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Abbreviation : DXR
Long Form : 1-deoxy-D-xylulose 5-phosphate reductoisomerase
No. Year Title Co-occurring Abbreviation
2019 A computational study of the molecular basis of antibiotic resistance in a DXR mutant. ---
2019 A novel strategy to enhance terpenoids production using cambial meristematic cells of Tripterygium wilfordii Hook. f. CMCs, DDCs, DXS, HMGS, MJ
2019 Evaluation, characterization, expression profiling, and functional analysis of DXS and DXR genes of Populus trichocarpa. DXP, DXS, MEP
2019 Inhibitory Activity of Plant Essential Oils against E. coli 1-Deoxy-d-xylulose-5-phosphate reductoisomerase. Ec, EOs, MEP, OV, ST, TQ, ZB
2019 iTRAQ-based analysis of leaf proteome identifies important proteins in secondary metabolite biosynthesis and defence pathways crucial to cross-protection against TMV. GGPS, iTRAQ, TMV
2019 Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb. CPT, HMG, MEP, MIA, MVA, SLS, STR
2019 Synthesis and Antimicrobial Evaluation of gamma-Borono Phosphonate Compounds in Escherichia coli and Mycobacterium smegmatis. ---
2018 Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to the Antimalarial Drug Fosmidomycin in E.coli. CREATE
2017 Antimicrobial mechanism of epigallocatechin gallate and gallocatechin gallate: They target 1-deoxy-d-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway. ---
10  2017 Biomass and terpenoids produced by mutant strains of Arthrospira under low temperature and light conditions. ---
11  2017 Comparative Expression Analysis of Rice and Arabidopsis Peroxiredoxin Genes Suggests Conserved or Diversified Roles Between the Two Species and Leads to the Identification of Tandemly Duplicated Rice Peroxiredoxin Genes Differentially Expressed in Seeds. CREs, Prxs, ROS
12  2017 Enzymatic production and emission of floral scent volatiles in Jasminum sambac. BAMT, BEAT, PAL, SAMT, TPS
13  2017 Solanesol Biosynthesis in Plants. DXS, GGPPS, IPI, MEP, SDB
14  2017 Transcriptome Sequencing Analysis Reveals a Difference in Monoterpene Biosynthesis between Scented Lilium 'Siberia' and Unscented Lilium 'Novano'. DEGs, DXS, HDR, HDS, IDI, MYS, OCS
15  2017 Unraveling Massive Crocins Transport and Accumulation through Proteome and Microscopy Tools during the Development of Saffron Stigma. ADH, CRTISO, DXS, ZDS
16  2016 Antimicrobial mechanism of theaflavins: They target 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway. DXP, MEP
17  2016 Functional classification of rice flanking sequence tagged genes using MapMan terms and global understanding on metabolic and regulatory pathways affected by dxr mutant having defects in light response. FSTs, GO, IRFGC, MEP, non-TE
18  2016 Inhibition of green tea and the catechins against 1-deoxy-d-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway. ---
19  2016 Magnesium and manganese interactively modulate parthenolide accumulation and the antioxidant defense system in the leaves of Tanacetum parthenium. COS, GAO, GAS, HDR, HMGR, Mn, PTS
20  2016 Organ- and Growing Stage-Specific Expression of Solanesol Biosynthesis Genes in Nicotiana tabacum Reveals Their Association with Solanesol Content. DXS, IPI
21  2016 Redirection of metabolite biosynthesis from hydroxybenzoates to volatile terpenoids in green hairy roots of Daucus carota. DXS, HBD, MEP, PAL, PHBA, PK, SKDH
22  2016 [Cloning and expression analysis of 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene (CcDXR1) in Cinnamomum camphora L.) Presl]. CcDXR1, RACE
23  2015 Engineering a Platform for Photosynthetic Pigment, Hormone and Cembrane-Related Diterpenoid Production in Nicotiana tabacum. ---
24  2015 Enhanced production of steviol glycosides in mycorrhizal plants: a concerted effect of arbuscular mycorrhizal symbiosis on transcription of biosynthetic genes. AMF, CPPS, KAH, MDS, MEP, Reb-A, SGs, Stev, stev, UDP
25  2015 Molecular Cloning and Characterization of DXS and DXR Genes in the Terpenoid Biosynthetic Pathway of Tripterygium wilfordii. DXS
26  2015 Molecular cloning, characterization and expression analysis of the gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Aquilaria sinensis (Lour.) Gilg. MEP, ORF, RACE, RT-PCR
27  2015 N-acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR. ---
