carcinoma cells. AMPK, EEKS, MMP
42  2015 Spatial dynamics of TRAIL death receptors in cancer cells. rhTRAIL, TRAIL
43  2015 Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by alpha-mangostin, a xanthone derivative. TNF
44  2015 [Strategy of probe selection for studying mRNAs that participate in receptor-mediated apoptosis signaling]. ---
45  2014 H-Ras regulation of TRAIL death receptor mediated apoptosis. TRAIL
46  2014 Histone deacetylase inhibitor sensitizes apoptosis-resistant melanomas to cytotoxic human T lymphocytes through regulation of TRAIL/DR5 pathway. ---
47  2014 Inhibitory effect of snake venom toxin on NF-kappaB activity prevents human cervical cancer cell growth via increase of death receptor 3 and 5 expression. NF-kappaB, SVT
48  2014 Myriocin induces apoptotic lung cancer cell death via activation of DR4 pathway. ---
49  2014 Structural studies of death receptors. TNF
50  2014 Targeting death receptors for TRAIL by agents designed by Mother Nature. TNF
51  2014 TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells. EC, HUV
52  2013 Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5. TRAIL
53  2013 Constitutive localization of DR4 in lipid rafts is mandatory for TRAIL-induced apoptosis in B-cell hematologic malignancies. FRET, TRAIL
54  2013 Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. HCMV
55  2013 Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions. HCMV, TNFRSF, TRAIL
56  2013 TRAIL induces apoptosis in oral squamous carcinoma cells--a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5. OSCC, rhTRAIL, TRAIL
57  2012 Apoptotic and survival signaling mediated through death receptor members during metamorphosis in the African clawed frog Xenopus laevis. DD, DR, FADD, RBCs, RIP, TNF
58  2012 Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. CHOP, ROS, TRAIL
59  2012 Effects of polymorphisms in TRAILR1 and TNFR1A on the response to anti-TNF therapies in patients with rheumatoid and psoriatic arthritis. PsA, RA, TNF-R1A, TRAIL-R1
60  2012 Human papilloma virus 16 E6 RNA interference enhances cisplatin and death receptor-mediated apoptosis in human cervical carcinoma cells. HPV, rhTRAIL, siRNA, XIAP
61  2012 Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells. FasL, TNFR1, TRAIL
62  2012 Molecular targets of TRAIL-sensitizing agents in colorectal cancer. CRC, TNF
63  2012 Programmed necrosis and autophagy in immune function. ---
64  2012 Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity. EGFR, scTRAIL, TRAIL
65  2012 TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer. DISC, TRAF2
66  2011 Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex. c-FLIP, cFLIP, IL-8, MAPK
67  2011 Death receptor signalling in central nervous system inflammation and demyelination. CNS, MS, TNFR
68  2011 Generation of bivalent and bispecific kringle single domains by loop grafting as potent agonists against death receptors 4 and 5. KD, LCRs
69  2011 RIP1-mediated regulation of lymphocyte survival and death responses. ---
70  2011 Targeting the extrinsic apoptosis signaling pathway for cancer therapy. TNF
71  2011 Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway. CHOP, ROS, TNF
72  2010 FADD: a regulator of life and death. FADD
73  2010 Fenretinide-dependent upregulation of death receptors through ASK1 and p38alpha enhances death receptor ligand-induced cell death in Ewing's sarcoma family of tumours. ESFT, TRAIL
74  2010 Mechanisms of Cell Death and Disease: Advances in Therapeutic Intervention and Drug Discovery--ESH's Eighth International Conference. October 14-17, 2010, Cascais, Portugal. IAP
75  2010 Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. TRAIL
76  2010 Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation. PARAs
77  2009 Death receptor signal transducers: nodes of coordination in immune signaling networks. DD
78  2009 Death receptors: targets for cancer therapy. TNF, TNFR, TRAIL-R
79  2008 Coordinate regulation of autophagy and apoptosis in T cells by death effectors: FADD or foundation. CASP8, FADD
80  2008 Targeting TRAIL death receptors. TRAIL
81  2007 From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. RIP1, ROS
82  2007 Hyperthermia enhances tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human cancer cells. DcRs, TRAIL
83  2007 Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation. RKIP, siRNA, XIAP, YY1
84  2007 The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis. ---
85  2006 Death-receptor activation halts clathrin-dependent endocytosis. ---
86  2006 Xenopus death-domain-containing proteins FADD and RIP1 synergistically activate JNK and NF-kappaB. AP-1, DD, FADD, RIP1, TAK1, TRAF2, xRIP1-DD
87  2005 Dimethyl sulfoxide potentiates death receptor-mediated apoptosis in the human myeloid leukemia U937 cell line through enhancement of mitochondrial membrane depolarization. DMSO, IAPs, TRAIL
88  2005 Homomeric and heteromeric interactions of the extracellular domains of death receptors and death decoy receptors. DcRs, ECDs
89  2005 Mechanism of apoptosis induced by a polysaccharide, from the loach Misgurnus anguillicaudatus (MAP) in human hepatocellular carcinoma cells. MMP, ROS
90  2005 Nonapoptotic functions of FADD-binding death receptors and their signaling molecules. DISC
91  2005 Regulation of death receptors--relevance in cancer therapies. FasR, TNFR
92  2004 Death receptors as targets of cancer therapeutics. TNFR1, TRAIL
93  2004 Human retinoblastoma cells are resistant to apoptosis induced by death receptors: role of caspase-8 gene silencing. FasL, Rb, TRAIL
94  2004 Instant decisions: transcription-independent control of death-receptor-mediated apoptosis. ---
95  2003 Apo2L/TRAIL and its death and decoy receptors. TNF
96  2003 Cellular FLICE-inhibitory protein: an attractive therapeutic target? AD, c-FLIP, MS, RA, TRAIL
97  2003 Identification of interleukin 8 as an inhibitor of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in the ovarian carcinoma cell line OVCAR3. DcRs, IL, TRAIL
98  2003 Protein-based therapeutic approaches targeting death receptors. ---
99  2003 Reovirus-induced apoptosis: A minireview. CNS, TNF
100  2003 Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo. ---