28  2015 Novel insights into structure-function mechanism and tissue-specific expression profiling of full-length dxr gene from Cymbopogon winterianus. DXP, MEP
29  2015 Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues. ---
30  2014 A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites. HAD, MEP
31  2014 Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin. ---
32  2014 Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR). ---
33  2014 Effects of Streptomyces pactum Act12 on Salvia miltiorrhiza hairy root growth and tanshinone synthesis and its mechanisms. DXS, GGPPS, HMGR
34  2014 Enhanced production of bioactive isoprenoid compounds from cell suspension cultures of Artemisia annua L. using beta-cyclodextrins. CDs, DIMEB
35  2014 Flowery odor formation revealed by differential expression of monoterpene biosynthetic genes and monoterpene accumulation in rose (Rosa rugosa Thunb.). AAT, DXS, LIS
36  2014 Virtual Screening of compounds to 1-deoxy-Dxylulose 5-phosphate reductoisomerase (DXR) from Plasmodium falciparum. ---
37  2014 [Roles of reactive oxygen species in Streptomyces pactum Act12-induced tanshinone production in Salvia miltiorrhiza hairy roots]. HMGR, ROS
38  2013 Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase. PfDXR, QSAR
39  2013 Cloning and characterization of 2-C-methyl-D-erythritol-4-phosphate pathway genes for isoprenoid biosynthesis from Indian ginseng, Withania somnifera. DXS, MVA, WsDXS
40  2013 Enzyme inhibitor studies reveal complex control of methyl-D-erythritol 4-phosphate (MEP) pathway enzyme expression in Catharanthus roseus. DXS, HDS, MEP, MIA
41  2013 Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase. TgDXR
42  2013 Mechanistic insights into 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a key enzyme of the MEP terpenoid biosynthetic pathway. DXP
43  2013 Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum. DXS, MEP, P. falciparum
44  2013 Significantly enhanced production of isoprene by ordered coexpression of genes dxs, dxr, and idi in Escherichia coli. dxs, IPP, IspS
45  2012 Crystal structure of Brucella abortus deoxyxylulose-5-phosphate reductoisomerase-like (DRL) enzyme involved in isoprenoid biosynthesis. DRL, DRL, MEP
46  2012 Different roles of the mevalonate and methylerythritol phosphate pathways in cell growth and tanshinone production of Salvia miltiorrhiza hairy roots. DXS, HMGR, MEP, MVA
47  2012 Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR). ---
48  2012 PEG and ABA trigger methyl jasmonate accumulation to induce the MEP pathway and increase tanshinone production in Salvia miltiorrhiza hairy roots. ABA, DXS, Fos, HMGR, IBU, MEP, MEV, MJ, MVA, PEG, TUN
49  2012 Resistance of Francisella novicida to fosmidomycin associated with mutations in the glycerol-3-phosphate transporter. Fos, GlpT, MEP
50  2012 Roles of reactive oxygen species in methyl jasmonate and nitric oxide-induced tanshinone production in Salvia miltiorrhiza hairy roots. CAT, HMGR, MJ, NO, ROS, SNP, SOD
51  2012 Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase. ITC
52  2012 [Cloning and expression regulation of 1-deoxy-D-xylulose-5-phosphate reductoisomerase cDNA from Alpinia officinarum]. MeJA, MEP, RACE
53  2011 A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling. ---
54  2011 Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. MEP
55  2011 Design, synthesis, and X-ray crystallographic studies of alpha-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase. MtDXR
56  2011 Expression of carotenoid biosynthetic pathway genes and changes in carotenoids during ripening in tomato (Lycopersicon esculentum). PDS, PSY, ZDS
57  2011 Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies. EcDXR, QSAR, SAR
58  2011 Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum. ---
59  2011 Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes. ---
60  2010 Computational analysis of the evolution of 1-deoxy-D-xylulose-5-phosphate Reductoisomerase, an important enzyme in plant terpene biosynthesis. cTP, lTP
61  2010 Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding. MEP, MPD, tDXR
62  2010 Crystallization and preliminary X-ray crystallographic study of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Plasmodium falciparum. DXP, MEP
63  2010 Disruption of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) gene results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis. ABA, GAs, MEP
64  2010 Effect of sugars on artemisinin production in Artemisia annua L.: transcription and metabolite measurements. AA, AB, ADS, AN, DHAA, DXS, FPS, HMGR
65  2010 Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene. ---
66  2010 Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase. ---
67  2009 Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. ---
68  2007 Apocarotenoid biosynthesis in arbuscular mycorrhizal roots: contributions from methylerythritol phosphate pathway isogenes and tools for its manipulation. AM, DXS, MEP
69  2007 Double ester prodrugs of FR900098 display enhanced in-vitro antimalarial activity. ---
70  2007 Elicitor induced activation of the methylerythritol phosphate pathway toward phytoalexins biosynthesis in rice. DXS, LIE, MEP
71  2007 Functional identification and differential expression of 1-deoxy-D-xylulose 5-phosphate synthase in induced terpenoid resin formation of Norway spruce (Picea abies). DXS, HDR, MEP
72  2007 Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycin. ---
73  2007 Synthesis and evaluation of alpha,beta-unsaturated alpha-aryl-substituted fosmidomycin analogues as DXR inhibitors. ---
74  2007 Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme. DXP, MEP, NADPH
75  2007 [Evaluation of in vitro antibacterial activity of fosmidomycin and its derivatives]. MEP
76  2006 Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase. ---
77  2006 Kinetic characterization of Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase mutants. ---
78  2005 A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. ---
79  2005 Mutation in the flexible loop of 1-deoxy-D-xylulose 5-phosphate reductoisomerase broadens substrate utilization. DXP
80  2005 The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. DXS, MVA
81  2005 The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation. ---
82  2005 [Effects of fosmidomycin and lovastatin treatment on taxol biosynthesis in suspension culture cells of Taxus chinensis]. HMGR, IPP, MJ
83  2004 1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview. DXP, MEP
84  2004 Cloning, characterization, and immunolocalization of a mycorrhiza-inducible 1-deoxy-d-xylulose 5-phosphate reductoisomerase in arbuscule-containing cells of maize. EST
85  2004 Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites. ABA, G10H, IPP, MECS, MEP, MIAs, MVA
86  2004 Crystal structure of 1-deoxy-d-xylulose-5-phosphate reductoisomerase from Zymomonas mobilis at 1.9-A resolution. ---
87  2004 Forest tent caterpillars (Malacosoma disstria) induce local and systemic diurnal emissions of terpenoid volatiles in hybrid poplar (Populus trichocarpa x deltoides): cDNA cloning, functional characterization, and patterns of gene expression of (-)-germacrene D synthase, PtdTPS1. DMNT, FTCs, HMGR, IPS, MeJA
88  2004 Inhibition of isoprene biosynthesis pathway enzymes by phosphonates, bisphosphonates, and diphosphates. FPPS, IPPI
89  2004 [Cloning and analysis of cDNA encoding key enzyme gene (dxr) of the non-MVA pathway in Taxus chinensis cells]. ---
90  2003 Characterization of native and histidine-tagged deoxyxylulose 5-phosphate reductoisomerase from the cyanobacterium Synechocystis sp. PCC6803. SDS-PAGE
91  2003 Isoprenoid biosynthesis via the MEP pathway. Synthesis of (3,4)-3,4-dihydroxy-5-oxohexylphosphonic acid, an isosteric analogue of 1-deoxy-D-xylulose 5-phosphate, the substrate of the 1-deoxy-D-xylulose 5-phosphate reducto-isomerase. DXP
92  2003 Scale-up of Artemisia annua L. hairy root cultures produces complex patterns of terpenoid gene expression. DXS, FPS, HMGR
93  2002 Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. ---
94  2002 Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with cofactors: implications of a flexible loop movement upon substrate binding. ---
95  2002 Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. ---
96  2000 Arbuscular mycorrhizal fungi induce the non-mevalonate methylerythritol phosphate pathway of isoprenoid biosynthesis correlated with accumulation of the 'yellow pigment' and other apocarotenoids. DXS, MEP
97  1999 Cloning and heterologous expression of a cDNA encoding 1-deoxy-D-xylulose-5-phosphate reductoisomerase of Arabidopsis thaliana. DOXP, MEP